Clinical trials: Development Disorders
Fractures in Children, Apophysitis
Total Genotype Score, Growth, Maturation and Loading Exposure as Risk Factors for Injury in Elite Male Youth Football
A total genotype risk score was generated based on the findings of previous research for non-contact injury, non-contact muscle injury, tendon injury, ligament injury, fracture injury and apophysitis injury.
- Conditions
- Fractures in Children, Apophysitis, Muscle Strain, Ligament Injury
- Trial name
- NCT05220969
- Testing
- Total Genotype Risk Score
- Where
- 2 sites in United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- St Mary's University College
Autism, Autism Disorders and Maternal Stress
Adapting the Sensory Environment to Reduce Stress in Children With Autism During Dental Visits
This study aims to evaluate the impact of a sensory-adapted dental environment (SADE) on the stress levels and behavioral responses of children with autism spectrum disorder (ASD) during dental visits.
- Conditions
- Autism, Autism Disorders and Maternal Stress, Sensory Integration Disorder, Stress Biomarkers
- Trial name
- SMILED (NCT07887243)
- Testing
- Sensory-Adapted Dental Environment
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Jagiellonian University
Cerebral Palsy, Infant Development
Relationship Between Prenatal Maternal Distress and the Quality of General Movements at 3 Months
Depression and anxiety symptoms are common during pregnancy which may disturb the intrauterine environment by affecting the mother's physiological responses to stress, and ultimately impair fetal and postnatal development.
- Conditions
- Cerebral Palsy, Infant Development, Maternal Distress
- Trial name
- NCT05694676
- Testing
- Assessment of the quality of Genaral Movements (GMs), State-Trait Anxiety Inventory-Trait, (STAI-T), Beck Depression Inventory, (BDI)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Karamanoğlu Mehmetbey University
Social Anxiety Disorder (SAD), Autistic Disorder
Autism Traits in Adolescents With Social Anxiety Disorder: Associations With Parental Broader Autism Phenotype
This observational study aims to examine autism-related traits in adolescents diagnosed with social anxiety disorder (SAD) and to evaluate their associations with broader autism phenotype (BAP) features in their parents.
- Trial name
- NCT07106840
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 109 people
- Sponsor
- Ankara City Hospital Bilkent
Anxiety, Depression
Metacognitive Therapy for Common Mental Health Problems in Autistic CYP: A Case Series
Anxiety and Depression are common in young people (CYP) and especially in CYP with a diagnosis of Autism. Autistic people often say therapy has not been adapted to meet their needs.
- Trial name
- NCT05980143
- Testing
- Metacognitive Therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Manchester
Adult Growth Hormone Deficiency
Metabolic Endocrinology and Growth Hormone in Adults
This is a multicentric, longitudinal, observational study with the prospective follow-up of Adult subjects with Growth Hormone Deficiency (AGHD) being treated with Saizen, every six months in the first year and then annually.
- Trial name
- MEGHA FRANCE (NCT01080755)
- Volunteers
- 90 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Speech Sound Disorder, Language Development Disorders
Exploratory Trial of the "HiDongDong" Language Rehabilitation App for Articulation Delay.
The purpose of this study is to evaluate the effectiveness of the AI-based application "HiDongDong" in improving articulation development in children aged 2 to under 14 years with suspected articulation delays.
- Conditions
- Speech Sound Disorder, Language Development Disorders, Phonological Disorder
- Trial name
- NCT07613268
- Testing
- HiDongDong Intervention, Standard Care / Speech Therapist Intervention
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Seoul National University Bundang Hospital
Dwarfism, Turner's Syndrome
The Effects of Hormones in Growth Hormone-Treated Girls With Turner Syndrome
Turners Syndrome is a genetic condition in females that is a result of abnormal chromosomes. Patients with Turner syndrome are typically short, have abnormal physical features, and lack the physical changes normally associated…
- Trial name
- NCT00001343
- Testing
- Humatrope, Oxandrolone
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Osteogenesis Imperfecta (OI), Osteogenesis Imperfecta
Prospective Observational Cohort Study of Cardiac Structure and Function in Children and Adults With Osteogenesis Imperfecta
This prospective observational investigation will examine the incidence and progression of cardiologic findings in individuals with OI across different age groups.
- Trial name
- OI Cardio (NCT07287241)
- Testing
- Imaging evaluation, Echocardiography
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Ortopedico Rizzoli
Autism
Improving Caregiver Engagement in Early Interventions
The goal of this study is to test the effectiveness of the FANS-EI program in supporting caregiver engagement in caregiver-mediated early interventions for young children with autism.
