Clinical trials: Cyst
Polycystic Ovarian Syndrome, Obesity
Oral Amino Acid Nutrition to Improve Glucose Excursions in PCOS
The Investigators will measure hepatic glucose and fat metabolism in obese girls with Polycystic Ovarian Syndrome (PCOS) and hepatic steatosis (HS) after taking 4 weeks of an essential amino acid (EAA) supplement or placebo and…
- Conditions
- Polycystic Ovarian Syndrome, Obesity, Hepatic Steatosis
- Trial name
- ORANGE (NCT03717935)
- Testing
- Essential Amino Acid (EAA) Supplement
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Colorado, Denver
Polycystic Ovarian Syndrome, Obesity
Post-Prandial Liver Glucose Metabolism in PCOS
The Investigators will measure if hepatic metabolism is upregulated in obese girls with PCOS and hepatic steatosis (HS), compared to PCOS without HS and obese controls without HS.
- Conditions
- Polycystic Ovarian Syndrome, Obesity, Hepatic Steatosis
- Trial name
- PLUM (NCT03041129)
- Testing
- oral glucose tolerance test, MRI of liver
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Polycystic Ovary Syndrome
Insulin Resistance, Polycystic Ovary Syndrome, and Bone Research Study
The purpose is to investigate the effects of 2 different treatments (drospirenone/ethinyl estradiol versus rosiglitazone) on insulin sensitivity and androgen levels, inflammatory markers, vascular markers and bone development in…
- Trial name
- NCT00640224
- Testing
- rosiglitazone, drospirenone/ethinyl estradiol
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Silva Arslanian
Type 2 Diabetes, PreDiabetes
Behavioral Economics for Activity Motivation in Adolescents (BEAM)
There is an urgent need to engineer targeted physical activity interventions that are effective and scalable for obese adolescents and young adults (AYA) with type 2 diabetes (T2D), who often have very low levels of physical…
- Conditions
- Type 2 Diabetes, PreDiabetes, Insulin Resistance, Polycystic Ovary Syndrome
- Trial name
- NCT04874415
- Testing
- 1RLD, 1RLW, 1RGD
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Pittsburgh
Polycystic Ovary Syndrome
Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy
Oral contraceptives are known to improve menstrual cycles and symptoms in PCOS, however may increase cholesterol. Metformin, a drug to improve insulin resistance, may benefit metabolic state.
- Trial name
- NCT00283816
- Testing
- Metformin, Oral Contraceptive Pill, Lifestyle Management Program
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Safety, Pharmacokinetics, Tolerability and Efficacy of Tolvaptan in Children and Adolescents With ADPKD (Autosomal Dominant Polycystic Kidney Disease)
The primary objective of the study is to assess the long term safety of treatment with tolvaptan in children and adolescents with autosomal dominant polycystic kidney disease (ADPKD).
- Trial name
- NCT02964273
- Testing
- Tolvaptan
- Where
- 20 sites in Belgium, Germany and 2 more
- Volunteers
- 91 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Keloid, Alopecia Areata
Pain Outcomes Following Intralesional Corticosteroid Injections
Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics.
- Conditions
- Keloid, Alopecia Areata, Acne, Hypertrophic Scar
- Trial name
- NCT03630198
- Testing
- Corticosteroid with lidocaine, Corticosteroid with normal saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Pilonidal Sinus, Sinus; Dermal, Pilonidal
Conservative Versus Surgical Treatment of Umbilical Pilonidal Disease
The aim of the study was to compare the results of conservative and surgical treatment, to create an algorithm for the management of the disease, and gain more information about the etiology, pathogenesis, and course of the…
- Conditions
- Pilonidal Sinus, Sinus; Dermal, Pilonidal, Umbilical Granuloma
- Trial name
- NCT01662765
- Testing
- Surgery, conservative
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Medical Park Gaziantep Hospital
Pilonidal Sinus
Limberg-flap: Prospective Data Collection
The investigators think, that the treatment of pilonidal sinus with excision and covering of the defect with a Limberg-flap is a very good treatment option.
- Trial name
- NCT00672555
- Testing
- Limberg-flap
- Where
- 2 sites in Switzerland
- Volunteers
- 70 people
- Sponsor
- Cantonal Hospital of St. Gallen
Chalazion, Hordeolum
Pediatric Zylet Safety and Efficacy Study
A multicenter study to evaluate the safety and efficacy of Zylet compared to vehicle in children aged 0-6 for the management of lid inflammation (chalazion/hordeolum)
- Trial name
- NCT00420628
- Testing
- loteprednol etabonate/tobramycin opthalmic suspension, vehicle
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Bausch & Lomb Incorporated
Polycystic Ovary Syndrome
Treatment of Adolescent Polycystic Ovary Syndrome (PCOS)
A 24 week study to compare the use of Metformin, birth control pills and a carefully planned intensive lifestyle program that includes weight loss and exercise.
