Clinical trials: Cognitive Functions
Ondine Syndrome (Congenital Central Hypoventilation Syndrome)
Locus Coeruleus and CCHS (Congenital Central Hypoventilation Syndrome)
This study investigates whether cognitive dysfunction in young patients with congenital central hypoventilation syndrome (Ondine Syndrome) is related to the severity of the disease and dysfunction of the locus coeruleus (a…
- Trial name
- ONDINE-LC (NCT07081464)
- Testing
- MRI, EEG, Pupillometry
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cannabis Use, Neurocognitive Dysfunction
Prospective Evaluation on Cognitive Function and Its Associated Genetic Vulnerability in Cannabis Users
Most of the studies assessing Cannabis Use Disorder (CUD) and neurocognitive functions are cross-sectional without examining the longitudinal changes in neurocognitive function at a within-subject level with respect to the…
- Conditions
- Cannabis Use, Neurocognitive Dysfunction, Genetic Predisposition
- Trial name
- SToP-C_PeCoG (NCT04373525)
- Testing
- Genome analysis
- Where
- Hong Kong
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Alzheimer's Disease, Behavioral Variant Frontotemporal Dementia
Open-Label Study of Leuco-methylthioninium Bis(Hydromethanesulfonate) (LMTM) in Subjects With Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia (bvFTD)
The purpose of this study is to provide subjects who have completed participation in a Phase 2 or Phase 3 trial of LMTM continued access to therapy and to evaluate the long-term safety of LMTM.
- Trial name
- NCT02245568
- Testing
- LMTM
- Where
- 135 sites in United States, Australia and 15 more
- Volunteers
- 913 people
- Sponsor
- TauRx Therapeutics Ltd
Cognitive Function, Growth
Long-term Effects of Iron and Zinc Supplementation During Infancy on Cognitive Performance and Growth
The hypotheses of this study are: 1. Compared to children who received a placebo, children who received iron or zinc or iron and zinc combined will perform better on cognitive tests and will have better growth status at ages 8 to…
- Trial name
- FeZn_FU (NCT00824304)
- Where
- Thailand
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Cerebral Palsy (CP), Balance
Sensory Integration Therapy and Function in Cerebral Palsy
Cerebral palsy (CP) is a non-progressive neurological disorder that affects movement, posture, and functional abilities. Children with CP frequently experience impairments in motor control, sensory processing, balance, postural…
- Conditions
- Cerebral Palsy (CP), Balance, Sensory Integration Disorder
- Trial name
- NCT07278635
- Testing
- Sensory Integration Therapy, Balance and Coordination Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Yeditepe University
Anesthesia
The Effect of Propofol or Etomidate on Cognitive Function for 1-3 Years Old Children
Based on China's guangxi guilin for a hernia operation in 1 to 3 years old preschool children propofol and etomidate on behavioral and cognitive function after intravenous anesthesia in according to beta protein in serum and…
- Trial name
- NCT02199990
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Guilin Medical University, China
Brain Injuries, Craniocerebral Trauma
DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury
The investigators intend to determine the effect of adrenergic blockade on 1) short-term physiology, behavior, and cognition and 2) long-term neuropsychological outcomes after severe Traumatic Brain Injury (TBI).
- Conditions
- Brain Injuries, Craniocerebral Trauma, Trauma, Nervous System, Traumatic Brain Injury
- Trial name
- NCT01322048
- Testing
- IV Propranolol and Per Tube Clonidine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University
Cognitive Decline
Mind-motor Exercise to Improve Cognition and Functional Fitness
This is a 3 month cluster randomized controlled trial using a square-stepping exercise program (a.k.a. mind-motor exercise) in retirement and long-term care residences to improve global cognitive functioning in older adults with…
- Trial name
- MIND-FUN (NCT02730013)
- Testing
- Square Stepping Exercise
- Where
- Canada
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Western Ontario, Canada
Cognitive Change
The Cognitive Effects of 6- and 12-weeks Administration of a Food Supplement Containing Phosphatidylserine in Healthy Children Aged 8 to 12 Years
The purpose of this study is to assess the cognitive effects (attention, learning, and memory) of 6 and 12 weeks administration of a supplement containing phosphatidylserine in comparison to a placebo in healthy children aged 8…
- Trial name
- NCT05177978
- Testing
- Phosphatidylserine
- Where
- United Kingdom
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Brain Health, Cognition
Exercise Effects on Cognition in School-Aged Children
Recent trends have identified decreasing levels of physical activity, fitness, and health in preadolescent children. Examining factors, such as physical activity behavior and aerobic fitness that positively influence cognitive…
- Conditions
- Brain Health, Cognition, Scholastic Achievement
- Trial name
- FITKids (NCT01334359)
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Postoperative Cognitive Dysfunction
Comparison of Desflurane With Sevoflurane for School-age Children in Postoperative Cognitive Function
This study compares desflurane with sevoflurane for school-age children in postoperative cognitive function.
