Clinical trials: Data Analysis
Computational Modeling of Individual Metabolic Pathways
Continuous N-of-1 Computational Feasibility Study of a Whole Genome Sequence
This is an observational, computational N-of-1 study that uses previously collected Whole Genome Sequencing (WGS) data from a single adult participant to evaluate the feasibility of a deterministic bioenergetic simulation model.
- Trial name
- B2026N1 (NCT07462234)
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Bioactify LLC
Coronary Artery Dissection, Spontaneous
Spontaneous Coronary Artery Dissection anaLysIs of the Brazilian Updated Registry
A retrospective and prospective registry will evaluate demographic and angiographic data in patients with spontaneous coronary artery dissection (SCAD) using medical records, invasive coronary angiography, intravascular imaging…
- Trial name
- SCALIBUR (NCT03398850)
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- Hospital Israelita Albert Einstein
Ulnar Longitudinal Deficiency, Ulnar Hand Deformity
Longitudinal Ulnar Deficit (ULNEER)
The management of patients with longitudinal ulnar deficiency is a clinical challenge due to the rarity of this condition and the wide variety of its manifestations.
- Trial name
- ULNEER (NCT07404514)
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Hopitaux de Saint-Maurice
Coronary Disease, Heart Diseases
VA HDL Intervention Trial (VA-HIT) Ancillary Study Data Analysis
To evaluate additional cardiovascular risk factors using data from the VA HDL Intervention Trial (VA-HIT).
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Carotid Artery Diseases
- Trial name
- NCT00035711
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Renal Insufficiency / Therapy
PD Catheter Data Collection
Peritoneal Dialysis (PD) is a Renal Replacement Therapy for patients with renal insufficiency that has been used more frequently in recent years.
- Trial name
- Catheter (NCT07156123)
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Severe Sepsis With Septic Shock
Evaluating a CytoSorb Score in Septic Shock
Systemic hyperinflammatory states, e.g. triggered by infection/sepsis, represent a major challenge for modern medicine. After an initially localized onset, inflammation can extend to an excessive, uncontrolled inflammatory…
- Trial name
- ECSISS (NCT03977688)
- Testing
- Cytokin Adsorption
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Klinikum Emden
Sickle Cell Disease
Retrospective Real World Oxbryta® Data Collection and Analysis Study
The aim of this study is to collect and analyze retrospective data on Oxbryta in a real-world setting. This is a multicenter, retrospective data collection and analysis study to characterize health outcomes in approximately 300…
- Trial name
- RETRO (NCT04930328)
- Testing
- Oxbryta® (voxelotor) 500-mg Tablets
- Where
- 12 sites in United States
- Volunteers
- 216 people
- Sponsor
- Pfizer
Data Analysis, Cancer Genetics
Exploratory Data Analysis for Disease Pedigrees and Cancer Genetics
The researchers have developed and distributed several software packages for pedigree analysis (FAST, CASPAR, PedHunter, IIC) and cancer genetics (oncotree, METREX).
- Trial name
- NCT00339508
- Where
- United States
- Volunteers
- 13,385 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Stunting, Thinness
The Double Burden of Malnutrition Among Adolescents in Low-income and Middle-income Countries
Individual-participant data analysis of the Global School-Based Student Health Survey and Health Behaviour in School-Aged Children surveys in 57 LMICs between 2003-2013.
- Conditions
- Stunting, Thinness, Obese
- Trial name
- NCT03346473
- Volunteers
- 129,276 people, healthy volunteers welcome
- Sponsor
- University of Warwick
Major Depressive Disorder
NeuroStar TMS Therapy System: Utilization and Outcomes
The major objective of this observational study is to describe clinical outcomes of patients receiving treatment with the NeuroStar TMS Therapy system in routine clinical practice.
