Clinical trials: Defects
Molar Incisor Hypomineralization, Hypersensitivity
Intraosseous Local Anesthesia System in Children With Molar Incisor Hypomineralization
The goal of this clinical trial is to compare in effectiveness of intraosseous anesthesia and inferior alveolar block anesthesia in children with molar incisor hypomineralization (MIH).
- Conditions
- Molar Incisor Hypomineralization, Hypersensitivity, Composite Restoration
- Trial name
- NCT06461143
- Testing
- %4 articaine with 1:200 000 adrenaline
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Molar Incisor Hypomineralization, Hypersensitivity
The Desensitising Effect of Nanosilver Fluoride in Molar-Incisor Hypomineralisation
The aim of the current study is to assess the desensitising effect of nanosilver fluoride on first permanent molars (FPMs) in patients with MIH in comparison to low-level laser therapy.
- Trial name
- NCT06348849
- Testing
- Low-level laser therapy, Nanosilver fluoride
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Alexandria University
Single-ventricle
Simple Non-invasive Breathing Device to Improve Pulmonary Flow Pusatility in Single Ventricle Post Fontan
This is a pilot study using a novel, minimal risk, portable, hands-free oral-positive pressure device (oPEP) in patients with Fontan palliation that will examine whether using this device in both the acute and chronic phase will…
- Trial name
- NCT05634226
- Testing
- Hands-free oral-positive pressure device (oPEP)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Tarek Alsaied
Dental Caries, Dental Fluorosis
Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes
Fluoride toothpaste has been associated not only with declining dental caries prevalence but also with an increase in dental fluorosis.
- Trial name
- NCT01589991
- Testing
- Toothpaste
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Facial Asymmetry
Measuring the Influence of Maxillary Obturator Prosthesis on Facial Morphology in Patient With Unilateral Maxillary Defects Using Stereophotogrammetry
Functional rehabilitation and quality of life after maxillofacial surgery have been emphasized in recent years. It depends mainly on outcomes of maxillofacial reconstruction and rehabilitation involving functions, esthetics…
- Trial name
- NCT05310149
- Testing
- Prosthetic intervention with maxillary obturator prosthesis
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Cairo University
Congenital Heart Disease
Continuous Infusion Versus Bolus Dosing for Pain Control After Pediatric Cardiothoracic Surgery
The investigators hypothesize that intermittent bolus doses of morphine and midazolam can provide the same pain control after pediatric cardiothoracic surgery as bolus doses plus infusions while using smaller total doses of both…
- Trial name
- NCT02112448
- Testing
- continuous infusion, as needed dosing, Acetaminophen
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Wake Forest University Health Sciences
Mild Asthma
PAXT: Pulmonary Imaging of Mild Asthma Using 129Xe MRI and Tc-99-Labeled-Carbon-Imaging (Tc99CImaging)
The goal of this observational study is to better understand how asthma affects the lungs in young adults (ages 17-35) with mild asthma.
- Trial name
- PAXT (NCT07143747)
- Testing
- Hyperpolarized 129Xe MRI, Tc-99m Technegas Ventilation Imaging
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Dr. Grace Parraga
Congenital Heart Disease
Theophylline Effects in the Fontan Circulation
A single group treatment phase 2 single-arm no-masking study to assess safety and efficacy of a short-term oral treatment with theophylline (ATC-no.
- Trial name
- THIEF (NCT05717049)
- Testing
- Theophylline Tablets
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Oslo University Hospital
Enamel Hypomineralization, Tooth Erosion
Hydroxyapatite Toothpastes and Enamel Remineralization:
This randomized controlled clinical trial aims to evaluate the efficacy of two commercially available toothpastes containing hydroxyapatite in the remineralization of early enamel lesions.
- Trial name
- HEREMI (NCT07069218)
- Testing
- Biorepair® Total Protection Plus Toothpaste, Bioniq® Toothpaste
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Turner Syndrome
A Study of PEG-somatropin Injection to Treat Children of Turner Syndrome
This study aims to explore the optimal dose of pegylated recombinant human growth hormone (PEG-rhGH) injection to treat children of Turner syndrome (TS), preliminarily evaluate its safety and efficacy and provide scientific and…
- Trial name
- NCT03189160
- Testing
- PEG-rhGH low dose, PEG-rhGH high dose, Non-treatment control group
- Where
- 9 sites in China
- Volunteers
- 180 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Secundum Atrial Septal Defects
Occlutech Septal Occluder (Figulla Flex II) Study
The objectives of the study are: To determine the efficacy of the Figulla Flex II device compared with that of the Amplatzer ASO device for transcatheter closure of secundum atrial septal defects To determine the safety of the…
- Trial name
- NCT04488120
- Testing
- transcatheter closure of secundum atrial septal defects in patients
- Volunteers
- 175 people
- Sponsor
- Occlutech International AB
Pyloric Stenosis;Acquired, Congenital Heart Disease
Effects of Prostaglandin E1 Treatment on Pyloric Wall in Newborns
Prostaglandin E1 (PGE1) has been used in the medical treatment of ductal dependent critical congenital heart disease in neonates.
