Clinical trials: Depressive Symptoms
Tinnitus, Misophonia
Mindfulness Application Effects on Mental Health Symptoms in Children With Severe Tinnitus and Misophonia
Children with "bothersome" tinnitus and misophonia have elevated anxiety and depression symptoms. The mainstay therapy for adults and children with these disorders is cognitive behavioral therapy (CBT).
- Trial name
- NCT06493825
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Major Depressive Disorder
Neural Correlates of Stress and Perceived Control in Adolescent Depression
Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived…
- Trial name
- NCT04788524
- Testing
- Computer Task Manipulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Depressive Symptoms, Anxiety
Evaluation of Mindfulness and Yoga in Basic Combat Training
The present study is a group randomized trial assessing the impact of mindfulness and yoga training on the health, performance, and well-being of soldiers in Basic Combat Training (BCT).
- Conditions
- Depressive Symptoms, Anxiety, Sleep, Emotion Regulation
- Trial name
- NCT05550610
- Testing
- Mindfulness Based Attention Training (MBAT) and Yoga
- Where
- United States
- Volunteers
- 1,896 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
Depression, Depressive Disorder
Evaluation of the Naturalistic User Experience of the Website "ich Bin Alles @Schule" (i Am Everything @school)
The aim of this study is to investigate the naturalistic user experience and acceptance of the German website "ich bin alles @Schule".
- Conditions
- Depression, Depressive Disorder, Depression in Children, Depression in Adolescence
- Trial name
- NCT06668688
- Testing
- "ich bin alles @Schule" (i am everything @school; www.schule.ich-bin-alles.de)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Medication Adherence, Depressive Symptoms
Testing THRIVE 365 for Black Sexual Minority Men (On The Daily)
The primary goal of this study is to test a minority stress model of psychological health outcomes for Black sexual minority men (BSMM) while using and not using a novel intervention named THRIVE 365.
- Conditions
- Medication Adherence, Depressive Symptoms, Anxiety Symptoms, Emotion Regulation
- Trial name
- OTD (NCT05376397)
- Testing
- iTHRIVE 365
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Premature Birth, Birth Weight
Fresh RX: NHS 2020
This study is an evaluation of the Fresh Rx: Nourishing Healthy Starts program administered by Operation Food Search, a St. Louis-based nonprofit organization.
- Conditions
- Premature Birth, Birth Weight, Post Partum Depression, Health Care Utilization
- Trial name
- NCT04845230
- Testing
- FreshRx Nourishing Healthy Starts
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Internet-based Intervention, Depression
Treatment Outcomes and Predictive Factors of the Effectiveness and Adherence of Moodpep: an Online Self-help Intervention for College Students With Depressive Symptoms
Depressive symptoms are prevalent among college students and often remain untreated. E-health interventions may help overcome treatment barriers by offering accessible and flexible support.
- Conditions
- Internet-based Intervention, Depression, Adherence, Predictors
- Trial name
- NCT07030244
- Testing
- Moodpep
- Where
- 2 sites in Netherlands
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Universiteit Leiden
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Depressive Symptoms
The Effect of Emotional Working Memory Training on Reducing Depressive Symptoms
The purpose of this study is to test whether emotional working memory training and attention bias modification training are an effective neurobehavioral therapy to improve depressive symptoms.That is whether emotional working…
- Trial name
- NCT04346771
- Testing
- Working memory training, Positive ABMT
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Hunan Normal University
Adolescent Development
PPI to Promote the Psychological Well-being of Children Living in Poverty
Positive psychology interventions use positive psychology techniques to identify meaning and value in life events to raise positive feelings and emotions.
- Trial name
- NCT04875507
- Testing
- Positive Psychology
- Where
- Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Depression / Major Depressive Disorder, Anxiety
Activating Voice Journaling for Mental Health With Voice Biomarkers
This retrospective observational study evaluated the relationship between voice characteristics and self-reported mental health symptoms using longitudinal data collected through the Kintsugi Voice Journaling app.
- Trial name
- NCT07789808
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Kintsugi Mindful Wellness, Inc.
Hyperbilirubinemia, Jaundice
Improving Health Outcomes for New Mothers and Babies
Because adherence to postnatal care guidelines across the United States (U.S.) is poor, newborns and mothers often are placed at undue risk for adverse medical and social outcomes.
- Conditions
- Hyperbilirubinemia, Jaundice, Dehydration, Postpartum Depression
- Trial name
- NCT00360204
- Testing
- Home Nurse Visit
- Where
- 2 sites in United States
- Volunteers
- 1,154 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Major Depressive Disorder
Neural Components Underlying the Treatment of Adolescent Depression
The goal of the study is to examine how cognitive behavioral therapy (CBT), a common treatment for adolescent depression, affects brain functioning.
- Trial name
- NCT01717508
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Major Depression, Depressive Episodes
Primary Care Internet Based Depression Prevention for Adolescents (CATCH-IT) Also Known as Promoting AdolescenT Health
The purpose of this randomized multiple-site clinical study is to determine whether a revised CATCH-IT (Internet-based depression prevention program) is more effective than a general health education Internet intervention (Health…
- Trial name
- CATCH-IT (NCT01893749)
- Testing
- CATCH-IT
- Where
- 7 sites in United States
- Volunteers
- 1,142 people, healthy volunteers welcome
- Sponsor
- Benjamin Van Voorhees, MD, MPH
Depressive Symptoms
Cognitive Behavioral vs. Interpersonal Therapy (IPT) Prevention of Depression in Adolescents
The purpose of this study is to evaluate the efficacy of a cognitive-behavioral vs. an interpersonal therapy program for preventing depressive symptoms in adolescents.
- Trial name
- NCT00374439
- Testing
- Cognitive-behavioral, Interpersonal Therapy
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
BPSD, Expressed Emotion
Intervention for Emotions in Caregivers of Dementia
This study aims to evaluate the effectiveness of a 6-week Caregivers Of dementia Processing Emotions (COPE) program using the integrative therapy to reduce EE (primary outcome) in family caregiver of PLwD to alleviate the…
- Conditions
- BPSD, Expressed Emotion, Depressive Symptoms
- Trial name
- NCT06359704
- Testing
- Caregivers Of dementia Processing Emotions (COPE) program
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII Pathway
Major depressive disorder(MDD) is a complex and heterogeneous mental disorder. Repeated transcranial magnetic stimulation (rTMS), as a non-invasive neuroregulatory technique, has shown a promising function in the treatment of…
- Trial name
- NCT05913960
- Testing
- accelerated intermittent theta burst stimulation, high frequency stimulation
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Depression, Depressive Disorder
Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic Evaluation
The patients with depression and obesity will receive add-on metformin with antidepressant therapy, which may result in greater improvement in depressive symptoms and BMI reduction compared to antidepressant monotherapy.
- Conditions
- Depression, Depressive Disorder, Overweight or Obesity, Depressive Symptoms
- Trial name
- NCT07654179
- Testing
- Metformin, Antidepressant Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Obsessive Compulsive Disorder, Major Depressive Disorder
Integrating Pharmacogenomic Testing Into a Child Psychiatry Clinic
The purpose of this study is to examine the feasibility, acceptability, and utility of pharmacogenomic (PGX) testing (specifically for the cytochrome P450 2D6 and 2C19 genes) prior to initiating treatment with an antidepressant…
- Conditions
- Obsessive Compulsive Disorder, Major Depressive Disorder, Anxiety
- Trial name
- PGX (NCT02855580)
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Florida
Menopause
The Effect of Emotional Freedom Technique on Depressive and Menopausal Symptoms in Postmenopausal Women
The aim of this study is to determine the effect of EFT (Emotional Freedom Technique), a nonpharmacological method, on menopausal symptoms and depression in postmenopausal women.
- Trial name
- NCT06338085
- Testing
- emotional liberation technique
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Meryem Vural Şahin