Clinical trials: Corneal Crosslinking
Infective Keratitis
The Role of Adjuvant Corneal Crosslinking in the Management of Infective Keratitis
This was a prospective, single centre, randomised controlled study to evaluate the clinical effectiveness of corneal collagen crosslinking as an adjuvant to antimicrobial therapy.
- Trial name
- NCT06967376
- Testing
- Corneal Collagen Cross-Linking Solutions, Topical Antimicrobial/Antifungal Medications
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Research Institute of Ophthalmology, Egypt
Keratoconus, Ectasia
Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia
This prospective, randomized study is being conducted to evaluate the safety and effectiveness of corneal cross-linking (CXL) in patients with keratoconus or post-refractive ectasia (post-LASIK or PRK) utilizing two techniques…
- Trial name
- CXL (NCT03080077)
- Testing
- Ricrolin+, Epi-Off
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Keratoconus
Fourier Transform of Videokeratography Data: Clinical Usefulness in Moderate and Frome Fruste Keratoconus
Primary objective of this study was evaluate the diagnostic capacity of fourier analysis of keratometric data in differentiating moderate KC and FFK from healthy corneas.
- Trial name
- FFTKC (NCT02617368)
- Where
- Greece
- Volunteers
- 185 people
- Sponsor
- Democritus University of Thrace
Ectasia
Corneal Collagen Cross-Linking for Ectasia (CXL)
Prospective, randomized multicenter study to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes with ectasia after refractive surgery.
- Trial name
- CXL (NCT00674661)
- Testing
- riboflavin ophthalmic solution, UVA Irradiation
- Where
- 10 sites in United States
- Volunteers
- 130 people
- Sponsor
- Glaukos Corporation
Keratoconus, Corneal Ectasia
Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia
This randomized study compares 2 variations of corneal crosslinking for treatment of keratoconus or corneal ectasia.
- Trial name
- NCT07841470
- Testing
- Riboflavin 0.1% ophthalmic solution and pulsed light, Riboflavin 0.1% ophthalmic solution and non-pulsed light
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Price Vision Group
Keratoconus
Evaluation of Topical Riboflavin Exposed to UVA Radiation and Implantation of Corneal Ring
The purpose of this study is to postpone the corneal transplantation in keratoconus and promote the stiffness of the cornea across the riboflavin-UVA corneal collagen crosslinking , and after, corneal ring surgery.
- Trial name
- NCT00832897
- Testing
- Corneal collagen crosslinking
- Where
- Brazil
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Keratoconus
Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking
This study aims to compare the use of Dextenza, an FDA-approved intracanilular drug-eluting insert that is designed to deliver a tapered dose of dexamethasone to the ocular surface for 30 days, to the standard of care, or the use…
- Trial name
- NCT06235567
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, topical prednisolone acetate 1% (PredForte) eye drops
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Maanasa Indaram, MD
Corneal Ectasia Disorders Including Keratoconus
The Effects of Corneal Collagen Cross-linking
The corneal collagen cross-linking treatment has been used with increasing success to treat corneal dystrophies such as "keratoconus." Recent advances have allowed different techniques for performing this cross-linking treatment.
- Trial name
- NCT01708538
- Testing
- CXL
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rush Eye Associates
Keratoconus
CXL-04 A Study of Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas
The purpose of this study is to evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional…
- Trial name
- NCT01956474
- Testing
- Theralight crosslinking and Riboflavin
- Where
- 6 sites in United States
- Volunteers
- 1,324 people
- Sponsor
- Cxlusa
Keratoconus, Ectasia of Cornea
Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases
The goal of this clinical trial is to study the effects of an experimental (not Food and Drug Administration (FDA)-approved) treatment called corneal crosslinking (CXL) for conditions in which the cornea becomes progressively…
- Conditions
- Keratoconus, Ectasia of Cornea, Pellucid Marginal Corneal Degeneration, Forme Fruste Keratoconus (FFK)
- Trial name
- NCT07124910
- Testing
- Epi-ON corneal cross-linking
- Where
- 12 sites in United States
- Volunteers
- 485 people
- Sponsor
- Woolfson Eye Institute
Keratoconus
Tobacco Smoking Among Crosslinked-keratoconus Patients
Certain studies reported that cigarette by-products may make the cornea more rigid, suggesting that it could lead to "natural" CXL of collagen fibers, hence a protective effect for KC.
