Clinical trials: Defects
Heart Defects, Congenital
The Fontan Education Study: A Randomized Control Trial
The Fontan Education Study is a cluster randomized controlled trial evaluating the impact of a novel education program in combination with usual care, versus usual care alone, on preparing parents of children undergoing Fontan…
- Trial name
- NCT02831790
- Testing
- Fontan Education Videos
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Heart Defects, Congenital, Adolescent
Rehabilitation of Adolescents and Young Adults With Congenital Heart Diseases
The investigators aim to measure the impact of a rehabilitation program in congenital cardiology in terms of health related quality of life.
- Conditions
- Heart Defects, Congenital, Adolescent, Young Adult
- Trial name
- QUALIREHAB (NCT03690518)
- Testing
- Cardiac rehabilitation
- Where
- 17 sites in France
- Volunteers
- 142 people
- Sponsor
- University Hospital, Montpellier
Patent Ductus Arteriosus
Nitric Oxide, Endothelin-1, and the Patency of Ductus Arteriosus in Preterm Infants
BACKGROUND Patent ductus arteriosus (PDA) is a frequent clinical event in preterm infant. The cardiopulmonary functions of these preterm babies may be adversely affected by the patency of ductus arteriosus.
- Trial name
- NCT00162903
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Turner Syndrome, Primary Ovarian Insufficiency (Poi)
Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome
This is a single-site open label non-randomized study comparing effects of sequential versus continuous use of progesterone supplementation amongst Turner Syndrome (TS) patients with primary ovarian insufficiency (POI) prescribed…
- Trial name
- BOOST (NCT06834594)
- Testing
- Micronized progesterone 200 MG, Micronized Progesterone 100 MG
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City
Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome
Hearts in Rhythm Organization (HiRO)National Registry and Bio Bank
The Hearts in Rhythm Organization (HiRO) is a national network of Canadian researchers/clinicians, working towards a better understanding of the rare genetic causes of sudden cardiac death (SCD).
- Conditions
- Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome, Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), Long QT Syndrome (LQTS)
- Trial name
- HiRO (NCT04189822)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- University of British Columbia
Hypoplastic Left Heart Syndrome, Hypoplastic Right-sided Heart Complex
Ambrisentan in Single Ventricle
Purpose: To evaluate the pharmacokinetics, bioavailability and hemodynamic efficacy of ambrisentan after Fontan surgical palliation of single ventricle heart defects.
- Trial name
- NCT02080637
- Testing
- Ambrisentan
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Kevin Hill
Congenital Heart Disease, Pulmonary Arterial Hypertension
4DFlow Magnetic Resonance Imaging in Patients With Pulmonary Hypertension Associated With Congenital Heart Disease
Congenital heart disease is the most common congenital anomaly. The life expectancy of children with congenital heart disease has increased considerably in recent years.
- Trial name
- 4DFlowHTAPCC (NCT03928002)
- Testing
- 4D Flow magnetic resonance imagery, Cardiac catheterization
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Patent Foramen Ovale
Internal Microstructure of Patent Foramen Ovale Related to Stroke
This study aims to (1) investigate the internal microstructure of patent foramen ovale related to cryptogenic stroke, transient ischemic attack or migraine and determine the effectiveness of transcatheter closure in these…
- Trial name
- IMPORT (NCT04686253)
- Testing
- not appliable
- Where
- 2 sites in China
- Volunteers
- 1,200 people
- Sponsor
- China National Center for Cardiovascular Diseases
Noonan Syndrome
A Study of Vosoritide in Children With Noonan Syndrome With Inadequate Growth During or After Human Growth Hormone Treatment
The purpose of this study in children with Noonan syndrome is to evaluate the effect of 3 doses of vosoritide on growth as measured by AGV after 6 months of treatment.
- Trial name
- NCT06668805
- Testing
- Vosoritide Injection
- Where
- 38 sites in United States, Australia and 5 more
- Volunteers
- 30 people
- Sponsor
- BioMarin Pharmaceutical
Congenital Heart Disease
Fontan Circulation and Cardiopulmonary Function: Prognostic Factors, Hemodynamics and Long-term Effects
Cross-sectional study of a national cohort of adolescents with univentricular congenital heart defects and Fontan type palliation.
