Clinical trials: Defects
Congenital Heart Disease, Cardiovascular Disease
Technical Development for Pediatric Cardiovascular MRI
This study will explore new ways of using magnetic resonance imaging (MRI) to evaluate pediatric patients with cardiovascular disease,congenital heart disease in patients of all ages, fetuses undergoing clinically indicated MR…
- Trial name
- NCT02892136
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Heart Defects, Congenital
Transcatheter Versus Surgical Closure of Ventricular Septal Defect: A Comparative Study
The aim of this study is to compare Safety, efiicacy and clinical effects of surgical versus transcatheter closure of ventricular septal defect (VSD ).
- Trial name
- NCT05306483
- Testing
- Ventricular septal defect closure surgery, Ventricular septal defect closure catheter
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Birth Defect, Newborn; Fit
The Pilot Study of High-throughput Sequencing in Neonatal Birth Defects
In China, birth defects can reach as high as 5.6%, about 900,000 new cases of birth defects are added each year, making it the second cause of death for infants, with a total death rate of 19.1%.
- Conditions
- Birth Defect, Newborn; Fit, Genetic Diseases, Multiple Malformation
- Trial name
- NCT03984266
- Testing
- NGS panel
- Where
- China
- Volunteers
- 3,423 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Congenital Heart Disease
Quality of Life and Neurodevelopment Assessment of Children With Congenital Heart Disease Aged 2 to 4 Years
Congenital heart diseases (CHD) are the firt cause of congenital malformations (8 for 1000 births). Since the 90's, great advances in prenatal diagnosis, pediatric cardiac surgery, intensive care, and cardiac catheterization have…
- Trial name
- QoLCHD (NCT04812210)
- Where
- France
- Volunteers
- 248 people
- Sponsor
- University Hospital, Montpellier
Abdominal Hernia, Abdominal Wall Defect
To Investigate the Use of a New Syringe "Visual Pressure Control (VPC)" for Epidural Anesthesia in Children Surgery
Pediatric epidural anesthesia has emerged as a safe and effective regional anesthesia technique for providing intraoperative and postoperative analgesia in thoracic and abdominal surgery.
- Conditions
- Abdominal Hernia, Abdominal Wall Defect, Abdominal Neoplasm, Urogenital Disease
- Trial name
- NCT05308771
- Testing
- VPC syringe
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire de Tivoli
Congenital Heart Disease, Cardiac Surgery
Perioperative Transfusion Strategies in Adult Congenital Heart Disease Patients Undergoing Cardiac Surgery
Due to better medical care, a growing number of patients with congenital heart disease reach adulthood. A large number of these patients needs a redo cardiac surgery.
- Conditions
- Congenital Heart Disease, Cardiac Surgery, Blood Transfusion, Morbidity, Multiple
- Trial name
- NCT04973514
- Testing
- Cardiac surgery in grown-up congenital heart disease patients
- Where
- Belgium
- Volunteers
- 500 people
- Sponsor
- Brugmann University Hospital
Increased Lordosis/Scoliosis, Hyporeflexia
Biomarker for Duchenne Muscular Dystrophy
International, multicenter, observational, longitudinal study to identify biomarker/s for Duchenne Muscular Dystropy (DMD) and to explore the clinical robustness, specificity, and long-term variability of these biomarker/s.
- Conditions
- Increased Lordosis/Scoliosis, Hyporeflexia, Duchenne Muscular Dystrophy, Red-Green Color Blindness
- Trial name
- BioDuchenne (NCT02994030)
- Where
- 12 sites in Albania, Egypt and 6 more
- Volunteers
- 103 people
- Sponsor
- CENTOGENE GmbH Rostock
Congenital Heart Disease
3D Cine Cardiovascular Magnetic Resonance
Conventional CMR is based on breath-hold 2D cine image acquisitions which are sequentially acquired in different imaging planes.
- Trial name
- NCT03583775
- Testing
- Cardiovascular Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Boston Children's Hospital
Heart Defects, Congenital
The Use of Music for Neonates Post-Cardiac Surgery
The purpose of this study is to explore the feasibility of implementing nurse-led music therapy in a cohort of neonates admitted to the Cardiac Intensive Care Unit (CICU) post congenital heart surgery.
- Trial name
- NCT03925584
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston Children's Hospital
Congenital Heart Disease, Psychological Intervention
Psychological Functioning of Children and Adolescents With CHD andTheir Parents, An Intervention Based Study
Almost 1% of infants are born with Congenital Heart Disease (CHD), an umbrella term referring to a range of anomalies in the heart's structure that are present at birth.
