Clinical trials: Critically Ill
Grief, Trauma
A Clinical Trial of Interventions to Support Family Surrogates of Critically Ill Patients
Hypotheses 1a and 1b: Compared to Supportive Conversation arm, the EMPOWER intervention will significantly decrease surrogate decision makers' symptoms of grief and Post Traumatic Stress Disorder (PTSD) (primary outcomes); and…
- Conditions
- Grief, Trauma, Psychotherapy, Critical Care
- Trial name
- NCT05587517
- Testing
- EMPOWER, Supportive Conversation
- Where
- 3 sites in United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Sepsis, Nutrition
Personalized Nutritional Formula for ICU Patients: A Study on Prognosis and Multidimensional Health Markers
This study aims to evaluate the effects of an individualized enteral nutrition formula on clinical outcomes in critically ill adult patients in the intensive care unit (ICU).
- Conditions
- Sepsis, Nutrition, Gut -Microbiota
- Trial name
- NCT07755033
- Testing
- Individualized Enteral Nutrition Formula, Standard Enteral Nutrition Formula
- Volunteers
- 1,200 people
- Sponsor
- Chinese Medical Association
Respiratory Failure
Safety and Efficacy of Endotracheal Intubation Using Glidescope Video-Laryngoscope
The safety and efficacy of a video-laryngoscope as a primary intubation tool in urgent endotracheal intubation of critically-ill patients has not been well-described in the literature.
- Trial name
- NCT01683526
- Testing
- Direct laryngoscopy, Video laryngoscopy (Glidescope)
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Beth Israel Medical Center
Critically Ill
Link Between Plasma Citrulline and Lipopolysaccharide Concentrations in the Critically Ill
In critically ill patients, the small bowel permeability is increased, leading to bacterial translocation, and systemic inflammatory response syndrome. Plasma citrulline is a validated biomarker of functional enterocyte mass.
- Trial name
- CITRANS (NCT02902276)
- Testing
- additional blood sample
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
COVID19
Characteristics of Critically Ill COVID 19 Patients
COVID19 is n outbreak with unpredictable outcome
- Trial name
- NCT04465058
- Testing
- COVID19
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Critical Illness, Ventilation Perfusion Mismatch
Arterial and End-Tidal CO2 Gradient as a Mortality Predictor in Critical Care Patients
Scoring systems (SOFA, APACHE-II etc.) are used to estimate the mortality rates of patients treated in the intensive care unit. . In the scoring systems used, the disfunction level of the organs of the patients is measured.
- Conditions
- Critical Illness, Ventilation Perfusion Mismatch, Shock, Pulmonary Embolism
- Trial name
- NCT05341258
- Testing
- EtCO2, PaCO2
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Weaning From Mechanical Ventilation
Post Extubation Chest Physiotherapy in ICU
The purpose of this study is to examine the efficacy of chest physiotheray treatment in preventing pulmonary complications and weaning faliure, in extubated critically ill patients.
- Trial name
- NCT01967108
- Testing
- chest physiotherapy
- Where
- Israel
- Volunteers
- 65 people
- Sponsor
- Rambam Health Care Campus
Acute Kidney Injury
Role of Renal Artery Doppler in Critically Ill Children With Acute Kidney Injury
To detect frequency of acute kidney injury in critically ill children in Assuit university hospital. To detect associated AKI risk factors, severity and outcomes . To assess the value of use of renal Doppler ultrasound in AKI.
