Clinical trials: Closed-Loop Glucose Control
Type 1 Diabetes
Dual-Hormone Closed-Loop Glucose Control in Adolescents With Type 1 Diabetes
Objective: To assess the efficacy and safety of an insulin-glucagon dual-hormone (DH) closed-loop system compared with an insulin-only single-hormone (SH) closed-loop system in adolescent with type 1 diabetes.
- Trial name
- DHCL2021 (NCT04949867)
- Testing
- Glucagon, Closed-loop System
- Where
- 2 sites in Denmark
- Volunteers
- 11 people
- Sponsor
- Steno Diabetes Center Copenhagen
Closed Loop, Diabetes Mellitus, Type 1
Diabeloop for Teens
An open-label, three-centers, controlled, randomized, and crossover study containing 14 days of baseline period with standard of care (SOC) therapy followed by two-sessions of 4-weeks home study phase with Diabeloop closed-loop…
- Conditions
- Closed Loop, Diabetes Mellitus, Type 1, Adolescents (12 to 17 Years Old)
- Trial name
- DBL4T (NCT04725591)
- Testing
- Dexcom G6 Continuous Glucose Monitoring, MEDISAFE WITH External Insulin Pump, Diabeloop Software (Model predictive control)
- Where
- 3 sites in Belgium, France and 1 more
- Volunteers
- 49 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type 1 Diabetes, Diabetes Mellitus
Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide
A closed-loop insulin system, often labelled the "artificial pancreas" (AP), consists of an insulin pump, a continuous glucose monitor, and an interface coordinating between them to regulate insulin dosage based on glucose…
- Trial name
- SEMA SMA (NCT06387199)
- Testing
- Semaglutide with 4 meal strategies
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Type 1 Diabetic Nephropathy
The Impact of Sitagliptin as an Add on Therapy With Closed Loop Control in Adolescents With Diabetic Nephropathy
Diabetic nephropathy (DN) is one of the most frequent microvascular complications of diabetes mellitus, affecting 25 to 40% of patients with type 1 diabetes (T1DM).
- Trial name
- NCT06115460
- Testing
- oral sitagliptin supplementation
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Ain Shams University
Type 1 Diabetes
Inpatient Evaluation of an Automated Closed-Loop Control-to-Range System
The purpose of this study is to test an insulin management system ("Control-to-Range (CTR) system") in an inpatient setting to see if the system is safe and effective enough to test in a future at-home study.
- Trial name
- CTR (NCT01271023)
- Testing
- Control-to-Range Automated Insulin Management System
- Where
- 7 sites in United States, France and 2 more
- Volunteers
- 57 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus, Type 1
Closed-Loop Control in Young Children 5-8 Years Old Using DiAs Platform
The overall aim of this proposed research is to determine the safety, feasibility and efficacy (AP vs at home use of SAP) of the Diabetes Assistant (DiAs) controller in day and night closed-loop control in young children 5-8…
- Trial name
- NCT02750267
- Testing
- Diabetes Assistant (DiAs) with Closed-Loop
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Type 1 Diabetes, Insulin Therapy
Study on the Use of the Insulin Pump Tandem X:2 With Control IQ Algorithm - Update
The aim of this observational clinical trial is to obtain data on the safety, efficacy and satisfaction of the Tandem T:Slim X:2 Pump System in patients with type 1 diabetes.
- Trial name
- UNIQUE (NCT05118945)
- Testing
- Insulin pump Tandem: t:slim X2
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Type 1 Diabetes Mellitus in Prepubertal Children
Efficacy of Closed-loop Insulin Therapy in Prepubertal Child in Free-life
The study is a randomized trial preceded by a run-in period and followed by a non-randomized study extension. After 3 weeks of outpatient use of study pump (1 week) and study pump+CGM (2weeks) as run-in period, patient and…
- Trial name
- FREELIFE-KID (NCT03739099)
- Testing
- Closed-loop insulin infusion driven by continuous glucose monitoring through an algorithm, in free-life conditions
- Where
- France
- Volunteers
- 122 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes, Closed Loop
Semi-closed Loop Automated Insulin Therapy in the Pediatric Population Aged 2-6 Years With Type 1 Diabetes: Impact on Quality of Life and Glycemic Control
The incidence of type 1 diabetes is increasing, with an incidence of +4% per year in France today. The treatment for type 1 diabetes is insulin therapy.
- Conditions
- Type 1 Diabetes, Closed Loop, Insulin, Quality of Life
- Trial name
- Diablife (NCT06875167)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Fondation Lenval
Type 1 Diabetes Mellitus
Reducing Risks and Improving Glucose Control During Extended Exercise in Youth With T1DM: The AP Ski Camp
The biggest challenges for glycemic control during the day time involve meals and exercise variations, which are impacted by age, fitness level, duration, intensity and history of exercise.
