Clinical trials: Development Disorders
Autism Spectrum Disorder
A Novel Framework for Impaired Imitation in ASD
There is long-standing recognition that people with autism spectrum disorders (ASD) have difficulty imitating others' actions; some investigators have highlighted impaired imitation as being a core contributor to the development…
- Trial name
- NCT03423160
- Testing
- None--observational
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Prediabetes / Type 2 Diabetes
Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study.
The aim of the study is to evaluate whether the Oral Fat Loading Test (OFLT) determines a different response in terms of the quantity, quality, and kinetics of triglyceride-rich lipoproteins in subjects with T2D, prediabetics…
- Trial name
- LIPINFAT (NCT07602023)
- Testing
- Oral Fat Load Test
- Where
- 2 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Angelina Passaro
Autism Spectrum Disorder, Neurodevelopmental Disorders
Platform for the Prospective Mother-child Study of the Determinants of Neurodevelopmental Disorders
Neurodevelopmental disorders such as attention deficit disorder with or without hyperactivity, autism spectrum disorder, language and social communication disorder, motor coordination disorder, learning disorder (dyslexia…
- Trial name
- MARIANNE (NCT05681923)
- Testing
- Questionnaires, Biospecimen collection, Neurodevelopmental assessment visit
- Where
- France
- Volunteers
- 7,320 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Gingival Cleft, Orthodontic Space Closure
Gingival Cleft Development at Two Time Points of Canine Retraction
The goal of this split-mouth randomized controlled trial is to assess whether the timing of extraction space closure-early vs. delayed initiation-affects the incidence of gingival cleft development in orthodontic patients.
- Trial name
- NCT07210762
- Testing
- Early space closure, Delayed space closure
- Where
- Pakistan
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Bahria University
Congenital Heart Disease, Periventricular Leucomalacia
Randomized Trial of Maternal Progesterone Therapy
Neurodevelopmental disability is now recognized as the most common long-term complication after cardiac surgery in neonates. Research studies have shown that progesterone is critical to the development of the brain and in a…
- Conditions
- Congenital Heart Disease, Periventricular Leucomalacia, Brain Development, Cardiac Surgery
- Trial name
- NCT02133573
- Testing
- Progesterone, Vaginal lubricant
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Children's Hospital of Philadelphia
Hiv, Hepatitis C
Development and Pilot Testing of a PHCI for Emergency Department Patients Who Decline Rapid HIV/ HCV Screening
The Centers for Disease Control and Prevention (CDC) recommends that emergency departments (EDs) and other health care facilities conduct HIV and HCV screening to identify and link to care those with undiagnosed infections.
- Trial name
- NCT04137094
- Testing
- Persuasive Health Communication Intervention
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Autism Spectrum Disorder
Autism Spectrum Disorders (ASD) Driving Study
The proposed pilot study will begin to assess whether driving impairments are included in the functional deficits associated with Autism Spectrum Disorders (ASDs).
- Trial name
- NCT01263756
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Idiopathic Membranous Nephropathy
Prognostic Model of TAC in the Treatment of MN
The goal of this observational study is to explore the factors that can predict the prognosis difference in patients with idiopathic membranous nephropathy (IMN) under the treatment of tacrolimus.
- Trial name
- NCT05667922
- Testing
- Tacrolimus
- Volunteers
- 50 people
- Sponsor
- Qianfoshan Hospital
Usage of Prescription Opioids
Determining Genetic Biomarkers Predictive of the Development of Prescription Opioid Addiction
This is a clinical study on patients who have been prescribed opioids (narcotic pain relievers) for the treatment of pain, to determine what genetic factors influence outcome of treatment.
- Trial name
- NCT01562353
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Analgesic Solutions
Autism Spectrum Disorder
A Chatbot-based Program to Promote Well-being in Caregivers of Children With Autism Spectrum Disorder
Autism spectrum disorder (ASD) is characterized by varying degrees of disability and deviation in social communication, cognitive growth, and emotional expression, as well as the existence of constrained, repetitive patterns of…
- Trial name
- NCT07059013
- Testing
- Chatbot
- Where
- Hong Kong
- Volunteers
- 130 people
- Sponsor
- Hong Kong Metropolitan University
Hyperkyphosis
Development and Validation of MPF to Prevent and Mitigate Postural Hyperkyphosis in Postmenopausal Women
Postural hyperkyphosis is common in postmenopausal women and leads to spinal dysfunction, pain, impaired balance, and increased fall risk.
