Clinical trials: Conn Syndrome
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Nodular Hyperplasia
First-in-human Evaluation of [18F]CETO
Purpose of this clinical phase 1 trial was to determine if para-chloro-2-[18F]fluoroethyletomidate positron emission computed tomography ([18F]CETO-positron emission computed tomography(PET)/computed tomography(CT)) can be used…
- Conditions
- Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Nodular Hyperplasia, Adrenal Cushing Syndrome, Non-Secretory Adrenal Adenoma
- Trial name
- NCT05361083
- Testing
- F18CETO
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Primary Aldosteronism, Hypertension
Comparing the Efficacy and Safety of Finerenone and Spironolactone in the Treatment of Primary Aldosteronism
Primary aldosteronism (PA) is thought to be the most common secondary endocrine form of hypertension. Compared with patients with essential hypertension with similar blood pressure, patients with PA have significantly higher…
- Trial name
- NCT05814770
- Testing
- Finerenone, Spironolactone
- Volunteers
- 96 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Primary Aldosteronism, Hypertension
Adrenal Artery Ablation Treats Primary Aldosteronism
Primary aldosteronism (PA) is one of the most common cause of endocrine and resistant hypertension. Current studies have shown that the activation of the renin-angiotensin-aldosterone system (RAAS) and the increased sympathetic…
- Trial name
- NCT03398785
- Testing
- Endovascular chemical Ablation of Adrenal Gland
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Third Military Medical University
Primary Aldosteronism
Renal Cysts and Primary Aldosteronism
During routine subtyping of confirmed primary aldosteronism by adrenal vein sampling extra plasma samples are drawn from both renal veins and from inferior vena cava.
- Trial name
- NCT05435703
- Where
- Finland
- Volunteers
- 115 people
- Sponsor
- Tampere University Hospital
Primary Aldosteronism, Essential Hypertension
Microvascular Function in Primary Aldosteronism
Patients with primary aldosteronism, which is the most prevalent form of secondary hypertension, have an increased rate of cardiovascular events, compared to patients with essential hypertension, even with equal severity of…
- Trial name
- NCT02096939
- Testing
- Adrenal extirpation, Antihypertensive medication
- Sponsor
- Maastricht University Medical Center
Adenoma
Arterial Stiffness Index as a Predictor of Surgically Correctable Primary Aldosteronism
Our main objective is to assess whether aortic stiffness is a predictor of blood pressure response after surgery in patients with an aldosterone producing adenoma or a unilateral adrenal hyperplasia.
- Trial name
- NCT01190501
- Testing
- complier device
- Where
- France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Toulouse
Hyperaldosteronism, Hypertension
Effects of Salt Intake on the Nervous Systems of Patients With Salt-Sensitive High Blood Pressure
Some patients with high blood pressure can experience an increase of blood pressure by 10 percent or more by taking in salt. These patients are referred to as having "salt-sensitive" (SS) hypertension.
- Trial name
- NCT00001176
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Primary Aldosteronism
The Effect of SAAE on Ventricular Remodeling in PA Patients
The study aims to assess the effect of superselective adrenal arterial embolization on ventricular remodeling in primary aldosteronism without lateralized aldosterone secretion by comparing it with spironolactone therapy.
- Trial name
- NCT05501080
- Testing
- Super selective adrenal artery embolization, Spironolactone
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Primary Aldosteronism
The Effect of SAAE on Vascular Endothelial Function in PA Patients
The study aims to assess the effect of superselective adrenal arterial embolization on vascular endothelial function in patients with primary aldosteronism based on brachial artery flow-mediated relaxation
- Trial name
- NCT05561361
- Testing
- Super selective adrenal artery embolization, Spironolactone
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Primary Aldosteronism With Bilateral Adrenal Lesions
68Ga-Pentixafor PET/CT for Guiding Surgical Treatment of Primary Aldosteronism With Bilateral Adrenal Lesions
Screening potential candidates who may benefit from surgery remains challenging for patients diagnosed with primary aldosteronism (PA) accompanied by bilateral adrenal lesions.
- Trial name
- NCT06247566
- Where
- China
- Volunteers
- 83 people
- Sponsor
- Central South University
Primary Aldosteronism, Secondary Hypertension
PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary Aldosteronism
This study is a randomized controlled trial to assess the clinical utility of gallium-68 pentixafor PET/CT in the management of primary aldosteronism (PA).
- Conditions
- Primary Aldosteronism, Secondary Hypertension, Aldosterone-Producing Adenoma, Idiopathic Hyperaldosteronism
- Trial name
- NCT07027254
- Testing
- 68Ga-pentixafor PET/CT
- Where
- 2 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Primary Aldosteronism
[11C]Metomidate PET-CT vs Usual Care for People With Primary Aldosteronism: a Proof-of-concept Study
The goal of this randomised open-label controlled study is to compare the biochemical and clinical responses following [11C]Metomidate-PET CT(MTO-PET) versus usual care with adrenal venous sampling as first lateralisation…
- Trial name
- NCT07814105
- Testing
- [11C] Metomidate PETCT, Adrenal Venous Sampling
- Where
- Hong Kong
- Volunteers
- 32 people
- Sponsor
- Chinese University of Hong Kong
Primary Hyperaldosteronism
Primary Hyperaldosteronism and Ischemia-reperfusion Injury
Patients with primary hyperaldosteronism experience more cardiovascular events compared to patients with primary hypertension, independent of the blood pressure level.
- Trial name
- PHA-FMD (NCT01978132)
- Testing
- forearm ischemia and reperfusion
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Positron-Emission Tomography
Application of 68Ga-Pentixafor PET/CT in Primary Aldosteronism and Pre-postoperative of SAAE
Primary aldosteronism is the most common cause of secondary hypertension. The two main types of primary aldosteronism are aldosteronoma(30%) and adrenal hyperplasia(60%).
- Trial name
- NCT05188872
- Testing
- 68Ga-Pentixafor
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Hyperaldosteronism
SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan.
Rationale: Primary hyperaldosteronism (PA) is the most frequent form of secondary hypertension. In PA autonomous hypersecretion of aldosterone by one or both adrenal glands causes hypertension that is often refractory to…
- Trial name
- SPARTACUS (NCT01096654)
- Testing
- Ct-scan or adrenal vein sampling
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Primary Aldosteronism
Primary Aldosteronism LC-MS/MS-specific Cutoffs
Aims to evaluation the LC-MS/MS-specific cutoffs of PA screening and CCT test.
- Trial name
- PM (NCT05959863)
- Testing
- Captopril Challenge Test
- Where
- 2 sites in China
- Volunteers
- 396 people
- Sponsor
- Chongqing Medical University
Primary Aldosteronism
AVS After 1mg DST to Determine Subtype in PA
To compare the effect of different procedures of AVS(after 1mg DST or not) in determining the subtypes and long-term outcomes of PA
- Trial name
- NCT04709185
- Testing
- Dexamethasone 1 MG Oral Tablet
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Shanghai Zhongshan Hospital
Primary Aldosteronism Due to Aldosterone Producing Adenoma
Renal Sympathetic Denervation From The Adventitia on Hypertension
Renal sympathetic denervation from the intima of renal arteries has become an important method for the treatment of resistant hypertension, but renal sympathetic nerve are mainly located in the adventitia, and there is no report…
- Trial name
- RSDAH (NCT02642445)
- Testing
- Renal Sympathetic Denervation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Hypertension, Primary Aldosteronism
Genetic Predisposition to High Blood Pressure
Primary aldosteronism (PA) is a known but underdiagnosed cause of high blood pressure. It is estimated that more than 10% of all people with high blood pressure (HT) suffer from PA, which is often caused by aldosterone-producing…
- Conditions
- Hypertension, Primary Aldosteronism, Genetic Predisposition to Disease
- Trial name
- NCT07181213
- Testing
- Adrenalectomy
- Where
- Sweden
- Volunteers
- 76 people
- Sponsor
- Linkoeping University
Primary Aldosteronism
Study on Cutoff Revision Effects and Evaluation of NNT in Primary Aldosteronism
The goal of this observational study is to evaluate the real-world impact of applying the revised aldosterone-to-renin ratio (ARR) cutoff recommended in the 2025 primary aldosteronism guideline in adults with hypertension and…
- Trial name
- SCREEN-PA (NCT07621458)
- Testing
- Saline Infusion Test
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital