Clinical trials: Developmental Trauma Disorder
Head and Neck Cancer, Radiotherapy Side Effect
DENTOFACIAL-PBT Stage 2 - Feasibility Study
What is the health problem? Proton beam therapy (PBT), a type of radiotherapy treatment, can be especially beneficial to children and teenagers with cancer.
- Conditions
- Head and Neck Cancer, Radiotherapy Side Effect, Adverse Effect of Radiation Therapy, Childhood Cancer
- Trial name
- NCT07057284
- Testing
- Orthopantomogram (or a set of Lateral Oblique Radiographs)
- Where
- 2 sites in United Kingdom
- Volunteers
- 255 people
- Sponsor
- Manchester University NHS Foundation Trust
Brain Concussion, Mild Cognitive Impairment
Development of a Neurocognitive Screening Test
This research study will evaluate a standalone software application and is designed to standardize and validate new neurocognitive screening testing for children aged 6 through 11, and adolescents and adults ages 12 through 75.
- Trial name
- NCT02597504
- Testing
- Pen and paper neuropsychological test, Quick Test
- Where
- 4 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- ImPACT Applications, Inc.
Developmental Dysplasia of Hip, DDH
8 vs 12 Weeks: A Pavlik Harness Trial
Developmental dysplasia of the hip is the most common bone and joint condition in babies. It is usually treated with a harness that holds the hips in a safe position so they can develop normally.
- Conditions
- Developmental Dysplasia of Hip, DDH, Developmental Dysplasia of the Hip, Developmental Dysplasia of the Hip (DDH)
- Trial name
- NCT07847619
- Testing
- Pavlik Harness
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- The Hospital for Sick Children
Spina Bifida, Cerebral Palsy
Grand Valley State University (GVSU) Skills on Wheels
Manual wheelchairs (MWCs) are widely used by children with physical disabilities, yet many of these children are unable to use their wheelchair independently. Instead, they depend on others to push them.
- Conditions
- Spina Bifida, Cerebral Palsy, Genetic Disease, Spinal Cord Injuries
- Trial name
- NCT05339932
- Testing
- Manual Wheelchair Skills Training
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Grand Valley State University
Bronchopulmonary Dysplasia
The Role of Volatile Organic Compounds (VOCs), Airway Mucins and the Microbiome in the Early Prediction of Bronchopulmonary Dysplasia (BPD)
Bronchopulmonary dysplasia (BPD), the most common respiratory complication of extremely preterm birth, significantly impacts healthcare with high morbidity and mortality rates.
- Trial name
- INFANCY (NCT06342752)
- Testing
- Breath test, Throat swabs, Placental samples
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Developmental Dysplasia of Hip
Should Graf IIc Hips be Treated for 12 Weeks
Children who are diagnosed with Developmental Hip Dysplasia (DDH) are often categorized depending on the severity of their hip malformation. Regardless of the severity, the accepted form of treatment is the Pavlik Harness.
- Trial name
- NCT03275805
- Testing
- Duration of Pavlik Harness treatment, 12 week standard of care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Connective Tissue Disorders, Osteogenesis Imperfecta
Evaluation and Treatment of Patients With Connective Tissue Disease
This study offers evaluation and treatment of patients with a suspected connective tissue disorder. The protocol is not designed to test new treatments; rather, patients receive standard care.
- Conditions
- Connective Tissue Disorders, Osteogenesis Imperfecta, Bone Diseases, Metabolic, Melorheostosis
- Trial name
- NCT00076830
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Metabolic Disease, Neurological and Mental Health Conditions
Singapore PREconception Study of Long-Term Maternal and Child Outcomes
We aim to test the following primary hypothesis that nutrition, lifestyle, and maternal emotional health prior to pregnancy and/or during the first trimester alter the expression of metabolic or neurodevelopmental endophenotypes…
- Conditions
- Metabolic Disease, Neurological and Mental Health Conditions, Genetics Predisposition, Skin Condition
- Trial name
- S-PRESTO (NCT03531658)
- Where
- Singapore
- Volunteers
- 1,054 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Perinatal Brain Injury
Neuro-MoD: Neuroplasticity With Motor Development
This study is for infants and toddlers between 8 and 24 months old who use one arm and/or hand differently following a perinatal brain injury.
- Trial name
- NCT07738432
- Testing
- Constraint-Induced Movement Therapy (CIMT), Transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Wisconsin, Madison
Bronchopulmonary Dysplasia
Gastrointestinal Microbiome Influence on the Development of Bronchopulmonary Dysplasia
The purpose of this study is to advance our knowledge of the factors that contribute to the development of bronchopulmonary dysplasia (BPD), a chronic lung affecting premature infants.
