Clinical trials: Development Disorders
Brain Concussion
Tissue Repository and Master Database for Concussion Biomarker and Risk Calculator Development
The purpose of this study is to prospectively collect a comprehensive, multi-modality set of diagnostics on patients who have had a concussion, repeating some of these tests serially over time, so that the investigators may then…
- Trial name
- NCT02519998
- Testing
- Concussion
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Molar Hypomineralization, Dental Restoration Failure of Marginal Integrity
CAD-CAM or Adhesive Approaches for MIH Treatment
Aim: This randomized controlled clinical study aimed to compare direct composite resin restorations and Computer Aided Design-Computer Aided Manufacturing (CAD-CAM) supported inlay or onlay restorations in young permanent molar…
- Trial name
- NCT06456619
- Testing
- Tooth restoration
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Baskent University
Lennox Gastaut Syndrome, Dravet Syndrome
Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution
This study will monitor for potential chronic liver injury and liver fibrosis, in participants treated with cannabidiol oral solution.
- Conditions
- Lennox Gastaut Syndrome, Dravet Syndrome, Tuberous Sclerosis Complex
- Trial name
- NCT05044819
- Testing
- Cannabidiol
- Where
- 26 sites in United States
- Volunteers
- 154 people
- Sponsor
- Jazz Pharmaceuticals
Child Development Disorder, Post Partum Depression
Optimization of Mother-child Dyad Follow-up by a Multidomain Application: Real-world Cross Sectional Study
After birth, the mother-child dyad can be impacted by issues which are usually under-detected or detected at early stage. Among these issues, neurodevelopmental disorders (NDD) such as autism spectrum disorder are common and…
- Trial name
- MALO_2 (NCT05215028)
- Testing
- web-application
- Where
- France
- Volunteers
- 4,346 people
- Sponsor
- Weprom
Developmental Dysplasia of Hip
Improving Neonatal Hip Screening With Artificial Intelligence
The goal of this trial is to pilot a portable ultrasound device that uses artificial intelligence to screen for hip dysplasia. Researchers will gather data to understand the feasibility of performing a larger trial in birthing…
- Trial name
- NCT07794644
- Testing
- Artificial intelligence augmented ultrasound
- Volunteers
- 100 people
- Sponsor
- Murdoch Childrens Research Institute
Developmental Disability
Occupational Performance Coaching With Parents of Young Children With Developmental Disability
Participation in community activities allows children to meet friends, learns new skills, fosters independence, and paves the foundation for lifelong health.
- Trial name
- NCT04796909
- Testing
- Occupational Performance coaching, Parent consultation
- Where
- 3 sites in Hong Kong
- Volunteers
- 50 people
- Sponsor
- The Hong Kong Polytechnic University
Challenging Behavior
A Single-Arm Pilot Trial for Mitigating Relapse of Severe Problem Behavior
The goal of this study is to improve how we teach self-control and communication skills to children and adolescents with challenging behaviors.
- Trial name
- NCT06732219
- Testing
- Functional Communication Training, Extinction-Correlated Stimuli, Caregiver Fading
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Auburn University
Otitis Media, Middle Ear Effusion
Middle Ear Disease Before Age 3, Treatment With Ear Tubes, and Literacy and Attentional Abilities at Ages 9 to 11
Middle-ear disease (infection and fluid) is the most common illness in young children after the common cold. Because hearing loss accompanies middle-ear disease, and because early life is a period of rapid development, concern…
- Trial name
- NCT00365092
- Testing
- Insertion of tympanostomy tubes
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Type 1 Diabetes, Eating Disorder
Develop and Validate a Self-Administered Instrument That Will Screen for Eating Disorder Symptoms in Persons Aged 12 and Older With Type 1 Diabetes.
The purpose of this study is to develop and validate a survey instrument to be used by persons with type 1 diabetes aged 12 and older to screen for an eating disorder.
- Trial name
- NCT00948311
- Where
- United States
- Volunteers
- 279 people
- Sponsor
- HealthPartners Institute
Eczema
GB-EZ-SIM03 Probiotics Study for Childhood Eczema
Eczema is the most prevalent chronic skin disease in young children, and skin infection is commonly seen during eczema flare. Dysbiosis is increasingly recognised in the stool and skin of these patients.
