Clinical trials: Diagnostic Accuracy
Melanoma, Skin Cancer
AI Augmented Training for Skin Specialists
Background: The worldwide incidence of skin cancer has been rising for 50 years, in particular the incidence of malignant melanoma has increased approx. 2-7% annually and is the most common cancer amongst Danes aged 15-34.
- Trial name
- AISC-SS (NCT04758988)
- Testing
- DermLoop Learn
- Where
- 2 sites in Denmark
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Viral Infection, Bacterial Infections
A Controlled, Blinded Study to Validate the Diagnostic Accuracy and Assess the Clinical Utility of a Host-response Based Diagnostic Tool for Distinguishing Between Bacterial and Viral Etiologies in Pediatric Patients Presenting to the ED With Suspicion of Acute Infection
To externally validate the diagnostic accuracy and assess the clinical utility of a host-response based diagnostic tool called ImmunoXpert™, for differentiating between bacterial and viral etiologies in pediatric patients >3…
- Conditions
- Viral Infection, Bacterial Infections, Antibiotic Misuse, Host Response Diagnostics
- Trial name
- ROSETTA (NCT04254991)
- Testing
- ImmunoXpert™
- Volunteers
- 525 people
- Sponsor
- MeMed Diagnostics Ltd.
Caries,Dental, Deep Caries
Comparative Evaluation of an Electrical Impedance Device Versus Digital Radiography in Estimation of Remaining Dentin Thickness
The research question was that in patients with carious posterior permanent teeth, would the electrical impedance device be as valid as digital radiography in estimation of remaining dentin thickness? The proposed hypothesis was…
- Trial name
- NCT06162182
- Testing
- electrical impedance device,, Reference test: Digital Radiographic examination
- Where
- 2 sites in Egypt
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Rawda Hesham Abd ElAziz
Diquat Poisoning
Diagnostic Accuracy of A Diquat Quantitative Detection Kit and A Portable Mass Spectrometry System for Quantifying Diquat Concentrations in Human Blood Samples
This is an observational, non-interventional diagnostic accuracy study designed to evaluate a diquat quantitative detection kit (ambient ionization mass spectrometry method) and a portable mass spectrometry analysis system for…
- Trial name
- NCT07399574
- Testing
- Portable Mass Spectrometry Analysis System for Quantitative Diquat Detection (with Diquat Quantitative Detection Kit; In-Situ/Ambient Ionization Mass Spectrometry Method)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Hypovolemia, Diuretic Toxicity
Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Intolerance.
Fluid overload increases morbidity and mortality of pediatrics patients in intensive care unit (ICU). It could be interesting to predict the decrease in stroke volume when diuretics are prescribed.
- Conditions
- Hypovolemia, Diuretic Toxicity, Fluid Overload
- Trial name
- NCT03145935
- Testing
- Abdominal compression (AC), blood sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hopital Louis Pradel
Caries, Dental
Accuracy Of Sopro-Life Camera In Comparison With ICDAS II For Detection Of Initial Caries
This study will be conducted to assess diagnostic predictive values of a light induced fluorescence intraoral camera versus those of the visual-tactile assessment method according to modified ICDAS-II criteria in clinical
- Trial name
- NCT03586713
- Testing
- light induced fluorescence camera
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Age Problem
Assessing the Precision of Convolutional Neural Networks for Dental Age Estimation From Panoramic Radiographs
The aim of this study is to assess the accuracy of a convolutional neural network in dental age estimation from digital panoramic radiographs. The reference standard will be the chronological age of the patient.
- Trial name
- NCT05901857
- Testing
- convolutional neural network
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Cairo University
Segmentation Techniques
Effect of Segmentation Techniques (Manual Versus Semiautomatic) on the Accuracy of the Reconstructed Mandibular Condyle Using CBCT
Effect of Segmentation Techniques (Manual versus Semiautomatic) on the Accuracy of the Reconstructed Mandibular Condyle using CBCT
- Trial name
- CBCT (NCT05435417)
- Testing
- CBCT radiation
- Where
- Egypt
- Volunteers
- 29 people
- Sponsor
- Cairo University
Fever
Tympanic Thermometers Accuracy
The aim of the present study is to evaluate the measurement precision and accuracy of the third-generation tympanic thermometer in relation to the measurement modalities considered gold standard.
- Trial name
- NCT06103604
- Testing
- latest generation tympanic thermometer
- Where
- 7 sites in Italy
- Volunteers
- 1,100 people
- Sponsor
- Istituto Ortopedico Rizzoli
Trichomonas Vaginalis
Accuracy and Acceptability of Self-Diagnostic Methods for Vaginitis in Adolescent Females
Symptoms of vaginitis are common among adolescent females, although studies have shown that neither experienced clinicians nor patients can accurately diagnose the cause of vaginitis based on symptoms alone.