- Trial name
- NCT02378857
- Where
- Norway
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Congenital Heart Disease
Perioperative Outcome of Congenital Heart Disease Surgery in Childhood
Congenital heart disease is the most common congenital malformation in the world with high morbidity and mortality. However, there is no data to assess the perioperative outcome of congenital heart disease surgery among Chinese…
- Trial name
- NCT04093011
- Testing
- Congenital Heart Disease Surgery
- Where
- China
- Volunteers
- 6,500 people
- Sponsor
- Nanjing Medical University
Developmental Disability
Interactive Digital Game for Improving Visual Perceptual Defects in Children With Developmental Disability
Visual perceptual defects in children can negatively affect their activities of daily living.The aims of this study were to develop and evaluate an interactive digital game system for correcting visual perceptual defects and to…
- Trial name
- NCT05016492
- Testing
- Visual-perceptual interactive game system, standard rehabilitation
- Where
- Taiwan
- Volunteers
- 23 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Cerebral Palsy, Spina Bifida
Virtual Peer Health Coaching for Adolescents With Disabilities
Participation in physical activity (PA) confers clear physical and psychosocial benefits. Yet, many adolescents with physical disabilities such as cerebral palsy and spina bifida do not engage in regular PA, putting them at…
- Trial name
- NCT05587634
- Testing
- Virtual Peer Health Coaching
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Septal Defect
Deep Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block in Pediatric Cardiac Patients Undergoing Primary Repair of Septal Defects Via Median Sternotomy
In this study we are aiming to compare the Erector Spinae Plane Block and the Deep Parasternal intercostal plane block as regard to their technique, application and outcome in order to describe the most suitable method for…
- Trial name
- NCT06873906
- Testing
- Deep Parasternal intercostal plane block, Erector Spinae Plane Block, conventional analgesic regimen
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Ain Shams University
Heart Failure, Transplant; Failure, Heart
EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study
The purpose of this study is to evaluate the device performance and monitor the safety and effectiveness of the Berlin Heart EXCOR Active Driving System while being used with the approved EXCOR Pediatric Ventricular Assist…
- Conditions
- Heart Failure, Transplant; Failure, Heart, Congenital Heart Disease
- Trial name
- NCT05610787
- Testing
- EXCOR Active Driving System for Pediatric VAD
- Where
- 17 sites in United States
- Volunteers
- 40 people
- Sponsor
- Berlin Heart, Inc
Paediatrics With Cataracts, Paediatrics With Glaucoma
Quality of Life in Children Glaucoma and Cataract
The management of childhood glaucoma (CG), childhood cataract (CC) and other birth defects affecting the eyes requires frequent hospital attendances and often multiple surgical and medical interventions, and are often associated…
- Trial name
- NCT02490267
- Testing
- Quality of Life questionnaire
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Myelomeningocele Spina Bifida, Spina Bifida, Open
Effectiveness of Multimodal Therapy for Urinary Incontinence in Pediatric Spina Bifida
Background: Overactive bladder and urinary incontinence in children have significant influence on psychosocial well-being and quality of life.
- Trial name
- MMICIUISP (NCT07338799)
- Testing
- Diet and Toileting Education, Pelvic Floor Physiotherapy, Abdominal Strengthening Program.
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Congenital Heart Disease
Neuro-cardiac Rehabilitation in Youth With Congenital Heart Disease (QUALINEUROREHAB)
Remarkable progress in paediatric cardiology and surgery have led to the substantial increase of congenital heart disease (CHD) survivors.
- Trial name
- NCT05670132
- Testing
- Neurocardiac rehabilitation program, Standard of care
- Where
- 6 sites in Belgium, France and 1 more
- Volunteers
- 192 people
- Sponsor
- University Hospital, Bordeaux
Syringomyelia, Type I Arnold Chiari Malformation
Genetic Analysis of the Chiari I Malformation
The purpose of this study is to better understand the genetic factors related to the Chiari I malformation. In people with this abnormality, the lower part of the skull is smaller than normal.
- Trial name
- NCT00004738
- Where
- 2 sites in United States, Russia
- Volunteers
- 152 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Gingival Recession
Platelet-rich Fibrin and Connective Tissue Graft in Recession Treatment
The aim of the trial is to evaluate the effectiveness of coronally advanced flap (CAF)+connective tissue graft(CTG)+platelet-rich fibrin(PRF) combination in Miller I and II recession treatment by comparing with CAF+CTG.
- Trial name
- NCT02397122
- Testing
- platelet-rich fibrin, connective tissue graft, coronally advanced flap
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
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