Clinical trials: Development Delay
Holoprosencephaly, HPE
Clinical and Genetic Studies on Holoprosencephaly
This study will examine how holoprosencephaly (HPE) affects people, how they change over time, and what genes may be involved in the cause of the disorder.
- Conditions
- Holoprosencephaly, HPE, Developmental Delay Disorders, Brain Disorders
- Trial name
- NCT00088426
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Prematurity, Development Delay
Maternal Voice and Quantitative EEG (qEEG)
A short-term randomized, blinded placebo-controlled trial, in premature infants in the neonatal intensive care unit (NICU) at 33-35 weeks post-conceptional age, of recorded maternal voice on quantitative EEG (spectral power…
- Conditions
- Prematurity, Development Delay, Premature Birth
- Trial name
- NCT05391633
- Testing
- Recorded Maternal Voice
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of New Mexico
Cerebral Palsy, Developmental Delay
Efficacy of the START-Play Program for Infants With Neuromotor Disorders
The purpose of this project is to evaluate the efficacy of Sitting Together And Reaching To Play (START-Play), an intervention designed to target sitting, reaching, and motor-based problem solving to improve development and…
- Conditions
- Cerebral Palsy, Developmental Delay, Infant Development
- Trial name
- START-Play (NCT02593825)
- Testing
- START-Play intervention, Business as usual
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Duquesne University
Development; Delayed, Mental, Anxiety
Adaptive Care in the Perioperative Setting
The overall purpose for conducting this research is to improve the safety and efficacy of care for perioperative patients who have developmental delays and behavioral challenges.
- Conditions
- Development; Delayed, Mental, Anxiety, Situational Anxiety, Fear of Other Medical Care
- Trial name
- ACT (NCT03353129)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Math Learning Disability, Child Development
Interventions in Mathematics and Cognitive Skills
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning…
- Conditions
- Math Learning Disability, Child Development, Developmental Disability, Learning Disabilities
- Trial name
- NCT05201534
- Testing
- Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Stanford University
Movement Disorders in Children, Neuro Developmental Delay
Pediatric Movement Disorders of Unknown Etiology in Vietnam (VPeMD)
This observational patient registry aims to describe the clinical phenotypes and genetic findings of Vietnamese children with movement disorders of unknown etiology.
- Conditions
- Movement Disorders in Children, Neuro Developmental Delay, Neurogenetic Disorders
- Trial name
- VPeMD (NCT07695610)
- Testing
- Whole-Exome Sequencing
- Where
- 2 sites in Vietnam
- Volunteers
- 50 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Autism Spectrum Disorder, Complication of Prematurity
Correlation of CXCR4 Expression in Premature Infants With a Diagnosis of Autism at 24 Months
Preterm children are at increased risk for autism spectrum disorders, with an estimated rate of 10%. In the US, about 1 in 8 pregnancies ends with a premature birth.
- Trial name
- ASD-CXCR4 (NCT01686685)
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Motor Delay, Motor Skills Disorders
Motor Skill Proficiency After Equine-assisted Activities and Brain-building Tasks
There is no current research to support the efficacy of a combination of equine-assisted activities (EAA) and brain building activities to influence motor skill competencies in youth with neurodevelopmental disorders (ND).
- Conditions
- Motor Delay, Motor Skills Disorders, Autism Spectrum Disorder, Attention Deficit Hyper Activity
- Trial name
- NCT04158960
- Testing
- Equine-assisted activities, GaitWay program
- Volunteers
- 25 people
- Sponsor
- Texas Woman's University
Preterm Birth, Developmental Delay
The Alkmaar MLPTI Cohort Study: Outcomes at 9 Years
Objective of the study: To examine cognition, motor function, executive functions, speech and language development, behaviour, psychosocial functioning,academic achievement, physical morbidities and growth of MLPTI at the age of…
- Conditions
- Preterm Birth, Developmental Delay, Growth Delay
- Trial name
- NCT05990582
- Testing
- CBCL, SDQ, CCC-2-NL
- Where
- Netherlands
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Noordwest Ziekenhuisgroep
Creatine Deficiency, X-linked
Observational Study of Males With Creatine Transporter Deficiency
The objectives of this study are to illustrate the clinical, neuro/electrophysiologic, biochemical, and developmental status and progression of patients with Creatine Transporter Deficiency (CTD) and to evaluate the utility of…
- Trial name
- Vigilan (NCT02931682)
- Where
- 10 sites in United States, Canada
- Volunteers
- 50 people
- Sponsor
- Ultragenyx Pharmaceutical Inc
Autism, Language Acquisition
Study of Toddlers With Language Delay
The purpose of this study is to learn more about risk factors for autism by studying the behavior and brain functioning of toddlers with early communication delays and typically developing toddlers.
