Clinical trials: Closed-Loop Glucose Control
Closed Loop, Diabetes Mellitus, Type 1
Diabeloop WP6.2 : Crossover Evaluation of Glycemic Control
The study will be conducted in crossover trial, with two 72-hour hospitalization separated by a period Wash-out of at least one week. Each hospitalization is a period of treatment.
- Trial name
- WP6-2 (NCT02627911)
- Testing
- Diabeloop System, Continuous Glucose Monitoring, Accelerometer and heart rate monitor
- Where
- 9 sites in France
- Volunteers
- 36 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 60 Hours in Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT01966393
- Testing
- 60-hours intervention
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes
Dual-Hormone Closed-Loop Glucose Control in Adolescents With Type 1 Diabetes
Objective: To assess the efficacy and safety of an insulin-glucagon dual-hormone (DH) closed-loop system compared with an insulin-only single-hormone (SH) closed-loop system in adolescent with type 1 diabetes.
- Trial name
- DHCL2021 (NCT04949867)
- Testing
- Glucagon, Closed-loop System
- Where
- 2 sites in Denmark
- Volunteers
- 11 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes
Closing the Loop in Adults With Type 1 Diabetes and HbA1C<7.5% Under Free Living Conditions
The main objective of this study is to determine whether day and night closed-loop insulin delivery for 4 weeks under free living conditions is superior to usual insulin pump therapy in adults with type 1 diabetes and HbA1C<7.5%.
- Trial name
- NCT02727231
- Testing
- Florence D2A or similar closed loop glucose control system, CSII with CGM
- Where
- 2 sites in Austria, United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Cambridge
Type 1 Diabetes, Type 2 Diabetes
Closed Loop Glucose Control in a Simulated ICU Setting
This is a proof of concept safety study of a rule-based closed loop glucose control system designed for use in the intensive care unit setting.
- Conditions
- Type 1 Diabetes, Type 2 Diabetes, Stress Induced Hyperglycemia
- Trial name
- NCT07646067
- Testing
- FUSION closed loop glucose control system
- Volunteers
- 6 people
- Sponsor
- Ideal Medical Technologies
Type 1 Diabetes, Type 2 Diabetes Treated With Insulin
Inpatient Closed Loop Glucose Control With the Gen 2 GlucoSTAT
The goal of this study is to perform a first-in-humans trial of a fully integrated, automated, closed-loop blood glucose control system designed for inpatient use.
- Trial name
- NCT04227626
- Testing
- GlucoSTAT
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes
Evaluation of The Postprandial Impact of Automated Priming Bolus for Full Closed Loop Insulin Delivery
The purpose of this study is to understand the impact of the automated priming boluses on the safety and feasibility of a new fully automated AP controller.
- Trial name
- Rocket-BPS (NCT05528770)
- Testing
- FCL+BPS, FCL
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Marc Breton
Perioperative Hyperglycaemia, Insulin Therapy
Fully Closed-Loop Insulin Delivery in Abdominal Surgery (CLAB)
The purpose of the study is to assess the efficacy, safety and usability of perioperative fully-automated closed-loop insulin delivery versus standard insulin therapy in patients with diabetes other than type 1 diabetes…
- Conditions
- Perioperative Hyperglycaemia, Insulin Therapy, Elective Surgery, Closed-Loop Glucose Control
- Trial name
- CLAB (NCT05392452)
- Testing
- CamAPS HX, Standard insulin therapy
- Where
- 2 sites in Switzerland
- Volunteers
- 38 people
- Sponsor
- Lia Bally
Hyperglycemia, Diabetes
Insulin Balanced Infusion System
The purpose of this study is to study the use of a counterbalancing system of glucose and insulin infusion with frequent blood glucose monitoring and combined adaptive algorithm can produce tight glycemic control without…
- Trial name
- NCT01291719
- Testing
- glucose and insulin infusions
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Admetsys Corporation
Diabetes Mellitus, Type 1
Project Nightlight: Efficacy and System Acceptance of Dinner/Night vs. 24hr Closed Loop Control
The purpose of this study is to use an investigational type of technology called Closed-Loop Control (CLC) Medical Platform System to help control blood sugar in people with type 1 diabetes mellitus in a home setting.
