Clinical trials: Diffusion-weighted MRI
Cholesteatoma
Detection of Cholesteatoma Using Diffusion Magnetic Resonance Imaging
Cholesteatoma is a retraction pocket lined with squamous epithelium lined with keratin debris occurring within pneumatized spaces of the temporal bone.
- Trial name
- NCT03305796
- Testing
- Diffusion magnetic resonance imaging
- Volunteers
- 30 people
- Sponsor
- Assiut University
Traumatic Injuries
Utility of Whole-body MRI in the Detection of Traumatic Injuries of Undetermined Origin in Children
The diagnosis of abuse in children relies heavily on the presence of skeletal and extraskeletal injuries. However, some lesions are not seen by initial skeletal survey.
- Trial name
- PEDIMA (NCT01743703)
- Testing
- diagnostic whole body MRI
- Where
- France
- Volunteers
- 199 people
- Sponsor
- Rennes University Hospital
Adult Supratentorial Primitive Neuroectodermal Tumor (PNET), Ewing Sarcoma of Bone
18F-FLT Positron Emission Tomography and Diffusion-Weighted Magnetic Resonance Imaging in Planning Surgery and Radiation Therapy and Measuring Response in Patients With Newly Diagnosed Ewing Sarcoma
This pilot trial studies fluorine F 18 fluorothymidine (18F-FLT) positron emission tomography and diffusion-weighted magnetic resonance imaging in planing surgery and radiation therapy and measuring response in patients with…
- Conditions
- Adult Supratentorial Primitive Neuroectodermal Tumor (PNET), Ewing Sarcoma of Bone, Extraosseous Ewing Sarcoma, Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
- Trial name
- NCT01825902
- Testing
- fluorine F 18 fluorothymidine, fludeoxyglucose F 18, positron emission tomography
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Gastrointestinal Stromal Tumors
WB-DWI for Early Prediction of Therapy Response in Patients With Advanced Metastatic GIST Treated With Regorafenib
The purpose of this study is to evaluate WB DWI as early predictor of response to treatment with regorafenib or placebo in patients with advanced metastatic GIST.
- Trial name
- NCT01265979
- Testing
- Whole body diffusion MRI
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cryptogenic Epilepsy
Diffusion Tensor Imaging in Epilepsy With Continuous Spikes and Waves During Sleep
Continuous Spikes and Waves during Sleep (CSWS) is a rare paediatric epileptic encephalopathy. Even if the correlation between the severity of the epilepsy and the cognitive consequences is well established, the mechanisms…
- Trial name
- POCS-DTI (NCT03035513)
- Testing
- Continuous spikes and waves during slow sleep (CSWS)
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Osteosarcoma
Diffusion Study on Patients With Osteosarcoma
The aim of the study is to assess the accuracy of dynamic contrast enhanced and diffusion-weighted MR Imaging in evaluating response to chemotherapy in osteosarcoma.
- Trial name
- NCT01615640
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Klinikum Stuttgart
Movement Disorders
Evaluation of Diffusion MRI as a Tool in Planning Deep Brain Stimulation (DBS)
The purpose of this study is to explore the relationship between deep brain stimulation implantation site and DTI (diffusion tensor imaging) derived measures for the region and later compare this to the clinical treatment…
- Trial name
- NCT01975532
- Volunteers
- 13 people
- Sponsor
- University of Aarhus
Endovascular Thrombectomy
Medical Imaging Screening for Posterior-circulation Ischemic Stroke
Patients with ischemic stroke in the posterior circulation continue to have high rates of mortality and disability, even with aggressive treatment.
- Trial name
- NCT06094569
- Testing
- Endovascular Therapy
- Where
- 4 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Tianjin Huanhu Hospital
Focal Epilepsy
Diffusion MRI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery
This project will test the accuracy of a novel diffusion-weighted magnetic resonance imaging (DWMRI) approach using a deep convolutional neural network (DCNN) to predict an optimal resection margin for pediatric epilepsy surgery…
- Trial name
- NCT04986683
- Testing
- Brain magnetic resonance imaging, Neuro-psychology testing
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Rett Syndrome
The Findings of MR Imaging in Rett Syndrome
Introduction: Rett Syndrome is a neurodevelopmental disease that primarily affects girls. Clinically, patients are normal before six months to one and half years old, and then develop progressive severe problems with…
- Trial name
- NCT02903056
- Testing
- Rett Syndrome
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Leukaemia
PUMA (Paediatric Osseous Marrow Assessment)
This is a pilot cancer imaging study investigating change in the apparent diffusion coefficient (ADC) at a single time point post-transplantation in patients.
