Clinical trials: Cognition Function
Cerebral Palsy
Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study
The study design is a single-subject ABA clinical trial that is investigating the feasibility including adherence, safety and tolerability of metformin in children aged 5 to 18 years with cerebral palsy (CP).
- Trial name
- NCT03710343
- Testing
- Metformin
- Where
- 2 sites in Canada
- Volunteers
- 3 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Cognitive Function, Academic Performance
Effect of Omega-3 LCPUFA Intervention on Learning, Cognition, Behaviour and Visual Processing.
The brain is primarily developed in the third trimester of pregnancy, but continues maturing through the late twenties, especially the prefrontal cortex.
- Conditions
- Cognitive Function, Academic Performance, Mental Health
- Trial name
- NCT02240264
- Testing
- Krill oil capsules
- Where
- 17 sites in Netherlands
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Open University
Epilepsy, Epilepsia
Physical Exercise in Subjects With Juvenile Myoclonic Epilepsy
Epilepsy is a chronic neurologic disorder characterized by seizures. Beside seizures people suffering from epilepsy experience several challenges related to education, work and everyday life such as learning-, problem-solving…
- Conditions
- Epilepsy, Epilepsia, Epileptic Seizures, Seizure Disorder
- Trial name
- EFA (NCT01450423)
- Testing
- Physical activity
- Where
- 2 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- Lars Bo Andersen
Quality of Life, Aortic Valve Stenosis
Frailty and Cognitive Function Assessment of TAVI Patients
Aortic stenosis (AS) is the most common valve disease among the adult population, in the majority of the cases it only requires treatment in advanced age.
- Conditions
- Quality of Life, Aortic Valve Stenosis, Heart Valve Disease
- Trial name
- NCT02650388
- Testing
- Cognitive fuction, quality of life
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Hungarian Institute of Cardiology
Congenital Heart Disease
Brain Function in Children With Congenital Heart Disease (CHD)
The purpose of the study is to determine whether the neurodevelopmental outcome and in particular executive functions in 9 to 14 year old school children with congenital heart disease who underwent cardiopulmonary bypass surgery…
- Trial name
- NCT02814539
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bea Latal
Mucopolysaccharidosis Type I, Mucopolysaccharidosis Type II
Longitudinal Studies of Brain Structure and Function in MPS Disorders
Neurobehavioral function and quality of life are compromised in many patients with mucopolysaccharidosis (MPS) disorders. The long-term goals of this research are to: 1) more accurately inform patients/parents regarding potential…
- Conditions
- Mucopolysaccharidosis Type I, Mucopolysaccharidosis Type II, Mucopolysaccharidosis Type VI, Mucopolysaccharidosis Type IV
- Trial name
- NCT01870375
- Where
- 4 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
ADHD
Cognitive Training in Children With Attention Deficit/ Hyperactivity Disorder (ADHD)
The purpose of this study is to determine the effect of computer program C8 on specific cognitive functions, symptoms and functional outcome compared to treatment as usual in children with ADHD.
- Trial name
- NCT01752530
- Testing
- Computer program C8, Treatment as usual
- Where
- 3 sites in Denmark
- Volunteers
- 70 people
- Sponsor
- Region Syddanmark
Typical Development
Omega-6 to Omega-3 Fatty Acid Ratio and Higher Order Cognitive Function in 7-to 9-year-olds
The purpose of this study is to investigate the role of the ratio of omega-6 to omega-3 fatty acids on executive functions. The investigators hypothesize that participants ages 7-9 years with a ratio closer to 4:1 will do better…
- Trial name
- NCT01823419
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Urea Cycle Disorder
Functional Evaluation in Patients With Urea Cycle Disorders (UCD) During a Driving Task
This study is being done to understand how the brain works while people with urea cycle disorder (UCD) perform driving tasks that range from easy to difficult and to look at how that compares to traditional tests of thinking and…
- Trial name
- NCT07701694
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Post-Acute COVID-19, Post-Acute COVID-19 Syndrome
Evaluating a Comprehensive Multimodal Outpatient Rehabilitation Program for PASC Program to Improve Functioning of Persons Suffering From Post-COVID-19 Syndrome: A Randomized Controlled Trial
About 10-20% of persons who contract SARS CoV-2 will experience persistent post-acute sequelae of SARSCoV-2 infection (referred here as PASC).
- Conditions
- Post-Acute COVID-19, Post-Acute COVID-19 Syndrome, Post-Acute COVID-19 Infection, Long COVID
- Trial name
- NCT06156202
- Testing
- Comprehensive Rehabilitation, Augmented Usual Care
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Pennsylvania
Executive Function, Motor Skills
Influence of a Parent-mediated mHealth Motor Skill Intervention on Preschool Children's Motor Skills and Cognitive Function
The proposed study uses a mHealth application "app" to help parents teach their preschool-age child motor skill (FMS) activities in the home environment.
