Clinical trials: Critically Ill
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Venous Thromboembolism (VTE)
Collaborative Risk-stratified Investigation in Thrombosis-prone Inpatients With Critical Illness: Anticoagulation With LMWH in Teens for ThromboProphylaxis (CRITICAL-Teens-TP).
Critically ill adolescents are at greatest risk for developing hospital-acquired venous thromboembolism. To date, no phase 3 randomized controlled trials have been conducted for pharmacological thromboprophylaxis as primary…
- Trial name
- NCT06628778
- Testing
- Enoxaparin
- Where
- United States
- Volunteers
- 802 people
- Sponsor
- Johns Hopkins All Children's Hospital
COVID19, Coronavirus Infection
Convalescent Plasma Collection and Treatment in Pediatrics and Adults
This is a prospective study, using plasma to help fight off infections of those suffering from COVID-19 in accordance with collection guidelines for plasma and FDA IND requirements.
- Conditions
- COVID19, Coronavirus Infection, Coronavirus, Virus Diseases
- Trial name
- NCT04376034
- Testing
- Convalescent Plasma
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- West Virginia University
Cardiac Output, Low
Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease
Babies having heart surgery often have problems after surgery with their blood pressure and getting enough blood to their bodies.
- Trial name
- Corti (NCT00590018)
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Baylor College of Medicine
Mechanical Ventilation Complication
National Approach to Standardize and Improve Mechanical Ventilation
This is a pre-post implementation cohort study. This is a data driven quality improvement project which aims to improve the care of mechanically ventilated patients through the implementation of a bundle of evidence based…
- Trial name
- NASAM (NCT03790150)
- Testing
- Evidence-based practices
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 27,966 people
- Sponsor
- King Abdullah International Medical Research Center
Critical Illness, Severe Sepsis
A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children
1. To research the current situation of severe infection in children in China, and to investigate the incidence, prognosis and disease burden of severe infection in children in different regions of China. 2.
- Trial name
- NCT04955210
- Testing
- Not applicable（Cohort study）
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Children's Hospital of Fudan University
Corona Virus Infection
Efficacy of Inhaled Nitroglycerin in Moderate to Critically Ill COVID-19 Patients
In current analysis moderate to severely ill Covid-19 infected patients will be nebulized with nitroglycerin, and they will be compared with the standard nebulization
- Trial name
- NCT04686760
- Testing
- Nitroglycerin
- Where
- Pakistan
- Volunteers
- 278 people
- Sponsor
- University of Lahore
Critical Illness, Hyperglycemia
Study of High Blood Sugars and Insulin in Hospitalized, Critically Ill Children
BACKGROUND AND PURPOSE Critical illness hyperglycemia (CIH) - elevated blood glucose in the critically ill patient population - has gained much interest among health care providers over the past several years.
- Trial name
- CIH (NCT00487006)
- Testing
- Serum Lab testing
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- Children's Healthcare of Atlanta
Shock
Effectiveness and Safety of Penehyclidine Hydrochloride for Improving Microcirculatory Dysfunction in Critically Ill Children
This prospective randomized controlled trial was designed to evaluate whether the M1/M3-selective antagonist penehyclidine hydrochloride could more effectively reverse pediatric microcirculatory dysfunction than traditional…
- Trial name
- NCT07519226
- Testing
- atropine control group, penehyclidine hydrochloride group
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Lihua Wen
ICU Length of Stay
Primary Intensivists and Primary Nurses to Decrease Pediatric ICU Length of Stay
This is a randomized control trial of PICU patients admitted for 7 days and expected to remain for at least another 3 days and who have a complex chronic condition.
- Trial name
- PIPRNs (NCT03364933)
- Testing
- Primary intensivist and nurses
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbia University
Contrast Induced Nephropathy, Critically Ill
N-Acetylcysteine in Critically Ill Patients Undergoing Contrast Enhanced Computed Tomography
Critically ill patients frequently undergo contrast enhanced computed tomography (CT) to establish diagnoses and direct management. Contrast agents can disturb kidney function and result in kidney dysfunction.