- Trial name
- EOPTOPWT (NCT04496050)
- Testing
- Prostaglandin E1
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Hacettepe University
Complications of Surgical Procedure, Neurogenic Bladder
Complications of Enterocystoplasty in Children
The goal of this observational study is to describe the complications in participants who underwent enterocystoplasty in childhood.
- Conditions
- Complications of Surgical Procedure, Neurogenic Bladder, Spina Bifida, Child, Only
- Trial name
- AVPED (NCT05840874)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Dr Christelle DESTINVAL
Adult Congenital Heart Disease, Pulmonary Hypertension
Heart Institute Biobank & Registry for Adult Congenital Heart Disease and Related Disorders
A repository of biospecimens and detailed phenotypic information collected longitudinally from adults with congenital heart disease and related conditions, with an aim to facilitate future research on biologic mechanisms of…
- Conditions
- Adult Congenital Heart Disease, Pulmonary Hypertension, Connective Tissue Disease, Other Cardiovascular Conditions
- Trial name
- HIBR-ACHD (NCT07477197)
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Congenital Heart Defects, Heart Valve Diseases
Cardiac Operation Under Totally Endoscope and Cardiopulmonary Bypass (CPB)
Conventional cardiac operations are performed with median sternotomy, which is related to great wound, morbidities, longer duration in hospital and most significantly, cosmetic problems.
- Trial name
- CPB (NCT00921596)
- Testing
- cardiac operation with totally endoscopic method
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Xijing Hospital
Spinal Cord Injury, Spinal Cord Involvement
Clinical Trial of a Serious Game for Individuals With SCI/D
This study will evaluate the efficacy of a newly developed serious game, SCI HARD, to enhance self-management skills, self-reported health behaviors, and quality of life among adolescents and young adults with spinal cord injury…
- Conditions
- Spinal Cord Injury, Spinal Cord Involvement, Spina Bifida, Transverse Myelitis
- Trial name
- NCT02341950
- Testing
- SCI Hard
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- University of Michigan
Premature Infants, Patent Ductus Arteriosus
Ibuprofen and Renal Function in Premature Infants
Purpose of the study: 1. To evaluate renal function maturation within the first month of life in very premature infants. 2. To determine whether a treatment with Ibuprofen for patent ductus arteriosus would alter renal function…
- Trial name
- NCT00217191
- Testing
- Ibuprofen
- Where
- 3 sites in France
- Volunteers
- 120 people
- Sponsor
- Maternite Regionale Universitaire
Chondral Defect, Osteochondral Defect
An Observational, Prospective Study of Patients With Chondral and/or Osteochondral Defects of the Knee Treated With NAMIC
It is a prospective observational study of hospital cases. The objective is to determine the decrease of lesion size and the regeneration of chondral tissue in femoral condyle cartilage defect treated with NAMIC.
- Trial name
- KNAMIC (NCT03625180)
- Testing
- NAMIC: nanofractured autologous matrix-induced chondrogenesis
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Jordi Villalba Modol
Molar Incisor Hypomineralisation
Molar Incisor Hypomineralisation and Dental Anomalies
Background/study aim: Molar incisor hypomineralisation (MIH) is a common disorder of tooth development. Affected teeth have weak enamel and adult molars often require extensive treatment or even extraction.
- Trial name
- NCT05812690
- Testing
- This is a non intervention - observation only study
- Where
- United Kingdom
- Volunteers
- 1,279 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Congenital Heart Disease
Imaging by 4 DFlow in Patients With Tetralogy of Fallot
Conventionnal cadiac magnetic resonance (CMR) is the reference to assess changes in right heart flow and pulmonary artery hemodynamics in patients with repaired Tetralogy of Fallot.
- Trial name
- 4DFlowFallot (NCT03542968)
- Testing
- magnetic resonance imaging
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
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