- Trial name
- NCT00706368
- Testing
- Point of care tests
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Potentially Malignant Lesions, Oral Lichen Planus
Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.
- Conditions
- Potentially Malignant Lesions, Oral Lichen Planus, Leukoplakia, Oral
- Trial name
- NCT05730855
- Testing
- Real-time Polymerase Chain Reaction technique
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Dehydration
Comparing the Diagnostic Accuracy of Clinical Dehydration Scales Among Small Children
The assessment of clinical dehydration scales diagnostic accuracy (CDS scale, WHO scale, Gorelick scale) among small children.
- Trial name
- NCT02249845
- Where
- Poland
- Volunteers
- 108 people
- Sponsor
- Medical University of Warsaw
Nasopharyngeal Carcinoma
Diagnostic Accuracy of EBV C Promoter Methylation Kit in Nasopharyngeal Carcinoma
This clinical study aims to evaluate the diagnostic performance of a new Epstein-Barr virus (EBV) C promoter methylation detection kit.
- Trial name
- NCT06445088
- Testing
- VCA-IgA, EBNA1-IgA, and EBV-DNA, EBV C Promoter Methylation Detection in nasopharyngeal swab samples
- Where
- 5 sites in China
- Volunteers
- 908 people
- Sponsor
- Sun Yat-sen University
Parkinson Disease
A Study to Analyze Symptoms Prevalent in Early PD (Dysphonia, Tremor)
This is a web-based study that involves monitoring hallmark symptoms of Parkinson's Disease (PD), specifically dysphonia and tremor, using smartphone sensor data.
- Trial name
- NCT04288804
- Testing
- Smartphone microphone sensor, Smartphone accelerometer sensor
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Goalspal LLC
Birch Pollen Allergy, Grass Pollen Allergy
Diagnostic Accuracy of the MADx Multi Array Xplorer (MAX 45k) Automated Laboratory System and the MADx Allergy Explorer Version 2 (ALEX²) - IgE Multiplex Test for the Diagnosis of Pre-defined Groups of Specific High-priority Allergens
About 20% of the general population are affected by an allergy - with an upward trend. Quite often, allergic people do not consider their disease as serious and suffer from subsequent complications, like allergic asthma, later in…
- Conditions
- Birch Pollen Allergy, Grass Pollen Allergy, House Dust Mite Allergy, Cat Allergy
- Trial name
- MADMAX (NCT04435678)
- Testing
- ALEX² test using the MAX 45k automated laboratory system
- Where
- 2 sites in Austria
- Volunteers
- 839 people
- Sponsor
- MacroArray Diagnostics GmbH
Ischemic Stroke, Acute
Accuracy of Transcranial Colour Coded Duplex in Comparing With CT Angiography
Investigator will compare accuracy of transcranial colour coded duplex with CT angiography in detecting arterial obstructions in patients presenting or with history of cerebrovascular ischemic strokes
- Trial name
- NCT06920303
- Testing
- transcranial colour coded duplex
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Asthma (Diagnosis)
First-Line Diagnostic Investigations for Suspected Adult Asthma
Asthma is a common long-term condition that can be difficult to diagnose accurately. Symptoms such as breathlessness, wheeze and cough can vary over time and may be caused by other conditions.
- Trial name
- NCT07792213
- Testing
- Spirometry, Fractional Exhaled Nitric Oxide, bronchodilator response
- Where
- United Kingdom
- Volunteers
- 2,176 people, healthy volunteers welcome
- Sponsor
- George Eliot Hospital
Abdominal Pain, Rectal Bloodloss
Head-to-head Comparison of Two Fecal Biomarkers to Screen Children for IBD
RATIONALE: A substantial proportion of children and teenagers with suspected inflammatory bowel disease (IBD) referred for endoscopy do not have the disease.
- Conditions
- Abdominal Pain, Rectal Bloodloss, Diarrhea, Inflammatory Bowel Disease
- Trial name
- CACATU (NCT02197780)
- Where
- 19 sites in Belgium, Netherlands
- Volunteers
- 355 people
- Sponsor
- University Medical Center Groningen
Otitis Media Acute
Clinical Development of Deep Learning for the OtoSight
The objective of this study is to clinically develop and evaluate a machine learning approach to improve the performance and data interpretation of the PhotoniCare OtoSight Middle Ear Scope in pediatric patients presenting at the…
- Trial name
- NCT04722770
- Testing
- PhotoniCare OtoSight Middle Ear Scope
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- PhotoniCare, Inc.
Fracture, Bone Fracture
AI Assisted Detection of Fractures on X-Rays (FRACT-AI)
This study has been added as a sub study to the Simulation Training for Emergency Department Imaging 2 study (ClinicalTrials.gov ID NCT05427838).
- Conditions
- Fracture, Bone Fracture, Dislocation, Fracture Multiple
- Trial name
- FRACT-AI (NCT06130397)
- Testing
- Cases reading, Ground truthing
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust