Clinical trials: Cognitive Functions
Cerebral Palsy, Infant Development
Neuroimaging of Babies During Natural Sleep to Assess Typical Development and Cerebral Palsy
Background: Early diagnosis of cerebral palsy (CP) is crucial, enabling intervention when neuroplasticity is at its highest. Magnetic resonance imaging (MRI) plays a vital role in CP diagnosis.
- Conditions
- Cerebral Palsy, Infant Development, Development, Infant
- Trial name
- NIBS-CP (NCT06396520)
- Testing
- No intervention, observational
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Danish Research Centre for Magnetic Resonance
Epilepsy
A Study With an Open-label Extension Phase to Evaluate the Effect of Perampanel (E2007) on Cognition, Growth, Safety, Tolerability, and Pharmacokinetics in Adolescents
This study is designed to investigate the short- and long-term effects of perampanel on cognition, growth, and development in adolescents.
- Trial name
- NCT01161524
- Testing
- Perampanel
- Where
- 37 sites in United States, Australia and 9 more
- Volunteers
- 133 people
- Sponsor
- Eisai Inc.
Erectile Dysfunction
Evaluation for Restoration of Erectile Dysfunction After Cardioversion Treatment Trial
Erectile and Cognitive function by using the questionnaire and assessment form before sinus conversion
- Trial name
- NCT02742896
- Testing
- Erectile dysfunction
- Where
- South Korea
- Sponsor
- Yong Seog Oh
Cognitive Function
Effect of Acetaminophen Preemptive Analgesia on Postoperative Cognitive Function
Patients undergoing gastrointestinal tumor surgery are prone to delayed recovery and postoperative cognitive dysfunction due to greater trauma and longer operation time.
- Trial name
- NCT06004687
- Testing
- acetaminophen mannitol, Normal saline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Affiliated Hospital of Nantong University
Physical Functional Impairment, Cognitive Impairment
PICS-p Longitudinal Cohort Study
Children who survive critical illness may develop new or worsening problems with physical health, cognitive status, emotional well-being, and social functioning.
- Conditions
- Physical Functional Impairment, Cognitive Impairment, Psychological Distress, Impaired Social Functioning
- Trial name
- PICSpLCS (NCT07876271)
- Volunteers
- 200 people
- Sponsor
- Children's Hospital of Fudan University
Tobacco Use Disorders
Varenicline on Reward Responses and Cognition in Adolescent Smokers
This is a pilot project using functional magnetic resonance imaging (fMRI) to examine the influence of varenicline on reward processing, cognitive control, and regulation of craving in adolescent smokers.
- Trial name
- GRAND (NCT01624428)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Yale University
Executive Function Deficits (EFD)
Unstuck-Early Childhood Effectiveness & Implementation Trial
The goal of this clinical trial is to learn if a new school-based, Tier 2 (selective) cognitive-behavioral intervention called Unstuck and On Target for Early Childhood (Unstuck-EC) can treat executive function deficits in young…
- Trial name
- NCT07832344
- Testing
- Unstuck and On Target for Early Childhood
- Volunteers
- 90 people
- Sponsor
- Children's National Research Institute
ADHD, Dyslexia
Computerized Working Memory Training
Prior research has found that children with attention-deficit hyperactivity disorder (ADHD) and reading difficulties (RD) are at an elevated risk of developing further cognitive deficits and developmental challenges.
- Trial name
- NCT06567444
- Testing
- Working memory intervention
- Where
- Hong Kong
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Education University of Hong Kong
Growth Failure, Atopy
The PREWEAN Study. Weaning of Preterm Infants During the First Year of Life.
In this Austrian observational study preterm infants born with a birth weight <1500 g and a gestational age <32 weeks will be investigated at the neonatal outpatient clinic.
