Clinical trials: Defects
Congenital Heart Disease, Single Ventricle
Cardiovascular, Pulmonary and Skeletal Muscle Evaluation Postoperative in Fontan Patients: Effects of Exercise Training
Introduction: The Fontan operation is the surgical treatment in most patients with either anatomic or functional single ventricles.
- Conditions
- Congenital Heart Disease, Single Ventricle, Univentricular Heart
- Trial name
- NCT02283255
- Testing
- Aerobic Exercise Training, Inspiratory Muscle Training, No Exercise Training
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Prematurity; Extreme, Low Birthweight, Extremely (999 Grams or Less)
Extremely Low Gestatonal Age Infants' Paracetamol Study
In the present trial, early, intravenous paracetamol is compared to placebo in extremely premature or low birth weight infants in order to evaluate the effect on ductal closure.
- Trial name
- Paras (NCT03641209)
- Testing
- Paracetamol 10mg/mL infusion solution
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Outi Aikio
Congenital Heart Disease, Neurodevelopment
Improving Neurodevelopment in Adolescents With Congenital Heart Disease
Executive dysfunction can profoundly impact all dimensions of a child's development. Impairments in executive function are a central component of the neurodevelopmental phenotype associated with CHD, and manifest as behavioral…
- Conditions
- Congenital Heart Disease, Neurodevelopment, Executive Function, Working Memory Training
- Trial name
- NCT02759263
- Testing
- Cogmed Working Memory Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston Children's Hospital
Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure
Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients
The purpose of this study is to determine whether inhaled iloprost is safe and effective in pediatric patients with pulmonary hypertension who are sick in the intensive care unit.
- Conditions
- Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure, Persistent Pulmonary Hypertension of Newborn, Congenital Heart Defects
- Trial name
- NCT00981591
- Testing
- Iloprost
- Sponsor
- Seattle Children's Hospital
Congenital Heart Disease
Transition Care Model for Adolescents With Congenital Heart Disease
The primary aim of this study is to assess the effectiveness of a standardized transition care model (TC) on the perceived mental and physical health of adolescents with congenital heart disease (CHD).
- Trial name
- TELEMACO (NCT05713591)
- Testing
- Transition care model
- Where
- Italy
- Volunteers
- 964 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Congenital Heart Disease
The Efficacy of Systematic Oral Feeding Education Program
After the intervention of Systematic Oral Feeding Education Program: 1. The feeding techniques scores of the main caregivers in the experimental group will be higher than those in the control group. 2.
- Trial name
- SOFEP (NCT06763497)
- Testing
- Systematic Oral Feeding Education Program
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Congenital Heart Disease, Physical Inactivity
Exergame-Based Physical Activity Promotion for Children and Adolescents With Congenital Heart Disease
The goal of this clinical trial is to learn whether a Nintendo Switch-based exergame physical activity program can help children and adolescents with congenital heart disease increase their physical activity.
- Trial name
- ExPACE-CHD (NCT07593118)
- Testing
- Nintendo Switch-Based Exergame Physical Activity Promotion Intervention
- Where
- China
- Volunteers
- 13 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Aortic Coarctation, Erector Spinae Plane Block
Erector Spinae Plane Block Versus Fentanyl Infusion in Pediatric Patients Undergoing Aortic Coarcitectomy
Pain is considered to be subjective, however in children it is believed to be felt rather than expressed, because they often depend on the caregiver for their safety and well-being.
- Conditions
- Aortic Coarctation, Erector Spinae Plane Block, Paediatric
- Trial name
- NCT04128540
- Testing
- Fentanyl, Erector spinae plane block
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Cairo University
Congenital Heart Disease
Study of RV Remodeling in Congenital Heart Disease
The primary aims of this study are to 1. Develop an automated method of quantitation of RV remodeling in terms of regional RV surface curvature and area strain and assess the feasibility, repeatability and accuracy in normal…
- Trial name
- RVShape (NCT02791061)
- Testing
- Cardiovascular Magnetic Resonance Imagine (MRI), Cardiopulmonary exercise testing (CPET), Echocardiography
- Where
- Singapore
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Tetralogy of Fallot (TOF), Congenital Heart Defects
Volution of Pulmonary Artery Dimensions in Tetralogy of Fallot
Tetralogy of Fallot is the most common cyanotic congenital heart disease. Management strategies vary between primary repair and staged approaches including palliative surgery.
- Trial name
- SEPT-TOF (NCT07864129)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Strasbourg, France
Congenital Heart Disease in Children, Malnutrition, Child
The Effect of High-Calorie Formula on Nutritional and Clinical Outcomes Among Infants After Congenital Heart Surgery
The goal of this clinical trial is to compare the effect of high-calorie density formula (HDF) and standard formula (SF) in infants with congenital heart surgery. The main questions it aims to answer are: 1.
