Clinical trials: Diagnostics
Viral Meningitis
A New Enzymatic Assay for Rapid Diagnosing of Central Nervous System Enteroviral Infection
A new enzymatic assay was developed by NMD Diagnostics for rapid diagnosis of Enteroviral CNS infection. This study will compare this assay to RT-PCR, by testing human CSF samples taken from children at the ER who are undergoing…
- Trial name
- NCT00864903
- Where
- 2 sites in Israel
- Sponsor
- Shaare Zedek Medical Center
Tuberculosis, Tuberculosis, Pulmonary
Diagnosing Tuberculosis in HIV Infected Children in Peru
Tuberculosis is a major cause of mortality among AIDS patients in the developing world. The diagnosis of tuberculosis in HIV infected children is complicated by inefficient and expensive tuberculosis tests and vague diagnostic…
- Conditions
- Tuberculosis, Tuberculosis, Pulmonary, HIV Infections
- Trial name
- NCT00054769
- Where
- Peru
- Volunteers
- 760 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dengue
Clinical Trial of Diagnostic Tests and Clinical Algorithms for Dengue in Febrile Subjects in Endemic Areas in Colombia
The present study aimed to develop a sensitive dengue diagnostic clinical algorithm using the resources that are available at the health care institutions, clinical expertise, and identification of signs and symptoms and…
- Trial name
- NCT04063774
- Testing
- Dengue calculator
- Where
- 3 sites in Colombia
- Volunteers
- 1,045 people
- Sponsor
- Lyda Osorio
Sarcoma
GENSARC 2008 : Medical Economic Evaluation of the Molecular Detection by FISH (Fluorescent in Situ Hybridization) and by PCR (Polymerase Chain Reaction) of Sarcomas Specific Translocations and Amplifications .
The clinical and histological diagnosis of sarcomas is often very difficult. The identification of chromosomal and molecular anomalies, such as amplifications, deletions or fusion genes is a powerful help for establishing a…
- Trial name
- GENSARC (NCT00847691)
- Where
- 8 sites in France
- Volunteers
- 350 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Crohn Disease
Advanced Non-Invasive Diagnostics in Inflammatory Bowel Disease
The purpose of this study is to determine whether Non-invasive endoscopic procedures (pillcam colon capsule endoscopy, PCCE) and non-ionizing radiological modalities (MR enterocolonography, MREC and ultrasound, US) - offer a…
- Trial name
- ANDI (NCT03134586)
- Testing
- Diagnostic imaging
- Where
- 3 sites in Denmark
- Volunteers
- 153 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
HIV
HIV Point-of-Care Test Evaluation in Infants
HIV Point-of-Care tests in Babies Study (BABY) - Operational evaluation of HIV Point-of-Care tests for very early infant HIV diagnostics in infants born to HIV infected mothers in Mbeya, Tanzania.
- Trial name
- BABY (NCT02545296)
- Testing
- In-vitro Diagnostics
- Where
- Tanzania
- Volunteers
- 604 people, healthy volunteers welcome
- Sponsor
- Michael Hoelscher
Food Allergy
Intranasal Diagnostics in Food Allergy: a Feasibility Study
The investigators will conduct low-dose intranasal allergen challenges on children/adolescents with a diagnosis of food allergy to egg/cow's milk/soya/wheat/peanut.
- Trial name
- INDY (NCT02159833)
- Testing
- Intranasal challenge with active substance (food protein)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Imperial College London
Patellofemoral Pain Syndrome
Multidimensional Diagnostics and Effect of Activity Modification in Young Adolescents With Patellofemoral Pain
Problem: Adolescent patellofemoral pain (PFP) is a major problem worldwide and affects 7% of adolescents. Adolescents with PFP have long-lasting severe pain and low quality of life.
- Trial name
- NCT02402673
- Testing
- Temporary activity modification and graded exercises
- Where
- Denmark
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Tuberculosis Diagnosis
Evaluation of New TB Diagnostic Tests (NATs) in Pakistan
This study evaluates two portable molecular tests for tuberculosis (TB), Pluslife MTBC and Ustar PortNAT, during community-based active case-finding activities in Pakistan.