- Trial name
- NCT02679287
- Testing
- CLC
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of Virginia
Closed Loop, Diabetes Mellitus, Type 1
Diabeloop for Teens
An open-label, three-centers, controlled, randomized, and crossover study containing 14 days of baseline period with standard of care (SOC) therapy followed by two-sessions of 4-weeks home study phase with Diabeloop closed-loop…
- Conditions
- Closed Loop, Diabetes Mellitus, Type 1, Adolescents (12 to 17 Years Old)
- Trial name
- DBL4T (NCT04725591)
- Testing
- Dexcom G6 Continuous Glucose Monitoring, MEDISAFE WITH External Insulin Pump, Diabeloop Software (Model predictive control)
- Where
- 3 sites in Belgium, France and 1 more
- Volunteers
- 49 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type 1 Diabetes
Closed-Loop Insulin Delivery During Pregnancy (IADIABENCEINTE)
The imbalance of diabetes is associated with an increased risk of maternal and fetal complications. In women, it can cause abortion, hypertension, preeclampsia, and obstructed labor; in the fetus, it increases the risk of many…
- Trial name
- IADIABENCEIN (NCT05661149)
- Testing
- Hybrid closed loop insulin delivery systems
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Sud Francilien
Diabetes Mellitus, Type 1
Early Feasibility Study 2 of Outpatient Control-to-Range - Testing System Efficacy (Italy)
An unblinded, randomized, cross-over design with each patient participating in two 40-hour outpatient admissions: (a) Experimental involving automated Control to Range (CTR) and (b) Control using Continuous Glucose Monitor (CGM)…
- Trial name
- NCT01727817
- Testing
- Diabetes Assistant (DiAs)
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1, Diabetes Mellitus, Brittle
Diabeloop for Highly Unstable Type 1 Diabetes
Feasibility study, comparing experimental treatment (DBLHU closed-loop system) with reference treatment (Low Glucose Predictive Suspend system) in 7 patients going through a series of N-of-1 trials.
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Brittle, Closed-Loop
- Trial name
- DBLHU (NCT04042207)
- Testing
- Low Glucose Predictive Suspend system, DBLHU System
- Where
- 2 sites in France
- Volunteers
- 7 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type 1 Diabetes, Diabetes Mellitus
Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide
A closed-loop insulin system, often labelled the "artificial pancreas" (AP), consists of an insulin pump, a continuous glucose monitor, and an interface coordinating between them to regulate insulin dosage based on glucose…
- Trial name
- SEMA SMA (NCT06387199)
- Testing
- Semaglutide with 4 meal strategies
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Type 1 Diabetic Nephropathy
The Impact of Sitagliptin as an Add on Therapy With Closed Loop Control in Adolescents With Diabetic Nephropathy
Diabetic nephropathy (DN) is one of the most frequent microvascular complications of diabetes mellitus, affecting 25 to 40% of patients with type 1 diabetes (T1DM).
- Trial name
- NCT06115460
- Testing
- oral sitagliptin supplementation
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Ain Shams University
Type 1 Diabetes Mellitus
HCL in Adults With T1DM, Markedly Elevated HbA1c, and Psychological Vulnerability
The objective of this study is to evaluate whether the mylife CamAPS FX hybrid closed loop (HCL) system improves glycemic control and quality of life in type 1 diabetes (T1DM) patients with a chronic lack of glycemic control and…
- Trial name
- Hi-Loop (NCT07509060)
- Testing
- mylife CamAPS FX hybrid closed-loop system
- Where
- 3 sites in Poland
- Volunteers
- 30 people
- Sponsor
- Jerzy Hohendorff
Type 1 Diabetes
Dual-hormone Artificial Pancreas Versus Single-hormone Under Exercise and a Meal Challenge
The present clinical trial aims to examine alternative strategies for preventing/mitigating hypoglycemic events among adults with type 1 diabetes utilizing a highly personalized control system.
- Trial name
- TAILOR/3 (NCT06082973)
- Testing
- Automated insulin delivery system algorithm with a dual-hormone configuration (insulin and glucagon) for glucose control, Automated insulin delivery system with a single-hormone configuration (insulin) with rescue carbohydrate recommendations for glucose control
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Universitat Politècnica de València
Type 1 Diabetes
Inpatient Evaluation of an Automated Closed-Loop Control-to-Range System
The purpose of this study is to test an insulin management system ("Control-to-Range (CTR) system") in an inpatient setting to see if the system is safe and effective enough to test in a future at-home study.
- Trial name
- CTR (NCT01271023)
- Testing
- Control-to-Range Automated Insulin Management System
- Where
- 7 sites in United States, France and 2 more
- Volunteers
- 57 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus, Type 1
Algorithm to Control Postprandial, Post Exercise and Night Glucose Excursions in a Portable Closed Loop Format
In previous studies, we tested the feasibility of a bi-hormonal closed loop system. This system for automated control of blood glucose in patients with type 1 diabetes was tested in the clinical research center as well as at the…
- Trial name
- APPEL4 (NCT02160275)
- Testing
- Artificial Pancreas (Inreda Diabetic BV), Insulin pump therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 16 people
- Sponsor
- J.H. DeVries