- Trial name
- NCT06202326
- Testing
- renal artery doppler
- Volunteers
- 45 people
- Sponsor
- Assiut University
Intensive Care Unit Delirium
Prevention of Delirium in ICU Using Multimodal Interventions
This study was designed to evaluate the impact of non-pharmacological multimodal interventions including ongoing orientation, sensory correction, setting of familiar circumstance and promotion of sleep enviromnet for prevention…
- Trial name
- NCT05950958
- Testing
- Multimodal therapy for prevention of delirium
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Seoul National University Hospital
Critical Illness, Muscle Atrophy
Skeletal Muscle Wasting in ICU Patients
Muscle wasting occurs rapidly in critically ill patients and impacts both short and long term outcomes. Altered protein metabolism drives muscle loss in ICU patients, with muscle protein breakdown exceeding muscle protein…
- Trial name
- IC-MPS (NCT06234826)
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Frank Vandenabeele
Critical Illness, Pupillometry
Dynamic Trajectories of Pupillary Light Reflex Parameters and Prognosis in Critically Ill Patients: A Multicenter Prospective Cohort Study
This multicenter prospective observational cohort study aims to investigate the association between early dynamic trajectories of pupillary light reflex parameters and clinical outcomes in critically ill patients admitted to…
- Conditions
- Critical Illness, Pupillometry, Prognosis
- Trial name
- PUPIL (NCT07616518)
- Volunteers
- 700 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Septic Shock, Acute Respiratory Distress Syndrome
Use of PiCCO System in Critically Ill Patients With Septic Shock and Acute Respiratory Distress Syndrome
PiCCO has been widely used in critical care settings for several decades. Together with pulmonary artery catheter, it is regarded as the important tool for guiding fluid management in patients with shock or acute respiratory…
- Trial name
- PiCCO (NCT01526382)
- Testing
- PiCCO monitoring (PULSION), central venous catheter
- Where
- 2 sites in China
- Volunteers
- 350 people
- Sponsor
- Jinhua Central Hospital
COVID-19 Acute Respiratory Distress Syndrome
Rehabilitation of Critically Ill Patients With SARS-CoV-2 Variants in ICU With Limited Resources
Acute rehabilitation in critically ill patients can improve post-intensive care unit (post-ICU) physical function. Scientific evidence has considered neuromuscular electrical stimulation (NMES) as a promising approach for the…
- Trial name
- NCT05450120
- Testing
- Functional Rehabilitation, Neuromuscular Electrical Stimulation
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Universidade Federal de Sao Carlos
Critically Ill
Cardioventilatory Coupling in Critically Ill Patients
This study measures the cardioventilatory coupling in critically ill patients during mechanical ventilation in controlled mode (pressure controlled) and in patient-driven mode (pressure support and neurally adjusted ventilatory…
- Trial name
- NCT02286869
- Testing
- Three different mechanical ventilation modes
- Where
- 2 sites in Italy
- Volunteers
- 22 people
- Sponsor
- ASST Fatebenefratelli Sacco
Critical Illness, Respiratory Failure
Treatment of Muscle Weakness in Critically Ill Patients
Patients who are admitted to the intensive care unit and require mechanical ventilation frequently develop profound respiratory and limb muscle weakness.
- Conditions
- Critical Illness, Respiratory Failure, Myopathy, Weakness
- Trial name
- NCT02247895
- Testing
- Electrical stimulation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gerald Supinski
Post Intensive Care Syndrome (PICS)
Post Intensive Care Accelerometery to Study and Support Recovery Outcomes
The primary purpose of this study is to find out whether a wrist-worn activity monitor can help healthcare professionals understand how people recover after they leave the intensive care unit (ICU), where they were cared for when…
- Trial name
- PICASSO (NCT07466446)
- Where
- 3 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
Critically Ill
Parasternal Intercostal Muscle Thickening as an Additive Weaning Criterion
Increased days of MV are not without hazards, including barotraumas and ventilator-associated pneumonia. Similarly, premature separation of MV is associated with increased mortality secondary to adverse cardiorespiratory events.
- Trial name
- NCT07143695
- Testing
- Parasternal intercostal thickening fraction
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
COVID-19
Effect of CytoSorb Adsorber on Hemodynamic and Immunological Parameters in Critical Ill Patients With COVID-19
This prospective randomized single Center study investigates to what extent the physical elimination of the inflammatory mediators using the CytoSorb adsorber reduces the morbidity of severely and critically ill patients with…
- Trial name
- CYTOCOV-19 (NCT04344080)
- Testing
- CytoSorb-Therapy
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acute Kidney Injury, Critical Illness
Predicting Adverse Kidney Events of Cardiac Surgery-Associated Acute Kidney Injury Using Novel Biomarkers
The aim of this study was to identify and validate novel biomarkers for predict acute kidney injury (AKI) subphenotype, major adverse kidney events and other poor outcomes.
- Conditions
- Acute Kidney Injury, Critical Illness, Kidney Failure
- Trial name
- NCT06351813
- Where
- China
- Volunteers
- 358 people
- Sponsor
- Shanghai Zhongshan Hospital
Ventilator-associated Pneumonia
Study of Biotene OralBalance Gel for Oral Care in Critically-Ill Mechanically Ventilated Neonates
The goal of this pilot study is to test the hypothesis that mechanically ventilated infants receiving Biotene OralBalance® gel for oral care would have a reduced intubation time compared to infants receiving oral care placebo.
- Trial name
- NCT01314742
- Testing
- Biotene OralBalance® gel, Sterile Water moisten cotton tipped applicator
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Wake Forest University Health Sciences
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