- Trial name
- TB (NCT06984887)
- Testing
- Paired tongue-swab and sputum-based molecular testing for tuberculosis
- Where
- 2 sites in Pakistan
- Volunteers
- 6,100 people, healthy volunteers welcome
- Sponsor
- Mercy Corps Pakistan
HIV Infection
Comparison of HIV Testing Algorithms
The primary objective of the study is to assess whether an improved MSF HIV diagnostic algorithm which includes a simple and easy to perform confirmation test has significantly better positive predictive value than WHO…
- Trial name
- NCT01716299
- Testing
- application of a confirmation test
- Where
- 2 sites in Ethiopia
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Medecins Sans Frontieres, Netherlands
Graft Vs Host Disease, Inflammatory Bowel Diseases
Precision Diagnostics in Inflammatory Bowel Disease, Cellular Therapy and Transplantation (The PREDICT Trial)
The goal of the Precision Diagnosis in Inflammatory Bowel Disease, Cellular Therapies, and Transplantation (PREDICT) trial is to apply a systems-biology approach to enable precision diagnostics for the key immunologic outcomes…
- Conditions
- Graft Vs Host Disease, Inflammatory Bowel Diseases, Functional Gastrointestinal Disorders
- Trial name
- PREDICT (NCT03369353)
- Where
- 4 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Boston Children's Hospital
Craniofacial Abnormalities
Stereo Photogrammetry Imaging in Normal Volunteers and Patients With Head and Facial Malformations
This study will use stereo photogrammetry to: 1) characterize facial features of genetic and congenital malformations; 2) define facial features associated with normal growth and development; and 3) determine if stereo…
- Trial name
- NCT00100529
- Where
- 3 sites in United States, Brazil and 1 more
- Volunteers
- 1,813 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
HIV Infections, Cytomegalovirus
CMV Disease and IRIS in HIV-1 Infected Persons
Various diagnostic methods are available for CMV infection. But none of them could be a standard and highly valuable. Our first goal is to setup a series of molecular diagnostic tools for HIV-1 infected person.
- Trial name
- NCT00456664
- Testing
- IE gene
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Soil-transmitted Helminth Infections
Validating Egg-based Diagnostics and Molecular Markers for the Spread of Anthelmintic Resistance
Soil-transmitted helminths (STHs) are a group of parasitic worms that infect millions of children in sub-tropical and tropical countries, resulting in malnutrition, growth stunting, intellectual retardation and cognitive…
- Trial name
- StarwormsWP1 (NCT03465488)
- Testing
- Albendazole Pill 400mg (GSK)
- Where
- 4 sites in Brazil, Ethiopia and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Ghent
Bacterial Infections
Evaluation of a mNGS Workflow for Infection Diagnosis Using Oxford Nanopore Sequencing.
This is a laboratory evaluation of a new testing methodology for microbiological diagnosis, whereby participant samples received as part of routine care will be divided between the standard diagnostic pathway and this new…
- Trial name
- NCT04864873
- Testing
- Metagenomic next generation sequencing using Oxford Nanopore, Standard microbiological diagnostic pathway
- Where
- New Zealand
- Volunteers
- 400 people
- Sponsor
- Capital and Coast District Health board
Healthy Controls
Healthy Control Population for PAIS-ME/CFS: Study to Evaluate Possible Biomarkers and Methods for Examination of PAIS-ME/CFS Diagnostics in Healthy Volunteers
Using the data from the HelP study, the underlying processes of the diseases ME/CFS and PAIS are to be researched and elucidated.
- Trial name
- HelP (NCT06653712)
- Testing
- Diagnostic Test
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Latent Tuberculosis Infection, Tuberculosis
Diagnosis of Tuberculosis Infection in HIV Co-infected Children
Background: The TB and HIV epidemics are closely linked in developing countries, where 450,000 children die from HIV annually. TB is a major cause of death in HIV-infected children and is reversing gains made in child survival.
- Conditions
- Latent Tuberculosis Infection, Tuberculosis, HIV Infections
- Trial name
- ThrasherIGRA (NCT00541294)
- Where
- South Africa
- Volunteers
- 250 people
- Sponsor
- Case Western Reserve University
Tuberculosis Infection
Evaluating Diagnostics for Paediatric Tuberculosis by Blood Culture
Detection of M. tuberculosis in clinical specimens of children has a low sensitivity because specimens are either difficult to collect or contain low levels of M. tuberculosis.
- Trial name
- NCT01434758
- Where
- Vietnam
- Volunteers
- 560 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Bacterial Infections
Diagnostic Evaluation Study of the BactInsight Blood Culture System in West-Africa
Diagnosis of bloodstream infections (BSI) is done by sampling blood in blood culture bottles that are checked for growth in the microbiology laboratory.
- Trial name
- SIMBLE-FIELD (NCT05722184)
- Testing
- BactInsight blood culture system
- Where
- 2 sites in Benin
- Volunteers
- 1,724 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Infectious Gastroenteritis
Implementation of a Molecular Diagnostic for Pediatric Acute Gastroenteritis: The FilmArray GI Panel IMPACT Study
BioFire Diagnostics, LLC (BioFire) has developed the FilmArray Gastrointestinal (GI) Panel, a rapid, easy to use PCR-based in vitro diagnostic test for the identification of 22 common microorganisms responsible for infectious…
- Trial name
- IMPACT (NCT02248285)
- Testing
- FilmArray™ Gastrointestinal (GI) Panel
- Where
- 5 sites in United States
- Volunteers
- 1,545 people
- Sponsor
- BioFire Diagnostics, LLC