Clinical trials: Cognitive Dysfunction, Cognitive Disorder
Delirium,, Dementia,
Long-term Outcome of General Anesthesia on Dysgnosia
Cognitive disorders in patients underwent general anesthesia are discussed for decades, but whether there were precise relationship between general anesthesia and dysgnosia is yet to be guaranteed.
- Conditions
- Delirium,, Dementia,, Amnestic,, Cognitive Disorders
- Trial name
- LOGAND (NCT01184638)
- Testing
- Sevoflurane, Propofol
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Nanjing Medical University
Mild Cognitive Impairment, Alzheimer's Disease
Impact of a Memory Group for Older Adults Reporting Memory Difficulties
Aims: To evaluate the efficacy of a brief intensive intervention for persons with mild cognitive impairment, assisted by family members or friends.
- Trial name
- NCT01998711
- Testing
- Memory group
- Where
- Australia
- Volunteers
- 62 people
- Sponsor
- Bayside Health
Severe Acute Malnutrition, Cognitive Impairment
Choline to Improve Malnutrition and Enhance Cognition
The goal of this clinical trial is to test adding choline to ready-to-use therapeutic food (RUTF) in children with severe acute malnutrition (SAM) in Malawi.
- Conditions
- Severe Acute Malnutrition, Cognitive Impairment, Wasting, Kwashiorkor
- Trial name
- CHIME-SAM (NCT06154174)
- Testing
- C-RUTF (Ready-to-Use Therapeutic Food with added choline), S-RUTF (Ready-to-Use Therapeutic Food without added choline), Amoxicillin
- Where
- 10 sites in Malawi
- Volunteers
- 1,500 people
- Sponsor
- Washington University School of Medicine
Psychotic Disorders, Cannabis Use Disorder
Investigating the Neural Correlates of Cognitive Function in Psychosis Patients and Non-Psychiatric Controls With Cannabis Use
Cognitive impairment is well established in people with psychosis and is associated with cannabis use. The current study will investigate the neurobiological basis of cognitive change associated with 28-days of cannabis…
- Conditions
- Psychotic Disorders, Cannabis Use Disorder, Cannabis Dependence, Cannabis Use
- Trial name
- NCT05445180
- Testing
- Contingency management
- Where
- Canada
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Intra Cerebral Hemorrhage, ICH - Intracerebral Hemorrhage
REpeated ASSEssment of SurvivorS in Intracerebral Hemorrhage Study
The investigators propose to perform serial detailed cognitive, motor, behavioral, and blood collection follow-up using longitudinal structured telephone interviews of an anticipated 350 ICH survivors enrolled in Minimally…
- Conditions
- Intra Cerebral Hemorrhage, ICH - Intracerebral Hemorrhage, ICH, Hemorrhage
- Trial name
- ICH03 (NCT05611918)
- Where
- 26 sites in United States
- Volunteers
- 350 people
- Sponsor
- Johns Hopkins University
Systemic Lupus Erythematosus
Role of Antibodies in Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus
This study will examine the possible relationship between certain antibodies found in patients with systemic lupus erythematosus (SLE) and cognitive (thought processing) impairment in these patients.
- Trial name
- NCT00042523
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Parkinson Disease, Mild Cognitive Impairment
Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease
The present study is a proof-of-concept clinical trial to test the efficacy of low doses of a repurposed anti-epileptic drug (levetiracetam) in treating memory problems in Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Mild Cognitive Impairment, Memory Impairment
- Trial name
- TRIP (NCT04643327)
- Testing
- Levetiracetam
- Where
- Australia
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Cognitive Impairment
Maze Balance Board Training Effects on Mobility and Motor Skills in Cognitively Impaired Children
The study will be a Randomized Controlled Trial including 22 children aged 6-10 years with deficits in functional mobility and gross motor skills.
- Trial name
- NCT07578896
- Testing
- Maze Balance Board traing, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Brain Concussion, Mild Cognitive Impairment
Development of a Neurocognitive Screening Test
This research study will evaluate a standalone software application and is designed to standardize and validate new neurocognitive screening testing for children aged 6 through 11, and adolescents and adults ages 12 through 75.
- Trial name
- NCT02597504
- Testing
- Pen and paper neuropsychological test, Quick Test
- Where
- 4 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- ImPACT Applications, Inc.
Agitation Associated With Alzheimer's Disease, Alzheimer's Type
Safety Follow-up Study for Subjects With Agitation Associated With Dementia of the Alzheimer's Type Who Previously Participated in a Double-blind Trial of Brexpiprazole or Placebo
To follow-up on the safety of subjects who were previously treated in a double-blind trial of brexpiprazole.
