Clinical trials: Cornea
Corneal Opacity
Characteristics of Trachomatous Corneal Opacity in Fayoum University Hospital
The purpose of this study is to assess the characteristics of trachomatous corneal opacity in patients with signs of trachoma using Anterior segment Optic coherence tomography and Pentacam
- Trial name
- Trachoma (NCT06000150)
- Testing
- Corneal topography
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Omar Said
Trachoma, Lymphatic Filariasis
Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis
Trachoma and lymphatic filariasis (LF) are two 'Neglected Tropical Diseases' (NTDs), infectious diseases that affect millions of poor people in countries in the developing world.
- Trial name
- AZIVAL2 (NCT01903057)
- Testing
- azithromycin, ivermectin, albendazole
- Where
- Mozambique
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Trachoma
Water Uptake for Health in Amhara Pilot
Trachoma is a blinding disease caused by ocular strains of Chlamydia trachomatis. The Carter Center and Proctor Foundation have been jointly conducting trachoma research in the Goncha Siso Enese woreda of Amhara for the past 8…
- Trial name
- WUHA (NCT02373657)
- Testing
- instruction in soap-making and hygiene education
- Where
- Ethiopia
- Volunteers
- 4,068 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Keratoconus, Ectasia
UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia
The primary objective of this study is to evaluate two different ultraviolet (UV) dosing regimens for corneal collagen cross linking to slow the progressive changes in corneal curvature in eyes with progressive keratoconus or…
- Conditions
- Keratoconus, Ectasia, Corneal Ectasia
- Trial name
- NCT01325298
- Testing
- UV-X Light, Riboflavin
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Mercy Center for Corrective Eye Surgery
Keratoconus, Corneal Ectasia
Corneal Tomographic Parameters in TGD
The current study involved analysis of the corneal tomographic parameters of patients with thyroid gland dysfunction (hyperthyroidism or hypothyroidism), including those with an autoimmune etiology, in comparison to healthy…
- Conditions
- Keratoconus, Corneal Ectasia, Thyroid Eye Disease
- Trial name
- NCT04433936
- Testing
- Pentacam tomography
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ameera Gamal Abdelhameed
Keratoconus
Treatment of Keratoconus Using Collagen Cross-Linking
The purpose of this study is to determine the effectiveness of collagen cross-linking in the cornea in halting the progression and possibly partially reversing the effects of keratoconus.
- Trial name
- NCT00841386
- Testing
- Riboflavin-5-phosphate
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Trachoma
Enhancing the A in SAFE for Trachoma
This study will assess the cost and feasibility of two strategies of enhanced Mass Drug Administration (MDA) of Zithromax to treat trachoma in the Republic of South Sudan.
- Trial name
- NCT05634759
- Testing
- Azithromycin for Routine Community-wide MDA, Two Additional Rounds of Azithromycin for Children, Azithromycin for Second Community-wide MDA
- Where
- South Sudan
- Volunteers
- 34,630 people, healthy volunteers welcome
- Sponsor
- Emory University
Trachoma, Chlamydia Trachomatis
Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger
Trachoma is a disease of poverty, which in the hyperendemic areas affects all individuals by the time they are two years old. Active disease is concentrated in children and occurs sporadically in adults.
- Trial name
- NCT00618449
- Testing
- Azithromcyin, Azithromycin
- Where
- 2 sites in United States, Niger
- Volunteers
- 1,139 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Corneal Perforation, Corneal Stromal Lenticule,Sandwich Technique
A Novel Sandwich Technique of Minimally Invasive Keratoplasty for Corneal Perforation
The goal of this type of study to describe a new sandwich technique of minimally invasive keratoplasty (STMIK) by using SMILE-extracted lenticules for treatment corneal perforation and effectiveness.