- Trial name
- NCT00714233
- Testing
- Metformin, Oral Contraceptive Pills (Yasmin), Lifestyle Modification
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Hepatic Steatosis, Polycystic Ovarian Syndrome
Liver and Fat Regulation in Overweight Adolescent Girls
Women with polycystic ovarian syndrome (PCOS) have increased rates of hepatic steatosis compared to weight similar women with regular menses. It is unclear if this is related to high testosterone or insulin resistance.
- Conditions
- Hepatic Steatosis, Polycystic Ovarian Syndrome, Obesity
- Trial name
- APPLE (NCT02157974)
- Testing
- Byetta 5Mcg Pen Injection
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Chalazion
Safety and Efficacy Study of SUN-131 Transdermal System (TDS) as Compared to Placebo TDS in Patients With a Chalazion
This protocol for SUN-131 1.5% TDS is developed for the treatment of chalazion. SUN-131 1.5% TDS is designed for local delivery of a corticosteroid, to the upper or lower eyelid.
- Trial name
- SUNRISE (NCT03248440)
- Testing
- SUN-131 1.5% TDS
- Where
- 65 sites in United States
- Volunteers
- 263 people
- Sponsor
- Senju USA, Inc.
Polycystic Ovary Syndrome, Hyperandrogenism
Effect of Metformin on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone
Many, but not all, girls with high levels of the male hormone testosterone go on to develop polycystic ovary syndrome (PCOS) as adults.
- Trial name
- NCT01427595
- Testing
- Metformin, Progesterone, estrace
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome
Intrauterine Environment in Polycystic Ovary Syndrome (PCOS) Probands
Polycystic ovary syndrome (PCOS) is among the most common endocrine disorders in premenopausal women, affecting 7-10% of this population.
- Trial name
- NCT00364949
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Desmoplastic/Nodular Medulloblastoma, Medulloblastoma
Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-metastatic Desmoplastic Medulloblastoma
This phase II trial studies how well combination chemotherapy works in treating younger patients with newly diagnosed, non-metastatic desmoplastic medulloblastoma.
- Conditions
- Desmoplastic/Nodular Medulloblastoma, Medulloblastoma, Medulloblastoma With Extensive Nodularity, Nevoid Basal Cell Carcinoma Syndrome
- Trial name
- NCT02017964
- Testing
- Carboplatin, Cognitive Assessment, Cyclophosphamide
- Where
- 173 sites in United States, Australia and 2 more
- Volunteers
- 26 people
- Sponsor
- Children's Oncology Group
Leukodystrophy, White Matter Disease
LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies
Leukodystrophies, and other heritable disorders of the white matter of the brain, were previously resistant to genetic characterization, largely due to the extreme genetic heterogeneity of molecular causes.
- Conditions
- Leukodystrophy, White Matter Disease, 4H Syndrome, Adrenoleukodystrophy
- Trial name
- NCT02699190
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Children's Hospital of Philadelphia
Polycystic Ovary Syndrome, Metabolic Syndrome
To Study Polycystic Ovary Syndrome in Taiwanese Women
Polycystic ovary syndrome (PCOS) is an extremely common disorder in women of reproductive age. Diagnosis of PCOS is principally based on clinical and physical findings.
- Conditions
- Polycystic Ovary Syndrome, Metabolic Syndrome, Cardiovascular Disease
- Trial name
- NCT01256944
- Where
- Taiwan
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Polycystic Ovary Syndrome, Hyperandrogenism
Effects of Androgen Blockade on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone
The purpose of this study is to understand the effects of elevated male hormones in adolescent girls and how they effect the development of polycystic ovary syndrome (PCOS).
- Trial name
- NCT01428193
- Testing
- Flutamide, Progesterone, estrace
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Virginia
Chalazion
Probiotics for Chalaziosis Treatment in Children
There is growing evidence encouraging the use of probiotics in many conditions in children. The aim of the investigator's study is to define the possible beneficial impact of probiotics on paediatric patients affected by…
- Trial name
- NCT04322500
- Testing
- probiotics, conservative treatment
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- University of Molise