- Conditions
- Congenital Heart Disease, Psychological Intervention, Parenting, Quality of Life
- Trial name
- CHDPIM (NCT05109806)
- Testing
- problem prevention therapy with CHD
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Government College University Faisalabad
Congenital Heart Disease
Nutritional Prehabilitation Program and Cardiac Surgery Outcome in Pediatrics
Nutritional Prehabilitation Program and Cardiac Surgery Outcome in Pediatrics. A randomized controlled trial.
- Trial name
- NCT02475759
- Testing
- Nutritional perioperative prehabilitation program for two weeks, Nutritional perioperative prehabilitation program for one week
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Ain Shams University
Pulmonary Valve; Failure, Percutaneous Pulmonary Valve Implantation
Transcatheter Pulmonary Valve Implantation With SAPIEN 3 Valve
Background Transcatheter pulmonary valve implantation (TPVI) is indicated to treat right ventricular outflow tract dysfunction in patients with congenital heart diseases.
- Conditions
- Pulmonary Valve; Failure, Percutaneous Pulmonary Valve Implantation, Infective Endocarditis, Congenital Heart Disease
- Trial name
- EUROPULMS3 (NCT05264181)
- Testing
- Percutaneous pulmonary valve implantation
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Congenital Heart Disease
Pre Bypass Ultrafiltration (PBUF) in Children Requiring Cardiopulmonary Bypass
Newborn babies and children with congenital heart defects who need heart surgery need to be placed on the heart-lung machine for heart surgery.
- Trial name
- PBUF (NCT03576534)
- Testing
- Use of prebypass ultrafiltration (PBUF)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Boston Children's Hospital
Congenital Heart Disease
Effect of Feeding With Nutrient Dense Formula in Malnourished Infants and Children With Congenital Heart Defects
Infants with congenital heart disease (CHD) are usually born with a normal weight but develop malnutrition over time, and about 20-50% of these children are usually malnourished. Malnutrition in these patients is multifactorial.
- Trial name
- NCT04795076
- Testing
- Infant formula
- Where
- Iran
- Volunteers
- 65 people
- Sponsor
- Shahid Beheshti University
Influenza, Human, Pregnancy
Afluria Pregnancy Registry
The study is a population based prospective cohort study designed to collect data on pregnancy outcomes and events of interest among women immunized with Afluria during pregnancy.
- Conditions
- Influenza, Human, Pregnancy, Birth Defect
- Trial name
- NCT03442582
- Testing
- Afluria Influenza Vaccine
- Where
- United States
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Seqirus
Congenital Heart Disease
Improving Critical Congenital Heart Disease Screening With Addition of Perfusion Measurements
The purpose of this research is to evaluate and create a new clinical prediction model for CCHD screening that combines non-invasive measurements of oxygenation and perfusion.
- Trial name
- NCT04056104
- Testing
- SpO2 and PIx Measurement
- Where
- 6 sites in United States
- Volunteers
- 543 people
- Sponsor
- University of California, Davis
Congenital Heart Disease
Dexmedetomidine Neuroprotection in Pediatric Cardiac Surgery
Neurodevelopmental disability is the most significant complication for survivors of infant surgery for congenital heart disease.
- Trial name
- NCT04484922
- Testing
- Dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Aortic Coarctation, Congenital Heart Disease
Contribution of Multimodal Imaging in Early Coarctation
The CT-Coarct-PED study is a multicentred observational study aiming to describe the population of early coarctation during the last 10 years in South of France.
- Trial name
- CT-COARCT-PED (NCT05203874)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Montpellier
Abdominal Wall Defect, Ventral Hernia
Clinical Study on the Safety of SAFIL® MESH
Observational, Retrospective, Multi-center Clinical Study on the Safety of SAFIL® MESH in Patients Undergoing Reinforcement of Soft Tissues After Abdominal Wall Surgery or Other Fascial Defects
- Conditions
- Abdominal Wall Defect, Ventral Hernia, Abdominal Hernia, Fascial Hernia
- Trial name
- SAFIL_MESH (NCT04947202)
- Testing
- Hernioplasty
- Where
- 2 sites in Spain
- Volunteers
- 152 people
- Sponsor
- Aesculap AG
Muscle Hypotonia, Down Syndrome
Assessment of Hypotonia in Children With Down Syndrome
Hypotonia is a common trait in infants with Down syndrome, resulting in pathologies and delays in gaining basic motor skills. There are no screenings available to aid in early diagnosis, therefore, the purpose of this study is to…
- Conditions
- Muscle Hypotonia, Down Syndrome, Muscle, Floppy, CHILD Syndrome
- Trial name
- NCT05131542
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universidad de Murcia