Clinical trials: Depressive Disorders, open to volunteers
Tinnitus, Misophonia
Mindfulness Application Effects on Mental Health Symptoms in Children With Severe Tinnitus and Misophonia
Children with "bothersome" tinnitus and misophonia have elevated anxiety and depression symptoms. The mainstay therapy for adults and children with these disorders is cognitive behavioral therapy (CBT).
- Trial name
- NCT06493825
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Major Depressive Disorder
Neural Correlates of Stress and Perceived Control in Adolescent Depression
Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived…
- Trial name
- NCT04788524
- Testing
- Computer Task Manipulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Depression - Major Depressive Disorder, Generalized Anxiety Disorder (GAD)
Microbiota Modulation for Psychiatry Patients
The investigators aim to confirm pilot study findings (REB 119638) on the effects of delayed release apple cider vinegar (drACV).
- Conditions
- Depression - Major Depressive Disorder, Generalized Anxiety Disorder (GAD), Anxiety
- Trial name
- ACV-MTPIES-002 (NCT07899424)
- Testing
- Dietary Supplement: Acetate (Apple Cider Vinegar)
- Volunteers
- 62 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Depression
Effect of Virtual Reality on Depression in Adolescent Females
The purpose of this study is to investigate the effect of virtual reality on depression in adolescent females.
- Trial name
- NCT07452341
- Testing
- Virtual reality headset, Selective serotonin reuptake inhibitors(SSRIs)
- Volunteers
- 48 people
- Sponsor
- Cairo University
Major Depressive Disorder (MDD), Probiotic Intervention
Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression
The objective of this clinical trial is to evaluate the efficacy and safety of sertraline combined with multi-strain probiotics in adolescents aged 12-18 with major depressive disorder.
- Trial name
- NCT07645157
- Testing
- Sertraline
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Anxiety Depression
A Metacognitive Group Therapy of Depression and Anxiety in Youth With Autism
The goal of this open clinical trial is to try out and evaluate a group metacognitive treatment protocol, for adolescents aged 15-18 years of age with anxiety and/or depression and an autism diagnosis.
- Trial name
- NCT06441786
- Testing
- A metacognitive group therapy of depression and anxiety in youth with autism
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Uppsala University
Major Depressive Diorder
Efficacy and Safety of DTMS in Adolescent Major Depressive Disorder
The goal of this randomized controlled trial is to explore the efficacy and safety of two different dTMS devices in adolescent depression: deep TMS H1 coil and deep TMS H7 coil.
- Trial name
- NCT06728280
- Testing
- deep transcranial magnetic stimulation with H1coil, deep transcranial magnetic stimulation with H7 coil
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Zhifen Liu
Depression, Sequestra
Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)
This project aims to investigate the effectiveness of existing common antidepressants and to provide new evidence for depressed children and adolescents who are not responding to their first treatment.
- Trial name
- STAR-AD (NCT05814640)
- Testing
- Fluoxetine, Sertraline, Vortioxetine
- Where
- China
- Volunteers
- 520 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Self Injurious Behavior, Self Injurious Behavior Without Suicidal Intent
Examining the Effectiveness of a Brief Therapeutic Intervention for Reducing Self-Harm Among Adolescents
Non-suicidal self-injury (NSSI), defined as deliberate self-inflicted destruction of body tissue without intent to die, is particularly prevalent during mid-adolescence, with prevalence estimated around 16-22% in community…
- Trial name
- NCT07913425
- Testing
- Cutting Down Program - a three-month cognitive-behavioral psychotherapy focused on reducing self-injury urges and behaviors in adolescents
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- University of Haifa
Perinatal Depression, Perinatal Anxiety
Testing "Doula Link", a Multi-Component Intervention to Improve Perinatal Mental Health
Doulas are trained individuals who offer informational, emotional, and physical support to their pregnant, birthing, and postpartum clients.
- Trial name
- Doula Link (NCT07217561)
- Testing
- Doula Link
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Depression, Cancer
Mindfulness-based Intervention for Depressive Symptoms Sent Via Text (MINDSET)
The purpose of this study is to develop and test a new intervention to reduce depressive symptoms in post-treatment cancer participants.
- Conditions
- Depression, Cancer, Stage III Breast Cancer, Stage II Breast Cancer
- Trial name
- NCT06811454
- Testing
- MINDSET, Enhanced Usual Care (EUC)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Case Comprehensive Cancer Center
Depression in Adolescence, Depression in Adults
INNOV5-MH-MAROC: Integrated Mental Health Care for Adolescents and Adults in Primary Care Centers and Schools in Morocco
Depression and anxiety are highly prevalent among adolescents and adults in Morocco, while access to evidence-based care in primary care centers and schools remains limited.
- Conditions
- Depression in Adolescence, Depression in Adults, Anxiety, Mental and Behavioural Disorders
- Trial name
- INNOV5-MH (NCT07258095)
- Testing
- INNOV5 Integrated Mental Health Program, Enhanced Treatment as Usual (TAU+)
- Where
- Switzerland
- Volunteers
- 146 people
- Sponsor
- Swiss Medical Academy Maroc
Depression - Major Depressive Disorder, Anxiety
Impact of Behavioral Activation on Depression and Quality of Life in Patients with Colon Cancer
The purpose of this randomized clinical trial is to study anxiety and depression symptoms at diagnosis in patients with colon cancer. Previous studies have shown that so-called.
- Conditions
- Depression - Major Depressive Disorder, Anxiety, Colon Cancer
- Trial name
- BAdepCa (NCT06745700)
- Testing
- Brief Behavioural Activation, Care as usual
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Region Västmanland
High-risk Pregnancy, Hospitalization
LLM-Generated Medical Summaries During Hospitalization to Improve Patient Activation in High-Risk Pregnancies
The goal of this clinical trial is to learn if AI-generated medical summaries help hospitalized pregnant participants better understand and actively participate in their own care.
- Conditions
- High-risk Pregnancy, Hospitalization, Patient Activation, Artificial Intelligence (AI)
- Trial name
- NCT07823517
- Testing
- LLM-Generated Medical Summaries
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Chronic Insomnia, Depression Disorders
Effect of WBT for CI With Depression
This randomized controlled trial aims to explore the therapeutic effects of Well-Being Therapy (WBT) on patients with Chronic Insomnia accompanied by depressive symptoms.
- Trial name
- NCT06968013
- Testing
- Well-Being Therapy, Sleep Hygiene Education
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Xuanwu Hospital, Beijing
Patients With Major Depressive Disorder
Cognitive Behavior Therapy Among Patients With Major Depressive Disorder-Multiple Episodes.
The main purpose of this study to teach the patients how to manage their depression, generalized Anxiety symptoms, mental health seeking attitude, motivation and attitude toward changing health, to improve the quality of life…
- Trial name
- NCT07300527
- Testing
- Cognitive Behavior Therapy, treatment as usual (TAU) (Control Group)
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Government College University Faisalabad
Depression
A Study on the Intervention Effect of Therapeutic Horticulture Based on the Healing System on Non-suicidal Self-injury in Adolescent Patients With Depression
Non-suicidal self-harm is a serious issue. Adolescents with depression are among the high-risk groups for non-suicidal self-harm behavior.
- Trial name
- NCT07115381
- Testing
- Therapeutic Horticulture, Routine treatment and nursing
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Lei Huang
Major Depressive Disorder, Mood Disorders
Mechanisms of Rumination Change in Adolescent Depression
This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with…
- Trial name
- RuMeChange (NCT03859297)
- Testing
- Rumination-Focused CBT, Relaxation-based Therapy
- Where
- 3 sites in United States
- Volunteers
- 183 people
- Sponsor
- Ohio State University
Internet-based Intervention, Waiting List Control Group
RCT: the Effectiveness of LifeHack in Improving Mental Wellbeing in University Students.
Psychological issues are common among university students and affect mental wellbeing. The Caring Universities (CU) project, involving nine Dutch universities, aims to enhance students' mental health through an annual online…
- Conditions
- Internet-based Intervention, Waiting List Control Group, Depression, Anxiety
- Trial name
- NCT06423417
- Testing
- LifeHack
- Where
- 2 sites in Netherlands
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Universiteit Leiden