Clinical trials: Corneal Injuries
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Epidermolysis Bullosa Dystrophica, Epidermolysis Bullosa Dystrophica, Recessive
A Natural History Study of Corneal Abrasions in Patients With Dystrophic Epidermolysis Bullosa (DEB)
This study is a non-interventional, observational study that will evaluate the natural history of corneal abrasions in patients with Dystrophic Epidermolysis Bullosa (DEB).
- Conditions
- Epidermolysis Bullosa Dystrophica, Epidermolysis Bullosa Dystrophica, Recessive, Epidermolysis Bullosa Dystrophica Dominans
- Trial name
- NCT06563414
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Krystal Biotech, Inc.
Dystrophic Epidermolysis Bullosa, DEB - Dystrophic Epidermolysis Bullosa
A Study Comparing KB803 and Matched Placebo in Patients With Dystrophic Epidermolysis Bullosa
KB803-EYE-01 is a Phase 3 double-blind, randomized, placebo-controlled, crossover study to evaluate the safety and efficacy of KB803 versus matched placebo in pediatric and adult subjects with recurrent corneal abrasions due to…
- Conditions
- Dystrophic Epidermolysis Bullosa, DEB - Dystrophic Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa, Dominant Dystrophic Epidermolysis Bullosa
- Trial name
- IOLITE (NCT07016750)
- Testing
- KB803
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- Krystal Biotech, Inc.
Eye Trauma
Treatment of Corneal Wounds Emergencies During the COVID-19 Shutdown: Absorbable 10-0 Vicryl Sutures as a Valuable Strategy.
Vicryl (polyglactin) 10-0 resorbable suture is rarely used, little known to ophthalmologists but may offer therapeutic and practical advantages in eligible cases of corneal trauma, particularly during a COVID-19 pandemic.
- Trial name
- NCT04733846
- Testing
- data collection
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cataracts Infantile, Subluxation of Lens
Anterior Versus Posterior Artisan Intraocular Lens Fixation in Aphakic Children With Insufficient Capsular Support.
The Artisan lens (Artisan Aphakic, Ophtec BV) is an iris- claw lens designed for implantation in children with insufficient capsular support.
- Conditions
- Cataracts Infantile, Subluxation of Lens, Intraocular Lens Complication, Corneal Endothelial Cell Loss
- Trial name
- NCT06396156
- Testing
- Anterior enclavation, Posterior enclavation
- Where
- 2 sites in Egypt
- Volunteers
- 32 people
- Sponsor
- Cairo University
Corneal Disease, Pterygium
Corneal Epithelium Repair and Therapy Using Autologous Limbal Stem Cell Transplantation
Corneal disease is a leading cause of blindness in the world. A shortage of corneal donor tissue has prevented many patients from regaining vision.
- Conditions
- Corneal Disease, Pterygium, Myopia, Hyperopia
- Trial name
- NCT02148016
- Testing
- LSCs and amniotic membrane (Modified Technique), Amniotic membrane only (Traditional Technique), PRK, LSCs, and amniotic membrane (Modified Technique)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Corneal Epithelial Wound Healing
Corneal Epithelial Wound Healing Difference Between Human Autoserum and Cord Blood Serum
Human serum eye drops have been successfully used in the treatment of severe ocular surface disorders and the enhancement of corneal wound healing.
- Trial name
- NCT00681642
- Where
- Taiwan
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Corneal Persistent Epithelial Defect
NEXAGON for the Treatment of Corneal Persistent Epithelial Defects Following Severe Ocular Injuries
This study will enroll participants with a non-infected, corneal persistent epithelial defect (PED) resulting from an ocular chemical and/or thermal ocular injury which is non-responsive or refractory to current standard of care…
- Trial name
- EXPEDE (NCT04081103)
- Testing
- Nexagon® (lufepirsen) High Dose Concentration, Nexagon® (lufepirsen) Low Dose Concentration, Vehicle
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Glaukos Corporation
Junctional Epidermolysis Bullosa, Epidermolysis Bullosa (EB)
Pilot Study of ELK-003 Eye Drops for Treating Ocular Manifestations of Epidermolysis Bullosa
This study consists of two phases: an Observational Phase to evaluate the natural history of ocular manifestations in subjects with Dystrophic and Junctional Epidermolysis Bullosa, followed by a Treatment Phase to assess the…
- Conditions
- Junctional Epidermolysis Bullosa, Epidermolysis Bullosa (EB), Dystrophic Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa
- Trial name
- GOTAS-ELK-EB (NCT06713434)
- Testing
- ELK-003 (Standarized Amniotic Fluid Secretome Eye Drops)
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Fundación DEBRA Chile, Niños Piel de Cristal
Limbal Stem Cell Deficiency, Stevens-johnson Syndrome
Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation
To investigate the effect of ocular surface reconstruction and assess the safety in cultivated oral mucosal epithelial cell sheet transplantation (COMET) regarding patients with cicatricial change of ocular surface.
