Clinical trials: Defects
Patent Ductus Arteriosus
Assessment of Therapeutic Effect of Rectal Vs. Intravenous Paracetamol in The Treatment of Patent Ductus Arteriosus (PDA) in Neonates
To compare the effectiveness of rectal vs. intravenous paracetamol in the medical treatment of significant PDA in neonates.
- Trial name
- NCT06256211
- Testing
- Paracetamol
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Soha mahmoud Hussien mahdy
Chronic Periodontitis
Locally Delivered Metformin and Aloe Vera for Treatment of Intrabody Defects in Chronic Periodontitis
Metformin (MF), a biguanide group of anti-diabetic drug has been shown to enhance osteoblasts differentiation and inhibit osteoclast differentiation in vitro, thus may exhibit a favorable effect on alveolar bone.
- Trial name
- NCT03204071
- Testing
- Aloevera, Metformin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Congenital Heart Disease (CHD), Postoperative Respiratory Dysfunction
Effect of Coughing Exercises Versus Incentive Spirometry on Respiratory Function and Recovery in Children After Cardiac Surgery.
This study examines the effects of coughing exercises and incentive spirometry (IS) on lung function and recovery in children who undergo heart surgery.
- Conditions
- Congenital Heart Disease (CHD), Postoperative Respiratory Dysfunction, Postoperative Recovery After Cardiac Surgery
- Trial name
- CEXIS (NCT07405333)
- Testing
- Coughing Exercises, Incentive Spirometry, Standard Postoperative Care
- Where
- 4 sites in Iraq
- Volunteers
- 99 people
- Sponsor
- University of Baghdad
Marfan Syndrome
The Oxford Marfan Trial
The primary objective of the trial is to estimate the effects of allocation to irbesartan, or doxycycline, or a combination of both irbesartan and doxycycline, compared with placebo, on measures of elastic function of the aorta…
- Trial name
- NCT01949233
- Testing
- Irbesartan 150-300mg capsules daily for 6 months, Doxycycline 100-200mg capsules daily for 6 months
- Where
- 2 sites in United Kingdom
- Volunteers
- 56 people
- Sponsor
- University of Oxford
Fontan Procedure
Clinical Outcomes in Fenestrated Extra-Cardiac Fontan in Low Preoperative Risk Profiles
Evaluation of fenestration benefit in Extra-cardiac total cavo-pulmonary connection (Fontan procedure) in single ventricle anomaly, comparing clinical outcomes of patients with low preoperative risk profiles in prospective study
- Trial name
- NCT03503032
- Testing
- Extracardiac Fontan, Fontan fenestration
- Where
- Saudi Arabia
- Volunteers
- 62 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Primary Ciliary Dyskinesia, Kartagener Syndrome
Genetics of Primary Ciliary Dyskinesia
This study is designed to study DNA sequencings for mutations in a research genetic test panel of genes (which contains all 32 known and/or published genes associated with PCD).
- Trial name
- NCT02389049
- Where
- 8 sites in United States, Canada
- Volunteers
- 320 people
- Sponsor
- University of North Carolina, Chapel Hill
Congenital Heart Disease, Telerehabilitation
The Effect of Telerehabilitation Exercises in Children With Congenital Heart Disease
This study aims to investigate the effects of functional inspiratory muscle training on physical performance and quality of life in pediatric patients with congenital heart disease.
- Conditions
- Congenital Heart Disease, Telerehabilitation, Functional Inspiratory Muscle Training
- Trial name
- CHD (NCT07854171)
- Testing
- Inspiratory Muscle Training, Functional Inspiratory Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Izmir Democracy University
Spina Bifida
The Study Aims to Improve the Accuracy of Detecting Spina Bifida During Early Ultrasound Scans. to Achieve This, an AI Model Has Been Developed to Provide Feedback About the Presence of Spina Bifida. a RCT Has Been Designed to Compare the Effectiveness of AI Feedback with No AI Feedback.
The study aims to improve the accuracy of detecting spina bifida during early ultrasound scans. To achieve this, an AI model has been developed to provide feedback about the presence of spina bifida.
- Trial name
- NCT06566014
- Testing
- Evaluation of XAI-assisted spina bifida diagnosis
- Where
- Denmark
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Arrhythmogenic Cardiomyopathy, PKP2-ACM
A Study to Assess Real-world Patient Characteristics and Clinical Course for Symptomatic Patients With PKP2-ACM
An observational study to assess real-world patient characteristics and clinical course of disease in participants with PKP2-ACM.