- Trial name
- NCT07500363
- Testing
- FANS-EI, Early Intervention
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, Davis
Childhood-onset Growth Hormone Deficiency, Pituitary Dwarfism
Cool.Click™ Adolescent Transition Study: Study of Saizen® in Subjects With Childhood-onset Growth Hormone Deficiency
The primary objective is to evaluate the efficacy and safety of two different dose regimens of r-hGH (Saizen®) in subjects with childhood-onset growth hormone deficiency (COGHD) during the transition phase from childhood to…
- Trial name
- NCT00109733
- Testing
- recombinant human growth hormone
- Where
- 9 sites in United States
- Volunteers
- 31 people
- Sponsor
- EMD Serono
Attention Deficit and Disruptive Behavior Disorders, Child Behavior Disorders
Study of Children at Risk for Disruptive Behavior Disorders
A conduct disorder is characterized by repetitive and persistent patterns of behavior where the basic rights of others and rules are violated.
- Conditions
- Attention Deficit and Disruptive Behavior Disorders, Child Behavior Disorders, Passive-Aggressive Personality Disorder
- Trial name
- NCT00001233
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Premature Births
Long-term Effect of The Mother Infant Transaction Program (MITP)
The purpose of this study is to investigate if a cost and time effective intervention in a previous RCT for preterm infants and their parents can reduce the parents experience of concern and stress, and improve the childrens…
- Trial name
- 2007/2/0150 (NCT00903149)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Preterm, Parent-Child Relations
Sensory Optimization of the Hospital Environment
The long-term goal of this project is to improve the health and well-being of preterm infants and their parents. Although there is evidence to support positive multisensory interventions in the NICU, these interventions are often…
- Conditions
- Preterm, Parent-Child Relations, Parents, Development, Infant
- Trial name
- SOOTHE (NCT05230199)
- Testing
- SENSE multisensory program, Monitored standard of care
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- University of Southern California
Pectus Excavatum
Magnetic Mini-Mover Procedure to Treat Pectus Excavatum
This is a medical research study. The study investigators have developed a method to gradually repair pectus excavatum (sunken chest) deformity by placing a magnet on the sternum (breastbone) and then applying an external…
- Trial name
- 3MP (NCT00466206)
- Testing
- Magnetic Mini-Mover Procedure (3MP), Magnatract (external magnet in a removable external brace), 3MP (Magnetic Mini-Mover Procedure)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Type 1 Diabetes Mellitus
Glycemic Control and the Brain in Children With Type 1 Diabetes
The purpose of this study is to determine if improving diabetes control by better controlling blood sugars, will help improve or normalize brain function as compared to routine diabetes care.
- Trial name
- NCT03428932
- Testing
- Closed Loop (Medtronic 670G), Standard Care
- Where
- 5 sites in United States
- Volunteers
- 46 people
- Sponsor
- Nemours Children's Clinic
Asthma, Health Personnel
Changes in Physician Performance Through Continuous Professional Development
The purpose of this study is to determine whether having physicians evaluate their management of certain diseases as part of board recertification results in improved patient care.
- Trial name
- NCT00115284
- Testing
- ABIM asthma practice improvement module
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Autistic Disorder, Autism
Withdrawal Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified Previously Treated With Memantine
The purpose of this randomized withdrawal study is to evaluate the safety, tolerability, and efficacy of memantine compared with placebo in pediatric patients with autism, Asperger's Disorder, or Pervasive Developmental Disorder…
- Conditions
- Autistic Disorder, Autism, Asperger's Disorder, Asperger Syndrome
- Trial name
- NCT01592747
- Testing
- Memantine Hydrochloride (HCl)
- Where
- 94 sites in United States, Belgium and 13 more
- Volunteers
- 479 people
- Sponsor
- Forest Laboratories
Leukemia
Combination Chemotherapy in Treating Patients With Relapsed Acute Myelogenous Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00003758
- Testing
- cytarabine, idarubicin, allogeneic bone marrow transplantation
- Where
- 16 sites in Belgium, Croatia and 5 more
- Volunteers
- 60 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Developmental Dysplasia of the Hip
Arthroscopically Assisted Versus Open Surgical Reduction of the Hip in Patients With Irreducible DDH Before the Walking Age
To determine the role of arthroscopy in treatment of the DDH.
- Trial name
- NCT06408987
- Testing
- arthroscopically assisted, open surgical reduction
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Assiut University
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