- Trial name
- NCT02604524
- Testing
- Closed-Loop Control, Sensor Augmented Pump Therapy
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Daniel Chernavvsky, MD, CRC
Diabetes Mellitus, Type 1
Safety and Efficacy of Artificial Pancreas With and Without a Meal Detection Module on Glycemic Control in Adolescents With Type 1 Diabetes After a Missed Bolus
Despite current treatments for type 1 diabetes, maintaining blood glucose levels within a good range is a difficult task. A primary source for poor glucose control in adolescents is skipping insulin boluses at mealtimes.
- Trial name
- NCT02909829
- Testing
- Closed Loop Delivery, Closed Loop Delivery with Meal Detection Module, Conventional Pump Therapy
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- McGill University
Type 1 Diabetes
Closing the Loop in Adolescents During Non-compliance Behaviours
The ultimate goal of the investigators ongoing research is the development of a closed-loop system for insulin delivery, which can help people with type 1 diabetes (T1D) attain a tight glucose control avoiding the risk of…
- Trial name
- NCT01629277
- Testing
- Closed-loop, standard insulin pump
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Cambridge
Type 1 Diabetes
Use of an Automated Insulin Delivery System Compared to Sensor Augmented Pump at Patients With Type 1 Diabetes (T1D)
Title: An open-label, three-center, randomized, cross-over study to evaluate the safety and efficacy of day and night closed-loop control using the MD-Logic automated insulin delivery system compared to sensor augmented pump…
- Trial name
- DREAM5 (NCT02636491)
- Testing
- MD-Logic-Automated Insulin Delivery System, MiniMed Paradigm® Veo™ System
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Type 1 Diabetes
Closing the Loop in People with Type 1 Diabetes
The main objective of this study is to determine whether home use of fully closed-loop glucose control applying age-approved ultra-rapid insulin (Phase 2) is superior to standard insulin pump therapy with continuous glucose…
- Trial name
- CLEAR Phase 2 (NCT05653050)
- Testing
- CamAPS HX, Standard insulin pump therapy with CGM
- Where
- 4 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Cambridge
Type 1 Diabetes
Safety Evaluation of an Advanced Hybrid Closed Loop System Using Lyumjev With the Tandem t:Slim X2 Insulin Pump With Control-IQ Technology in Adults, Adolescents and Children With Type 1 Diabetes
Prospective, multi-center, single-arm study in adults and children ages 6 to 80 with type 1 diabetes to evaluate the safety of Lyumjev with Control-IQ technology to achieve labeling updates for Lyumjev and the t:slim X2 insulin…
- Trial name
- NCT05403502
- Testing
- t:slim X2 insulin pump with Control-IQ technology 1.5
- Where
- 13 sites in United States
- Volunteers
- 183 people
- Sponsor
- Tandem Diabetes Care, Inc.
Type 1 Diabetes
Multi-center Trial in Adult and Pediatric Patients With Type 1 Diabetes Using Hybrid Closed Loop System and Control at Home
The purpose of this study is to evaluate the safety and effectiveness of the Hybrid Closed Loop system (HCL) in adult and pediatric patients with type 1 diabetes in the home setting.
- Trial name
- NCT02748018
- Testing
- 670G and 770G Insulin Pump, Subject's Current Diabetes Therapy
- Where
- 36 sites in United States, Canada and 7 more
- Volunteers
- 959 people
- Sponsor
- Medtronic MiniMed, Inc.
Diabetes Mellitus, Type 1
The Impact of Hybrid Closed-loop Insulin Delivery in Type 1 Diabetes on Glycemic Control and PROMs
Since February 2019 the first hybrid closed-loop insulin pump, the Medtronic MiniMed 670G system, has been offered to people with type 1 diabetes in Belgium.
- Trial name
- INRANGE (NCT04414280)
- Testing
- Medtronic MiniMed 670G, Medtronic MiniMed 780G, Tandem Control-IQ
- Where
- 38 sites in Belgium
- Volunteers
- 1,600 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Type 1 Diabetes
Closed-loop Control of Overnight Glucose Levels in Adults and Adolescents With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT01905020
- Testing
- Carbohydrate-rich meal, Exercise
- Where
- 3 sites in Canada
- Volunteers
- 28 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes Mellitus
The Artificial Pancreas in Very Young Children With T1D - Pilot (KidsAP01)
The suggested clinical trial is part of the KidsAP project funded by the European Commission's Horizon 2020 Framework Programme.
- Trial name
- NCT03101865
- Testing
- FlorenceM
- Where
- 7 sites in Austria, Germany and 2 more
- Volunteers
- 24 people
- Sponsor
- University of Cambridge
Diabetes Mellitus, Type 1
Achieving Rapid, Safe and Sustained Glucose Control in Adolescents With Suboptimally Controlled Type 1 Diabetes Using Advanced Hybrid Closed Loop Systems
The rational of this study is to assess if AHCL systems are able to achieve a better metabolic control (better glucometric data) after 2 weeks, 1 months.
- Trial name
- NCT06305377
- Testing
- Tandem Control IQ
- Volunteers
- 20 people
- Sponsor
- Giulio Frontino