- Conditions
- Growth Failure, Atopy, Adiposity, Cognitive Impairment
- Trial name
- PREWEAN (NCT02936219)
- Where
- Austria
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Epilepsy
Spectral Dynamic Imaging of Cognitive Functions in Epileptic Patients Explored Stereoelectroencephalography
This prospective research aims to develop the use of Spectral Imaging in addition Dynamics of cortical electrical stimulation to identify major anatomical and functional networks in epileptic patients candidates for surgery and…
- Trial name
- ISDETSEEG (NCT02869698)
- Testing
- Spectral Dynamic Imaging, Hybride electrode, Macro electrode
- Where
- 2 sites in France
- Volunteers
- 192 people
- Sponsor
- University Hospital, Grenoble
Cognitive Intervention to Promote Healthy Development of Executive Function (EF) Skills in Young Children
Parent-Child EF Intervention
Koronis Biomedical Technologies Corporation (KBT) is developing a cognitive intervention to promote healthy development of Executive Function (EF) skills in young children by leveraging a smartphone-based training regime designed…
- Trial name
- NCT06924307
- Testing
- Executive Function Intervention
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Koronis Biomedical Technologies
Postoperative Cognitive Dysfunction, Postoperative Delirium
Perioperative GDNF as a Predictive Factor for Postoperative Delirium and Adverse Neurological Outcomes in Pediatric Surgery
To observe the dynamic changes in serum levels of inflammatory cytokines (e.g., IL-6, TNF-α), Brain-Derived Neurotrophic Factor (BDNF), and Glial Cell Line-Derived Neurotrophic Factor (GDNF) during the perioperative period in…
- Trial name
- NCT07192549
- Testing
- Sevoflurane group, Propofol group
- Volunteers
- 200 people
- Sponsor
- General Hospital of Ningxia Medical University
Duchenne / Becker Muscular Dystrophy, Osteogenesis Imperfecta (OI)
Social Cognition in Dystrophinopathies and Neurodevelopmental Disorders
The primary aim of this observational study is to investigate specific aspects of social cognition in dystrophinopathies. Body awareness, interpersonal distance and emotional processing will be measured in a sample of patients…
- Conditions
- Duchenne / Becker Muscular Dystrophy, Osteogenesis Imperfecta (OI), Social Cognition
- Trial name
- NCT06874166
- Testing
- Electroencephalography (EEG), Social Cognition Tasks
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Stress, Complete Psychological Check Up
Cognition and Health in Adolescents, Mindfulness as Prevention of Stress.
The purpose of this study is to determine whether mindfulness is useful as primary prevention for psychological health in highschool students, primarily related to stress, and whether mindfulness can improve cognitive function.
- Conditions
- Stress, Complete Psychological Check Up, Sleep, Cognition - Other
- Trial name
- CHAMPS (NCT01457222)
- Testing
- Mindfulness intervention, Music relaxation
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Region Skane
Down Syndrome
Non-drug Study to Assess the Suitability of Assessment Scales in Japanese Individuals With Down Syndrome Aged 6-30
To evaluate the suitability (i.e. number of tests completed and number of participants completing the tests, variance estimate of baseline and of the change from baseline values) of neurocognitive tests and functioning scales in…
- Trial name
- NCT02431117
- Where
- 7 sites in Japan
- Volunteers
- 43 people
- Sponsor
- Chugai Pharmaceutical
Patient With Bipolar Disorder, Euthymic Status
Cognitive Remediation on Patients With Bipolar Disorder and Memory Complaints
Bipolar disorder is a major health concern. Intercritical periods are marked with residual symptoms, both thymic and cognitive, which affects quality of life of patients, but also the quality of observance.
- Conditions
- Patient With Bipolar Disorder, Euthymic Status, Wirh Memory Complaints
- Trial name
- COGMED (NCT02988518)
- Testing
- COGMED program
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Montpellier
Cognitive/Functional Effects, Colorectal Cancer
Neurological Effects of Chemotherapy and Radiation Therapy in Patients With Colon Cancer
RATIONALE: Learning about the long-term effects of chemotherapy and radiation therapy on brain function may help doctors plan cancer treatments.
- Conditions
- Cognitive/Functional Effects, Colorectal Cancer, Long-term Effects Secondary to Cancer Therapy in Adults
- Trial name
- NCT00410618
- Testing
- cognitive assessment, magnetic resonance imaging, management of therapy complications
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Arizona
ADHD - Attention Deficit Disorder With Hyperactivity, ADHD
Advancing Identification of Circadian Delay in ADHD Youth: Associations With Clinical Heterogeneity and Cognition
The purpose of this study is to better understand sleep and circadian functioning in children with ADHD using home-based measures, parent report, and a lab based melatonin assessment.
- Trial name
- CIRCA (NCT06971640)
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Duke University
Medulloblastoma, Childhood, Healthy Volunteers
Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition
One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized…
- Conditions
- Medulloblastoma, Childhood, Healthy Volunteers, Fossa Posterior Tumor, Low-grade Glioma
- Trial name
- CervIRM (NCT04174820)
- Testing
- Functional Magnetic Resonance Imaging (fMRI)
- Where
- 5 sites in France
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Neurovascular Coupling Mechanism and Cognitive Function
Study on the Neurovascular Coupling Function in Patients Undergoing Cardiac Surgery
Existing researches show that brain is an organ highly dependent on continuous blood supply. Energy and oxygen required for normal physiological activities in the brain are stably maintained by a neurovascular regulatory…
- Trial name
- NCT02977455
- Volunteers
- 30 people
- Sponsor
- Xiangya Hospital of Central South University
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