Clinical trials: Defects
Congenital Heart Diseases
Transition From Adolescents to Adulthood for Patients With Congenital Heart Diseases
The Investigators aim to measure the impact of a transition program in congenital cardiology in terms of health-related quality of life.
- Trial name
- NCT03005626
- Testing
- Therapeutic education, Standard follow-up
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Rhinovirus, Congenital Heart Disease
'The Impact of Rhinovirus Infections in Paediatric Cardiac Surgery'
This is a prospective single- center observational study in the Leiden University Medical Center in approximately 250 children (<12 years) undergoing elective cardiac surgery, for congenital heart disease.
- Conditions
- Rhinovirus, Congenital Heart Disease, Respiratory Infections, Post-operative Complications
- Trial name
- RISK (NCT02438293)
- Testing
- rhinovirus diagnostics
- Where
- Netherlands
- Volunteers
- 166 people
- Sponsor
- Leiden University
Congenital Heart Defect, Blood Coagulation Disorder
Bedside Evaluation of Coagulation in Children With Congenital Heart Disease
The purpose of this study is to assess coagulation and platelet function in children with congenital heart disease, measured with a bedside device (thromboelastometry and impedance aggregometry).
- Trial name
- POCHEMO (NCT02387944)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Congenital Heart Disease
Platelets or Fibrinogen as First-line Treatment for Bleeding During Pedatric Heart Surgery
The study aims to test whether platelet transfusion or fibrinogen concentrate is the most effective treatment of intraoperative bleeding, when performing open heart surgery with cardiopulmonary bypass on children with congenital…
- Trial name
- NCT04807621
- Testing
- Platelet transfusion, Fibrinogen concentrate
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Sahlgrenska University Hospital
Atrial Septal Defects
Safety and Effectiveness Study of the Solysafe Septal Occluder
Prospective mono-center clinical study to evaluate the safety and effectiveness of an intracardiac septal closure device in patients with atrial septum defect (ASD)
- Trial name
- NCT00353509
- Testing
- Device Closure of a Septal Defect
- Where
- Serbia
- Sponsor
- Carag AG
Transposition of Great Vessels, Surgery
MRI Study After Arterial Switch Operation in Patients With Transposition of the Great Arteries
This study involves adolescents operated with arterial switch procedure for transposition of the great arteries during the neonatal period.
- Trial name
- NCT01916499
- Testing
- 3 tesla magnetic resonance imaging findings; coronary artery status, 3 tesla magnetic resonance imaging findings; ventricular function and morphology
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Oslo University Hospital
Heart Defects, Congenital
Genetics of Ventriculo-arterial Discordance
Number of centres planned : 16 centres in France Type of study / Study design : Research Involving the Human Person category 2. Multicentric. Prospective Planning of the study : Total duration: 57,5 months.
- Trial name
- PreciPed (NCT05330338)
- Testing
- Genetic analyses: whole genome sequencing
- Where
- 16 sites in France
- Volunteers
- 600 people
- Sponsor
- Nantes University Hospital
Molar Incisor Hypomineralization
Prevalence of Molar Incisor Hypominerlization (MIH) Among a Group of Egyptian Children
To determine the Prevalence of MIH in a group of Egyptian children attending the Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Cairo University.
- Trial name
- MIH (NCT03498209)
- Volunteers
- 100 people
- Sponsor
- Cairo University
Acute Kidney Injury, Congenital Heart Disease
Nitric Oxide During Cardiopulmonary Bypass in Neonates to Reduce Risk of Acute Kidney Injury
Acute kidney injury following cardiac surgery for congenital heart defects in children is a major cause of both short- and long-term morbidity and mortality, affecting up to 60% of high risk patients.
- Trial name
- NCT04259684
- Testing
- gases Nitric Oxide (gNO)
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Congenital Heart Disease, Transition
Evaluation of Web-based Transition Education to Enhance Transition Readiness
The study looks to learn more about the helpfulness of web-based transition education and its effect on transition readiness and health service utilization in the adolescent and young adult congenital heart disease population.
- Conditions
- Congenital Heart Disease, Transition, Pediatric Congenital Heart Disease
- Trial name
- NCT03303248
- Testing
- Web-based Educational Intervention
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Michigan
Osteochondritis Dissecans of Ankle and Joints of Foot
the Effect of Weight Bearing Status on Healing and Pain Outcomes After Surgery for Osteochondral Defects of the Ankle
The rationale for this research study is to evaluate the effect on clinical outcomes of weight bearing as tolerated after forage surgery for the treatment of osteochondral defects of the ankle, thus potentially eliminating the…
- Trial name
- NCT01405664
- Testing
- Weight-Bearing as Tolerated
- Where
- Canada
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Marfan Syndrome
Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome
Marfan syndrome is a hereditary connective tissue disorder. Many individuals with this condition die because of the associated heart and blood vessel abnormalities.
