Clinical trials: Co-occurring Mental and Substance Use Disorders
Adolescent Substance Abuse, Attention Deficit Hyperactivity Disorder
Family-Based Protocol for Medication Integration in Treatment of Comorbid ASU/ADHD in Routine Care
The goal of this proposal is to develop and pilot a brief protocol designed to systematically integrate pharmacological interventions for attention deficit hyperactivity disorder (ADHD) into behavioral treatment services for…
- Trial name
- NCT01539941
- Testing
- Medication integration protocol
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The National Center on Addiction and Substance Abuse at Columbia University
Substance Use, Mental Health Issue
Adolescent Screening and Personalized Intervention Resource for Enhancement of Behavioral Health and Substance Use
Only a small fraction of youth who are beginning to experience behavioral health problems and use alcohol or illicit drugs receive needed treatment services due to the lack of accessible, effective early intervention resources.
- Trial name
- ASPIRE (NCT06306287)
- Testing
- ePACE Personalized Intervention, eFACE Fixed Intervention
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Substance Use Disorders, PTSD
Evaluation of RRFT for Co-occurring SUD and PTSD Among Teens
Psychosocial traumatic events during childhood, serve as strong and consistent predictors of substance use problems (SUP) during adolescence and adulthood.PTSD that extends from such trauma often co-occurs with SUP.
- Trial name
- STAR (NCT05384223)
- Testing
- RRFT (Risk Reduction through Family Therapy), ENCOMPASS (Integrated Treatment for Adolescents and Young Adults)
- Where
- 2 sites in United States
- Volunteers
- 212 people
- Sponsor
- Medical University of South Carolina
Depression, Substance Use Disorders
Effectiveness of Depression and Substance Use Module for Patients With Co-occurring Disorders
The purpose of this study is to evaluate the adaptation and effectiveness of an integrated treatment module, the Depression and Substance Use Disorder Module (D-SUD-M), for male patients experiencing co-occurring depression and…
- Trial name
- D-SUD-M (NCT07705113)
- Testing
- Experimental Group: Treatment Module D-SUD-M, Control Group
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- International Islamic University, Islamabad
Substance Use, Substance-Related Disorders
Clinician Practice Companion to Address Youth Substance Use
Substance use, including the use of opioids, cannabis, and other drugs, is common among adolescents and young adults, and overdose has become a leading cause of death among youth in Canada and the United States.
- Conditions
- Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use
- Trial name
- NCT07725289
- Testing
- Practice Companion
- Where
- 5 sites in United States, Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cannabis-Related Disorder, Substance-Related Disorders
First Episode Schizophrenia and Cannabis-Related Disorder Study
Many individuals with schizophrenia abuse cannabis at the onset of their illness, portending a poorer course of illness and poorer treatment response.
- Conditions
- Cannabis-Related Disorder, Substance-Related Disorders, Schizophrenia, Psychotic Disorders
- Trial name
- NCT00573287
- Testing
- clozapine, risperidone
- Where
- 5 sites in United States
- Volunteers
- 14 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Substance Use Disorders, Bipolar Disorder
Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation
This study proposes to use quetiapine as an adjunct treatment to treatment as usual to improve both substance use disorder (SUD) and mood symptoms in youth with SUD and severe mood dysregulation (SMD).
- Conditions
- Substance Use Disorders, Bipolar Disorder, Mood Disorders
- Trial name
- NCT02845453
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Boston Medical Center
ADHD, Cannabis Use Disorder
Delayed-Release, Extended-Release Methylphenidate (Jornay PM) for Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Cannabis Use Disorder
The goal of this clinical trial is to look at how delayed-release, extended-release methylphenidate (Jornay PM), an FDA-approved medication for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD), works to treat ADHD…
- Trial name
- NCT07838311
- Testing
- Delayed-release, extended-release methylphenidate
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Massachusetts General Hospital
Posttraumatic Stress Disorder, Alcohol Use Disorders
CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders
The proposed study will examine the efficacy of doxazosin in the treatment of PTSD and alcohol use disorder or substance use disorders.
- Trial name
- Doxazosin (NCT02500602)
- Testing
- doxazosin
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- VA Office of Research and Development
Co-Occurring Disorders, Homelessness
Maintaining Independence and Sobriety Through Systems Integration, Outreach, and Networking
This study seeks to implement wrap around services for Veterans suffering from co-occurring mental illness and substance use and who are homeless.
- Conditions
- Co-Occurring Disorders, Homelessness, Substance Abuse Disorder, Mental Illness
- Trial name
- MISSION-HPACT (NCT02942979)
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- VA Office of Research and Development