Clinical trials: Cognitive Disorders
Duarte Galactosemia
Intervention and Outcomes in Duarte Galactosemia
The purpose of this study is to learn about Duarte galactosemia (DG). This study will examine the possible effects of Duarte galactosemia (DG) in children, and determine whether dietary exposure to milk in infancy or early…
- Trial name
- NCT02519504
- Where
- United States
- Volunteers
- 566 people, healthy volunteers welcome
- Sponsor
- Emory University
Child Sexual Abuse, Post-Traumatic Stress Disorder, PTSD
Intensive Inpatient Trauma-Focused Cognitive Behavioral Therapy (II-TF-CBT) for Adolescents With PTSD Following Sexual Abuse
This study looks at a treatment program for children and teens who have post-traumatic stress disorder (PTSD) after sexual abuse. The program is called II-TF-CBT.
- Trial name
- NCT07732335
- Testing
- II-TF-CBT
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Breast Cancer, Cognitive Dysfunction
Remotely Supervised Computerized Cognitive Stimulation to Reduce Post-chemotherapy Cognitive Difficulties in Patients Treated for Localized Breast Cancer
Investigator propose the first French randomized comparative study to assess the efficacy of a remotely supervised online cognitive stimulation program, compared to an unsupervised online cognitive exercise intervention, in…
- Trial name
- COG STIM 2 (NCT06027632)
- Testing
- Cognitive exercises with supervision, Cognitive exercises without supervision
- Where
- 25 sites in France
- Volunteers
- 300 people
- Sponsor
- Centre Francois Baclesse
Obsessive-Compulsive Disorder
Smart Sensory Technology in Psychotherapy for Pediatric OCD
Telemedicine interventions enable the improvement of behavioral state-of-the-art treatment of OCD, as therapy can be delivered in the patients' immediate home environment, allowing for more valid symptom actualization.
- Trial name
- SSTeP-KiZ (NCT05291611)
- Testing
- Online-based Cognitive-behavioral Therapy for OCD
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Congenital Heart Defect, Executive Function
Improving Neurodevelopmental Outcomes in Children With Congenital Heart Disease: An Intervention Study
Each year, approximately 1 child in every 100 is born with Congenital Heart Disease (CHD), making it the most common birth defect.
- Conditions
- Congenital Heart Defect, Executive Function, Children, Neurodevelopmental Disorders
- Trial name
- NCT03023644
- Testing
- Cogmed Working Memory Training
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Boston Children's Hospital
Math Learning Disability, Child Development
Interventions in Mathematics and Cognitive Skills
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning…
- Conditions
- Math Learning Disability, Child Development, Developmental Disability, Learning Disabilities
- Trial name
- NCT05201534
- Testing
- Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Stanford University
Autism Spectrum Disorder (ASD)
Omega-3 Fatty Acids Monotherapy in Children and Adolescents With Autism Spectrum Disorders
The primary aim of this study is to examine the efficacy and tolerability of short-term omega-3 fatty acids monotherapy in youth with Autism Spectrum Disorders (ASD).
- Trial name
- NCT01248130
- Testing
- Omega-3 Fatty Acid
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Attention Deficit Hyperactivity Disorder
Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Pilot Phase I and Randomized Controlled Phase II Trial
Background: Children with attention deficit hyperactivity disorder (ADHD) often have cognitive problems. It may be hard for them to control their behaviors, concentrate for long periods, or make decisions.
- Trial name
- NCT05608434
- Testing
- Non-adaptive Floreo VR control, Floreo Virtual Reality application
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- National Institute of Mental Health (NIMH)
Obsessive-Compulsive Disorder
SMART ERP for the Behavioral Treatment of Youth With Obsessive Compulsive Disorder (OCD)
This randomized pilot study examines a graduated behavioral treatment approach for youth with obsessive compulsive disorder. Youth will be randomized to receive treatment in the community or at the hospital.
- Trial name
- NCT03672565
- Testing
- Phase One: Standardized Brief Intensive ERP, Phase Two: Flexible Patient Driven Intensive ERP, Follow-Up Phase: Booster Calls
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Anxiety, Depression
Mental Health INtervention With Digital APPlications (MIND-APP): Evaluating the Effectiveness of the Tankevirus and Grubl Mental Health Apps
The MIND-APP trial is a 3-arm randomized controlled trial (1:1:1 allocation) conducted fully remotely via a bespoke smartphone research platform.