- Trial name
- STMIK (NCT06233409)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Keratoconus
Astigmatism in Keratoconus Patients
Keratoconus is a bilateral (but usually asymmetrical) non-inflammatory progressive thinning process of the cornea. It manifests as characteristic cone-like ectasia of the cornea associated with irregular stromal thinning…
- Trial name
- NCT03450213
- Testing
- Pentacam
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Trachoma
A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation: The ASANTE Trial
Infection with C. Trachomatis has decreased substantially in trachoma endemic areas following repeated annual mass drug administration (MDA) with azithromycin, although not as rapidly as anticipated.
- Trial name
- ASANTE (NCT01767506)
- Testing
- Surveillance and treatment with azithromycin of newcomer and traveler families, Usual care
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cornea; Ectasia, Refractive Errors
Corneal Elastography and Patient Specific Modeling
The goal of this research is to develop measurement tools and simulation technology for characterizing and predicting individual responses to corneal treatments and for advancing understanding of corneal ectasia risk factors.
- Conditions
- Cornea; Ectasia, Refractive Errors, Keratoconus
- Trial name
- NCT03030755
- Testing
- Optical coherence tomography
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Keratoconus
Keratoconus Detection by Ultrasound
Keratoconus (KC) is a corneal disease which will in many cases ultimately require corneal transplantation to maintain vision. Early detection, which is not possible with current technology, would allow early treatment and prevent…
- Trial name
- NCT01403129
- Testing
- Artemis Ultrasound Exam, Optical Coherence Tomography (OCT) Exam
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Columbia University
Pellucid Marginal Corneal Degeneration, Keratoconus
A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea
The purpose of this research study is to find out if the new Brillouin Ocular Scanner can measure the variation (difference) of the corneal elastic changes involved in the onset of corneal ectasia, induced by LASIK surgery and…
- Conditions
- Pellucid Marginal Corneal Degeneration, Keratoconus, Keratectasia
- Trial name
- NCT03220529
- Testing
- Brillouin Ocular Scanner
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Trachoma
Trachoma Elimination Study by Focused Antibiotic (TESFA)
The study population consists of all households residing in eligible kebeles (sub-districts) within districts in Amhara National Regional State which are identified as having a high prevalence of trachoma and infection measured…
- Trial name
- NCT03523156
- Testing
- Azithromycin mass treatment, Azithromycin targeted treatment
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Trachoma
Azithromycin Reduction to Reach Elimination of Trachoma
The investigators propose a randomized controlled trial of discontinuation versus continuation of annual mass azithromycin distribution in hypoendemic communities of Maradi, Niger.
- Trial name
- ARRET (NCT04185402)
- Testing
- Azithromycin
- Where
- Niger
- Volunteers
- 3,931 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Keratitis
Ozone-based Eye Drops as Adjuvant Therapy in Microbial Keratitis
To compare the therapeutic effect of ozone-based eye drops as an adjuvant therapy to that of the conventional topical antimicrobial agents in patients with microbial keratitis .
- Trial name
- NCT05689996
- Testing
- Ozone-Based Agent
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Keratoconus, Corneal Ectasia
Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulose
This study is being conducted to evaluate the safety and efficacy of isotonic riboflavin for corneal collagen crosslinking for keratoconus and corneal ectasia.
- Trial name
- CXL (NCT04897503)
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Trachoma
Testing Insect Repellents Against Musca Sorbens, the Vector of Trachoma
Musca sorbens, a fly that feeds from ocular and nasal discharge on humans, is thought to be the vector of trachoma. We are developing methods of fly control that specifically target this species, in the hope of interrupting Ct…
- Trial name
- NCT03813069
- Testing
- IR3535, Permethrin lower dose, Permethrin higher dose
- Where
- 2 sites in Ethiopia, United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Corneal Diseases
Dynamic Light Scattering and Keratoscopy for Corneal Examination
This pilot study will examine the usefulness of a new instrument called the Dynamic Light Scattering (DLS) device for documenting and monitoring changes in the cornea, the front part of the eye where contact lenses are placed.
- Trial name
- NCT00050466
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)