Clinical trials: Conflict, open to volunteers
Chronic Graft-versus-host-disease
A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)
This is a Phase 2 study to evaluate the efficacy, safety, and tolerability of axatilimab at 3 different dose levels in participants with recurrent or refractory active chronic graft versus host disease (cGVHD) who have received…
- Trial name
- AGAVE-201 (NCT04710576)
- Testing
- Axatilimab
- Where
- 121 sites in United States, Australia and 14 more
- Volunteers
- 296 people
- Sponsor
- Syndax Pharmaceuticals
Developmental Language Disorder
Syntactic Intervention for Cantonese-speaking Children With DLD
The goal of this clinical trial is to compare the efficacy of explicit vs. implicit intervention on subject relative clause production in Cantonese-speaking children with Developmental Language Disorder (DLD).
- Trial name
- NCT06954194
- Testing
- Explicit intervention (Shape Coding+syntactic priming), Implicit intervention (syntactic priming only)
- Where
- Hong Kong
- Volunteers
- 32 people
- Sponsor
- The Hong Kong Polytechnic University
Child Behavior, Pain, Acute
The Effect of Two Different Cognitive-Behavioral Combined Programs in Blood Collection
The aim of this study is to investigate the effect of two different cognitive-behavioral combined programs, including video games or kaleidoscope, on the pain, fear and anxiety experienced by children who apply for therapeutic or…
- Conditions
- Child Behavior, Pain, Acute, Fear
- Trial name
- NCT05263297
- Testing
- control group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Karamanoğlu Mehmetbey University
Sphenoid Sinus, Endoscopic Sinus Surgery
Different Endoscopic Approaches for Sphenoid Sinus
Identification of the most effective approach for different lesion types Correlation between approach and complication rates
- Trial name
- NCT07702188
- Testing
- endoscopic sinus surgery
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Anklyosing Spondylitis, Telerehabilitation
Effectiveness of Telerehabilitation in Ankylosing Spondylitis
Purpose of the study: Ankylosing spondylitis (AS) is a chronic disease that affects the spine and joints, causing pain, stiffness, fatigue, and reduced quality of life.
- Trial name
- NCT07503327
- Testing
- Synchronous Telerehabilitation Exercise Program, Asynchronous Telerehabilitation Exercise Program, Brochure Program
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Inonu University
Child Development, Endometrial Preparation
Development of IVF/ICSI Children Born From Different Endometrial Preparation Protocols
The efficacy and safety of endometrial preparation regimens remain controversial. In the most recent meta-analysis, using natural and modified natural cycle protocol to prepare the endometrium in frozen embryo transfer resulted…
- Trial name
- MONARTBABIES (NCT05502770)
- Testing
- Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3, Physical development and General Health, Developmental Red flags
- Where
- Vietnam
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Mỹ Đức Hospital
Facial Neoplasms
A Comparison of Accuracy Between Different Facial Scanning Techniques
Conventional alginate impressions are still a burden to both the patient and the operator especially in extraoral maxillofacial rehabilitations cases.
- Trial name
- NCT07557212
- Testing
- portable scanning, stationery scanning, mobile app scanning
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Cystic Fibrosis
Testing Drug Efficacy in Cystic Fibrosis Through N-of-1 Trials
The purpose of this study is to validate and utilize a personalized medicine approach to identify potential treatments with current FDA approved CFTR modifiers for non-approved CF gene mutations.
- Trial name
- Nof1 (NCT04580368)
- Testing
- CFTR Modulators
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Surgical Smoke
The Effect of Masks on Surgical Smoke Exposure
Surgical smoke refers to the gaseous plume released into the air as a result of the thermal destruction of tissues by energy-based devices used in operating rooms.