- Trial name
- NCT01114477
- Where
- 44 sites in United States
- Volunteers
- 307 people
- Sponsor
- Neuronetics
Schizophrenia, Treatment-resistant Schizophrenia
Multidisciplinary Design to Optimize Schizophrenia Treatment Based on Multi-omics Data and Systems Biology Analysis
SchizOMICS is a Phase IV, multicenter, dose-flexible, open-label, randomized controlled clinical trial to evaluate the efficacy and safety of aripiprazole versus paliperidone using multi-omics data in patients with a first…
- Conditions
- Schizophrenia, Treatment-resistant Schizophrenia, Side Effect, Lipid Metabolism Disorders
- Trial name
- SchizOMICS (NCT06060886)
- Testing
- Aripiprazole, Paliperidone
- Volunteers
- 244 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Mucormycosis
Amphotericin B Versus Isavuconazole for Mucormycosis: A Comparative Efficacy and Safety Study
Background: Mucormycosis is a serious but rare fungal infection that requires rapid and effective treatment. The two main antifungal medicines used are amphotericin B and isavuconazole.
- Trial name
- AIM (NCT07191756)
- Testing
- Amphotericin B, Isavuconazole
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Qiu Ye
Asthma, Gastroesophageal Reflux Disease
Reflux Disease Therapy in the Management of Childhood Asthma-data Entry and Analysis Only
There have been a number of studies which attribute causality between reflux disease and asthma. In addition, clinicians typically treat chronic asthmatics with high dose acid suppressing medications (e.g. lansoprazole).
- Trial name
- NCT01536457
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Children's Center for Digestive Health Care
Neurological Observations
Additional Post Hoc Analysis and Clinical Data Collection
The purpose of this study is to collect additional Investigational cognitive tasks and additional clinical data for subjects tested with ElMindA's Brain Network Activation (BNA™).
- Trial name
- BNA™ (NCT02860416)
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
ALLERGIC OR HYPERSENSITIVITY
VALIDATION OF THE CHAPTER "ALLERGIES AND HYPERSENSITIVITY" OF THE INTERNATIONAL DISEASE CLASSIFICATION (CIM)
Allergic diseases, including allergic asthma, allergic rhinitis and anaphylaxis are not properly classified in current classifications of diseases.
- Trial name
- AHCIM11 (NCT03213808)
- Testing
- No intervention: analysis of health data from patients with
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Hereditary Diseases
Multicenter Analysis of Genomic and Metabolic Data of Neonatal Genetic Diseases
object name: Multicenter analysis of genomic and metabolic data of neonatal genetic diseases. goal of study:(1) Gene sequencing data (138 genes related to 133 common genetic diseases) and tandem mass spectrometry metabolomics…
- Trial name
- MAOFGAMDNGD (NCT06183138)
- Testing
- Genomic sequencing
- Where
- China
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Colorectal Cancer (CRC) and Pancreatic Cancer (PaCa)
Allocating Resources for Cancer Care in Times of the Sars-CoV-2 Outbreak. Health Care Research
The focus on treatment of COVID19 patients during the Sars-CoV-2 outbreak has most likely implications for the extent and quality of diagnosis and treatment of non-COVID19 patients.
- Trial name
- NCT05479292
- Testing
- Sars-CoV-2 outbreak
- Where
- Germany
- Volunteers
- 6,500 people
- Sponsor
- Technische Universität Dresden
Hymenoptera Sting Allergy
Frequency of Hymenoptera-stings in Patients Under Allergen-Specific Immunotherapy (SIT)
In Switzerland, 3.5% of the population are suffering from hymenoptera venom allergy. The only causal treatment of hymenoptera alelrty is venom specific immunotherapy.
- Trial name
- ZU-HVA-001 (NCT00742794)
- Testing
- Observation
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
Migraine
Real-World Evidence (RWE) Data Analysis of 1-year Consecutive Use of Remote Electrical Neuromodulation (REN)
This is a Post-marketing study investigating the long-term safety, utilization, and efficacy of REN during 12 consecutive months of using Nerivio in migraine patients.
- Trial name
- NCT05760638
- Testing
- Nerivio
- Where
- 2 sites in United States, Israel
- Volunteers
- 409 people
- Sponsor
- Theranica