Clinical trials: Computer Aided Diagnosis
Osteogenic Sarcoma
Accuracy of Deep-learning Algorithm for Detection and Risk Stratification of Lung Nodules
Osteosarcoma is regarded as most common malignant bone tumor in children and adolescents. Approximately 15% to 20% of patients with osteosarcoma present with detectable metastatic disease, and the majority of whom (85%) have…
- Trial name
- NCT04022512
- Testing
- computed tomography
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Denture, Complete, Jaw, Edentulous
Milled Versus Printed CAD/CAM Complete Dentures
A crossover clinical trial investigates two novel CAD/CAM techniques for complete removable dental prostheses for edentulous patients, milling and rapid prototyping (3D-printing) in a clinical setting of an undergraduate student…
- Trial name
- MILLPRINT (NCT04873219)
- Testing
- manufacturing a complete dental prosthesis
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Diagnosis
Mitigating Automation Bias in Physician-LLM Diagnostic Reasoning Using Behavioral Nudges
The goal of this randomized controlled trial is to evaluate whether behavioral nudges can reduce automation bias, the uncritical acceptance of automated output, in physicians using large language models (LLM) like ChatGPT-5.1 for…
- Trial name
- NCT07328815
- Testing
- Behavioral Nudge Intervention
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Lung Cancer Metastatic
Clinical Validation of the M5L Lung CAD
To compare the diagnostic performance and time efficiency of Computer-Aided Detection (CAD) assisted reading for the identification of pulmonary nodules in chest Computed Tomography (CT) from oncological patients with that of…
- Trial name
- NCT03179150
- Testing
- Computed Tomography
- Where
- Italy
- Volunteers
- 237 people
- Sponsor
- Candiolo Cancer Institute - IRCCS
Diagnosis
The Impact of Large Language Models on Diagnostic Reasoning Among LLM-Trained Medical Doctors
This study aims to evaluate whether large language model-trained medical doctors demonstrate enhanced diagnostic reasoning performance when utilizing ChatGPT-4o alongside conventional resources compared to using conventional…
- Trial name
- NCT06774612
- Testing
- ChatGPT-4o
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Orbital Fractures
Computer Aided Evaluation of Orbital Volume
A retrospective review to assess the performance and clinical predictive value of a novel software program (Maxillo) designed to perform complex volumetric analysis with application in the field of orbital trauma.
- Trial name
- NCT00584506
- Volunteers
- 250 people
- Sponsor
- University of California, Davis
Ventilation, ARDS
Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Reducing the Number of Ventilator Associated Events, Injury Created by the Ventilator and Unsafe Setting of Alarms.
Ventilator associated events (VAE) is a quality metric defined by 48 hours of stability followed by 48 hours of escalation of ventilator settings within the ICU.
- Conditions
- Ventilation, ARDS, Respiratory Failure, Mechanical Ventilation
- Trial name
- NCT06737432
- Testing
- RKP Monitoring Software
- Where
- United States
- Volunteers
- 875 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Diagnosis, Tuberculosis
Active Close Contact Investigation of Tuberculosis Through Computer-aided Detection and Stool Xpert MTB/RIF Among People Living in Ethiopia
Tuberculosis is the 13th cause of death from all causes, infecting roughly the 25% of the world population, and Ethiopia is listed among the 30 high-burden countries both for TB and for HIV/TB.
- Conditions
- Diagnosis, Tuberculosis, geneXpert
- Trial name
- CADOOL (NCT05818059)
- Testing
- Diagnosis of Tuberculosis with computer-aided detection (CAD) software
- Where
- Ethiopia
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Doctors with Africa - CUAMM
Tuberculosis, Pulmonary
Comparative Efficacy of CUS, CXR and CAD in TB Diagnosis in LMIC
Pulmonary Tuberculosis (TB) remains a significant global health concern, particularly in low- and middle-income countries (LMIC), where resources for healthcare are often limited.
- Trial name
- CUSTB (NCT06409780)
- Testing
- Comparative analysis of CUS, CAD and CXR in pulmonary TB
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Bari
COVID-19
COVID-19 Volumetric Quantification on Computer Tomography Using Computer Aided Diagnostics
The aim of the study is to asses the influence of computer aided diagnostic to the process of lung affection quantification on computer tomography in COVID-19 confirmed patients.