- Trial name
- PUMA (NCT03466944)
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Endometrial Lesions
DWI MRI for Differentiating Endometrial Lesions in Comparison With Histopathology
The aim of this study is to evaluate the diagnostic accuracy of Diffusion Weighted Magnetic Resonance Imaging (DW MRI) in differentiating benign from malignant endometrial lesions, using histopathological examination as the…
- Trial name
- MRI in ELs (NCT07402421)
- Testing
- Diagnostic imaging (DWI MRI) in comparison with histopathology
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Ovarian Carcinoma
Whole-body Diffusion MRI for Staging, Response Prediction and Detecting Tumor Recurrence in Patients With Ovarian Cancer
The aim of this study is to assess whole body diffusion weighted imaging (WB-DWI) as a non-invasive method for accurate staging of patient suspected having ovarian cancer early treatment assessment detecting tumor recurrence
- Trial name
- S53580 (NCT01657747)
- Testing
- Whole body diffusion-weighted MRI
- Where
- Belgium
- Volunteers
- 350 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Middle Ear Cholesteatoma
How Long Must the MRI Follow-up Last to Safely Identify Middle Ear Residual Cholesteatoma
Previous studies demonstrated the high diagnostic value of non-echoplanar diffusion weighted magnetic resonance imaging (non-EP DWI) for residual cholesteatoma.
- Trial name
- NCT04489550
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Montpellier
Gastro-intestinal Tumor, Accurate Staging
Whole Body Diffusion MRI for Non-invasive Lesion Detection and Therapy Follow-up: Study With Patients With Gastro-intestinal Tumors
The aim of the study is to assess the value of whole body diffusion weighted MR imaging (WB-DWI) as a non-invasive method. On one hand for pretreatment lesion detection and post-therapeutic tumor recurrence but also for early…
- Conditions
- Gastro-intestinal Tumor, Accurate Staging, Whole-body Diffusion Weighted MRI, Non-invasive
- Trial name
- s51240 (NCT01224990)
- Testing
- Whole body diffusion MRI
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ewing Sarcoma, Osteosarcoma
Osteosarcoma and Ewing Sarcoma Treatment Response Assessment With Functional MRI Imaging in Children and Young Adults
The purpose of the study was to investigate whether functional MRI imaging (diffusion weighted imaging) is useful for monitoring the therapeutic response of bone sarcomas in children and young adults.
- Trial name
- FUBEO (NCT01780779)
- Testing
- MRI
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Mediastinal Tumor
Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging
Differentiation between benign and malignant mediastinal tumors as well as characterization and grading of malignancy which is essential for treatment planning as well as for prognosis
- Trial name
- NCT03214341
- Testing
- MRI diffusion
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Assiut University
Premature Infant
Cincinnati Infant Neurodevelopment Early Prediction Study (CINEPS)
The Early Prediction Study is a longitudinal population-based cohort study for very preterm infants ≤32 weeks gestational age. Preterm infants recruited from three greater Cincinnati and two Dayton area neonatal intensive care…
- Trial name
- NCT03345069
- Where
- United States
- Volunteers
- 393 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sarcoma, Bone, Sarcoma, Soft Tissue
Diffusion Weighted Magnetic Resonance in Imaging Younger Patients With Newly Diagnosed Bone or Soft Tissue Sarcomas
Children with sarcomas are routinely assessed with a variety of imaging techniques that involve the use of ionizing radiation. These include computed tomography (CT), nuclear bone scan, and positron emission tomography-CT…
- Conditions
- Sarcoma, Bone, Sarcoma, Soft Tissue, Osteosarcoma, Sarcoma, Ewing
- Trial name
- NCT02415816
- Testing
- Diffusion Weighted Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- St. Jude Children's Research Hospital
Cerebral Palsy, Infant Development
Neuroimaging of Babies During Natural Sleep to Assess Typical Development and Cerebral Palsy
Background: Early diagnosis of cerebral palsy (CP) is crucial, enabling intervention when neuroplasticity is at its highest. Magnetic resonance imaging (MRI) plays a vital role in CP diagnosis.
- Conditions
- Cerebral Palsy, Infant Development, Development, Infant
- Trial name
- NIBS-CP (NCT06396520)
- Testing
- No intervention, observational
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Danish Research Centre for Magnetic Resonance