Clinical trials: Diagnostic Value
Lung Diseases
Diagnostic Value of Chest Ultrasound in Pediatrics Lung Diseases
To evaluate the accuracy of chest ultrasound for diagnosis of different lung lesions in comparison to the gold standard among children.
- Trial name
- NCT04326972
- Testing
- ultrasound
- Volunteers
- 50 people
- Sponsor
- Assiut University
Rectum Diameter, Constipation
Measurement of Ultrasonographic Rectal Diameter in Children With Constipation
The aim of this study is to evaluate the diagnostic accuracy of rectal diameter measured by ultrasonography in predicting constipation defined by clinical criteria.
- Conditions
- Rectum Diameter, Constipation, Rome IV Functional Constipation
- Trial name
- NCT07656896
- Testing
- Ultrasonographic rectal diameter measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Congenital Heart Disease
Calprotectin and Gut Disease Study
Necrotising enterocolitis (NEC) is a serious gut disease that can develop in infants born with cardiac defects. It causes inflammation and injury to the gut mucosa and may be life-threatening.1 The aetiology of NEC in cardiac…
- Trial name
- SAFE NEC (NCT07112794)
- Volunteers
- 300 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Hyperthyroidism/Thyrotoxicosis
Clinical Value of Microvascular Ultrasonography in Real-time Differential Diagnosis of Thyrotoxic Patients
This study aims to verify the clinical value of thyroid ultrasound with microvascular flow imaging in thyrotoxic patients for differential diagnosis between hyperthyroidism and thyroiditis.
- Trial name
- NCT04879173
- Testing
- RS85 Ultrasound device
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Dong Jun Lim
Value of Smartphone in Epilepsy
Diagnostic Value of Smartphone Video in Epileptic Seizures
1. Accuracy of seizure diagnosis based on smartphone seizure semiology anaysis 2. Assess the factors that affect the diagnostic reliability of smartphone videos
- Trial name
- NCT05574725
- Testing
- Smartphone
- Volunteers
- 84 people
- Sponsor
- Assiut University
Mediastinal Lymphadenopathy
Transbronchial Mediastinal Cryobiopsy Combined With EBUS-TBNA in the Diagnosis of Mediastinal Lesions
The clinical study is aimed to prospectively evaluate the diagnostic accuracy and the safety of adding transbronchial mediastinal cryobiopsy to standard sampling in mediastinal diseases.
- Trial name
- NCT04572984
- Testing
- EBUS-TBMCB
- Where
- 2 sites in China, Germany
- Volunteers
- 271 people
- Sponsor
- Third Military Medical University
Hepatoblastoma, Hepatic Hemangioendothelioma
PIVKA-II Combined With Alpha-Fetoprotein for Diagnostic and Prognostic Value of Hepatic Tumors in Infants
Although hepatic tumors are uncommon in the perinatal period they are associated with significant morbidity and mortality in affected patients.
- Trial name
- PIVKA-II (NCT03645655)
- Testing
- PIVKA-II
- Where
- China
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Shanghai Children's Medical Center
Neonatal Sepsis
Clinical Value of Metagenomic Sequencing in Neonatal Sepsis
This study aimed to enroll 2000 neonatal patients with suspected sepsis or clinical diagnosed sepsis. These patients will undergo both conventional methods and metagenomics sequencing to detect the pathogenic microorganisms of…
- Trial name
- NCT05416918
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Children's Hospital of Fudan University
Infection
Biological Markers for the Diagnosis of Central Nervous System Infective Diseases
Bacterial meningitis is a potentially life-threatening disease that is associated with substantial neurological morbidity and mortality. Accurate diagnosis is essential to improve outcome and prevent antibiotic overuse.
- Trial name
- NCT02278016
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Endometriosis
Diagnosis of Pelvic Endometriosis in MRI
Purpose： Evaluate the feasibility of R2 star multiple fast gradient recalled echo (R2*MFGRE) imaging in the diagnosis of pelvic endometriosis.
- Trial name
- NCT06157528
- Testing
- Magnetic resonance imaging
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zhenshen Ma
Gastric Cancer
The Value of TFF3 in Diagnosis of Gastric Cancer
Gastric cancer (GC), is a cancer developing from the inner lining of the stomach .The most common cause is infection by the bacterium Helicobacter pylori,which accounts for 60% of cases.