- Conditions
- Executive Function, Motor Skills, Healthy
- Trial name
- COSMIC (NCT07680075)
- Testing
- COSMIC
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Learning Problem
Applying Herrmann's Brain Quadrant Model to Learning Styles in Anesthesiology Residents
the ability to learn and adapt to clinical demands is essential in the training of residents. The Herrmann Brain Model categorizes thinking styles based on the preference for utilizing brain quadrants, serving as an applied tool…
- Trial name
- NCT06479044
- Testing
- Herrmann Brain Model
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
microRNAs in Attention-deficit/Hyperactivity Disorder
Epigenetics in ADHD
Attention-deficit/hyperactivity disorder (ADHD) is among the most common psychiatric disorders in children and adolescents. ADHD's nosology is largely based on clinical phenomenology that includes such symptoms as inattention…
- Trial name
- NCT04860024
- Where
- Taiwan
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Vitamin D Deficiency, Musculoskeletal Diseases
Vitamin D in School Children
The primary purpose of this study it to investigate total circulating 25-hydroxyvitamin D (25(OH)D) in school children (aged 4-11years) in Northern Ireland; thereby establishing the prevalence of vitamin D status (deficiency…
- Conditions
- Vitamin D Deficiency, Musculoskeletal Diseases, Cognitive Delay, Mild
- Trial name
- DVinCHI (NCT05018988)
- Testing
- Oral vitamin D spray
- Where
- United Kingdom
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Disruptive Mood Dysregulation Disorder, Attention Deficit Hyperactivity Disorder
Symptoms and Mechanisms of Child Psychiatric Disorders
In this study the investigators will examine psychiatric symptoms, central neurocognitive functions, parental stress and attachment styles, and biological factors that can give new knowledge about some of the mechanisms present…
- Conditions
- Disruptive Mood Dysregulation Disorder, Attention Deficit Hyperactivity Disorder, Oppositional Defiant Disorder, Severe Irritability
- Trial name
- NCT05049356
- Where
- 2 sites in Norway
- Volunteers
- 218 people
- Sponsor
- Oslo University Hospital
Healthy
Magnetic Resonance Imaging of Calculus Problem Solving
This study will use magnetic resonance imaging (MRI) to identify brain regions involved in solving algebraic math problems. It will examine brain activation according to the level of difficulty and the number of steps required to…
- Trial name
- NCT00060658
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Autism
Therapeutic Intervention Effects of rTMS on Children With Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a common and complex neurodevelopmental disorder, which is characterized by impairments of social communication, social reciprocity, as well as restricted and repetitive behaviors (RRB).
- Trial name
- NCT05140356
- Testing
- Applied high amplitude repeated transcranial magnetic stimulation, Applied low amplitude repeated transcranial magnetic stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- University of Electronic Science and Technology of China
Bipolar Disorder in Remission
rTMS-tACS Stimulation on Improving Cognitive Function in Bipolar Disorder
Based on the individualized positioning technology of diffusion tensor imaging (DTI), the purpose of this study is to explore a new stimulation target and protocol for the treatment of bipolar disorder in remission through the…
- Trial name
- NCT05964777
- Testing
- rTMS（repeated transcranial magnetic stimulation）, tACS（transcranial alternating current stimulation）
- Where
- China
- Volunteers
- 116 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Autism Spectrum Disorder
Metabolic Processes in Adults and Adolescents With Autism Spectrum Disorder
The objective of this study is to gain preliminary information and knowledge on metabolic profile in ASD. The benefit of this study will be to expand our insight of the potential relationship in metabolic processes and…
- Trial name
- ASD (NCT02733120)
- Testing
- stable isotope infusion
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Altitude Training Adaptation, Cognitive Function
Effects of Bicarbonate Spring Water Immersion on Cognitive Reliability and Post-Maximal Exercise Recovery in Adolescent Rowers During Altitude Training: A Sex-Stratified Three-Arm Randomized Controlled Trial
This randomized controlled trial aims to investigate the effects of hot spring bath therapy on cognitive function recovery, cerebral hemodynamics, and athletic performance in athletes undergoing altitude training.
- Conditions
- Altitude Training Adaptation, Cognitive Function, Cerebral Hemodynamics, Exercise Performance
- Trial name
- NCT07608913
- Testing
- Control Group：Natural Recovery, Hot water immersion group, hot spring immersion group
- Where
- China
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Macao Polytechnic University