Clinical trials: Constriction
Fibromuscular Dysplasia, Renal Artery Stenosis
Renal Arteries Dysplastic Aneurysms: Anatomopathological and Genetic Study
Fibromuscular dysplasia (FMD) is localized structural defects in the arterial wall, whose innate or acquired character is still unknown.
- Trial name
- NCT02528149
- Testing
- tissue of adjacent part and aneurysm of renal aneurysm, blood sample
- Where
- 17 sites in France
- Volunteers
- 34 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Aortic Stenosis
Microembolic Signals and Serum Markers of Neuronal Damage During Transcatheter Aortic Valve Implantation.
Transcatheter Aortic Valve Implantation (TAVI) using femoral access is an option for definitive treatment of aortic stenosis when open-heart surgery is considered inappropriate.
- Trial name
- NCT01237743
- Testing
- Transcatheter aortic valve implantation.
- Where
- Sweden
- Volunteers
- 21 people
- Sponsor
- Sahlgrenska University Hospital
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Degenerative Disc Disease in Cervical Spine, Stenosis Cervical Spine
PMCF Study Fortilink-SC
This study is setup to be able to gather information on the safety and performance of the Fortilink-SC Ti cage of Paradigm Spine GmbH, up to one year after the surgery.
- Trial name
- NCT07834749
- Testing
- Cervical interbody fusion surgery (standalone)
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- BAAT Medical Products B.V.
Urethral Meatal Stenosis
The Improvement in Uroflow and Postvoid Residual Urine After Urethral Meatotomy in Children With Meatal Stenosis
The improvement in uroflow and postvoid residual urine in children after urethral meatotomy for meatal stenosis. The hypothesis is that there is an improvement in both parameters, thus justifying the procedure.
- Trial name
- NCT01214525
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Meir Medical Center
Coronary Artery Stenosis
Prospective Multicenter Study to Characterize the REAL-WORLD EVIDENCE Regarding Safety and Performance of the PTCA NC Catheters Family
The purpose of this post market study is to collect clinical data of the Arthesys PTCA NC catheters family during angioplasty intervention of coronary vessels or coronary bypass graft stenosis to support MDR submission.
- Trial name
- NCT05536180
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Arthesys
Pyloric Stenosis, Intubation, Pediatric
Conventional Direct Laryngoscopy Vs. Video Laryngoscopy With The C-MAC For Pyloromyotomy
The purpose of this study is to compare two different ways of placing breathing tubes for surgery. Both ways are used currently to place breathing tubes and are safe and effective.
- Trial name
- NCT02775214
- Testing
- Video Laryngoscopy
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Indiana University
Class III Malocclusion, Maxillary Deficiency
Evaluation of Pain and Functional Impairments When Treating Class III Malocclusion Using Two Treatment Procedures
A clinical examination of each recalled candidate patient will be carried out at Adib Al Lahham Centre at the Ministry of Health Damascus to ensure that he/she meets the inclusion criteria.
- Trial name
- NCT06877780
- Testing
- RMR with SME, BAIMT with RME
- Where
- Syria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Damascus University
Cardiovascular Diseases, Heart Diseases
Logical Analysis of Data and Cardiac Surgery Risk
To use a new statistical method, the Logical Analysis of Data (LAD), to predict cardiac surgery risk.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Aortic Valve Stenosis
- Trial name
- NCT00081666
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aortic Valve Insufficiency, Aortic Valve Stenosis
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4/X4S Transcatheter Heart Valve (THV) in subjects who are at high or greater risk with a failing aortic bioprosthetic valve.
- Trial name
- NCT05172973
- Testing
- SAPIEN X4/X4S THV
- Where
- 37 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Edwards Lifesciences
Primary Cardiomyopathy, Dilated Cardiomyopathy
Risk Stratification in Children and Adolescents With Primary Cardiomyopathy
RIKADA is a prospective study performing systematic family screening including clinical and genetic testing in pediatric patients with primary cardiomyopathy and their first-degree relatives with the aim to facilitate risk…
- Conditions
- Primary Cardiomyopathy, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Left Ventricular Noncompaction
- Trial name
- RIKADA (NCT03572569)
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- German Heart Institute
Cardiac Valve Disease, Aortic Valve Stenosis
Remote ECG Monitoring of TAVI Patients
After surgery, patients who undergo transcatheter aortic valve implantation (TAVI) are at risk of developing cardiac arrhythmias such as heart blocks and atrial fibrillation.