- Conditions
- Arrhythmogenic Cardiomyopathy, PKP2-ACM, PKP2-ARVC
- Trial name
- SNAPSHOT- PKP2 (NCT06976606)
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- Lexeo Therapeutics
Ischemic Stroke, Embolic Stroke of Undetermined Source
SENIOR: Stroke Prevention in the Elderly by Patent Foramen Ovale closuRe vs Anticoagulation
Patent foramen ovale (PFO) is an important mechanism of embolic stroke of undetermined source (ESUS). Current guidelines recommend PFO closure for high-risk PFO in patients younger than 60 years, and a recent retrospective cohort…
- Conditions
- Ischemic Stroke, Embolic Stroke of Undetermined Source, Patent Foramen Ovale (PFO), Elderly
- Trial name
- SENIOR (NCT07479147)
- Testing
- PFO closure, Medication
- Where
- 3 sites in Taiwan
- Volunteers
- 400 people
- Sponsor
- Taichung Veterans General Hospital
Patent Foramen Ovale, PFO
Lifetech Cera™ PFO Occluder Post-Market Clinical Follow-Up
The objective of this post-market registry is to assess the clinical use of the Lifetech Cera™ PFO Occluder in a real-world and on-label fashion.
- Trial name
- NCT05893758
- Testing
- The Cera™ PFO Occluder
- Where
- 5 sites in Poland
- Volunteers
- 94 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Oral Cancer, Oropharyngeal Cancer
Speech-based AI-driven Diagnostics and Rehabilitation for Oral and Oropharyngeal Cancer.
Participants diagnosed with oral cancer, oropharyngeal cancer, or oral potentially malignant lesions, as well as healthy controls, had their speech audio recordings collected for the development and validation of AI-driven models…
- Trial name
- speech omics (NCT07347899)
- Where
- China
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Yudong Xiao
Nasal Defect
Deviation Parameters of Intraorfal Scanning in Capturing Different Intraoral Defects
For all participants, a conventional facial impression will be done using silicone material then poured and scanned using a desktop scanner which represented the control group (Group 1).
- Trial name
- NCT06315621
- Testing
- Scanning using intraoral scanner with markers, Scanning using intraoral scanner without markers, Physical Impression
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cairo University
Coarctation of the Aorta, Tetralogy of Fallot
Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance
The purpose of this study is to determine whether patients with repaired congenital heart disease show differences in size or function of their heart atria compared to normal controls and depending on the nature of their heart…
- Conditions
- Coarctation of the Aorta, Tetralogy of Fallot, Transposition of the Great Arteries
- Trial name
- NCT02161471
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Alveolar Ridge Atrophy
HydroGraft for Mandibular Horizontal Ridge Atrophy Augmentation.
This randomized controlled trial aims to evaluate the efficacy of a hydrogel-enhanced allograft compared with a standard particulate allograft, both used in conjunction with a resorbable collagen membrane, for horizontal alveolar…
- Trial name
- NCT07865299
- Testing
- Control Arm (Allograft + Collagen Membrane), Study Arm (Hydrogel-enhanced Allograft + Collagen membrane)
- Volunteers
- 18 people
- Sponsor
- Damascus University
Treatment of Periodontal Intra-bony Defects
The Present Study Was Performed to Evaluate the Efficacy of Lyophilized-PRF in Treatment of Periodontal Intra-bony Defects
The present study will be performed to evaluate the efficacy of lyophilized platelet-rich fibrin alone and combined with nanocrystalline hydroxyapatite in treatment of periodontal intra-bony defects through: 1.
- Trial name
- NCT06625528
- Testing
- open flap debridement
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Maxillary Obturators
Accuracy of Maxillary Obturator Bulb in Maxillectomy Defects
Treatment of tumors in the paranasal region often requires maxillectomy procedures. While surgical reconstruction is preferred, prosthetic reconstruction using obturators becomes necessary when surgery is not feasible.
- Trial name
- NCT06403930
- Testing
- Maxillary Obturator
- Where
- Egypt
- Volunteers
- 19 people
- Sponsor
- Badr University
Congenital Heart Disease, Cardiovascular Disease
Pilot Study of B-Type Natrieutic Peptide (BNP) Levels in Patients With Congenital Heart Disease(BNP)
The object of this study is to measure the levels of B-type Natriuretic Peptide (BNP) in patients with congenital heart disease, normal individuals, and patients with acquired heart failure, and compare the results from each…
- Trial name
- NCT00308230
- Testing
- Six minute walk test, Minnesota Living with Heart Failure Questionnaire
- Volunteers
- 34 people
- Sponsor
- Emory University
Persistent Corneal Epithelial Defect
ST266 Eye Drops for the Treatment of Persistent Corneal Epithelial Defects
The primary aim of the study is to evaluate the clinical response of ST266 treated subjects with persistent corneal epithelial defects during 28 days of therapy.
- Trial name
- NCT03687632
- Testing
- ST266
- Where
- 8 sites in United States
- Volunteers
- 13 people
- Sponsor
- Noveome Biotherapeutics, formerly Stemnion
Visual Snow Syndrome, Color Blindness
Study of Visual Perception Phenomena: Phosphene Mapping Induced by TMS and Its Relationship With Eye Movements
The purpose of this basic science study is to better understand human visual perception. Phosphenes are flashes of light that can be induced using Transcranial Magnetic Stimulation (TMS).
- Conditions
- Visual Snow Syndrome, Color Blindness, Healthy Volunteer
- Trial name
- NCT07110493
- Testing
- Transcranial Magnetic Stimulation (TMS), Electroencephalography (EEG), Eye-Tracking
- Where
- Russia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
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