Clinical trials: Diffusion MRI
Brain Injury, Fetus and Neonate
Diffusion-Tensor Magnetic Resonance Imaging (MRI) and the Evaluation of Perinatal Brain Injury
The researchers' objective is to use diffusion-tensor imaging (DTI) to evaluate infants diagnosed with cerebral white matter injury during the neonatal period and identify antenatal risk factors, electronic fetal heart rate…
- Trial name
- NCT00131859
- Testing
- Diffusion-tensor imaging
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Auto-immune Encephalitis
Diffusion Imaging in Acute Auto-immune Encephalitis
The aim of this non randomised retrospective study is to investigate the imaging (MRI) of auto-immune encephalitis at presentation, especially in diffusion-weighted sequences.
- Trial name
- NCT04339205
- Testing
- Analysis of every MRI at presentation of the symptoms and then over a period of 3 to 24 months if available.
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Autism
Magnetic Resonance Imaging of Brain Development in Autism
The purpose of this study is to investigate brain development in autism by longitudinally assessing children with autism, as well as typically developing controls, using advanced MR techniques.
- Trial name
- NCT00449566
- Where
- Netherlands
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Ewing Sarcoma, Osteosarcoma
Osteosarcoma and Ewing Sarcoma Treatment Response Assessment With Functional MRI Imaging in Children and Young Adults
The purpose of the study was to investigate whether functional MRI imaging (diffusion weighted imaging) is useful for monitoring the therapeutic response of bone sarcomas in children and young adults.
- Trial name
- FUBEO (NCT01780779)
- Testing
- MRI
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Late Infantile Metachromatic Leukodystrophy
Imaging Study of the White Matter Lesions in Children With Metachromatic Leucodystrophy
High-field MRI and diffusion tensor imaging with 3D reconstruction of the myelin tracks, in combination with multivoxel proton spectroscopy, will allow to precise more accurately the evolution of the white matter lesions in…
- Trial name
- HCIT-MLD (NCT01325025)
- Testing
- High-field MRI (3 Teslas)
- Where
- 3 sites in France
- Volunteers
- 29 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ovarian Carcinoma
Whole-body Diffusion MRI for Staging, Response Prediction and Detecting Tumor Recurrence in Patients With Ovarian Cancer
The aim of this study is to assess whole body diffusion weighted imaging (WB-DWI) as a non-invasive method for accurate staging of patient suspected having ovarian cancer early treatment assessment detecting tumor recurrence
- Trial name
- S53580 (NCT01657747)
- Testing
- Whole body diffusion-weighted MRI
- Where
- Belgium
- Volunteers
- 350 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Infant Development
Developing Advanced MRI Methods for Detecting the Impact of Nutrients on Infant Brain Development
The purpose is to study the effect of infant nutrition on brain development, as measured using Magnetic Resonance (MR) techniques.
- Trial name
- NCT02058225
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Cholesteatoma
Detection of Cholesteatoma Using Diffusion Magnetic Resonance Imaging
Cholesteatoma is a retraction pocket lined with squamous epithelium lined with keratin debris occurring within pneumatized spaces of the temporal bone.
- Trial name
- NCT03305796
- Testing
- Diffusion magnetic resonance imaging
- Volunteers
- 30 people
- Sponsor
- Assiut University
Thyroid Nodule
B-mode Ultrasound, Sono-Elastography, and Diffusion-weighted Imaging MRI in Thyroid Nodules
To compare the accuracy of the conventional Ultrasound 'TI-RADS', US elastography, DWI MRI, and its ADC value in characterization and differentiation of thyroid nodules.
- Trial name
- NCT06029946
- Testing
- elastography, ultrasound
- Volunteers
- 50 people
- Sponsor
- Assiut University
Stroke, Hemiparesis
Perinatal Stroke: Understanding Brain Reorganization
The incidence of perinatal stroke is relatively common, as high as 1 in 2,300 births, but little is known about the resulting changes in the brain that eventually manifest as cerebral palsy (CP).