- Trial name
- NCT05945459
- Testing
- High-calorie density formula (1 kcal/ml), Standard formula (0.67 kcal/ml)
- Where
- Indonesia
- Volunteers
- 158 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Mandibular Tumors
Aesthetic Reconstruction of Onco-surgical Mandibular Defects Using FFF With and Without CAD/CAM Customized Cutting Guide
The purpose of this study is to compare Aesthetic results and operation time of free fibular flap with and without CAD/CAM customized osteotomy guide for reconstruction of mandibular defects.
- Trial name
- NCT03757273
- Testing
- FFF with CAD/CAM customized cutting guide, FFF without customized cutting guide
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Cairo University
Congenital Heart Disease
Effectiveness of a Transition Program for Adolescents With Congenital Heart Disease in the Transition to Adulthood
This study is part of a larger research project known as Swedish Transition Effects Project Supporting Teenagers with chrONic mEdical conditionS (STEPSTONES).
- Trial name
- NCT02675361
- Testing
- Transition program
- Where
- 7 sites in Sweden
- Volunteers
- 189 people
- Sponsor
- Göteborg University
Hypoplastic Left Heart, Tetralogy of Fallot
Understanding Dexmedetomidine In Infants Post-Operative From Cardiac Surgery
This study is being conducted to determine what dexmedetomidine does to the body and in turn, what how the body handles the medication.
- Conditions
- Hypoplastic Left Heart, Tetralogy of Fallot, Tricuspid Atresia
- Trial name
- InfantDex (NCT00573066)
- Testing
- Dexmedetomidine
- Volunteers
- 56 people
- Sponsor
- Athena Zuppa
Congenital Heart Disease
Stress Response and Neurodevelopmental Outcome After Cardiac Surgery Utilizing CPB in Children: A Prospective, Double Blinded and Randomized Study
The overall goal of this project is to determine the role of anesthetic management in children undergoing cardiac surgery utilizing CPB in the setting of fast tracking and early extubation.
- Trial name
- NCT02492269
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Aymen N Naguib
Gingival Recession
Platelet-rich Fibrin and Connective Tissue Graft in Recession Treatment
The aim of the trial is to evaluate the effectiveness of coronally advanced flap (CAF)+connective tissue graft(CTG)+platelet-rich fibrin(PRF) combination in Miller I and II recession treatment by comparing with CAF+CTG.
- Trial name
- NCT02397122
- Testing
- platelet-rich fibrin, connective tissue graft, coronally advanced flap
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Congenital Heart Disease, Postoperative Pulmonary Complications
Perioperative Lidocaine for Lung Protection in Infants Undergoing Cardiac Surgery
Cardiopulmonary bypass-associated pulmonary injury is a common complication after infant cardiac surgery and may contribute to impaired oxygenation, prolonged mechanical ventilation, and longer intensive care stay.
- Conditions
- Congenital Heart Disease, Postoperative Pulmonary Complications, Acute Lung Injury
- Trial name
- PLICS (NCT07499154)
- Testing
- Lidocaine %2 ampoule, Normal Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 320 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Ciliary Dyskinesia, Primary, Kartagener Syndrome
Dyskinesia, Heterotaxy and Congenital Heart Disease
This study will examine genetic material obtained from blood and tissue samples of patients with congenital heart disease (CHD) and heterotaxy (an abnormality in the left-right positioning of organs in the body, also called situs…
- Conditions
- Ciliary Dyskinesia, Primary, Kartagener Syndrome, Congenital Heart Defects, Situs Inversus
- Trial name
- NCT00608556
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
PHACE Syndrome
Genetic Analysis of PHACE Syndrome (Hemangioma With Other Congenital Anomalies)
1. PHACE syndrome(OMIM database number 606519) is the association of a vascular birthmark (hemangioma) on the face along with one or more of the following conditions: congenital heart defects, congenital anomalies of the cerebral…
- Trial name
- PHACE (NCT01016756)
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- Medical College of Wisconsin
Pulmonary Hypertension, Congenital Heart Disease
Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
This study looks to develop a multi-scale computational model of Pulmonary Hypertension, this clinical model will be calibrated using longitudinal, retrospectively and prospectively acquired human clinical data.
- Conditions
- Pulmonary Hypertension, Congenital Heart Disease, Pediatric Congenital Heart Disease
- Trial name
- NCT03564522
- Testing
- cardiac catheterization, Cardiac MRI
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan
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