Clinical trials: Cognitive Decline in Older Adults
Technology
Therapeutic Effectiveness of PARO Companion Robot for Elderly With Mild Cognitive Impairment/Dementia in Elderly Residential Setting: A Quasi-experimental Study
The main trial is a 2-group quasi-experimental trial of comparing the outcome indicators between joining and not joining the 10-week personal assistive robot (PARO) training program in residents with dementia or mild cognitive…
- Trial name
- NCT05404802
- Testing
- Experimental group intervention, Control group intervention
- Where
- 2 sites in Hong Kong
- Volunteers
- 37 people
- Sponsor
- The University of Hong Kong
Dementia
Group Digital Gaming: Experiences of Older Adults Living With Dementia in an Activity for Cognitive Impairment
The study examines the effects of a group digital gaming intervention on cognitive function, mood, and behaviors in people with early to moderate levels of dementia, using Obie Technology by employing a pretest and posttest…
- Trial name
- PLwD (NCT07541144)
- Testing
- Group-Based Digital Gaming
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Mason University
Memory Disorders, Alzheimer Disease
Impact of Covid-19 on Frequent Social Interaction Through Communication Technologies in the Cognitive Status of Socially-isolated Older Adults
The current study will examine the impact of frequent social interaction through communication technologies during COVID-19 pandemic in the cognitive status of socially-isolated older adults with and without cognitive impairment.
- Conditions
- Memory Disorders, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- NCT04480112
- Testing
- Technology based social interactions, No research related technology based social interactions
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Boston University
Dementia, Paratonia
Safety and Effectiveness of Botulinum Toxin in Elderly Patients With Dementia and Muscle Stiffness
Aim of the study is to perform a pilot study to assess the impact of Botulinum toxin on muscle tone, and caregiver burden in individuals who are cognitively impaired and who are fully dependent.
- Trial name
- NCT02212119
- Testing
- Botulinum Toxin, Saline
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Assistive Technology Clinic, Canada
Mild Cognitive Impairment (MCI), Moderate Cognitive Impairment
Comparative Effects of Integrated Versus Sequential Approaches to Dual-Task Training in Elderly With Mild to Moderate Cognitive Impairment
Mild and Moderate cognitive impairment is a condition characterized by a noticeable decline in cognitive abilities, including memory and thinking skills, which is greater than expected for an individual's age but does not…
- Trial name
- nill (NCT07775079)
- Testing
- Integrated Dual-Task Training, Sequential Dual-Task Training
- Where
- Pakistan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Shifa Tameer-e-Millat University
Emotion, Impaired Cognition
Examining the Effects of (MiM) Treatment on Emotional and Cognitive Functioning of Residents in Long-term Care
To examine the effects of a music, imagery, and movement (MiM) intervention on emotional and cognitive functioning in residents living in a community-based adult long-term care facility.
- Trial name
- MiM (NCT02219620)
- Testing
- Music, Imagery, Movement, Social Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- George Mason University
Dementia
IDEA Study Cognitive Stimulation Therapy (CST) Trial in Tanzania
This trials of cognitive stimulation therapy (CST) in Tanzania is part of the larger Identification and Intervention for Dementia in Elderly Africans (IDEA) study.
- Trial name
- IDEA (NCT02229474)
- Testing
- CST Intervention
- Where
- Tanzania
- Volunteers
- 34 people
- Sponsor
- William Keith Gray
Down Syndrome, Cognitive Dysfunction
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 11 To 17
The purpose of this study is to determine the efficacy and safety of donepezil hydrochloride (Aricept) in the treatment of the cognitive dysfunction shown by children with Down syndrome, aged 11 to 17.
- Trial name
- NCT00754052
- Testing
- Aricept (donepezil hydrochloride)
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Eisai Inc.
Down Syndrome (Trisomy 21)
AEF0217 in Participants With Down Syndrome
The goal of this clinical trial is to identify if AEF0217 show an improvement in adaptive behaviors (daily life activities) in adults and older adolescents with Down Syndrome. It will also learn about the safety of AEF0217.
- Trial name
- NCT07334912
- Testing
- AEF0217 100 µg, AEF0217 300 µg
- Where
- 10 sites in France, Italy and 1 more
- Volunteers
- 188 people
- Sponsor
- Aelis Farma
Dementia
IDEA Study Cognitive Stimulation Therapy (CST) Trial in Nigeria
This trials of cognitive stimulation therapy (CST) in Tanzania is part of the larger Identification and Intervention for Dementia in Elderly Africans (IDEA) study.
- Trial name
- IDEA (NCT02233530)
- Testing
- CST intervention
- Where
- Nigeria
- Volunteers
- 8 people
- Sponsor
- William Keith Gray
Down Syndrome, Cognitive Dysfunction
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10
The purpose of this study is to determine the efficacy and safety of donepezil hydrochloride (Aricept) in the treatment of cognitive dysfunction shown by children with Down syndrome, aged 6 to 10 years.
- Trial name
- NCT00754013
- Testing
- Aricept (Donepezil hydrochloride)
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Eisai Inc.
Technology, Cognitive Impairments
Tablet-based Interactive Games in Elderly With Cognitive Impairment and Persons With Intellectual Disability
The study has 10 research questions regarding the cognitive training program and tablet-based interactive games: Primary study questions: 1.
- Conditions
- Technology, Cognitive Impairments, Intellectual Disability
- Trial name
- NCT05822596
- Testing
- Tablet-based interactive games experimental group intervention
- Where
- 5 sites in Hong Kong
- Volunteers
- 68 people
- Sponsor
- The University of Hong Kong
Dementia, Neurocognitive Disorders
Effectiveness and Cost-Effectiveness of Cognitive Stimulation Therapy - Spain (CST-ES) in People Living With Dementia
This study aims to evaluate the effectiveness and cost-effectiveness of CST-ES, the Spanish adaptation of Cognitive Stimulation Therapy (CST), to improve cognition and quality of life in people with mild to moderate dementia.
- Conditions
- Dementia, Neurocognitive Disorders, Mild Cognitive Impairment
- Trial name
- NCT06372002
- Testing
- Cognitive Stimulation Therapy (CST)
- Where
- 46 sites in Spain
- Volunteers
- 683 people
- Sponsor
- Instituto de Mayores y Servicios Sociales (IMSERSO)