- Conditions
- Limbal Stem Cell Deficiency, Stevens-johnson Syndrome, Ocular Cicatricial Pemphigoid, Chemical Burn
- Trial name
- NCT02149732
- Testing
- cultivated oral mucosal epithelial sheet transplantation
- Where
- 2 sites in South Korea
- Sponsor
- Seoul National University Hospital
Corneal Burn
Modified Corneal EA With Middle LKP for Severe Corneal Burn
The purpose of this pilot study is to explore whether modified corneal epithelial autograft (EA) combined with allogeneic middle lamellar keratoplasty (AMLK) is more effective than limbal autograft (LA) with AMLK for ocular…
- Trial name
- NCT03498846
- Testing
- Modified EA and AMLK, LA and AMLK
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-sen University
Myopia
Corneal Endothelial Cell Injury Induced by Mitomycin-C
our study will investigate the effecacy of Mitomycin-C in TransEpi single step photorefractive keratectomy (PRK) and alcohol assisted PRK
- Trial name
- NCT05548478
- Testing
- Transepithelial PRK/MMC, Alcohol-Assisted PRK/MMC
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Pterygium, Corneal Ulcer
The Application of Fibrin Glue in Ocular Surface Diseases
This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries, which includes pterygium surgery, corneal melting/perforation, Gunderson's flap, conjunctival laceration, and…
- Trial name
- NCT00155402
- Testing
- tissue fibrin glue application (Tisseel)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
CNLDO - Congenital Nasolacrimal Duct Obstruction, Amblyopia
Improving the Follow up Rate for Pediatric Patients
Follow-up of pediatric patients is important for their regular ocular morbidity monitoring, especially for amblyopia management.
- Conditions
- CNLDO - Congenital Nasolacrimal Duct Obstruction, Amblyopia, Conjunctivitis, Eye Injuries
- Trial name
- NCT04837534
- Testing
- Counseling group, SMS and phone call reminder group
- Where
- Nepal
- Volunteers
- 264 people
- Sponsor
- Seva Foundation
Corneal Perforation, Corneal Stromal Lenticule,Sandwich Technique
A Novel Sandwich Technique of Minimally Invasive Keratoplasty for Corneal Perforation
The goal of this type of study to describe a new sandwich technique of minimally invasive keratoplasty (STMIK) by using SMILE-extracted lenticules for treatment corneal perforation and effectiveness.
- Trial name
- STMIK (NCT06233409)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Corneal Ulcer, Corneal Perforation
Topical Insulin - Utility and Results in Neurotrophic Keratopathy in Stages 2 and 3
Purpose: To evaluate the clinical outcome of patients with refractory Neurotrophic Keratopathy (NK) in stages 2 and 3 treated with topical insulin.
- Conditions
- Corneal Ulcer, Corneal Perforation, Corneal Epithelium Defect, Neurotrophic Keratitis
- Trial name
- NCT04820010
- Testing
- Topical Insulin
- Where
- Portugal
- Volunteers
- 20 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Pain, Postoperative, Pain, Chronic
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury
- Trial name
- NCT04439552
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Corneal Perforation
Combined Amniotic Membrane and Platelet Rich Plasma Clot for Management of Central Corneal Perforation
Use of amniotic membrane(AMT) and platelet rich plasma (PRP) clot for closure of central corneal perforation
- Trial name
- NCT03500796
- Testing
- Platelet rich plasma clot implantation, Wound closure with amniotic membrane
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Minia University
Eye Injuries, Critically Ill
Does the Use of a Moisture Chamber Decrease the Incidence of Corneal Abrasions in Critically Ill Pediatric Patients?
The purpose of this study is to identify the incidence of scratches on the surface of the eye in children who cannot blink due to medication use and to identify how best to reduce the risk of a scratch on the surface of the eye…
- Trial name
- NCT00129077
- Testing
- plastic wrap over eye & lubrication applied q6 hrs
- Where
- 2 sites in United States
- Volunteers
- 207 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Keratoconus, Cornea Disease
Effects of Topical Insulin on Corneal Epithelium Healing After Corneal Crosslinking in Patients With Keratoconus
The cornea plays a fundamental role in vision, being a complex tissue essential for ocular health. In ophthalmological practice, there are situations such as corneal crosslinking, where damage to the corneal epithelium occurs.
- Conditions
- Keratoconus, Cornea Disease, Eye Diseases, Wound Heal
- Trial name
- NCT06601101
- Testing
- Insulin
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Campinas, Brazil