Clinical trials: Conn Syndrome
Primary Aldosteronism
Intensive vs. Standard Blood Pressure Control in Primary Aldosteronism
The goal of this clinical trial is to evaluate whether an intensive blood pressure control strategy (systolic blood pressure target <120 mmHg) is more effective than a standard strategy (systolic blood pressure target <140 mmHg)…
- Trial name
- Intensia-Aldo (NCT07673445)
- Testing
- Intensive BP control, Standard BP control
- Where
- China
- Volunteers
- 3,830 people
- Sponsor
- Chongqing Medical University
Adrenal Tumors, Adrenocortical Carcinoma
Adrenal Tumors - Pathogenesis and Therapy
The pathogenesis of adrenal tumors is still not fully elucidated and the treatment options for malignant tumors are poor. The current study investigates different aspects of the pathogenesis of adrenal tumors and evaluates…
- Conditions
- Adrenal Tumors, Adrenocortical Carcinoma, Cushing Syndrome, Conn Syndrome
- Trial name
- NCT00669266
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Wuerzburg
Adrenal Gland Neoplasm, Hypertension
Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks
Background: The adrenal gland makes the hormone aldosterone. This helps regulate blood pressure. An adrenal gland tumor that makes too much aldosterone can cause high blood pressure and low potassium.
- Conditions
- Adrenal Gland Neoplasm, Hypertension, Bone Diseases, Metabolic, Cardiovascular Disease
- Trial name
- NCT03374215
- Where
- United States
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hyperaldosteronism Primary
Is the Evolution of the Aldosterone-renin Ratio Pre- Versus Post-operative on Day 1 Following Unilateral Adrenalectomy for Primary Hyperaldosteronism Predictive of Blood Pressure Outcomes
Primary hyperaldosteronism is characterised by excessive and autonomous aldosterone secretion by the adrenal glands, independent of renin.
- Trial name
- vRAR (NCT07110155)
- Volunteers
- 110 people
- Sponsor
- Central Hospital, Nancy, France
Hyperaldosteronism, Hypertension
Effects of Salt Intake on the Nervous Systems of Patients With Salt-Sensitive High Blood Pressure
Some patients with high blood pressure can experience an increase of blood pressure by 10 percent or more by taking in salt. These patients are referred to as having "salt-sensitive" (SS) hypertension.
- Trial name
- NCT00001176
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Outcome of Patients With Primary Aldosteronism
Majority of patients with hypertension have primary hypertension (without an underlying cause). Primary aldosteronism (PA) is the most common cause of secondary hypertension, and can be found in 5-10% of patients locally.
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral), Adrenalectomy; Status
- Trial name
- PA_Outcome (NCT04428827)
- Testing
- Unilateral adrenalectomy in patients with unilateral disease
- Where
- Singapore
- Volunteers
- 600 people
- Sponsor
- Changi General Hospital
Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion
Accuracy of 68Ga-Pentixafor PET/CT for Subtypting Diagnosis in Patients With Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion
To evaluate the accuracy of 68Ga-Pentixafor PET-CT in the classification diagnosis of primary aldosteronism concurrent with autonomous cortisol secretion patient, using AVS and/or postoperative remission as the reference standard…
- Trial name
- ABOARD (NCT06635993)
- Testing
- 68Ga-Pentixafor PET/CT
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Qifu Li
Primary Aldosteronism
Short- and Long-term Outcomes of Adrenalectomy for Primary Aldosteronism
The proposed study is this. Short- and long-term outcomes of adrenalectomy for Primary Aldosteronism (PA) in a single centre. PA is a relatively common problem and considers as the commonest cause of secondary hypertension and…
- Trial name
- NCT06192810
- Testing
- Laparoscopic/open adrenalectomy
- Volunteers
- 84 people
- Sponsor
- University College London Hospitals
Hypertension, Primary Aldosteronism
Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Primary Aldosteronism
To evaluate the effect of anti-hypertensive medication on efficiency of primary aldosteronism screening and confirmatory test, and to determine the appropriate diagnostic cutoff value for Chinese hypertension patients during…
- Trial name
- HASA (NCT04991961)
- Testing
- withdraw antihypertensive drugs
- Where
- 2 sites in China
- Volunteers
- 341 people
- Sponsor
- Chongqing Medical University
Primary Aldosteronism
Optimizing Diagnosis Of Primary Aldosteronism
To optimize the confirmatory tests for primary aldosteronism.
- Trial name
- ODPA (NCT02755519)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chongqing Medical University
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Idiopathic Hyperaldosteronism, Hyperaldosteronism
Superselective Adrenal Arterial Embolization Versus Oral Spironolactone for Treatment of Idiopathic Hyperaldosteronism
Idiopathic hyperaldosteronism (IHA) represents about 65% of primary hyperaldosteronism cases. Although mineralocorticoid receptor antagonists (MRAs) are the standard first-line treatment, they are often limited by adverse…
- Trial name
- NCT07328230
- Testing
- Superselective Adrenal Arterial Embolization, Spironolactone
- Where
- 3 sites in China
- Volunteers
- 172 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
A Novel and Efficient Biochemical Screening Strategy for Glucocorticoid-Remediable Aldosteronism: Combined 1-mg Overnight Dexamethasone Suppression Test and Steroid Profile
This prospective observational study evaluates a simplified biochemical screening strategy to differentiate Glucocorticoid-Remediable Aldosteronism (GRA) from Aldosterone-Producing Adenoma (APA).
- Trial name
- NCT07700888
- Testing
- 1 mg overnight dexamethasone inhibition test
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital