Clinical trials: Condition
Sickle Cell Disease, Sickle Cell Hemoglobin C
Home-based Assessment of PRO Measures in SCD Using A Smartphone App Platform: A Feasibility Study
The overarching goal of this proposal is to identify modifiable behavioral strategies based on patient-reported outcomes (PROs) and health-related quality of life (HRQOL) that will improve hydroxyurea (HU) adherence among…
- Conditions
- Sickle Cell Disease, Sickle Cell Hemoglobin C, Sickle Beta Zero Thalassemia, Sickle B+ Thalassemia
- Trial name
- NCT04678037
- Testing
- PROs assessment using sickle cell disease mobile app (SCD-app)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Brain Tumor, Vascular Lesion
Factor XIII and Pulmonary Embolism in Neurosurgical Patients
Two studies (Gerlach et al. 2000; Gerlach et al. 2002) described the impact of factor XIII on the risk of prospective hemorrhage for patients undergoing craniotomy.
- Conditions
- Brain Tumor, Vascular Lesion, Factor XIII Deficiency, Pulmonary Embolism
- Trial name
- NCT01106937
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Child, Only, Chronic Diseases in Children
Effects of Colour-By-Number Mandalas ın Children Hospitalised Due to A Chronic Disease
Purpose: This study was conducted to find out the effects of colour by number mandala in decreasing the stress of hospitalized children with chronic disease. Design: A randomized controlled study.
- Trial name
- NCT05524272
- Testing
- This study aims to evaluate the effects of colour by number mandala in decreasing the stress of children hospitalized due to their chronic disease.
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Firat University
Non-small Cell Lung Cancer, Radiation Toxicity
Detecting Radiation-Induced Cardiac Toxicity After Non-Small Cell Lung Cancer Radiotherapy
Lung cancer is the most common cause of cancer death in Canada. For approximately 30% of patients that present with locally-advanced non-small cell lung cancer (NSCLC), the standard treatment is curative-intent concurrent…
- Trial name
- RICT-LUNG (NCT03416972)
- Testing
- Standard platinum-based chemoradiotherapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Venous Thromboembolism, Pediatrics
Using a Real-Time Risk Prediction Model to Predict Pediatric Venous Thromboembolism (VTE) Events
The study will evaluate the effectiveness of a novel, real-time risk prediction model for identifying pediatric patients at risk for developing in-hospital blood clots (or venous thromboembolism [VTE]) based on data easily…
- Conditions
- Venous Thromboembolism, Pediatrics, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- NCT04574895
- Testing
- Hematology Review
- Where
- United States
- Volunteers
- 17,427 people
- Sponsor
- Vanderbilt University Medical Center
Malaria
Artemisinin Resistance In Malaria Treated With IV Artesunate
The spread of artemisinin resistant falciparum malaria presents new challenges to both the control and treatment of malaria. Loss of ring stage susceptibility to the artemisinins might jeopardize the use of parenteral artesunate…
- Trial name
- ARIMTIA (NCT02640495)
- Testing
- Intravenous Artesunate as part of standard medical practice
- Sponsor
- University of Oxford
Colorectal Carcinoma, Cancer
Primary Colorectal Signet Ring Cell Carcinoma and the Risk of Multiple Primary Gastrointestinal Malignancies
This original research investigates the critical issue of gastrointestinal (GI) second primary malignancies (SPMs) in patients with signet ring cell carcinoma (SRCC), a rare and aggressive subtype of colorectal cancer.
- Conditions
- Colorectal Carcinoma, Cancer, Signet Ring Adenocarcinoma of the Colon
- Trial name
- NCT06978595
- Where
- Egypt
- Volunteers
- 8,171 people
- Sponsor
- asmaa salama ibrahim
Spastic Cerebral Palsy, Dysarthria
Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy
Lateral cord stimulation (LCS) was discovered by the author as the producer of an average threshold increase for abnormal muscle contraction responses, in experimental pathological conditions, as described and referred.
- Trial name
- NCT03676439
- Testing
- Magnetic Spinal Stimulation
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Sociedad Argenttina de Neuromodulación
Incisional Hernia
Incisional Hernia Repair With Mesh at Waitemata District Health Board - A 15 Year Retrospective Cohort Study'
A retrospective review of all incisional hernia repairs at North Shore Hospital (NSH), Auckland, NZ was performed between January 2004 and July 2019.
- Trial name
- NCT05482139
- Testing
- Incisional hernia repair with mesh
- Volunteers
- 718 people
- Sponsor
- Waitemata District Health Board
Inborn Errors of Metabolism, Propionic Aciduria
Characterization of Intestinal Microbiota in Children With Inborn Errors of Metabolism (IEM)
Study around children with inborn errors of metabolism (IEM) and their healthy siblings. Collection of stool and urine to assess contribution of microbiota to disease severity.
