Clinical trials: Cognitive Deficits
Relapsing-Remitting Multiple Sclerosis
GER-009-06-AVX Early Therapy in Multiple Sclerosis
This study is being done to increase awareness for early therapy with Avonex for Multiple Sclerosis (MS) and the cognitive dysfunction that accompanies MS, and to record safety data for Avonex.
- Trial name
- FIT (NCT00492570)
- Volunteers
- 230 people
- Sponsor
- Biogen
Memory Disorders
AIT-082 Phase 1B Study
AIT-082 is a novel small molecule that crosses the blood-brain barrier to enhance nerve function by increasing levels of neurotrophic growth factors and encouraging nerve sprouting in the brain.
- Trial name
- NCT00000180
- Testing
- AIT-082
- Where
- 4 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Attention Deficit Hyperactivity Disorder, Healthy
The Effects of EPA/DHA Supplementation on Cognitive Control in Children With ADHD
Forty children with and 40 children without Attention deficit Hyperactivity Disorder (ADHD) receive Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) or placebo via a dietary intervention.
- Trial name
- NCT01554462
- Testing
- Eicosapentaenoic acid / Docosahexaenoic acid
- Where
- Netherlands
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
ADHD
QbTest Utility for Optimising Treatment in ADHD (QUOTA)
Attention Deficit/Hyperactivity Disorder (ADHD) is a condition that affects 3-5% of young people under 18-years-old. Young people with ADHD have difficulties with attention, impulsivity and hyperactivity that make it harder for…
- Trial name
- QUOTA (NCT03368573)
- Testing
- QbTest
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Nottinghamshire Healthcare NHS Trust
ADHD - Attention Deficit Disorder With Hyperactivity, Autism Spectrum Disorder
Virtual Reality-assisted Cognitive Rehabilitation in Autistic Youth With ADHD
This study aims to evaluate the effectiveness of a virtual reality-based intervention using the Virtual Reality Rehabilitation System (VRRS) to improve executive functions in autistic and ADHD youth aged 8 to 18 years.
- Trial name
- NCT07426302
- Testing
- VRRS Cognitive Training, Treatment as Usual (TAU)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Irritability, Disruptive Mood Dysregulation Disorder
Psychotherapy for Irritability in Youth: Comparing Active Treatment to Nonactive Psychoeducation Supportive Psychotherapy
Background: Irritability is defined as proneness to anger that may impair a person's ability to function. It is a common reason for why some children need mental health care.
- Conditions
- Irritability, Disruptive Mood Dysregulation Disorder, Oppositional Defiant Disorder, Attention Deficit Hyperactivity Disorder
- Trial name
- NCT07640802
- Testing
- Psychotherapy
- Where
- United States
- Volunteers
- 410 people
- Sponsor
- National Institute of Mental Health (NIMH)
Alzheimer Disease, Mild Cognitive Impairment
Transcranial Magnetic Stimulation in Mild Cognitive Impairment and Alzheimer Disease
The investigators reviewed 12 years of clinical use in an outpatient neurology setting of transcranial magnetic stimulation (TMS) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) to evaluate safety…
- Trial name
- NCT04771845
- Testing
- Transcranial Magnetic Stimulation
- Volunteers
- 73 people
- Sponsor
- The New York Memory Services
Huntington Disease, Hereditary Breast and Ovarian Cancer
Genetic Risk: Whether, When, and How to Tell Adolescents
This study is being conducted to learn more about family communication of genetic risk information. Semi-structured interviews lasting up to one hour will be conducted with three populations: parent/child pairs at risk for…
- Conditions
- Huntington Disease, Hereditary Breast and Ovarian Cancer, Hereditary Cancer, Hereditary Non-polyposis Colon Cancer
- Trial name
- NCT03421327
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Emotions, Memory Deficits
Brain Response to Treatment for Pediatric PTSD
This study will examine how brain activation changes as a result of behavioral treatment for posttraumatic stress disorder (PTSD) in adolescents.
- Conditions
- Emotions, Memory Deficits, Post-traumatic Syndrome
- Trial name
- NCT01806701
- Testing
- Trauma-focused cognitive behavioral therapy
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Stanford University
Acceptance and Commitment Therapy, Mental Health, Cognitive Impairment,Colorectal Cancer
Effect of Acceptance and Commitment Therapy Based Interventions on Mental Health and Cognitive Impairment for Patients With Advanced Colorectal Cancer
The present study aims to: Determine the effect of acceptance and commitment therapy-based interventions on mental health and cognitive impairment for patients with advanced colorectal cancer.
- Trial name
- NCT05741255
- Testing
- Acceptance and Commitment Therapy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Neurofibromatosis Type 1
Effect of Lamotrigine on Cognition in NF1
The purpose of this study is to determine whether lamotrigine can improve cognitive and neurophysiological deficits in adolescents with Neurofibromatosis type 1.