- Conditions
- Autism, Language Acquisition, Language Development, Toddlers
- Trial name
- NCT01339767
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Developmental Delay (Disorder)
Mindful Movement And GAME BASED Training In Developmental Delay
Developmental delay in children is characterized by delayed acquisition of cognitive, motor, language, and social skills and is commonly associated with conditions such as cerebral palsy, autism spectrum disorder, and genetic…
- Trial name
- MINDGAME (NCT07575165)
- Testing
- Mindful movement, Game based training
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Developmental Delay
Effects of Insoles on Children With Developmental Delays
Using double blind, randomized controlled design to investigate the short-term therapeutic effects of function of customized insoles on children with developmental delays
- Trial name
- NCT03191006
- Testing
- MEI BIN insoles
- Where
- Taiwan
- Volunteers
- 52 people
- Sponsor
- Taipei Medical University
Epilepsy; Seizure, Neuromuscular Diseases
North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2
The "North Carolina Clinical Genomic Evaluation by Next-gen Exome Sequencing, 2 (NCGENES 2)" study is part of a larger consortium project investigating the clinical utility, or net benefit of an intervention on patient and family…
- Conditions
- Epilepsy; Seizure, Neuromuscular Diseases, Brain Malformation, Intellectual Disability
- Trial name
- NCGENES2 (NCT03548779)
- Testing
- Pre-visit prep, usual care + exome seq
- Where
- 3 sites in United States
- Volunteers
- 548 people
- Sponsor
- University of North Carolina, Chapel Hill
Gross Motor Development Delay, Cerebral Palsy
Small Step Intervention for Infants With Cerebral Palsy and Other Neurodevelopmental Disorders
Children with cerebral palsy (CP) have life-long motor disorders and are typically subjected to extensive treatment throughout childhood.
- Trial name
- smallstep (NCT02166801)
- Testing
- Early intervention for infants, usual care
- Where
- Sweden
- Volunteers
- 39 people
- Sponsor
- Karolinska Institutet
Language Delay, Language Development
Combined Oral Motor Stimulation and Language on Preterm Infant Feeding
This is a randomized controlled trial to study an oromotor stimulation in combination with a reading curriculum in the NICU among preterm infants using oral muscle exercises, Language Environment Analysis (LENA) recordings…
- Conditions
- Language Delay, Language Development, Feeding; Difficult, Newborn, Mother-Infant Interaction
- Trial name
- NCT05861531
- Testing
- Oromotor stimulation, Reading curriculum, LENA recording
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Development Delay, Motor Skills Disorders
Effect of a Telerehabilitation-Supported, Family-Centered Early Intervention Program on Neurodevelopmental and Parental Outcomes in Infants at Mild-to-Moderate Risk
The goal of this pilot randomized controlled trial is to learn whether a family-centered early intervention program, delivered remotely to parents and carried out at home, can support the development of infants who were treated…
- Conditions
- Development Delay, Motor Skills Disorders, Neurodevelomental Disorders, High Risk Infant
- Trial name
- NCT07878819
- Testing
- Remote Family-Centered Early Intervention Program, Standard Information and Routine Follow-up
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bengisu Boz Gürboğa
Autism, Development Delay
Use of Virtual Reality Game Playing During Venipuncture
To evaluate the impact of using virtual reality, VR, game playing on successful completion and reduction of distress and pain in pediatric venipuncture, and to increase adherence in obtaining the desired blood volume.
- Conditions
- Autism, Development Delay, Typical Development
- Trial name
- NCT03518346
- Testing
- Virtual Reality, Standard of Care
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, Davis
Developmental Delays, Global Developmental Delay
Animal Assisted Therapy in a Pediatric Setting
The primary purpose for this study is to determine if children who receive Occupational Therapy while they are an inpatient in the hospital will be more motivated to participate in therapy as well as increase the amount of time…
- Conditions
- Developmental Delays, Global Developmental Delay, Stroke, Cancers
- Trial name
- AAT (NCT01441674)
- Testing
- Animal Assisted Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Language Development, Language Delay
A Language Intervention Study of Preterm Infants
This is a randomized controlled trial to study a reading intervention in the NICU among preterm infants using LENA (Language Environment Analysis) recordings, linguistic feedback, and a language curriculum to improve the neonatal…
- Conditions
- Language Development, Language Delay, Mother-Infant Interaction, Maternal Behavior
- Trial name
- NCT03688386
- Testing
- Reading intervention, Infant bonding, LENA recording
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island