Clinical trials: Cognitive Therapy
Insomnia, Traumatic Brain Injury
Non-Pharmacological Treatments for Insomnia in Chronic Traumatic Brain Injury
The purpose of this clinical trial is to assess the relative efficacy of two non-pharmacological interventions for insomnia in Veterans suffering from chronic mild traumatic brain injury (mTBI).
- Trial name
- NCT03261674
- Testing
- CBT-I, ABT-I
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, PTSD
D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents
The purpose of this study is to show whether D-cycloserine in combination with cognitive behavioral therapy (CBT) is more effective than CBT plus placebo to reduce symptoms of posttraumatic stress disorder (PTSD) in 13-18…
- Trial name
- NCT01157429
- Testing
- D-cycloserine, CBT
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Tulane University School of Medicine
Anxiety Disorders in Youth With Autism, Asperger's Syndrome, and Pervasive Developmental Disorder Not Otherwise Specified
Cognitive Behavioral Therapy (CBT) for Anxiety Disorders in Autism: Adapting Treatment for Adolescents
Comorbid anxiety disorders affect as many as 80% of youth with autism spectrum disorders, causing substantial distress and impairment over and above the autism spectrum diagnosis alone.
- Trial name
- NCT01177969
- Testing
- Cognitive-Behavioral Therapy, Wait-list
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Autism Spectrum Disorder
Tetrahydrobiopterin Treatment in Children With Idiopathic Cognitive Developmental Disorders
The purpose of this study is to develop biomarkers for central nervous system BH4 concentration in children with autism so they can be easily screened to determine if they may benefit from BH4 supplementation.
- Trial name
- NCT01141595
- Testing
- sapropterin dihydrochloride
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center, Houston
Visual Rehabilitation, Visual Impairment, Autism Spectrum Disorder, Developmental Disabilities, Intellectual Disability, Behavioral Symptoms
Evaluation of a Program to Enhance Ophthalmic Compliance in Children and Adolescents With Special Needs
The goal of this clinical trial is to learn about the effects of the structured program incorporating contextual, behavioral, and cognitive strategies to improve compliance of children and adolescents with special needs during…
- Trial name
- NCT06717282
- Testing
- visual rehabilitation for ophthalmic compliance, Using contextual, behavioral, and cognitive-based stragegies to develop training programs
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Post-traumatic Stress Disorder
Cognitive Behavioral Treatments for Post-traumatic Stress Disorder (PTSD) Sleep Disturbance
The purpose of this study is to compare the effectiveness of two cognitive behavioral group psychotherapy interventions in controlling the subjective sleep disturbance in veterans with Post-traumatic Stress Disorder.
- Trial name
- NCT00108628
- Testing
- Imagery Rehearsal, Sleep and Nightmare Management
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- US Department of Veterans Affairs
Schizophrenia, Schizophreniform Disorder
DECIFER: Depression and Citalopram In First Episode Recovery
This study seeks to examine the effectiveness of citalopram added to treatment with any oral or injectable second-generation antipsychotic plus standardized psychoeducation in first episode schizophrenia patients.
- Trial name
- DECIFER (NCT01041274)
- Testing
- Citalopram, Psychoeducation, Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- NYU Langone Health
Anxiety Disorder
Early Intervention for Children at Risk for Anxiety
The aim of this study was to develop and pilot a cognitive-behavioral therapy (CBT) parent-child intervention for 4-7-year-old children at risk for anxiety disorders.
- Trial name
- NCT00865306
- Testing
- "Being Brave: A Program for Coping with Anxiety for Young Children and Their Parents."
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes Mellitus, Cognitive Change
The VRIF Trial: Hypoglycemia Reduction With Automated-Insulin Delivery System
The objective of this pilot study is (i) to test the use of an Artificial Pancreas (AP) System as a viable therapy treatment for two vulnerable populations: 6 to 10 year-old and adults older ≥65 years old with T1D; (ii) to assess…
- Trial name
- NCT03674281
- Testing
- SAP, CLC
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
HIV-1-infection
Group-Based Intervention to Improve Mental Health and Adherence Among Youth Living With HIV in Low Resource Settings
IMPAACT 2016 was a multi-site, two-arm, individually randomized, controlled study to evaluate whether an Indigenous Leader Outreach Model (ILOM) of trauma-informed cognitive behavioral therapy (TI-CBT) delivered by Indigenous…
- Trial name
- NCT04024488
- Testing
- Youth TI-CBT Intervention Arm, Youth Discussion Control Arm, Caregiver TI-CBT Intervention Arm
- Where
- 8 sites in Botswana, Malawi and 2 more
- Volunteers
- 484 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Binge Eating, Eating Disorders in Adolescence
Cognitive Behavioral Therapy for Adolescent Binge Eating and Loss of Control Eating
This study will develop and test a cognitive-behavioral intervention for adolescents with binge/loss-of-control eating.