- Trial name
- NF1-EXCEL (NCT02256124)
- Testing
- Lamotrigine
- Where
- 3 sites in Belgium, Netherlands and 1 more
- Volunteers
- 41 people
- Sponsor
- Erasmus Medical Center
Malaria, Cerebral
Rehabilitation Program for Cognitive Deficits in Ugandan Children After Cerebral Malaria
The purpose of this study is to determine whether computerised cognitive rehabilitation training improves cognition in children who have had cerebral malaria.
- Trial name
- NCT00658450
- Testing
- Cognitive rehabilitation training
- Where
- Uganda
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Makerere University
Attention Deficit Hyperactivity Disorder
Standardized Lycium Chinense Fruit Extract Enhances Attention and Cognitive Function in Healthy Young People
Lycium chinense fruit (LCF) is widely distributed in East Asia that has been used traditionally for anti-aging purposes. This study was performed to examine the effects of LCF on attention and cognitive function in healthy young…
- Trial name
- NCT03439111
- Testing
- Standardized Lycium chinense Fruit Extract (LCF) capsules
- Where
- South Korea
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Biomix
Hunter Syndrome
Study of Long Term Safety and Clinical Outcomes of Idursulfase IT and Elaprase Treatment in Pediatric Participants Who Have Completed Study HGT-HIT-094
This extension study will allow participants that completed Study HGT-HIT-094 to continue receiving Elaprase treatment in conjunction with idursulfase IT or to continue receiving Elaprase treatment and begin concurrent IT…
- Trial name
- NCT02412787
- Testing
- Idursulfase-IT, Elaprase
- Where
- 9 sites in United States, Australia and 5 more
- Volunteers
- 56 people
- Sponsor
- Shire
Huntington's Disease
Effects of Lithium and Divalproex'on Brain-Derived Neurotrophic Factor in Huntington's Disease
This study will examine whether lithium carbonate, given alone or with divalproex, increases the amount of brain-derived neurotrophic factor (BDNF) in the spinal fluid of patients with Huntington's disease (HD), a hereditary…
- Trial name
- NCT00095355
- Testing
- Lithium, Divalproex
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Mild Cognitive Impairment
An Intergenerational, Cognitively Enriched Intervention for MCI Patients and Their Children.
In 2018, approximately 50 million people received a diagnosis of dementia, which is projected to triple by 2050. To mitigate the increase in dementia, it is crucial to prevent cognitive decline in at risk groups, such as older…
- Trial name
- MCI-project (NCT06221579)
- Testing
- No intervention, interviews with MCI patients as part of the development phase
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- University Ghent
Attention Deficit Hyperactivity Disorder
Neurofeedback and Computerized Cognitive Training in Different Settings for Children and Adolescents With ADHD
Attention deficit/hyperactivity disorder (ADHD) is among the most common childhood-onset psychiatric disorders, with a negative and long-lasting impact on academic achievement, social integration and quality of life.
- Trial name
- NCT02358941
- Testing
- Neurofeedback training, Computerized cognitive training
- Where
- Switzerland
- Volunteers
- 102 people
- Sponsor
- University of Zurich
Tuberous Sclerosis Complex, Aspirin
Aspirin as an add-on Treatment of Refractory Epilepsy in Tuberous Sclerosis Complex
There had been much evidence in aspirin controlling tumorous conditions conducted by basic researches, especially through mammilian target of rapamycin (mTOR) pathway.
- Conditions
- Tuberous Sclerosis Complex, Aspirin, Epilepsy, Cognitive Decline
- Trial name
- NCT03356769
- Testing
- Aspirin, AED
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Peking Union Medical College Hospital
Post-traumatic Stress Disorder, Depression
Randomized Control Trial of Group Intervention With Former War-affected Boys in the Democratic Republic of Congo
The purpose of this study is to evaluate, in a randomised control trial (RCT), the effectiveness of group-based, trauma-focused Cognitive Behaviour Therapy (TF-CBT) in reducing psychological distress in former child soldiers and…
- Conditions
- Post-traumatic Stress Disorder, Depression, Conduct Disorder
- Trial name
- NCT01494831
- Testing
- TF-CBT
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Attention-Deficit/Hyperactivity Disorder (ADHD)
Reward Effects on Cognition, Motor Skills, and Motivation in Children
This interventional study aimed to aimed to evaluate the effects of rewards on cognitive function, motor skills, and motivation in 8- to 10-year-old children with ADHD following 3- and 6-week interventions.
- Trial name
- ADHD (NCT06798337)
- Testing
- Conventional Physiotherapy group, Reward based physiotherapy group
- Where
- Lithuania
- Volunteers
- 67 people
- Sponsor
- Lithuanian Sports University