- Trial name
- NCT03810820
- Testing
- mobile Cardiac Arrhythmia Diagnostics Service (m-CARDS)
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Population Health Research Institute
Aortic Valve Stenosis
Sentinel Low Risk Registry
This registry is designed to quantify embolic debris capture rate in patients at low surgical risk treated with the Sentinel System during TAVI.
- Trial name
- NCT04131127
- Testing
- Sentinel Device
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- CVPath Institute Inc.
Hypertrophic Cardiomyopathy
Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: A Pilot Study
This study will test the feasibility of a modified procedure for treating obstructive hypertrophic cardiomyopathy (OHC). Patients with OHC have a thickening of the heart muscle that obstructs blood flow out of the heart, causing…
- Trial name
- NCT00035386
- Testing
- trans-right ventricular alcohol septal ablation (TRVASA)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aortic Stenosis
Association of Type of Anesthetic and Outcomes in Transfemoral Aortic Valve Replacement
This study proposes to perform a descriptive analysis and pilot observational study looking at the types and quantity of anesthetic agents used and their associations with outcomes among patients scheduled to receive transfemoral…
- Trial name
- NCT02786264
- Testing
- Dexmedetomidine with propofol, Propofol
- Volunteers
- 186 people
- Sponsor
- Yale University
Bicuspid Aortic Valve (BAV)
A Study of Chinese Congenital Bicuspid Aortic Valve
Pervious studies indicated that the prevalence of bicuspid aortic valve（BAV） might be higher in China. There is a familial predisposition to the development of BAV.
- Trial name
- NCT06802016
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruijin Hospital
Degenerative Disc Disease, Spinal Stenosis
Spine Patient Outcomes Registry for Biomet/EBI (Electro-Biology, Inc)
The purpose of this patient registry is to prospectively collect data on patients who are having spinal surgery with EBI and Interpore Cross Spine Products.
- Trial name
- SPO (NCT00726284)
- Where
- 5 sites in United States
- Volunteers
- 651 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Apnea, Obstructive Sleep
Associations Apnoea Hypopnoea Index (AHI) and Malocclusions in Growing Patients With Maxillary Constriction
The aim of this prospective clinical study is to evaluate the association between the Apnoea Hypopnoea Index (AHI) and the type of malocclusion in pediatric patients with maxillary constriction.
- Trial name
- NCT07009535
- Testing
- Polysomnography
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Pavia
Maxillary Constriction in Growing Children, Transverse Maxillary Deficiency
Effects of BREA and MFT Expansion Appliances on Upper Airway Dimensions
This retrospective study evaluated whether orthodontic expansion using two types of appliances, a bimaxillary removable expansion appliance (BREA) and a maxillary fixed three screw palatal expander (MFT), influences upper airway…
- Conditions
- Maxillary Constriction in Growing Children, Transverse Maxillary Deficiency, Upper Airway Morphology in Children, Orthodontic Expansion Effects
- Trial name
- NCT07456917
- Testing
- Maxillary fixed three screw palatal expander (MFT), Bimaxillary removable expansion appliance (BREA)
- Where
- Poland
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Esophageal Stenosis, Esophageal Dilation
An Innovative Endoscopic Cap for Dilating Benign Esophageal Strictures in Children
The goal of this study is to find out if using the BougieCap device is a safe and effective way to stretch narrow areas in the esophagus (food pipe) in children.
- Trial name
- BOUGIE-PED (NCT06675825)
- Testing
- BougieCap, Savary-Bougie (A) or balloon dilation (B)
- Where
- 3 sites in Italy, Switzerland
- Volunteers
- 40 people
- Sponsor
- University Children's Hospital, Zurich