- Trial name
- NCT07161609
- Testing
- Particle counter
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Mersin University
Hearing Loss
Hearing and Brain Development Cohort in Children and Adolescents
This bidirectional observational cohort study aims to establish a Hearing and Brain Development (HBD) cohort in children and adolescents with hearing loss across different hearing management pathways, including hearing aid…
- Trial name
- HBD-Cohort (NCT07625462)
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Child, Only, Temperature Regulation; Disorder
Effect of Sevoflurane on Sweat Threshold in Children of Different Ages
Hypothermia is a common complication in pediatric anesthesia. Hypothermia will prolong the recovery time of anesthesia, and may also lead to increased oxygen consumption, prolonged blood coagulation time, and affect the…
- Conditions
- Child, Only, Temperature Regulation; Disorder, Low Body Temperatures, Sevoflurane
- Trial name
- NCT07035782
- Testing
- temperature monitoring, Sevoflurane
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Treatment Outcome
Lubinus SPII Hip Stem Target Trial Emulation
The research questions this study aims to answer are as follows: Primary research question: "Do primary total hip arthroplasties for patients with OA, hip fracture or osteonecrosis with the 150mm Lubinus SPII hip stem have better…
- Trial name
- LARGE (NCT06367829)
- Testing
- Lubinus SPII hip stem 130mm, Lubinus SPII hip stem 150mm
- Where
- Netherlands
- Volunteers
- 110,000 people
- Sponsor
- JointResearch
Neuromuscular Blocking Agents, Residual Neuromuscular Block
Measuring of the Duration of Action of Different Doses of Rocuronium-induced Neuromuscular Block in Infants During Surgical Treatment of Craniosynostosis
The use of intravenous muscle relaxants during anaesthesia can significantly facilitate endotracheal intubation and reduce the chance of possible airway complications during intubation.
- Conditions
- Neuromuscular Blocking Agents, Residual Neuromuscular Block, Neuromuscular Blockade Monitoring
- Trial name
- NCT07080528
- Testing
- Sevofluorane, Propofol
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Tamas Vegh, MD
Congenital Ectopia Lentis
Effect of Different Needle Insertion Positions on the Clinical Outcomes of YAMANE Technique
This is a single-blind, single-center, parallel-group randomized controlled trial with the following objectives: First, researchers aim to compare the clinical efficacy of 2mm and 2.5mm post-limbal needle insertion in YAMANE…
- Trial name
- NCT07446829
- Testing
- YAMANE technique(Suture Needle Insertion at 2.5 mm Posterior to the Limbus)
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Root Perforation at the Bifurcation Area
Evaluation for Healing of Iatrogenic Perforation After Repair With Different Materials
The goal of this clinical trial is to evaluate healing potentiality of MTA and bioceramics materials as a root perforation repair material.
- Trial name
- NCT06976411
- Testing
- MTA, Bioceramic putty
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mohamed Salah Elwakeel
Dental Caries, Insufficient Dental Filling
A Clinical Trial to Compare the Safety and Performance of Two Different Curing Modes in the Direct Filling Therapy in Deciduous Teeth
The overall aim of this clinical investigation is to assess the clinical performance and safety of composite restorations cured with fast curing mode (5 seconds with 2000 mW/cm²) in primary molars.
- Trial name
- NCT07212660
- Testing
- Fast curing mode, Conventional curing mode
- Where
- 2 sites in Switzerland
- Volunteers
- 70 people
- Sponsor
- Ivoclar Vivadent AG
Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF)
Phase 2 Study to Assess the Safety and Efficacy of ANG003
In this study, ANG003, a pancreatic enzyme replacement therapy (PERT; commonly called "enzymes"), is being investigated as a potential treatment for exocrine pancreatic insufficiency (EPI).
- Trial name
- NCT07450547
- Testing
- ANG003 Dose A, ANG003 Dose B, Creon
- Where
- 28 sites in United States
- Volunteers
- 113 people
- Sponsor
- Anagram Therapeutics, Inc.
Rabies Prevention
A Phase III Clinical Trial on Immunogenicity and Safety of Lyophilized Rabies Vaccine for Human Use (Human Diploid Cell)
Neutralizing antibody seroconversion rate and geometric mean concentration in seronegative participants of each group at 14 days after the first dose of immunization.
- Trial name
- NCT07500207
- Testing
- Experimental Lyophilized Human Rabies Vaccine (Human Diploid Cell), approved Rabies vaccine
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Changchun BCHT Biotechnology Co.
Pediatric Epilepsies
Natural History and Prognosis of Pediatric Epilepsies With Different Etiology
Epilepsy is one of the most common neurological diseases in Italy, affecting about 500,000 people. Pediatric age represents one of the most affected groups with a consequent significant impact on the quality of life of the…
- Trial name
- NCT07588971
- Where
- Italy
- Volunteers
- 2,300 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Preterm Birth, Feeding Methods
How to Optimize Enteral Feeding of the Full Enteral Feeding Preterm Infant
Very low-birth-weight premature infants (VLBWs) are fed via nasal or oro-gastric tube for a long time because of the physiological inability to coordinate swallowing, sucking, and breathing until at least 34 weeks of gestational…
- Trial name
- NCT06760832
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna