Clinical trials: Consciousness
Traumatic Brain Injury
Effectiveness of Amantadine Hydrochloride for Treatment of Severe Traumatic Brain Injury (TBI)
This is a controlled trial of amantadine to improve level of function following severe traumatic brain injury. The purpose of this study is: 1.
- Trial name
- NCT00970944
- Testing
- Amantadine Hydrochloride
- Where
- 11 sites in United States, Denmark and 1 more
- Volunteers
- 184 people
- Sponsor
- JFK Medical Center
Blood Pressure, Depression
Essential Hypotension and Allostasis Registry
The essential arterial hypotension and allostasis registry is a prospective, observational research that has the purpose of demonstrating that essential blood pressure (BP) disorders and the associated comorbidities are a result…
- Conditions
- Blood Pressure, Depression, Panic Attack, Fibromyalgia
- Trial name
- ESSENTIAL (NCT02018497)
- Where
- Colombia
- Volunteers
- 5,000 people
- Sponsor
- CES University
General Anesthesia-Induced Altered Consciousness
Brain Activity and Changes in Consciousness During General Anesthesia
This study aims to investigate how general anesthetics alter brain activity and consciousness across different age groups. The study will evaluate four anesthetic agents with different mechanisms of action: propofol, remimazolam…
- Trial name
- NCT07836205
- Testing
- Propofol (Group P), Remimazolam group, Esketamine group
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Encephalopathy, Psychosis
Neuroimmunology Registry and Biobank
A variety of antineuronal antibodies have been detected in the cerebrospinal fluid (CSF) of patients with neurological diseases.
- Conditions
- Encephalopathy, Psychosis, Impaired Consciousness, Epilepsy
- Trial name
- NCT06958341
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Acute Brain Injuries, Consciousness Disorders
CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG
Detecting preserved consciousness in brain-injured patients by traditional clinical means requires presence of motor function. Otherwise, patients may be erroneously classified as being in a vegetative state.
- Trial name
- CONNECT-ME (NCT02644265)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mild Cognitive Impairment, Neurocardiogenic Syncope
VINCI-AD: An Investigation of Transcutaneous Vagus Nerve Stimulation in Mild Cognitive Impairment.
The VINCI-AD study will investigate the impact of non-invasive vagus nerve stimulation (VNS) on memory in participants with existing mild memory impairment. VNS is a safe, existing treatment, licensed in epilepsy and depression.
- Conditions
- Mild Cognitive Impairment, Neurocardiogenic Syncope, Memory Impairment, Inflammatory Response
- Trial name
- NCT05514756
- Testing
- Active t-VNS, Baseline assessments
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- Tallaght University Hospital
Anxiety, Depression
Evaluating Knowledge Insight Tools (KIT) for Reducing Anxiety and Low Mood in UK Secondary School Students
Background and Study Aims: Secondary school students are reporting unprecedented levels of anxiety and mood difficulties. To ensure that the needs of all young people are met, there is a need to evaluate more accessible forms of…
- Conditions
- Anxiety, Depression, Internalizing Problems, Low Mood
- Trial name
- NCT06188962
- Testing
- CBT-informed school-based counselling
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University College, London
Anxiety, Anxiety Disorders
A Single-session Growth Mindset Intervention for Children and Young People With Mental Health Difficulties
The present study aims to evaluate whether an online, self-administered, single session intervention (SSI) increases children and adolescents' perceptions of control over external threats and their emotional experience and…
- Conditions
- Anxiety, Anxiety Disorders, Depression, Low Mood
- Trial name
- NCT04652362
- Testing
- Growth Mindset Online Single-Session Intervention, Supportive Therapy Online Single-Session Intervention (Control)
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Royal Holloway University
Brain Death
Nutritional Status and Enteral Absorption Capability After Brain Death
The investigators propose to assess 36 donors' nutritional status using accepted parameters (prealbumin, resting energy expenditure); to assess nutrient intestinal absorption through 13Curacil breath tests; and to evaluate serum…
- Trial name
- HRSA Nutrition (NCT00858390)
- Testing
- enteral feeding with Oxepa® and Glutasolve®
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- The University of Texas Health Science Center, Houston
Impaired Consciousness
FOUR Score in Children With Non-traumatic Impairment of Consciousness
Hypothesis: FOUR score is a better predictor of outcome (in hospital mortality and functional outcome at discharge) than GCS in children 5- 18 years age admitted in pediatric ward/ ICU with non-traumatic impaired consciousness.
