Clinical trials: Developmental Disabilities
Autism Spectrum Disorder
School-Age Children With Autism With Limited Expressive Language Skills
This project will address a major challenge to the field of autism research: improving expressive communication in children with autism who have reached school age but have not acquired functional spoken language (non-verbal…
- Trial name
- NCT01529580
- Testing
- Non-Verbal School Aged Children with Autism (NVSACA) Intervention
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Congenital Hypothyroidism
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.
Congenital hypothyroidism (CH) is a rare disease that affects 1 in 3500 newborn. This condition is detected consistently since the late 1970s in France, which has led to early care and a significant improvement in prognosis and…
- Trial name
- HYPOTYGEN (NCT01916018)
- Testing
- Clinical and radiologic exams and blood samples
- Where
- France
- Volunteers
- 558 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autism Spectrum Disorder, Food Selectivity
Clinical Trial of "Exploradores de Sabores" to Improve Food Selectivity in ASD Kids
The goal of this randomized, single-blind clinical trial is to evaluate the effectiveness of the Exploradores de Sabores parent-mediated nutrition intervention in reducing food selectivity and improving dietary variety, mealtime…
- Trial name
- NCT07727018
- Testing
- Exploradores de Sabores Parent-Mediated Nutrition Intervention, Education as Usual (EAU)
- Where
- Mexico
- Volunteers
- 72 people
- Sponsor
- Universidad Autonoma de Baja California
Child Development Disorder
Postural Control Among Children with and Without Dyslexia
As Chinese-speaking children with dyslexia typically have different cerebellar sign behavior from non-Chinese-speaking counterparts, this study compared the effect of visual occlusion on the static balance between dyslexic and…
- Trial name
- NCT05072418
- Testing
- Eye-opened and Eye-closed
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Intellectual Disability, Autism
Sensors for Communication for Persons Who Cannot Communicate Unequivocally
Some persons with intellectual disability or comprehensive cerebral palsy cannot communicate unequivocally how they are, how they react to situations and people, whether they are in pain or experience discomfort, anger or fear.
- Conditions
- Intellectual Disability, Autism, Cerebral Palsy
- Trial name
- NCT04199299
- Testing
- Heart rate and respiration rate sensors
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- University of Oslo
Head and Neck Cancer, Radiotherapy Side Effect
DENTOFACIAL-PBT Stage 2 - Feasibility Study
What is the health problem? Proton beam therapy (PBT), a type of radiotherapy treatment, can be especially beneficial to children and teenagers with cancer.
- Conditions
- Head and Neck Cancer, Radiotherapy Side Effect, Adverse Effect of Radiation Therapy, Childhood Cancer
- Trial name
- NCT07057284
- Testing
- Orthopantomogram (or a set of Lateral Oblique Radiographs)
- Where
- 2 sites in United Kingdom
- Volunteers
- 255 people
- Sponsor
- Manchester University NHS Foundation Trust
Autism Spectrum Disorders
Effects of the Anti-inflammatory Flavonoid Luteolin on Behavior in Children With Autism Spectrum Disorders
Background. Increasing evidence indicates that brain inflammation is important in the pathogenesis of neuropsychiatric disorders, including at least a significant proportion of subjects with Autism spectrum disorder (ASD).
- Trial name
- NCT01847521
- Testing
- Luteolin, Quercetin and Rutin combined in a capsule
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Attikon Hospital
Autism Spectrum Disorder
Transcranial Photobiomodulation for Reducing Autism Symptoms in Children
The hypothesis of the study is that photobiomodulation reduces symptoms of autism. Participants will be children between the ages of 2 and 6, who have been diagnosed with moderate to severe autism.