- Trial name
- MiBPD (NCT03229967)
- Testing
- 16S rRNA stool microbiome sequencing.
- Where
- 2 sites in United States
- Volunteers
- 197 people
- Sponsor
- University of Tennessee
Diabetes, Endocrine System Diseases
Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial
The Transition Navigator Trial (TNT) is a pragmatic randomized controlled trial evaluating the effectiveness of usual care plus a patient navigator service versus usual care plus newsletters and other educational materials, to…
- Conditions
- Diabetes, Endocrine System Diseases, Gastro-Intestinal Disorder, Neuro-Degenerative Disease
- Trial name
- TNT (NCT03342495)
- Testing
- Patient Navigator, Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 337 people
- Sponsor
- University of Calgary
Traumatic Brain Injury, Cerebral Palsy
Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy
This prospective observational study collects real world data on participants receiving regenerative therapies administered internationally and delivered intranasally via the Kurve Therapeutics ViaNase device.
- Conditions
- Traumatic Brain Injury, Cerebral Palsy, Hypoxic Ischemic Encephalopathy, Neurologic Disorders
- Trial name
- MuSE-INSIGHT (NCT07521384)
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Healing Hope International
Sleep Initiation and Maintenance Disorders, Anxiety
HIRREM Developmental Study
The purpose of this study is to explore the functional and physiological effects associated with the use of High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM), as supplemental care, for symptoms of…
- Conditions
- Sleep Initiation and Maintenance Disorders, Anxiety, Post-Traumatic Stress Disorder, Hot Flashes
- Trial name
- NCT02709369
- Testing
- HIRREM
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Wake Forest University Health Sciences
Anxiety Disorders, Anxiety State
Intergenerational Study of War-Affected Youth
War-related violence is a leading driver of mental disorders and illness affecting children in low- and middle-income countries (LMICs).
- Conditions
- Anxiety Disorders, Anxiety State, Depressive Disorder, Mood Disorders
- Trial name
- ISWAY (NCT06440460)
- Where
- Sierra Leone
- Volunteers
- 804 people
- Sponsor
- Boston College
Hip Dysplasia
Ultrasound Screening for Developmental Dysplasia of the Hip in Newborns
The aim of the randomized controlled trial was to determine whether the addition of a general or of a selective ultrasound screening program resulted in more appropriate criteria for treatment and a reduced prevalence of late DDH…
- Trial name
- NCT01818934
- Testing
- hip ultrasound
- Where
- Norway
- Volunteers
- 11,925 people, healthy volunteers welcome
- Sponsor
- University of Bergen
TBI (Traumatic Brain Injury)
Brain Development in Young Children Following Mild Traumatic Brain Injury - Pilot Study
Concussions (also known as mild traumatic brain injury) are common in young children. In some children, they can lead to short- and long-term difficulties.
- Trial name
- KAOUENN (NCT06024122)
- Testing
- IRM exam
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pain, Side Effects
Comparison of IV PCA and Wound Infusion After Repair of Pectus Excavatum
Postoperative pain management is a major problem after repair of pectus excavatum.Various methods of pain management have been introduced.
- Trial name
- NCT01908491
- Testing
- IV PCA, Continuous wound infusion
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- The Catholic University of Korea
Pain, Traumatic Brain Injury
The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study
Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated…
- Conditions
- Pain, Traumatic Brain Injury, Major Trauma, Multiple Sclerosis
- Trial name
- NCT06726135
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ThomasCorbett
Child Development, Early Child Development
Intergenerational Risk and Resilience of Rohingya in Displacement
The iRRRd study is an ongoing prospective longitudinal prenatal birth cohort study based in Cox's Bazar, Bangladesh. Between February 2023 and March 2024, 2,888 pregnant women were enrolled (approximately 80% Rohingya refugees…
- Conditions
- Child Development, Early Child Development, Mental Health, PTSD - Post Traumatic Stress Disorder
- Trial name
- iRRRd (NCT07758283)
- Where
- Bangladesh
- Volunteers
- 2,200 people
- Sponsor
- New York University
Depression, Anxiety
Phone-Delivered Psychological Intervention (t-CETA) for Mental Health Problems in 8-17 Year-Old Syrian Refugee Children
This study evaluates the effectiveness of t-CETA, a version of Common Elements Treatment Approach (CETA) adapted to be delivered over the telephone, in treating common mental health problems in 8-17 year old Syrian refugee…
- Conditions
- Depression, Anxiety, PTSD, Conduct Disorder
- Trial name
- t-CETA (NCT03887312)
- Testing
- t-CETA, Médecins du Monde treatment as usual
- Where
- Lebanon
- Volunteers
- 21 people
- Sponsor
- Queen Mary University of London