- Trial name
- NCT02743728
- Testing
- Magnetic Resonance Imaging, Transcranial Magnetic Stimulation, General Movement Assessment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Tourette Syndrome in Children
The Findings of Magnetic Resonance Imaging in Subtypes of Tics-related Disorders
The findings of resting-state functional magnetic resonance imaging and diffusion spectrum imaging in subtypes of tics-related disorders
- Trial name
- NCT05566496
- Testing
- Brain MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Lymphoma, Hodgkin Lymphoma
Whole-body Diffusion-weighted Magnetic Resonance Imaging for Staging and Treatment Prediction of Lymphoma
Whole body diffusion-weighted imaging is a functional magnetic resonance imaging technique that characterizes tissue by probing changes in water diffusion secondary to differences in the tissue microstructure.
- Conditions
- Lymphoma, Hodgkin Lymphoma, Non-Hodgkin Lymphoma (Follicular, Diffuse B-cel Lymphoma, PTLD and Mantle Cel Lymphoma)
- Trial name
- NCT01231269
- Testing
- MRI
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cervical Spine Herniation
Diffusion Tensor (Magnetic Resonance) Imaging and Tractography in Herniation of the Cervical Spine
This is an investigator-iniated pilot study to determine if MRI with diffusion tensor imaging (DTI) and tractography will yield useful information in patients suspected of having cervical spine disc herniation to provide imaging…
- Trial name
- NCT00599183
- Testing
- MRI-Diffusion Tensor Imaging and Tractrography
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Cedars-Sinai Medical Center
Focal Cortical Dysplasia, Epilepsy
Determining the Extent of Diffusion Tensor Abnormalities in Focal Cortical Dysplasia
Focal cortical dysplasia (FCD) is a common finding in epilepsy surgery in pediatric patients. Children with intractable epilepsy would have extensive tests to identify the cause of epilepsy; this includes MR brain, video EEG and…
- Trial name
- FCP (NCT00687024)
- Testing
- Magnetoencephalography, MR imaging, Diffusion Tensor Imaging
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- The Hospital for Sick Children
Carotid Endarterectomy, Percutaneous Transluminal Angioplasty
Study of Blood Flow Changes and Microemboli During Carotid Surgery
The purpose of this study is to determine the clinical and radiologic implications of the intraoperative microemboli during carotid revascularization.
- Conditions
- Carotid Endarterectomy, Percutaneous Transluminal Angioplasty, Cognitive Aspects, Diffusion Weighted MRI
- Trial name
- NCT01343615
- Testing
- carotid stenting, carotid endarterectomy
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Campinas, Brazil
Sensorineural Hearing Loss
Role of Diffusion Tensor-magnetic Resonance Imaging in Investigating Sensorineural Hearing Loss
DTI and auditory tractography can be incorporated into the diagnostic toolkit for patients who are scheduled to undergo cochlear implantation and whose standard assessments have been unable to determine the functional integrity…
- Trial name
- NCT06434129
- Testing
- DTI
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Assiut University
Renal Disease
Diffusion Weighted Magnetic Resonance Imaging in Chronic Kidney Disease
Chronic kidney disease (CKD) is a common global public health problem and the average incidence of end-stage renal disease in developing countries is 150 per million population, which is lower than that in the developed world
- Trial name
- NCT03174899
- Testing
- Diffusion weighted magnetic resonance imaging
- Volunteers
- 31 people
- Sponsor
- Assiut University
Head and Neck Squamous Cell Carcinoma, Magnetic Resonance Imaging
Temporal Diffusion Spectroscopy MRI in Predicting the CPS of PD-L1 Expression and the Efficacy of Neoadjuvant Therapy
The goal of this observational study is to explore the application of temporal diffusion spectroscopy MRI in head and neck squamous cell carcinoma (HNSCC).
- Conditions
- Head and Neck Squamous Cell Carcinoma, Magnetic Resonance Imaging, Neoadjuvant Therapy
- Trial name
- NCT05964595
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Twin Pregnancy With Antenatal Problem
Diffusion Weighted Magnetic Resonance Imaging of Brain in Monochorionic Twin Pregnancies With Demise of One Fetus
Diffusion weighted imaging (DWI) can reflect the microstructure and pathological changes of tissue, and diffusion tensor imaging (DTI) can quantitatively evaluate the fine structure of white matter in brain.
- Trial name
- NCT04966039
- Testing
- No intervention.
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Endovascular Thrombectomy
Medical Imaging Screening for Posterior-circulation Ischemic Stroke
Patients with ischemic stroke in the posterior circulation continue to have high rates of mortality and disability, even with aggressive treatment.
- Trial name
- NCT06094569
- Testing
- Endovascular Therapy
- Where
- 4 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Tianjin Huanhu Hospital