- Trial name
- NCT01537913
- Volunteers
- 70 people
- Sponsor
- All India Institute of Medical Sciences
Drug Effect
Dose Finding Study for Remimazolam in Children
This study aims to find effective dose of remimazolam for inducing loss of consciousness in children aged 2 to 8 years old. We will explore ED90 of remimazolam for loss of consciousness in 2 minutes after intravenous injection…
- Trial name
- NCT05975255
- Testing
- Remimazolam besylate
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Brain Injuries, Acute, Brain Injuries, Traumatic
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness.
- Conditions
- Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia
- Trial name
- NCT06081283
- Testing
- Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Conscious Sedation
Nasal Versus Oral Midazolam Sedation in Routine Pediatric Dental Care
The general objective of the study is to compare the efficacy of administering midazolam orally as syrup versus nasally with nasal atomizer.
- Trial name
- NCT02679781
- Testing
- oral midazolam, nasal midazolam
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Chest Pain, Stroke Acute
Evaluation and Optimization of Telephone Triage Using Artificial Intelligence (AI) Models for the Detection of Demands for Time-dependent Pathology at the Emergency and Urgent Care Coordination Center (CCUE).
Improving Telephone Triage in Emergency Calls with AI The Coordinating Centre for Urgencies and Emergencies in Andalusia (CCUE) handles thousands of calls every day.
- Conditions
- Chest Pain, Stroke Acute, Respiratory Failure, Cardiac Arrest (CA)
- Trial name
- TrIAje Project (NCT07247669)
- Where
- Spain
- Volunteers
- 5,000,000 people
- Sponsor
- Centro de Emergencias Sanitarias 061 Andalucía
Disorder of Consciousness
Information of the Coma Recovery Scale-Revised for Neurobehavioral State and Recovery of Consciousness Prediction
Background: The Coma Recovery Scale-Revised (CRS-R) is the most recommended instrument to examine the neurobehavioral condition of individuals with disorders of consciousness (DOCs).
- Trial name
- CRS-R_Info (NCT05819177)
- Testing
- Rehabilitation program
- Where
- 2 sites in Spain
- Volunteers
- 171 people
- Sponsor
- Hospitales Nisa
Migraine, Near Death Experience
Near Death Experience (NDE) and Migraine
Migraine is a common disabling primary headache disorder. Epidemiological studies have documented its high prevalence and high socio-economic and personal impacts. Migraine affects more than 20% of the French population.
- Trial name
- NCT02854930
- Testing
- questioning
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Early Childhood Caries
Midazolam Efficacy for Sedating Preschoolers Undergoing Dental Treatment
Evaluation of oral midazolam to improve children's behavior and reduces the stress and anxiety during dental treatment
- Trial name
- Pedsed-I (NCT01795222)
- Testing
- Midazolam
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Universidade Federal de Goias
Syncope, Vasovagal
Cardioneuroablation: Fragmented Atrial Potentials, Intracardiac Echocardiography and Computed Tomography
Cardioneuroablation (CNA) is a new method for the treatment of asystolic reflex syncope, however, optimal methods for identification of presumed sites of ganglionated plexi (GP), which are the target for CNA and are located in…
- Trial name
- Roman5 (NCT06472102)
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Centre of Postgraduate Medical Education
Syncope
Eastbourne Syncope Assessment Study II
Syncope (commonly called collapses or blackouts) is defined as loss of consciousness which is transient, self limiting and usually leads to falling.
- Trial name
- EaSyAS II (NCT00517023)
- Testing
- Sleuth Implantable Loop Recorder, Other
- Where
- United Kingdom
- Volunteers
- 240 people
- Sponsor
- East Sussex Healthcare NHS Trust
Syncope
Multi-Site Near Infrared Spectroscopy (NIRS) Monitoring of Children During Tilt Table Testing
PURPOSE OF THE STUDY This study will explore the use of multi-site NIRS monitoring during tilt table testing, combining somatic and cerebral saturations data with hemodynamic data to establish the non-invasive assessment of…
- Trial name
- NIRS & Tilt (NCT00659464)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin