Clinical trials: Coma
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Disorders of Consciousness, Severe Brain Injury
Effect of Repeated tDCS Sessions on Cognitive Improvement in Patients With Disorders of Consciousness
In this study, researchers will show to caregivers of patients how to use a tDCS device (this device was designed to be easy to use, with fixed parameters and only one button to press to run the stimulation).
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Post-comatose Non-communicative Patients
- Trial name
- rtDCS in DOC (NCT02394691)
- Testing
- transcranial direct current stimulation
- Where
- Belgium
- Volunteers
- 37 people
- Sponsor
- University of Liege
Chest Pain, Stroke Acute
Evaluation and Optimization of Telephone Triage Using Artificial Intelligence (AI) Models for the Detection of Demands for Time-dependent Pathology at the Emergency and Urgent Care Coordination Center (CCUE).
Improving Telephone Triage in Emergency Calls with AI The Coordinating Centre for Urgencies and Emergencies in Andalusia (CCUE) handles thousands of calls every day.
- Conditions
- Chest Pain, Stroke Acute, Respiratory Failure, Cardiac Arrest (CA)
- Trial name
- TrIAje Project (NCT07247669)
- Where
- Spain
- Volunteers
- 5,000,000 people
- Sponsor
- Centro de Emergencias Sanitarias 061 Andalucía
Coma
Use of Music and Voice Stimulus on Coma Patients
Objectives: (1) To check music and voice message influence on vital signs and facial expressions of patients in physiological or induced comas; (2) To connect the existence of patient's responsiveness with the Glasgow Coma Scale…
- Trial name
- NCT00959829
- Testing
- Music and message
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Carbon Monoxide Poisoning
Hyperbaric Oxygen Therapy for Comatose Patients With Acute Carbon Monoxide Poisoning
Carbon monoxide poisoning still places a burden on the healthcare system worldwide. While oxygen therapy is the cornerstone treatment, the role and practical modalities of hyperbaric oxygen therapy (HBO) remain controversial.
- Trial name
- NCT01099995
- Testing
- Hyperbaric oxygen therapy
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University of Versailles
Brain Death, Liver Disease
Pre-recovery Bedside Liver Biopsy in Brain Death Organ Donors
This study's objective is to obtain preliminary data to test the hypotheses that percutaneous liver biopsy in brain death donors is safe and provides reliable histological information.
- Trial name
- PPB (NCT01810640)
- Testing
- Percutaneous Liver Biopsy
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Rutgers, The State University of New Jersey
Organ Donation
Organ Procurement : Usefulness of a Guide for Meeting With the Next of Kin
A dedicated guide for physicians and organ procurement nurses meeting with the next of kin could be associated with a reduction in organ donation refusal rate, and in anxiety of professionals involved in such meetings
- Trial name
- CANEVAS (NCT02854267)
- Where
- France
- Volunteers
- 322 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Death, Organ Donation
Donation Network to Optimize Organ Recovery Study
This study consists in an cluster-randomized clinical trial involving near 60 Brazilian intensive care units (ICUs) with a high notification rate of potential donors of organs and tissues.
- Trial name
- DONORS (NCT03179020)
- Testing
- Checklist use, Usual care
- Where
- 63 sites in Brazil
- Volunteers
- 1,535 people
- Sponsor
- Hospital Moinhos de Vento
Disorders of Consciousness, Severe Brain Injury
Use of Analgesic Treatment to Reduce Signs of Pain in Patients With Disorders of Consciousness.
The purpose of this study is to characterize and improve pain and nociception management in patients with disorders of consciousness (DOC).
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Post-comatose Non-communicative Patients, Vegetative State
- Trial name
- NCT04330547
- Testing
- Analgesic administration
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- University of Liege
Malaria, Seizures
Aggressive Antipyretics for Fever Reduction in CNS Malaria
The study will examine whether prophylactic and scheduled treatment with acetaminophen and ibuprofen can decrease the maximum temperature experienced during the acute illness in children with CNS malaria.