- Trial name
- MIND-APP (NCT07627204)
- Testing
- Tankevirus, Grubl
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Akershus
Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese
From Skin Fibroblasts to Neural Stem Cells to Investigate in Vitro the Impact of Diabetes on Adult Neurogenesis
Obesity and glucose intolerance or overt diabetes are increasing at an alarming rate in the population, and are bound to become a public health issue and a major cause of disability, loss of independence and high social costs in…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese, Diabetes Mellitus Type 2 in Nonobese, Obesity
- Trial name
- NCT05755321
- Testing
- Skin biopsy
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Depression, Anxiety
Internet-Delivered Cognitive Behaviour Therapy for Adolescent Depression
The purpose of this study is to determine whether tailored internet-administrated cognitive behaviour therapy (CBT) is a feasible approach in the treatment of depressive symptoms and comorbid anxiety symptoms.
- Trial name
- NCT02363205
- Testing
- Tailored Internet-administrated CBT-Treatment
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Linkoeping University
Parkinson's Disease
Deep Brain Stimulation of the Subthalamic Nucleus (STN) and Cognitive Control
In this study, the investigators will follow patients who have had stimulators implanted, at their usual clinic follow-up appointments 3, 6, 9 and 12 months after surgery.
- Trial name
- COVOLT (NCT00917722)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Washington University School of Medicine
Schizophrenia, Cognitive Impairment
From Brain Currents to Interpersonal Flow: Investigating the Social Processing Stream of Schizophrenia
The overall objective of this project is to identify the neural signature of the impaired ability to relate socially seen in individuals with schizophrenia.
- Conditions
- Schizophrenia, Cognitive Impairment, Social Competence
- Trial name
- ecoval (NCT03543553)
- Testing
- This is not an intervention study
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Anxiety Disorders
School-based Treatment for Anxious Children
This study will determine the effectiveness of a school-based cognitive behavior therapy in urban, predominantly low-income, African-American children diagnosed with an anxiety disorder.
- Trial name
- NCT00536094
- Testing
- Cognitive behavioral therapy (CBT), Treatment as usual (TAU)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Anorexia Nervosa
Efficacity of Cognitive Remediation Treatment Compared to a Controlled Group in Young Patient With Anorexia Nervosa
The aim of research is to test in a randomized clinical trial with active sessions, the efficacy of cognitive remediation therapy in children anorexia nervosa compared to a controlled group.
- Trial name
- RECOGAMEA (NCT02400541)
- Testing
- Cognitive remediation therapy, relaxation therapy
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dementia, Neurocognitive Disorders
Effectiveness and Cost-Effectiveness of Cognitive Stimulation Therapy - Spain (CST-ES) in People Living With Dementia
This study aims to evaluate the effectiveness and cost-effectiveness of CST-ES, the Spanish adaptation of Cognitive Stimulation Therapy (CST), to improve cognition and quality of life in people with mild to moderate dementia.
- Conditions
- Dementia, Neurocognitive Disorders, Mild Cognitive Impairment
- Trial name
- NCT06372002
- Testing
- Cognitive Stimulation Therapy (CST)
- Where
- 46 sites in Spain
- Volunteers
- 683 people
- Sponsor
- Instituto de Mayores y Servicios Sociales (IMSERSO)
Last Year Medical Student
Use of Cognitive Aid Methods in the Management of Status Epilepticus
This study aims to evaluate whether cognitive aids improve the management performance of sixth-year Emergency Medicine interns during simulated status epilepticus scenarios.
- Trial name
- NCT07603843
- Testing
- Management of status epilepticus with paper cognitive aids, Management of status epilepticus with digital cognitive aids, Management of status epilepticus with no cognitive aid
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Ankara University
Cardiovascular Disease, Aortic Valve Stenosis
Evaluating the Risk of Cognitive Impairment After Surgical and Transcatheter Aortic Valve Replacement
The investigators are conducting a pilot study to compare cognitive outcomes among Veterans with severe aortic valve stenosis who are scheduled to undergo either aortic valve replacement.
- Conditions
- Cardiovascular Disease, Aortic Valve Stenosis, Cognitive Assessments, Valve Surgery
- Trial name
- CAVIAR (NCT02971020)
- Testing
- Observational/Cognitive Assessment
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Minnesota Veterans Medical Research and Education Foundation
Turner Syndrome, Isolated Growth Hormone Deficiency
Neuropsychological Assessment of Children and Adolescents With Turner Syndrome
Turner syndrome (TS) is a rare chromosomal disorder characterized by partial or complete loss of one of the X chromosomes that affects about one in every 2000 female babies born.
- Conditions
- Turner Syndrome, Isolated Growth Hormone Deficiency, Cognitive Functions, Social Cognition
- Trial name
- ENEAST (NCT03812913)
- Testing
- psychological evaluation
- Where
- 3 sites in France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Angers
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