- Trial name
- TOBACOLINK (NCT03462355)
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Keratoconus, Corneal Ectasia
Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulose
This study is being conducted to evaluate the safety and efficacy of isotonic riboflavin for corneal collagen crosslinking for keratoconus and corneal ectasia.
- Trial name
- CXL (NCT04897503)
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Keratoconus, Corneal Ectasia
Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia
Corneal collagen crosslinking (CXL) has been demonstrated as an effective method of reducing progression of both keratoconus and corneal ectasia after surgery, as well as possibly decreasing the steepness of the cornea in these…
- Trial name
- NCT04905108
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Keratoconus
One-Year Outcomes After Conventional vs Accelerated Epi-Off Corneal Cross-Linking in Progressive Keratoconus (Observational Cohort)
Prospective, observational (consecutive eligible eyes) continuation of a previously published 6-month cohort from the same center, extending follow-up to 12 months.
- Trial name
- KCXL-1Y (NCT07194538)
- Where
- Croatia
- Volunteers
- 20 people
- Sponsor
- Clinical Hospital Centre Zagreb
Keratoconus, Ectasia
Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)
To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within or…
- Conditions
- Keratoconus, Ectasia, Degeneration
- Trial name
- NCT01097447
- Where
- 5 sites in United States
- Volunteers
- 2,619 people
- Sponsor
- Cxlusa
Keratoconus
Efficacy of Customized Corneal Cross-linking vs. Standard Corneal Cross-linking
The standard or Dresden protocol was established in 2003 and treats the entire cornea. However, recent ultra-structural research showed that keratoconus is localized.
- Trial name
- C-CROSS (NCT04532788)
- Testing
- Customized crosslinking, Standard crosslinking
- Where
- 3 sites in Netherlands
- Volunteers
- 124 people
- Sponsor
- Maastricht University Medical Center
Down Syndrome (DS), Keratoconus
Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome
The goal of this clinical trial is to study the effects of an experimental (not Food and Drug Administration (FDA)-approved) treatment called corneal crosslinking (CXL) for conditions in which the cornea becomes progressively…
- Conditions
- Down Syndrome (DS), Keratoconus, Pellucid Marginal Degeneration, Forme Fruste Keratoconus (FFK)
- Trial name
- NCT07135167
- Testing
- Epi-ON corneal cross-linking (CXL)
- Where
- 12 sites in United States
- Volunteers
- 225 people
- Sponsor
- Woolfson Eye Institute
Unstable Corneas
Corneal Cross-Linking Comparing Variables
The purpose of this study is to evaluate the Safety and Efficacy of Corneal Cross Linking in a Continuous Beam versus Pulsed Treatments across epithelium on and epithelium off surfaces.
- Trial name
- NCT02095730
- Testing
- Epithelium-On Riboflavin, Epithelium-Off Riboflavin, UV Light - Continuous Beam
- Where
- 16 sites in United States
- Volunteers
- 500 people
- Sponsor
- Crowd Health Research, LTD
Keratoconus, Ectasia
Progressive Keratoconus or Ectasia Treatment Plan
Keratoconus and pellucid marginal degenerations are genetically based ocular conditions and post surgical ectasia is an iatrogenic condition.
- Trial name
- NCT01384773
- Testing
- Riboflavin Solution, UV-X Illumination System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stephen Trokel
Keratoconus, Ectasia Corneal
Comparison of Standard vs. Accelerated Corneal Crosslinking
The study objective is to compare accelerated and standard corneal crosslinking for treatment of progressive keratoconus or corneal ectasia.
- Trial name
- NCT03922542
- Testing
- riboflavin 0.1%
- Where
- United States
- Volunteers
- 508 people
- Sponsor
- Price Vision Group