Clinical trials: Concussion, Intermediate
Brain Injuries, Concussion, Mild
Evaluation and Validation of a Multimodal Brain Function Biomarker With NPC
This study is designed to collect data which will be used to associate changes in EEG, neurocognitive performance, eNPC and clinical symptoms in concussion subtypes.
- Conditions
- Brain Injuries, Concussion, Mild, Concussion, Brain, Near Point Convergence
- Trial name
- BSC-CI-NPC (NCT04074486)
- Testing
- BrainScope Ahead 300iP-O, SCAT5, Near Point Convergence
- Where
- 6 sites in United States
- Volunteers
- 1,318 people, healthy volunteers welcome
- Sponsor
- BrainScope Company, Inc.
Mild Traumatic Brain Injury, Concussion, Mild
Facilitating Access to Specialty Treatment
The goal of this hybrid implementation-effectiveness study is to evaluate the effectiveness (hastened recovery times) and feasibility (fidelity in connecting to concussion specialty care) of a novel mobile health intervention…
- Conditions
- Mild Traumatic Brain Injury, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
- Trial name
- NCT05741411
- Testing
- RPM-assisted specialist access
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Children's Hospital of Philadelphia
Concussion; Syndrome
Correlation Between Changes in Measures of the Visual System and Changes in Concussion-associated Symptoms
Sports-related concussion affect 1.6 to 3.8 million people each year in the United States. Despite increased media attention and awareness campaigns, the exact number is difficult to determine due to underreporting by athletes.
- Trial name
- NCT03259178
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- McGill University
Brain Concussion, Cerebral Concussion
Use of Eye Movement Tracking to Detect Oculomotor Abnormality in Traumatic Brain Injury Patients
The purpose of this study is to determine the sensitivity and specificity of an aid in assessment of concussion based on eye-tracking, in comparison to a clinical reference standard appropriate for the Emergency Department (ED)…
- Conditions
- Brain Concussion, Cerebral Concussion, Concussion, Intermediate, Concussion, Mild
- Trial name
- DETECT (NCT02776462)
- Testing
- EyeBox CNS
- Where
- 2 sites in United States
- Volunteers
- 321 people
- Sponsor
- Oculogica, Inc.
Brain Injuries, Traumatic, Concussion, Mild
Objective Brain Function Assessment of mTBI/Concussion
This study (Part 3) is designed to build a database including EEG, neurocognitive performance, clinical symptoms, history and other relevant data, which will be used to derive a multimodal EEG based algorithm for the…
- Conditions
- Brain Injuries, Traumatic, Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- CAS13-25 (NCT03963804)
- Testing
- BrainScope Ahead 300iP
- Where
- 4 sites in United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- BrainScope Company, Inc.
Concussion, Mild, Sport Injury
A Comparison Between Cardiovascular Exercise Modes Following Sport Related Concussion
Primary Aim: Compare physiological (e.g., heart rate) and clinical responses (e.g., symptom provocation) of adolescent and adult athletes (14-35 years of age) completing either a structured treadmill running or a dynamic aerobic…
- Trial name
- NCT04586179
- Testing
- Aerobic (treadmill) Exercise, Dynamic (Agility) Exercise
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pittsburgh
Pediatric ALL, Concussion, Mild
Concussion Active Rehabilitation
In this study, the investigator plans a randomized trial of active rehabilitation and standard care for acute concussion management.
- Conditions
- Pediatric ALL, Concussion, Mild, Concussion, Brain, Concussion, Intermediate
- Trial name
- NCT04248218
- Testing
- Active Rehabilitation Group/Case
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Concussion, Brain
Developing a Tool to Support Shared Decision Making Post-Concussion Between Adolescents, Parents and Clinicians
Investigators will conduct a pilot efficacy test of a decision aid about contact sport participation post-concussion.