- Trial name
- TPBMASD (NCT04660552)
- Testing
- Cognilum TM: Light Treatment Condition
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- JelikaLite LLC
Autism Spectrum Disorder, Neurodevelopmental Disorders
AIRB-4: Self-Determined Learning Model of Instruction
The AIRB research team will compare the use and effectiveness of each intervention (Mind the Gap, Remaking Recess and Self Determined Learning Model of Instruction) with and without the addition of our implementation strategy…
- Trial name
- SDLMI (NCT04972851)
- Testing
- Self-Determined Learning Model of Instruction (SDLMI)
- Where
- 3 sites in United States
- Volunteers
- 358 people
- Sponsor
- Health Resources and Services Administration (HRSA)
Autism Spectrum Disorder, Mental Health Disorder
Adaptation and Implementation of an ASD Executive Functioning Intervention in Children's Mental Health Services
The purpose of this project is to conduct a feasibility test of an ASD executive functioning intervention adapted for mental health settings, including examining the effectiveness and process of implementing this adapted…
- Conditions
- Autism Spectrum Disorder, Mental Health Disorder, Executive Dysfunction
- Trial name
- NCT04295512
- Testing
- Unstuck and on Target
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- San Diego State University
Autism Spectrum Disorders
Emotional and Change-related Attention in Autism
Several studies seem to indicate that emotional attention and change-related attention are impaired in ASD. The goal of this study is to identify the relationships between those two types of automatic attention in visual and…
- Trial name
- AUTATTEN (NCT02160119)
- Testing
- MRI-based techniques, EEG
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
PTEN Gene Mutation, PTEN Hamartoma Tumor Syndrome
RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome
Phosphatase and TENsin homolog (PTEN) gene germline mutations are associated with a spectrum of clinical manifestations characterized by neurocognitive deficits, intellectual disability, autism symptomatology, skin lesions…
- Trial name
- NCT02991807
- Testing
- RAD001
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- Boston Children's Hospital
Autism Spectrum Disorder
Mindfulness-Enhanced Pivotal Response Group Treatment on Parenting Stress
This project tests the feasibility and preliminary proof of concept for a mindfulness-enhanced adaptation of Pivotal Response Treatment on parenting stress and child communication, using a randomized controlled design.
- Trial name
- NCT05948202
- Testing
- Pivotal Response Treatment
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Behavior Problem, Developmental Delay
Stamford Group Family Nurture Intervention
The purpose of this current study is to investigate the efficacy of a group model of Family Nurture Intervention in ameliorating behavioral problems in preschool-aged children.
- Conditions
- Behavior Problem, Developmental Delay, Emotional Disturbances, Family Conflict
- Trial name
- NCT03442439
- Testing
- Nutrition and Play Intervention, Family Nurture Intervention
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Columbia University
Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
Evaluation of the Efficacy of Hippotherapy for Children With Developmental Disorders
Hippotherapy is every program of horseback riding meant to treat people with physiological, mental, social, cognitive or behavioral problems.
- Trial name
- NCT00717392
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Maternal Depression
Reducing Risk After an Adverse Pregnancy Outcome
This application to the Boston University Medical Center Institutional Review Board outlines a research plan devoted to identifying and managing maternal depression in Early Intervention (EI).
- Trial name
- NCT01182363
- Testing
- Project Solve Education
- Where
- 4 sites in United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Autism Spectrum Disorder
Do Sleep and Circadian Rhythm Disturbances Impact the Cognitive and Behavioural Development of Children With Autism?
The primary objective of this study is to undertake a longitudinal investigation of the impact of sleep and circadian rhythm disturbances on cognitive and behavioural trajectories in children with autism spectrum disorder (ASD)…
- Trial name
- NCT02878499
- Testing
- polysomnography
- Where
- 5 sites in France
- Volunteers
- 105 people
- Sponsor
- University Hospital, Strasbourg, France
Developmental Disability
Developing and Examine the Efficacy of the Family-Centered Multi-Sensory Environment Intervention on Parent's Empowerment and Children's Engagement (MSE-PEACE) in Children With Developmental Disabilities and Their Parents: A Mixed Methods Study
The goal of this clinical trial is to learn whether a family-centered multi-sensory environment (MSE-PEACE) can help children with developmental disabilities and support their parents.
- Trial name
- MSE-PEACE (NCT07118293)
- Testing
- MSE-PEACE
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Cheng Kung University
Intellectual Disability, Variable, Autism Spectrum Disorder (ASD)
School-Based Sensory Processing and Daily Living Skills-Focused Occupational Therapy Program
This study aims to develop and evaluate a school-based occupational therapy program focused on sensory processing and activities of daily living for children with Autism Spectrum Disorder and Intellectual Disability.
- Trial name
- NCT07326267
- Testing
- Individual School-Based Occupational Therapy Sessions, Sensory Preparation Using Proprioceptive, Vestibular, and Tactile Input, Task-Oriented Activities of Daily Living Training
- Volunteers
- 40 people
- Sponsor
- Çankırı Karatekin University
Autism Spectrum Disorder, Disruptive Behaviours
Feasibility Study on Parents Skill Training Program for Reducing Parental Distress and Disruptive Behavior of Their Children With Autism Spectrum Disorder (ASD)
Children with Autism Spectrum Disorder (ASD) usually exhibt problematic behavioral issues such as hitting, non-compliance, tantrums, spitting, headbanging and aggression, this not only cause distress for the child but also has a…
- Trial name
- NCT04339153
- Testing
- Parent Training for Disruptive Behaviours
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad