Clinical trials: Developing Countries
Pneumonia, Bronchiolitis
Diagnosing Pneumonia Under Low-resource Conditions
Pneumonia is the commonest cause of death in children worldwide, killing 1.5 million children under the age of 5 years, every year. This is more than the number of children dying from AIDS, malaria and tuberculosis combined.
- Conditions
- Pneumonia, Bronchiolitis, Asthma
- Trial name
- NCT01997047
- Where
- Canada
- Volunteers
- 502 people
- Sponsor
- University of British Columbia
Gastroschisis
Multi-Centre Gastroschisis Interventional Study Across Sub-Saharan Africa
This study is a multi-centre interventional study at seven tertiary paediatric surgery centres in Ghana, Zambia, Malawi and Tanzania aimed at reducing mortality from gastroschisis.
- Trial name
- NCT03724214
- Testing
- Pre-hospital interventional care bundle, In-hospital interventional care bundle
- Where
- 9 sites in Canada, Ghana and 4 more
- Volunteers
- 235 people
- Sponsor
- King's College London
Mortality, Morbidity
Vitamin A With BCG Vaccine
Two studies from Asia have suggested a beneficial effect of vitamin A supplementation given at birth. Hypotheses: Vitamin A supplementation administered at birth together with BCG vaccination is associated with a 30% reduction in…
- Trial name
- NCT00168597
- Testing
- Vitamin A
- Where
- Guinea-Bissau
- Volunteers
- 4,800 people
- Sponsor
- Bandim Health Project
Hearing Loss, Bone Anchored Hearing Aids
Attitude Change Of Hearing Health Professionals On Bone-Anchored Hearing Devices Over Time In a Developing Country
This study aims to examine shifts in attitudes about bone-anchored hearing instruments (BAHIs) among hearing health professionals over a period of time.
- Trial name
- NCT06215599
- Testing
- Survey
- Where
- Turkey (Türkiye)
- Volunteers
- 243 people
- Sponsor
- Pamukkale University
Preterm Birth
Trial of the Use of Antenatal Corticosteroids in Developing Countries
Multi-country two-arm, parallel cluster randomized controlled trial to reduce neonatal mortality through increasing the rate of antenatal corticosteroid administration to eligible women.
- Trial name
- ACT (NCT01084096)
- Testing
- Increasing use of Antenatal Corticosteroids (ACS)
- Where
- 7 sites in Argentina, Guatemala and 4 more
- Volunteers
- 103,117 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Critical Illness, Invasive Mechanical Ventilation
MOdifiable facTors to Improve VentilAtion ThErapy in ICU
ABSTRACT Introduction: Invasively ventilated patients in low and middle-income countries (LMICs) experience significantly higher mortality compared to those in High income countries (HICs).
- Conditions
- Critical Illness, Invasive Mechanical Ventilation, ICU Mortality, Developing Countries
- Trial name
- MOTIVATE-ICU (NCT06288724)
- Volunteers
- 625 people
- Sponsor
- Nat Intensive Care Surveillance - MORU
Anxiety Disorder, Depressive Disorder
Sub-Trial of the Youth Readiness Intervention (YRI): Treatment of Control Group and Addition of Stress Biomarkers
This research is a continuation of the Youth Readiness Intervention (YRI) randomized clinical trial by adding additional pre and post intervention data collection upon treatment of the control group (N=222) with the intervention…
- Conditions
- Anxiety Disorder, Depressive Disorder, Social Problems, Stress, Psychological
- Trial name
- NCT02128568
- Testing
- Youth Readiness Intervention
- Where
- Sierra Leone
- Sponsor
- Harvard School of Public Health (HSPH)
Cataract
China OLIMPICS: China Ophthalmic Learning and Improvement Initiative in Cataract Surgery Trial
This is a prospective, investigator-masked randomised controlled education-intervention trial of intense simulation-based surgical education plus conventional training versus a current six-week standard training course.
- Trial name
- NCT03458442
- Testing
- Simulation-based surgical training, Standard surgical training
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Sun Yat-sen University
Hypothermia
Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV
The overall hypothesis is that plastic bags used in combination with WHO thermoregulation care will reduce the incidence of hypothermia in preterm/low birth weight and full term infants when compared to routine WHO…
- Trial name
- NCT01604447
- Testing
- Hypothermia prevention with plastic bag, Hypothermia prevention without plastic bag
- Where
- Zambia
- Volunteers
- 118 people
- Sponsor
- University of Alabama at Birmingham
Hypothermia
Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part II
The overall hypothesis is that plastic bags used in combination with WHO thermoregulation care will reduce the incidence of hypothermia in preterm/low birth weight and full term infants when compared to routine WHO…
- Trial name
- NCT01604421
- Testing
- Thermoregulation-standard care, Thermoregulation with plastic bag
- Where
- Zambia
- Sponsor
- University of Alabama at Birmingham
Hypothermia, Newborn
Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates
The overall hypothesis is that placing infants 1000-2500 grams in plastic bags when compared to routine care will reduce the risk of hypothermia (< 36.5 degrees C) without increasing hyperthermia (> 37.5 degrees C).