- Trial name
- NCT00830193
- Testing
- N-acetylcysteine
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Unity Health Toronto
Hemodynamic Instability
Hemodynamic Optimalization in Pediatric Patients
Hemodynamic unstability, defined by macrocirculation and/or microcirculation dysfunction or alteration is common in critically ill pediatric patients.
- Trial name
- HOPED (NCT04227821)
- Testing
- Vasopressor and/inotrope therapy
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Head Injury, Traumatic Brain Injury
Outcomes of Early Versus Late Tracheostomy in Critically Ill Patients Due to Head Injury: A Randomized Controlled Trial
Tracheostomy is a surgical procedure that involves creating an opening in the trachea and bringing it to the skin surface to form a stoma. It may be performed as an emergency or elective operation.
- Trial name
- NCT07872865
- Testing
- Tracheostomy
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- University Of Anbar
ICU, Critical Illness
Paediatric Early Rehabilitation & Mobilisation During InTensive Care (PERMIT) Feasibility
19,000 children and young people (CYP)/year are admitted to Paediatric Intensive Care Unit (PICU). The investgators want to see if patients recover quicker if rehabilitation starts early and they are encouraged to get moving…
- Trial name
- PERMIT (NCT04909762)
- Testing
- Early Rehabilitation and Mobilisation (ERM)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Birmingham
Sodium Balance
Comparing Sodium to Fluid Balance in Predicting Respiratory Dysfunction in Critically Ill Septic Patients
Critically ill septic patients are at risk of positive sodium balance due to inadvertent excess administration, which may be over twice the daily requirement of sodium for healthy individuals This research will estimate sodium…
- Trial name
- NCT06771869
- Testing
- Sodium balance
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Child, Only, Infant, Newborn, Diseases
Capnography Monitoring in Ventilated Children
End-tidal CO2 measurements in children will be assessed for their accuracy with arterial CO2 measurements.
- Conditions
- Child, Only, Infant, Newborn, Diseases, Critical Illness, ARDS, Human
- Trial name
- NCT04354220
- Testing
- capnography monitoring, arterial blood gas
- Where
- Switzerland
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Vincenzo Cannizzaro
Sepsis, Severe
Effect of Probiotics on Cytokines in Sepsis in Children
To assess the effect of probiotics on cytokine's level(interleukin 6 and Transforming growth factor-β1)in children admitted to PICU with sepsis.
- Trial name
- NCT05467605
- Testing
- probiotics( Lactobacillus acidophilus, lactobacillus delbruekii and lactobacillus fermentum 10 billions),, maltose dissolved in distilled water
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
COVID-19, Critical Illness
Recovery of Patients From COVID-19 After Critical Illness
Patients who are critically ill with COVID-19 requiring life support in an intensive care unit (ICU) have increased risk of morbidity and mortality.
- Trial name
- NCT04401254
- Where
- 29 sites in Australia
- Volunteers
- 536 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Severe Acute Respiratory Infection
Viral Etiology of Severe Acute Respiratory InFection in CriticallY Ill Patients Registry
SARI is a major public health problem in Saudi Arabia and leads to considerable morbidity and mortality. Most SARI-related mortality occurs in patients admitted to ICUs across the country.
- Trial name
- VERIFY (NCT06627166)
- Where
- Saudi Arabia
- Volunteers
- 13 people
- Sponsor
- King Abdullah International Medical Research Center
Sepsis, Critical Illness
Study of MSC-Exo on the Therapy for Intensively Ill Children
At present, a number of projects related to MSCs have been approved for graft-versus-host disease, myocardial infarction, Crohn's disease and other diseases, indicating a strong therapeutic potential of MSCs.
- Trial name
- NCT04850469
- Where
- China
- Sponsor
- Children's Hospital of Fudan University