- Trial name
- NCT03894384
- Testing
- Trefoil factor family 3 (TFF3),Pepsinogen 1(PG1)
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Neonatal Bacterial Infection
Value for Cord Blood Procalcitonin to Diagnose Early Neonatal Bacterial Infection
After birth, in the presence of risk factors for early neonatal bacterial infection (IBNP), the pediatrician must make a difficult decision quickly or not to prescribe additional examinations and / or hospitalize or not the…
- Trial name
- PCT_CORDON (NCT02858700)
- Testing
- dosage of the umbilical cord blood Procalcitonin for diagnosing of IBNP
- Where
- France
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Dyspnea, Chronic Renal Failure
POCUS VS CT in Diagnosis of Acute Dyspnea in Chronic Hemodialysis Patients
Estimate the predictive value of POCUS in diagnosis of different causes of acute dyspnea in hemodialysis patients and compare between POCUS and CT in differentiation the causes of acute dyspnea in those population.
- Trial name
- NCT05729035
- Testing
- POCUS
- Volunteers
- 100 people
- Sponsor
- Randa Ahmed Sarhan
Cow Milk Allergy
Serum Esnophilic Cationic Protein Level as Diagnostic Marker in Cow Milk Protein Allergy Infants
Characterize the degree of the activation of serum eosinophilc cationic protein (sECP) by measuring its level and establishing whether it is a useful parameter in monitoring oral cow's milk allergy Measure the MPV and NLR levels…
- Trial name
- NCT04684329
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Assiut University
Childhood Cancer, Childhood Solid Tumor
PRecISion Medicine for Children With Cancer
This is a multicentre prospective study of the feasibility and clinical value of a diagnostic service for identifying therapeutic targets and recommending personalised treatment for children and adolescents with high-risk cancer.
- Conditions
- Childhood Cancer, Childhood Solid Tumor, Childhood Brain Tumor, Childhood Leukemia
- Trial name
- PRISM (NCT03336931)
- Testing
- Molecular profiling and drug testing
- Where
- 8 sites in Australia
- Volunteers
- 550 people
- Sponsor
- Sydney Children's Hospitals Network
Genetic, Diagnostic Strategies
A Study of the Value of Trio Genome Sequencing in the Etiological Evaluation of Early-Onset and/or Atypical Psychiatric Disorders Without Intellectual Disability or Congenital Anomalies
According to the World Health Organization, one in eight people worldwide has a mental disorder, defined as a significant impairment in thinking, emotional regulation, or behavior.
- Trial name
- PSYGEN (NCT07686653)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 255 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Developmental Anomalies
Study of the Diagnostic Value of "Rapid" High Throughput Genome Sequencing Analysis in Diagnostic Emergency Situations
Rare diseases (affecting less than one in 2,000 people) are a major public health issue. There are about 8,000 rare diseases and they affect more than 3 million people in France.
- Trial name
- FASTGEN (NCT03956069)
- Testing
- blood sample, genome sequencing
- Where
- France
- Volunteers
- 57 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Complicated Twin Pregnancy
The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies
Recent years, women with infertility have become more and more and thus assisted reproductive technology has been applied in a broad range. And the quantities of twin pregnancies are larger and larger.
- Trial name
- NCT02732717
- Testing
- ultrasound (observation)
- Where
- China
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Perforated Appendicitis
Diagnostic Value of Hyperbilirubinaemia as a Predictive Factor for Appendiceal Perforation in Acute Appendicitis
The values of laboratory examinations which are useful for the diagnoses of appendicitis are white blood cell count (WBC), C-reactive protein (CRP) and erythrocyte blood sedimentation rate (ESR).
- Trial name
- NCT00677417
- Volunteers
- 538 people
- Sponsor
- Ruhr University of Bochum
Latent Tuberculosis Infection, Tuberculosis
Prospective Comparison of the Tuberculin Skin Test and Interferon-Gamma Release Assays in Diagnosing Infection With Mycobacterium Tuberculosis and in Predicting Progression to Tuberculosis
This is a prospective cohort study of persons tested for latent tuberculosis infection at either high risk for exposure to Mycobacterium tuberculosis or high risk for progression to tuberculosis disease.
- Trial name
- NCT01622140
- Where
- 10 sites in United States
- Volunteers
- 21,334 people
- Sponsor
- Centers for Disease Control and Prevention