- Conditions
- Binge Eating, Eating Disorders in Adolescence, Overweight and Obesity
- Trial name
- NCT04088097
- Testing
- Cognitive-Behavioral Therapy for Adolescent Binge/Loss-of-Control Eating, Control Condition
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Autism Spectrum Disorder
Oxytocin and Social Cognitive Skills Groups
The purpose of this study is to evaluate the feasibility, safety, and preliminary efficacy of integrating targeted dosing of intranasal oxytocin with a social cognitive skills group therapy for school-aged children with autism…
- Trial name
- ION-ASD (NCT02918864)
- Testing
- Oxytocin, Social Cognitive Skills Training, Facilitated Play Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rush University Medical Center
Gulf War Illness, Insomnia
Cognitive Behavioral Therapy for Insomnia for Gulf War Illness
Sleep disturbance is a common complaint of Veterans with Gulf War Illness (GWI). Because there is clinical evidence that sleep quality influences pain, fatigue, mood, cognition, and daily functioning, this study will investigate…
- Trial name
- CBTi GWI (NCT02782780)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBTi)
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- VA Office of Research and Development
Childhood Traumatic Grief, Post Traumatic Stress
Randomized Controlled Trial of Trauma-focused CBT in Tanzania and Kenya
The primary goal is to study the effectiveness of Trauma-focused Cognitive Behavioral Therapy (TF-CBT) in treating traumatic grief and traumatic stress for orphaned children and young adolescents in two East African sites with…
- Conditions
- Childhood Traumatic Grief, Post Traumatic Stress, Post Traumatic Stress Disorder, Depressive Symptoms
- Trial name
- NCT01822366
- Testing
- Trauma-focused Cognitive Behavioral Therapy
- Where
- 3 sites in United States, Kenya and 1 more
- Volunteers
- 1,280 people
- Sponsor
- Duke University
Sturge-Weber Syndrome
Novel Cognitive Treatment Targets for Epidiolex in Sturge- Weber Syndrome
The purpose of this study is to better understand the utility of cannabidiol (CBD/ Epidiolex) for improving the treatment of cognitive impairments in Sturge-Weber syndrome (SWS).
- Trial name
- NCT04447846
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Anne Comi, MD
Child Abuse, Posttraumatic Stress
Integrating Animal-Assisted Therapy Into Trauma-Focused Cognitive-Behavioral Therapy for Maltreated Youth
This study will examine the incremental benefit of animal-assisted therapy (AAT) as an adjunct intervention when combined with Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT) for the treatment of maltreated youth.
- Trial name
- TF-CBT+AAT (NCT03135119)
- Testing
- TF-CBT, TF-CBT+AAT
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Milton S. Hershey Medical Center
Depression
CBT Enhanced With Social Cognitive Training
Depression in youth is a serious public health concern for which more personalized treatments are needed. This study will test the effect of an intervention aimed at enhancing depressed children's social cognitive capacities…
- Trial name
- CBT+SCT (NCT03954392)
- Testing
- Cognitive behavior therapy with social cognitive training (CBT+SCT), CBT-only
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Vanderbilt University
Evidence-Based Practices, CBT
A Hybrid Type 2 Trial of Trauma-Focused Cognitive Behavioral Therapy and a Pragmatic Individual-Level Implementation Strategy
This research project is a hybrid type 2 effectiveness-implementation trial that simultaneously examines (1) the effectiveness of a trauma-focused intervention for youth in the education sector and (2) the impact of a…
- Conditions
- Evidence-Based Practices, CBT, School Health Services, Trauma, Psychological
- Trial name
- NCT04451161
- Testing
- Beliefs and Attitudes for Successful Implementation in Schools (BASIS), Trauma-Focused Cognitive-Behavioral Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- University of Washington
Minimal Hepatic Encephalopathy
Study of Lactulose in Children With Chronic Liver Disease
Pediatric patients with chronic liver disease may have Minimal Hepatic Encephalopathy(MHE)which can cause changes in behavior,intelligence and neurological function.By utilizing cognitive and developmental testing we will…
- Trial name
- MHE (NCT00811434)
- Testing
- Lactulose
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Indiana University
Hunter Syndrome
A Safety and Dose Ranging Study of Idursulfase (Intrathecal) Administration Via an Intrathecal Drug Delivery Device in Pediatric Patients With Hunter Syndrome Who Have Central Nervous System Involvement and Are Receiving Treatment With Elaprase®
Elaprase (idursulfase), a large molecular protein, is not expected to cross the blood brain barrier at therapeutic levels when administered intravenously.
- Trial name
- NCT00920647
- Testing
- Control, Idursulfase IT (1 mg), Idursulfase IT (10 mg)
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 16 people
- Sponsor
- Shire