- Trial name
- NCT01403623
- Testing
- Resuscitation and post resuscitation care with plastic bag, Resuscitation- no plastic bag for temperature regulation
- Where
- Zambia
- Volunteers
- 106 people
- Sponsor
- University of Alabama at Birmingham
Complementary Feeding, Infant Growth
First Bites: Complementary Feeding - A Global Network Cluster Randomized Controlled Trial
The specific aims of this project is to determine the impact of a daily intake of one half ounce of lyophilized meat between 6-18 months of age (0.5 oz for 6-12 mo; 0.75 oz for 12-18 mo) on linear growth velocity, zinc and iron…
- Trial name
- First Bites (NCT01084109)
- Testing
- Lyophilized meat, Cereal
- Where
- 4 sites in Guatemala, Pakistan and 2 more
- Volunteers
- 1,236 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
HIV Infections, Pregnancy
Maternal/Infant Peripartum NVP, Versus Infant Only Peripartum NVP, or Maternal LPV/r in Addition to Standard ZDV Prophylaxis for the Prevention of Perinatal (PMTCT) HIV in Thailand
The purpose of this study is to compare the efficacy of two doses of nevirapine (NVP) given only to the infants or lopinavir/ritonavir (LPV/r) from 28 weeks gestation with single dose (SD) NVP given to the mothers plus two doses…
- Trial name
- PHPT-5 (NCT00409591)
- Testing
- Maternal and infant nevirapine, Maternal lopinavir+ritonavir, zidovudine
- Where
- 43 sites in Thailand
- Volunteers
- 435 people
- Sponsor
- Institut de Recherche pour le Developpement
Pediatric Acute Myeloid Leukemia Induction
Low Dose Induction for Pediatric Acute Myeloid Leukemia Patients
the standard induction treatment for pediatric acute myeloid leukemia has high early morbidity and mortality that jeopardize the outcome especially in developing countries.
- Trial name
- NCT07867600
- Testing
- Low dose Ara C/ anthracycline combined with GCSF
- Where
- 2 sites in Egypt
- Volunteers
- 33 people
- Sponsor
- Azza Shibl Sayed
Paediatric Surgery, Perioperative/Postoperative Complications
An African, Multi-centre Evaluation of Patient Care and Clinical Outcomes for Paediatric Patients Undergoing Surgery
Access to safe surgery is a basic human right. This is highlighted by the work of the Lancet Commission on Global Surgery. There is a large burden of surgical disease in the paediatric surgical population with a large unmet need.
- Conditions
- Paediatric Surgery, Perioperative/Postoperative Complications, Perioperative Outcomes, Hospital Mortality
- Trial name
- ASOS-Paeds (NCT05061407)
- Where
- 2 sites in South Africa, Sudan
- Volunteers
- 8,625 people
- Sponsor
- University of KwaZulu
Depressive Symptoms, Anxiety
Pilot Feasibility Trial of the Family Strengthening Intervention in Rwanda (FSI-R)
The research will examine the following Specific Aims: Specific Aim 1: To adapt a U.S.-developed family-focused and strengths-based prevention program to the context of HIV/AIDS-affected families in Rwanda (the…
- Conditions
- Depressive Symptoms, Anxiety, Parenting
- Trial name
- NCT01509573
- Testing
- Family Strengthening Intervention in Rwanda (FSI-R)
- Where
- Rwanda
- Volunteers
- 82 people
- Sponsor
- Harvard School of Public Health (HSPH)
Postpartum Hemorrhage
Misoprostol for Secondary Prevention of Postpartum Hemorrhage at the Community Level in India
This study compares two community-level strategies: selective administration of 800 mcg sublingual misoprostol to women at 350 mL blood loss for secondary prevention of postpartum hemorrhage (PPH) with universal use of 600 mcg…
- Trial name
- NCT01462422
- Testing
- Misoprostol
- Where
- India
- Volunteers
- 3,032 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Immune Thrombocytopenia Purpura
Outcome Study of Conventional Steroids Vs. Steroids Combined with Mycopehnolate in Newly Diagnosed Immune Thrombocytopenia Purpura.
Immune thrombocytopenia Purpura (ITP) is an autoimmune condition delineated by humoral as well as cell mediated immune response against thrombocyte surface proteins GPIIb/IIIa receptors, affecting primary homeostasis leading to…
- Trial name
- NCT06288932
- Testing
- Mycophenolate Mofetil (MMF) Treatment
- Where
- Pakistan
- Volunteers
- 118 people
- Sponsor
- National Institute of Blood and Marrow Transplant (NIBMT), Pakistan
Hemorrhagic Fever, Ebola
Emergency Evaluation of Convalescent Plasma for Ebola Viral Disease (EVD) in Guinea
This is an emergency, phase 2/3, open-label, non-randomized, clinical trial that will evaluate Convalescent Plasma (CP) added to standardized supportive care (SC) in patients with confirmed Ebola Virus Disease (EVD).
- Trial name
- Ebola-Tx (NCT02342171)
- Testing
- Convalescent Plasma
- Where
- Guinea
- Volunteers
- 606 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Asphyxia Neonatorum
First Breath: Neonatal Resuscitation in Developing Countries
In developing countries, neonatal death from birth asphyxia is a major problem. This study will be conducted in several countries to determine if the combined Neonatal Resuscitation Program/Essential Newborn Care Program compared…
- Trial name
- NCT00136708
- Testing
- Neonatal Resuscitation
- Where
- 7 sites in Argentina, Guatemala and 4 more
- Volunteers
- 120,009 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health