- Trial name
- NCT05282056
- Testing
- CAD analysis
- Where
- Romania
- Volunteers
- 200 people
- Sponsor
- Bogdan Bercean
Hypoplastic Left Heart Syndrome (HLHS), Aortic Arch Hypoplasia
Seeking for Perfected Aortic Arch Reconstruction Using a Graphically Designed Patient-specific Surgical Patch
Vascular Reconstruction is one of the most challenging areas of surgery, the surgeon has to create a completely watertight reconstruction without any narrowing or deformity that will restore normal flow characteristics, even at…
- Trial name
- NCT06853054
- Testing
- Personalized patch template
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Colorectal Polyp, Linked Color Imaging
Computer-assisted Diagnosis System Based on Linked Colour Imaging
Linked color imaging (LCI)，a new endoscopy modality, creates clear and bright images by using short wavelength narrow band laser light. LCI can make red area appear redder and white areas appear whiter.
- Conditions
- Colorectal Polyp, Linked Color Imaging, Computer-aided Diagnosis
- Trial name
- NCT03359343
- Where
- 2 sites in China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Tuberculosis (TB)
Effectiveness of Computer-Aided Detection Chest X-Ray Screening for Improving Tuberculosis Diagnostic Yield in Chinese Primary Health Care Settings: Study Protocol for a Prospective Cluster Randomized Controlled Trial
The global incidence rate and mortality of tuberculosis (TB) pose a challenge to achieving the goals set out in the tuberculosis eradication strategy and the SDGs by 2030.
- Trial name
- NCT06963606
- Testing
- Artificial intelligence-assisted chest X-ray in TB screening, Routine doctors analyze the process of chest X-rays
- Where
- China
- Volunteers
- 22,000 people, healthy volunteers welcome
- Sponsor
- Xuelin Yang
Wilms' Tumor, Neuroblastoma
Computer Aided Diagnostic Tool on Computed Tomography Images for Diagnosis of Retroperitoneal Tumor in Children
The aim of this study was to evaluate the diagnostic efficacy of computer aided diagnostic tool for retroperitoneal tumor using machine learning and deep learning techniques on computed tomography images in children.
- Conditions
- Wilms' Tumor, Neuroblastoma, Teratoma, Lymphoma
- Trial name
- NCT05179850
- Testing
- Radiomic Algorithm
- Where
- China
- Volunteers
- 400 people
- Sponsor
- West China Hospital
Prostate Cancer Diagnosis
PROVIZ - a Machine Learning Software, to Support Targeting of Prostate Biopsies on MR Images in Biopsy-naive Patients
To perform a traditional feasibility clinical investigation, as defined in ISO 14155:2020, to investigate preliminary feasibility, safety, and clinical performance information of a near-final design of the investigational…
- Trial name
- NCT06000046
- Testing
- Automatic image analysis
- Where
- Norway
- Volunteers
- 82 people
- Sponsor
- Norwegian University of Science and Technology
Heart Murmurs, Mitral Valve Prolapse
Automatic Differentiation of Innocent and Pathologic Murmurs in Pediatrics
The purpose of this preliminary clinical study is to assess the quality of a computational algorithm that automatically classifies murmurs of phonocardiograms (PCGs) as either pathologic (AHA class I) or as no- or innocent (AHA…
- Conditions
- Heart Murmurs, Mitral Valve Prolapse, Systolic Murmurs
- Trial name
- NCT02512341
- Testing
- Computer Aided Auscultation (CAA)
- Where
- Canada
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- CSD Labs GmbH
Maxillofacial Injury
Computer Modeling With Reconstruction of Maxillofacial Skeleton
Investigator initial study to evaluate the use of preoperative computer modeling and the intraoperative navigation to guide reconstruction of the maxillofacial skeleton.
- Trial name
- NCT00583856
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of California, Davis
Diabetic Retinopathy, Glaucoma
AI for the Detection of Retinal Disease and Glaucoma in Patients With Diabetes Mellitus in Primary Care
Background: Diabetic retinopathy (DR) is one of the most important causes of blindness worldwide, especially in developed countries.
- Conditions
- Diabetic Retinopathy, Glaucoma, Age-Related Macular Degeneration, Choroidal Nevus
- Trial name
- NCT04132401
- Testing
- algorithm
- Where
- Spain
- Volunteers
- 902 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Radiology Information Systems
Development and Evaluation of Techniques for Computer Aided Detection and Diagnosis From Existing Radiologic Images
Background: Radiologic images are getting more complex. They are also being used more often. Medical personnel are overwhelmed with data. Computer Aided Detection (CAD) and diagnosis may be able to improve medical care.
- Trial name
- NCT04579237
- Where
- United States
- Volunteers
- 144,625 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Lung Cancer
Testing of Computer Aided Detection Software for Riverain Medical Group
This is a clinical trial using retrospective data of two different software devices developed by Riverain Medical Group: Softview and OnGuard 5.0. The two studies will be run concurrently.
- Trial name
- NCT00906789
- Testing
- Software
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Georgetown University