- Trial name
- NCT00429364
- Testing
- Losartan Potassium, Atenolol
- Where
- 26 sites in United States, Belgium and 1 more
- Volunteers
- 608 people
- Sponsor
- Carelon Research
Birth Defects, Pregnancy Complications
UCB Antiepileptic Drugs (AED) Pregnancy Registry (Formerly the Keppra® Pregnancy Registry)
This is a prospective, observational, exposure-registration and follow-up study of women and their offspring exposed to Keppra® (levetiracetam) and Keppra XR® at the time of conception (i.e., any time from the first day of the…
- Conditions
- Birth Defects, Pregnancy Complications, Epilepsy, Seizures
- Trial name
- NCT00345475
- Where
- United States
- Volunteers
- 516 people
- Sponsor
- UCB Pharma
Congenital Disorders
Resynchronization of Left Ventricular Contraction After Reimplantation of Anomalous Left Coronary Artery
Spontaneous resynchronization of dyskinetic segments of the left ventricle occurs after coronary bypass surgery in adults and has been shown in some children.
- Trial name
- NCT00268112
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Children's Healthcare of Atlanta
Post Traumatic Soft Tissue Defects That Could be Reached by Pedicled Anterolateral Thigh Flap, Post Tumor Excision Soft Tissue Defects
Reliability and Versatility of Pedicled Anterolateral Thigh Flap in Reconstruction of Soft Tissue Defects
a prospective case series study for evaluation of the reliability and versatility of pedicled anterolateral thigh flap in the reconstruction of soft tissue defects as regards flap survival and complications, donor site morbidity…
- Conditions
- Post Traumatic Soft Tissue Defects That Could be Reached by Pedicled Anterolateral Thigh Flap, Post Tumor Excision Soft Tissue Defects, Post Debridement Soft Tissue Defects
- Trial name
- NCT06841419
- Testing
- surgical reconstruction of a soft tissue defects by a pedicled flap
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Hypoplastic Left Heart Syndrome, Heart Defects, Congenital
Safety of Autologous Cord Blood Cells in HLHS Patients During Norwood Heart Surgery
This study aims to evaluate the safety and feasibility of coronary infusion of autologous placental cord blood mononuclear cells during the Norwood heart operation in newborn hypoplastic left heart syndrome (HLHS) patients.
- Conditions
- Hypoplastic Left Heart Syndrome, Heart Defects, Congenital, Pediatric Disorder
- Trial name
- NCT03431480
- Testing
- Autologous Human Placental Cord Blood Mononuclear Cells
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Murdoch Childrens Research Institute
Cerebral Palsy, Stroke
Feasibility of the Portable YouGrabber System
The aim of the study is to determine the feasibility of the portable version of the YouGrabber® system in children with central motor disorders.
- Conditions
- Cerebral Palsy, Stroke, Traumatic Brain Injury, Meningomyelocele
- Trial name
- YouGrabber (NCT02368223)
- Testing
- YouGrabber
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University Children's Hospital, Zurich
Congenital Heart Disease (CHD)
The Effect of Therapeutic Play on Preoperative Anxiety in Hospitalized Children With Congenital Heart Disease
Congenital Heart Disease (CHD) is the most common congenital malformation in children and the leading cause of death from birth defects in infancy.
- Trial name
- TP-CHD (NCT07643168)
- Testing
- Therapeutic Play Intervention, Routine Preoperative Nursing
- Volunteers
- 204 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Turner's Syndrome
Initiating Transdermal Estradiol Therapy in Turner's Syndrome
This is a multicenter, randomized, controlled, semi-blinded study to compare two low doses of estradiol administered by recently available transdermal patches for the initiation of puberty in Turner syndrome girls 11.5-13.0 years…
- Trial name
- NCT00870220
- Testing
- Norditropin, Menostar 14mcg patch, Vivelle dot 25mcg patch
- Where
- 3 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of Chicago
Syncope, Pediatric
Pediatric Adhesion and New Dermal Approach Study
The purpose of this study is to see if the Zio® monitor device can be worn by children for up to 14-days and to determine if the skin preparation process will provide good adherence to the skin and clear signal quality.
- Conditions
- Syncope, Pediatric, Congenital Athymia, Congenital Heart Disease
- Trial name
- PANDA (NCT07118124)
- Testing
- Zio monitor
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- iRhythm Technologies, Inc.
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