- Trial name
- NCT07068360
- Testing
- Strength Training +Postural Correction Exercises + Balance Training +Flexibility Exercises, Standard Intervention (Control Group)
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Superior University
Stuttering, Stuttering, Adult
Exploring the Nature, Assessment and Treatment of Stuttering
The purposes of this study are to 1) investigate potential speech, language, and psychosocial contributions to the experience of stuttering in monolingual and multilingual speakers, and to 2) evaluate interdisciplinary…
- Conditions
- Stuttering, Stuttering, Adult, Stuttering, Childhood, Stuttering, Developmental
- Trial name
- NCT05908123
- Testing
- The Blank Center CARE Model(TM) for Individuals who Stutter
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Down Syndrome, Edwards Syndrome
Expanded Noninvasive Genomic Medical Assessment: The Enigma Study
In January 2007, the American Congress of Obstetricians and Gynecologists (ACOG) revised its guidelines that now recommend physicians are ethically obligated to fully inform all pregnant women that screening for fetal chromosomal…
- Conditions
- Down Syndrome, Edwards Syndrome, Patau Syndrome, Klinefelter Syndrome
- Trial name
- NCT02787486
- Testing
- Blood sampling for Laboratory Developed Test (LDT) analysis
- Where
- 8 sites in United States
- Volunteers
- 760 people
- Sponsor
- Progenity, Inc.
Cervical Fusion
Clinical and Radiological Outcomes of Posterior Cervical Fusion Supplemented With Interfacet Spacers
This is a prospective study to assess fusion rates and cervical sagittal parameters following posterior cervical arthrodesis procedures supplemented with CIS.
- Trial name
- NCT04041583
- Testing
- Cervical Interfacet Spacers
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Ohio State University
Painful Peripheral Neuropathy, Diabetic Peripheral Neuropathic Pain (DPN)
SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.
The goal of this clinical trial is to determine whether quantitative sensory testing (QST) can be used to classify participants into pain sub-groups and predict who will respond best to certain pain treatments in participants…
- Conditions
- Painful Peripheral Neuropathy, Diabetic Peripheral Neuropathic Pain (DPN), Chemotherapy Induced Peripheral Neuropathy (CIPN), Idiopathic Peripheral Neuropathy
- Trial name
- NCT06614322
- Testing
- Pregabalin, Duloxetine
- Where
- 7 sites in United States
- Volunteers
- 190 people
- Sponsor
- University of Rochester
Development of Standardized Assessment TAVI and MitraClip Procedures by Echocardiography, Aortic Stenosis
Examination of Valve Insufficiency Before and After MitraClip or TAVI Procedure by 3D Echocardiography Compared to MRI
Aim of the study is the definition of criteria for a standardized assessment of heart function by 3D echocardiographic procedures.
- Conditions
- Development of Standardized Assessment TAVI and MitraClip Procedures by Echocardiography, Aortic Stenosis, Mitral Valve Insufficiency
- Trial name
- 3D_TTE_TAVI (NCT01966146)
- Testing
- Echography GE Healthcare Vivid E9
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- RWTH Aachen University
Atherosclerosis, Subclinical Atherosclerosis
DETECTion of the Prevalence of Silent Atherosclerosis Across Adult Life - Phase I of REACT
Atherosclerosis is preventable, yet it continues to significantly contribute to global morbidity and mortality. Atherosclerosis may occur early in life and may present in all vascular territories.
- Conditions
- Atherosclerosis, Subclinical Atherosclerosis, Cardiovascular Diseases
- Trial name
- DETECT (NCT06692127)
- Where
- 5 sites in Denmark, Spain
- Volunteers
- 16,808 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Anxiety, Autism Spectrum Disorder
Adaptation and Feasibility of the Community-Based Anxiety Program Tailored for Autism (CAPTA)
Anxiety is very common in autistic youth. Recently, an intervention has been created by the investigators to target these symptoms in autistic youth in a community setting.
- Conditions
- Anxiety, Autism Spectrum Disorder, Separation Anxiety, Generalized Anxiety Disorder
- Trial name
- NCT06046170
- Testing
- Cognitive Behavioral Therapy, Treatment as Usual
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- Baylor College of Medicine
GAINS Expert Guiding Technology to Coach Life Skill Teaching
GAINS Expert Guiding Technology to Coach Life Skill Teaching
Based on proven techniques in operant conditioning, the expert behavior guiding functionality in GAINS to teach life skills will be evaluated.
- Trial name
- NCT07203105
- Testing
- GAINS expert guiding technology to coach life skill teaching
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Guiding Technologies Corporation
Host and Microbiome, Pregnancy Outcomes
Human Genes and Microbiota in Early Life
The long-term goal of the Human Genes and Microbiota in Early Life (HuGME) is to explore the short- and long-term effects of maternal microbiota during pregnancy and the microbiota colonization of their offspring early in life…
- Conditions
- Host and Microbiome, Pregnancy Outcomes, Pregnancy Complications, Neurodevelopmental Disorders
- Trial name
- HuGME (NCT06926166)
- Testing
- No intervention
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
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