- Conditions
- Malaria, Seizures, Coma, Parasitemia
- Trial name
- NCT03399318
- Testing
- Acetaminophen, Ibuprofen
- Where
- 3 sites in Malawi, Zambia
- Volunteers
- 256 people
- Sponsor
- University of Rochester
Brain Death, Liver Steatosis
"LiverColor": Machine Learning in Liver Photographs
The main goal of this project is to create a machine learning model in order to quantify liver steatosis in liver donor faster, more objective and reliable than histological analysis and surgeons point-of-view.
- Trial name
- NCT05202886
- Testing
- Liver from deceased donors
- Where
- Spain
- Volunteers
- 246 people
- Sponsor
- Hospital Vall d'Hebron
Sepsis, Septicemia
Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests
We propose to develop novel diagnostic tests for severe sepsis and community acquired pneumonia (CAP). This program, entitled Community Acquired Pneumonia \& Sepsis Outcome Diagnostics (CAPSOD), is a multidisciplinary…
- Conditions
- Sepsis, Septicemia, Sepsis Syndrome, Shock, Septic
- Trial name
- NCT00258869
- Where
- 3 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- National Center for Genome Resources
Status Epilepticus, Coma
Rapid-Response EEG in Children With Suspected Status Epilepticus
Seizures are common in children (~350 per 100,000 patients per year) and require immediate medical attention. If the seizure is prolonged (> 5 minutes) it is called status epilepticus and delayed treatment leads to higher risk in…
- Trial name
- RECS (NCT06564662)
- Testing
- Rapid Response EEG
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital at Montefiore
Brain Death
Computed Tomography Angiography Accuracy in Brain Death Diagnosis
The purpose of this study is to assess the reliability of computed tomography angiography (CTA) to diagnose brain death, face of several conditions that make impossible to define such diagnosis using clinical criteria exclusively.
- Trial name
- NCT02045407
- Where
- Brazil
- Volunteers
- 106 people
- Sponsor
- Sergio Brasil, MD MSc
Coma, Wounds and Injuries
Cervical Spine Clearance in Obtunded Trauma Patients
The optimal method of clearing the cervical spine in obtunded trauma patients is unclear. Computed tomography (CT) identifies most injuries but may miss ligamentous injuries.
- Trial name
- CSclearance (NCT00573014)
- Testing
- Cervical Spine Clearance
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- MetroHealth Medical Center
Acute Brain Injury Coma
Circadian Rhythmicity During Coma Awakening
Acute brain injury is a major cause of admission to intensive care units, as well as of mortality and morbidity, worldwide and for all age groups.
- Trial name
- COMARHYTHM (NCT06245434)
- Testing
- Repeated behavioural assessment, Act-Pass paradigm, Biological measures of circadian and monoamines biomarkers
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Carbon Monoxide Poisoning
Hyperbaric Oxygen Therapy for Acute Domestic Carbon Monoxide (CO) Poisoning
Carbon monoxide poisoning still places a burden on the healthcare system worldwide. While oxygen therapy is the cornerstone treatment, the role and practical modalities of hyperbaric oxygen therapy (HBO) remain controversial.
- Trial name
- NCT01100515
- Testing
- normobaric oxygen therapy, Hyperbaric oxygen therapy
- Where
- France
- Volunteers
- 179 people
- Sponsor
- University of Versailles
Brain Death, Respiration, Artificial
Miniature In-line Respirator
This first-in-human pilot study will test an investigational miniature breathing device called the Hope inVent. The device is a small, single-use, in-line respirator that connects to a breathing tube and uses compressed oxygen to…
- Trial name
- NCT07768215
- Testing
- Hope inVent
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Brain Death
Evaluation of CTA on the Assessment of Brain Death
At present, different countries have different standards for the diagnosis of brain death, but according to the classic brain death confirmation test, it needs to be combined with transcranial Doppler, EEG, evoked potential and…
- Trial name
- NCT04914039
- Testing
- Combination Product, NO CTA examination
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coma
Optic Nerve Sheath Diameter as a Screening Test for Increased Intracranial Pressure
Patients admitted to the ICU may have delayed awakening after their critical illness has resolved. Though most either are due to metabolic causes or delayed elimination of sedative medications, more serious pathologies such as…
- Trial name
- NCT02338284
- Testing
- ultrasound of globe
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- King Faisal Specialist Hospital & Research Center