- Trial name
- NCT05607511
- Testing
- Probiotics baby immunity formula (SIM03)
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Marfan Syndrome
Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome
Marfan syndrome is a hereditary connective tissue disorder. Many individuals with this condition die because of the associated heart and blood vessel abnormalities.
- Trial name
- NCT00429364
- Testing
- Losartan Potassium, Atenolol
- Where
- 26 sites in United States, Belgium and 1 more
- Volunteers
- 608 people
- Sponsor
- Carelon Research
Autism Disorder
TRIal of PPF3 vs. PlaCEbo in the TReatment of Children and AdolescenTs With NeurOdeveloPmental DisorderS
A Randomized Placebo-Controlled TRIal of PPF3 vs. PlaCEbo in the TReatment of children and AdolescenTs with NeurOdeveloPmental DisorderS
- Trial name
- TRICERATOPS (NCT07893964)
- Testing
- PPF3
- Where
- 4 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Autism Spectrum Disorder
Early Detection of Autism Spectrum Disorder in Children
Rationale: Autism Spectrum Disorder (ASD) is defined by deficits in social interaction and communication identified before the age of 3 years.
- Trial name
- NCT01646866
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Craniofacial Microsomia, Hemifacial Microsomia
Craniofacial Microsomia: Longitudinal Outcomes in Children Pre-Kindergarten (CLOCK)
This study is a multi-center, longitudinal cohort study of 125 infants with craniofacial microsomia (CFM) and 100 infants without craniofacial anomalies.
- Conditions
- Craniofacial Microsomia, Hemifacial Microsomia, Oculo-Auriculo-Vertebral-Syndrome, Goldenhar Syndrome
- Trial name
- CLOCK (NCT02224677)
- Where
- 5 sites in United States
- Volunteers
- 417 people
- Sponsor
- Seattle Children's Hospital
Autism Spectrum Disorder
Intestinal Microbiota, Tryptophan and Autism
Autism Spectrum Disorder refers to complex neuro-developmental disorders that affect social communication and behavioral adaptation.
- Trial name
- MTA (NCT03751930)
- Testing
- Samples
- Where
- 2 sites in France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Diabetes, Diabetes Mellitus, Type 1
An Observational Study to Assess Longitudinal Variation of Immune Biomarkers in Subjects at Risk for Development of Type 1 Diabetes
This study is conducted in the United States of America (USA). The aim of the study is to assess longitudinal variation of immune biomarkers in subjects at risk for development of type 1 diabetes (T1D).
- Trial name
- NCT01846312
- Testing
- No treatment given
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Autistic Disorder
Research in Autism: Parent Intervention
The purpose of this research project was to systematically compare two widely used types of intervention programs for children with autism within a parent training model.
- Trial name
- NCT01258465
- Testing
- Pivotal Response Training, Picture Exchange Communication System
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- University of California, San Diego
Craniosynostosis, Muenke Syndrome
Clinical Study of Muenke Syndrome (FGFR3-Related Craniosynostosis)
This study will explore the range and type of medical and developmental problems in patients with Muenke syndrome, a condition that results when one or more of the suture between the bones of the skull close before birth.
- Trial name
- NCT00106977
- Where
- 2 sites in United States
- Volunteers
- 137 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Autism
Fluoxetine Essay in Children With Autism
This study is a comparative, double blind, placebo controlled trial of 6-months duration designed to evaluate 1) the effects of fluoxetine in 5 to 12 years old autistic children, 2) the effects of fluoxetine on serotoninergic…
- Trial name
- FAIR (NCT00873834)
- Testing
- fluoxetine
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autism Spectrum Disorder
VR for Joint Attention Support in ASD
The overall objective of this study is to determine the effectiveness of the Floreo VR Joint Attention Module in improving social communication skills in children with ASD.
- Trial name
- NCT04016701
- Testing
- Floreo Joint Attention Module, Regularly Scheduled Therapy
- Where
- United States
- Sponsor
- Floreo, Inc.
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