- Trial name
- NCT02909413
- Testing
- Desflurane, sevoflurane
- Volunteers
- 600 people
- Sponsor
- Shengjing Hospital
Mild Dementia, Mild Cognitive Impairment
The Swedish BioFINDER - Memory Clinic Study
The diagnosis of diseases causing memory difficulties or dementia is often challenging. Without the use of advanced methods such as cerebrospinal fluid tests, approximately 25-30% do not receive a correct diagnosis today.
- Conditions
- Mild Dementia, Mild Cognitive Impairment, SCD, Alzheimer Disease
- Trial name
- Validate (NCT06122415)
- Testing
- Plasma Amyloid Probability Score 2 (APS 2) score, Plasma ptau217/nptau217, Plasma ptau217
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Skane University Hospital
Brain Structure, Cognitive Performance
Effects of Long-Duration Spaceflight on General and Spatial Cognition and Its Neural Basis
This study investigates the effects of extended-duration spaceflight (12-month International Space Station missions) on general cognitive performance (measured with the Cognition test battery), spatial cognition, structural and…
- Trial name
- NCT04856410
- Testing
- Spaceflight, Controls
- Where
- 3 sites in United States, Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy Volunteers
Quality of Life and Behavioral Change of Retired Persons
Researchers have found that the first phase of aging, called "frailty", is insidious, silent and slowly progressive. It begins well before the first signs of aging and possibly before retirement age with physiological reserves…
- Trial name
- R-FORM' (NCT06432010)
- Testing
- Group nutrition and physical activity coaching, Group cognition coaching
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Early Childhood Development
Evaluating Effects of Integrating ECD Activities Into Bangladesh Government's Urban Lactating Mothers Allowance Program for the Poor on Children's Cognition and Behavior in Rangpur City Corporation, Bangladesh
Burden: Provision of health care to urban poor population is a great challenge because of supply and demand barriers in the urban health system, which is considered patchy and fragmented.
- Trial name
- NCT03753646
- Testing
- Lactating allowance and psycho social stimulation
- Where
- Bangladesh
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Cognition, Embolism, Fat
Cognition Following Computer Assisted Total Knee Arthroplasty
A significant number of patients experience postoperative cognitive changes following total joint arthroplasty. Among other causes, the mental status change may be the result of fat and bone marrow debris embolization.
- Trial name
- Minimental (NCT00830986)
- Testing
- Total Knee Arthroplasty Implant (Scorpio®)
- Volunteers
- 100 people
- Sponsor
- Rothman Institute Orthopaedics
Alzheimer's Disease
Mifepristone as Adjunctive Therapy in Alzheimer's Disease
The purpose of this study is to evaluate the effects of C-1073 (Mifepristone) on cognition in patients with Alzheimer's disease (AD) who are also taking an acetylcholinesterase inhibitor (Aricept, Exelon or Reminyl).
- Trial name
- NCT00105105
- Testing
- Mifepristone
- Where
- 21 sites in United States
- Volunteers
- 160 people
- Sponsor
- Corcept Therapeutics
Duchenne Muscular Dystrophy, Duchenne Disease
Evaluating VM100 Nutritional Supplement for Improving Quality of Life in Duchenne Muscular Dystrophy Patients
This pilot study will investigate the potential efficacy of VM100, a nutritional supplement specifically formulated for patients with DMD, on quality of life and physical symptoms.
- Conditions
- Duchenne Muscular Dystrophy, Duchenne Disease, Muscular Dystrophy in Children, DMD
- Trial name
- NCT07766980
- Testing
- VM100 Nutritional Supplement
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
ASD, Functional Magnetic Resonance Imaging
MRI-Eye Tracking Pairing, a Tool for Assessing Social Cognition in Children With ASD
Most studies use static visual percepts that are less representative of joint attention versus an ecological environment. This has the consequence of decreasing the perception of an interaction with a social partner, which is an…
- Conditions
- ASD, Functional Magnetic Resonance Imaging, Eye Tracking, Social Cognition
- Trial name
- IRM-ET (NCT05194254)
- Testing
- MRI-ET
- Where
- France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Autism
Examination of Differential Valuation of Leisure Items and Attention as Reinforcers in Children With Autism
The purpose of this study is to compare how children with autism, typically developing children, and children with other developmental delays value social attention and toys.
- Trial name
- NCT03152383
- Testing
- Training trials, Progressive Ratio Session, Re-test
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Emory University
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