- Conditions
- Agitation Associated With Alzheimer's Disease, Alzheimer's Type, Mental Disorder, Nervous System Diseases
- Trial name
- NCT02192554
- Where
- 84 sites in United States, Bulgaria and 10 more
- Volunteers
- 450 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Alzheimer's Disease
Clinical Research Center for Dementia of South Korea (CREDOS)(or CRCD)
The objective of this study is to present evidence-based medicine for development of clinical practice guideline through prospective study of Alzheimer's disease(AD) and mild cognitive impairment(MCI) in korea
- Trial name
- CREDOS (NCT01198093)
- Where
- South Korea
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Breast Cancer, Cognitive Dysfunction
Remotely Supervised Computerized Cognitive Stimulation to Reduce Post-chemotherapy Cognitive Difficulties in Patients Treated for Localized Breast Cancer
Investigator propose the first French randomized comparative study to assess the efficacy of a remotely supervised online cognitive stimulation program, compared to an unsupervised online cognitive exercise intervention, in…
- Trial name
- COG STIM 2 (NCT06027632)
- Testing
- Cognitive exercises with supervision, Cognitive exercises without supervision
- Where
- 25 sites in France
- Volunteers
- 300 people
- Sponsor
- Centre Francois Baclesse
Cognitive Deficits, Cognitive Ability, General
Childhood Anesthesia and Cognitive Function
The purpose of this study is to determine whether pediatric anesthesia is associated with long-term hippocampal dysfunction
- Trial name
- UCSF-Anes-01 (NCT01359215)
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University
Niemann-Pick Disease, Type C
VTS-270 to Treat Niemann-Pick Type C1 (NPC1) Disease
Due to different study designs, the sponsor separated Part C into a separate registration (NCT04958642), leaving Parts A/B here in NCT02534844.
- Trial name
- NCT02534844
- Testing
- Parts A/B: Adrabetadex
- Where
- 29 sites in United States, Australia and 7 more
- Volunteers
- 56 people
- Sponsor
- Mandos LLC
Parkinson Disease, Cognitive Impairment
Effect and Mechanism of Brain Stimulation for Parkinson's Disease With Cognitive Impairment
This study intends to apply structural and functional brain network neuroimaging techniques combined with image post-processing methods to explore the differences in brain network changes in PD patients with cognitive impairment…
- Trial name
- NCT06090682
- Testing
- Deep Brain Stimulation(DBS) and Transcranial Magnetic Stimulation(TMS)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tianjin Huanhu Hospital
Parkinson Disease
Frailty and Cognitive Function in Parkinson's Disease.
Introduction: Parkinson's disease (PD) is the association of tremor, rigidity, akinesia-bradykinesia and loss of postural reflexes. Non-motor symptoms such as cognitive impairment may also develop.
- Trial name
- NCT05388526
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- University of Oviedo
Biliary Atresia, Cognitive Impairment
BILACO Trial: Biliary Atresia - a Severe Complex Congenital Liver Disease
Biliary atresia is the most severe form of cholestatic liver disease. The children have high morbidity and mortality and get devastating pruritus and fatigue, failure to thrive, progressive hepatic failure and impaired…
- Trial name
- BILACO (NCT05399745)
- Testing
- Neurocognitive monitoring
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Oncology, Support Care
Breast Cancer and Chemobrain : Effects of Photobiomodulation on the Improvement of Perceived Cognitive Impairment
Breast cancer is one of the most common cancers in metropolitan France, with over 60,000 new cases in 2023. Mostly a female cancer, it can affect a young population, with around 20% of breast cancers occurring in women under 50.
- Conditions
- Oncology, Support Care, Cognitive Disorders
- Trial name
- REGAIN (NCT06995443)
- Testing
- Photobiomodulation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier de Valenciennes
Cognitive Impairment, Cognitive Decline
Lithium Treatment to Prevent Cognitive Impairment After Brain Radiotherapy
Randomized, placebo-controlled, double-blinded, parallel group clinical trial to investigate if 6 months of oral lithium tablets (S-lithium 0,5-1,0 mmol/l) will prevent cognitive decline after brain radiotherapy in pediatric…
- Conditions
- Cognitive Impairment, Cognitive Decline, Radiotherapy Side Effect, Radiotherapy; Complications
- Trial name
- LiBRA (NCT06051240)
- Testing
- Lithium
- Where
- 2 sites in Sweden
- Volunteers
- 84 people
- Sponsor
- Region Stockholm