- Conditions
- Inborn Errors of Metabolism, Propionic Aciduria, Methylmalonic Aciduria, Urea Cycle Disorder
- Trial name
- IEM (NCT05330039)
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Emma Marie Caroline Slack
Newborn
Comparison of Open and Closed Aspiration in Newborns
Endotracheal aspiration is a necessary procedure performed by nurses in neonatal intensive care units to increase oxygenation and remove secretions from the airways.
- Trial name
- NCT06435572
- Testing
- Suction
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Izmir Katip Celebi University
Infant, Premature, Diseases, Mothers
Home Support for Mothers Whose Premature Infants
Premature births are a challenging process for parents in many ways. Especially after the treatment and care in the hospital, they are concerned about whether they will be able to provide adequate care for their baby at home.
- Trial name
- NCT04741672
- Testing
- Providing guidance after discharge routine procedure and calling one week after discharge., Discharge routine procedure.
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia
Mitoxantrone and Clofarabine for Treatment of Recurrent NHL or Acute Leukemia
The combination of mitoxantrone and clofarabine as reinduction therapy will be safe, well tolerated and effective in children, adolescents and young adults with poor risk refractory/relapsed acute leukemia and high grade…
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia, Lymphoblastic Lymphoma, Diffuse Large B-cell Lymphoma
- Trial name
- MITCL (NCT01842672)
- Testing
- Clofarabine, Mitoxantrone
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- New York Medical College
Gastreoesophageal Reflux Disease
Pharmacokinetics of Enteral Omeprazole Suspension in Patients With Cerebral Palsy and Mental Retardation
Gastroesophageal reflux disease and reflux-esophagitis are a major chronic problem in most children with cerebral palsy and mental retardation.
- Trial name
- NCT00426595
- Testing
- Administration of omeprazole suspension, omeprazole administered as a multi-unit-pellet system
- Where
- Belgium
- Volunteers
- 14 people
- Sponsor
- University Hospital, Ghent
Premature Infants, Bronchopulmonary Dysplasia
Optimization of Saturation Targets And Resuscitation Trial (OptiSTART)
This study is designed to answer one of the fundamental gaps in knowledge in the resuscitation of preterm infants at birth: What is the optimal target oxygen saturation (SpO2) range that increases survival without long-term…
- Conditions
- Premature Infants, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage, Neurodevelopmental Outcomes
- Trial name
- OptiSTART (NCT05849077)
- Testing
- Sat75, Sat50
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- University of Texas Southwestern Medical Center
Hypothermia, Neonatal Outcome
Hypothermia and the Effect of Ambient Temperature 2
Neonatal hypothermia is associated with increased risk of mortality as well as multiple morbidities. The prior HEAT study conducted at our institution showed a difference in neonatal hypothermia with a change in ambient operating…
- Conditions
- Hypothermia, Neonatal Outcome, Cesarean Section
- Trial name
- HEAT2 (NCT03008577)
- Testing
- Change in ambient operating room temperature
- Where
- United States
- Volunteers
- 5,221 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hemangioma, Vascular Anomalies
Genetic Basis of Hemangiomas
The purpose of this study is to determine if there are genes that are common in children with infantile hemangioma. This information will allow physicians to improve care for patients who have been diagnosed with this disease and…
- Trial name
- NCT00466375
- Testing
- Cheek cell samples or blood sample (4mL), Cheek cell sample or blood sample (4mL)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Medical College of Wisconsin
Lung Cancer, Abdominal Cancer
Respiratory Tumor and Normal Tissue Motion
Primary Objectives: To collect accurate and reliable respiration-induced anatomic structure motion data using four-dimensional (4-D) imaging technology.
- Trial name
- NCT00415675
- Testing
- Motion CT Scans
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- M.D. Anderson Cancer Center
Drug Resistant Epilepsy
Epileptogenic Network Visualisation With Advanced MRI
The goal of this clinical trial is to improve non-invasive identification of epileptogenic networks in drug-resistant epileptic patient.
- Trial name
- EPIVAM (NCT06059157)
- Testing
- Advanced MRI
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Relapsed/Refractory Acute Myeloid Leukemia
LILRB4 STAR-T Cells in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia
This is a single-center, single-arm, open-label phase I clinical study to determine the safety and efficacy of LILRB4 STAR-T cells in relapsed/refractory acute myeloid leukemia subjects.
- Trial name
- NCT05518357
- Testing
- LILRB4 STAR-T
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Hebei Yanda Ludaopei Hospital
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