- Trial name
- NCT04777864
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Brain Injuries, Traumatic, Concussion, Brain
Objective Brain Function Assessment of mTBI/Concussion in High School Athletes
This study (Part 2) is designed to build a database including EEG, neurocognitive performance, clinical symptoms, history and other relevant data, which will be used to derive a multimodal EEG based algorithm for the…
- Conditions
- Brain Injuries, Traumatic, Concussion, Brain, Concussion, Mild, Concussion, Intermediate
- Trial name
- AheadCAS-HS (NCT02661633)
- Testing
- BrainScope Ahead 200iD, Advanced MRI Neuroimaging
- Where
- 4 sites in United States
- Volunteers
- 177 people
- Sponsor
- BrainScope Company, Inc.
Concussion, Brain, Dynamic Vision Tests
A Comparison of Dynamic Vision Between College Athletes & Controls
The purpose of this study is to establish baseline reference values for tests of static and dynamic visual acuity and gaze stabilization in collegiate athletes and non-athletes, and to determine if there are differences in vision…
- Trial name
- NCT05819489
- Testing
- Dynamic Vision Testing
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Mild Traumatic Brain Injury
Post-Concussion Differences Between Buffalo Concussion Treadmill Test (BCTT) and Modified Dynamic Exertion (mEXiT) Test
This study aims to compare symptom provocation, physiologic response, and rate of perceived (RPE) between the Buffalo Concussion Treadmill Test (BCTT) and a Modified Dynamic Exertion (mEXiT) test after sport related concussion in…
- Trial name
- NCT06276660
- Testing
- BCTT, Dynamic ExIT
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
Concussion, Mild, Concussion, Intermediate
Assessment of the Effects of Concussion on Adolescent Rugby Union Players
200 adolescent rugby players (aged 15-19) from the Senior Cup Teams of 5 Rugby Playing schools (Members of Irish Schools Rugby) will be invited to enroll for inclusion in the study.
- Conditions
- Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- NCT03624634
- Where
- Ireland
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Sports Surgery Clinic, Santry, Dublin
Brain Injuries, Traumatic, Concussion, Mild
Validation of Brain Function Assessment Algorithm for mTBI/Concussion
This study is Part 2 of data collection from 13-25 years old subject population for validation of previously derived algorithms.
- Conditions
- Brain Injuries, Traumatic, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
- Trial name
- CAS13-25V (NCT03671083)
- Testing
- BrainScope Ahead 300iP
- Where
- 5 sites in United States
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- BrainScope Company, Inc.
Concussion, Brain
Development of a Concussion Management Platform for Children and Youth
This multi-centred, randomized controlled trial will evaluate the effectiveness of a pilot tested mobile device Application built to guide youth in recovery from concussion.
- Trial name
- Back2PlayApp (NCT05471791)
- Testing
- Back2Play App
- Where
- 2 sites in Canada
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- McMaster University
Concussion, Mild, Concussion, Intermediate
Biomarkers in Concussion
This will be an observational study measuring serum Neurofilament Light Chain concentrations and associated symptoms, with a control branch, and a post-concussion branch.
- Conditions
- Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- NCT05943561
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Traumatic Encephalopathies, Chronic, Concussion, Mild
Use of Adipose-Derived Stem/Stromal Cells in Concussion and Traumatic Brain Injuries
Concussion is the most common type of brain injury throughout life. Study is seeking improvement of long-term residua following adolescent and adult post-traumatic injuries often associated with contact sports and accidental…
- Conditions
- Traumatic Encephalopathies, Chronic, Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- C-TBI (NCT02959294)
- Testing
- Microcannula Harvest Adipose, Centricyte 1000, Sterile Normal Saline IV deployment AD-cSVF
- Where
- United States
- Sponsor
- Robert W. Alexander, MD, FICS
Sports Injury, Concussion, Mild
Turkish Translation of SportsConcussion Assesment Tool 6
Concussions, a significant type of sports injury caused by head, face, or neck trauma, are common in contact sports and require serious attention due to potential fatal consequences of mismanagement.
- Conditions
- Sports Injury, Concussion, Mild, Concussion, Brain, Concussion, Severe
- Trial name
- SCAT 6-tr (NCT06739785)
- Testing
- SCAT6-tr
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ordu University