Clinical trials: Diffusion-weighted MRI
Osteosarcoma, Paget's Disease
Quantitative Imaging Biomarkers of Treatment Response in Osteosarcoma and Ewing Sarcoma
The objective of these studies is to use changes in 3 Tesla MRI measurements of tumor protein content, cell density, and microvessel perfusion, obtained before and after a single cycle of NAC, to predict eventual tumor response…
- Conditions
- Osteosarcoma, Paget's Disease, Ewing Sarcoma
- Trial name
- NCT01882231
- Testing
- DCE-MRI, DW-MRI, MT-MRI, and CEST-MRI
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Gastro-intestinal Tumor, Accurate Staging
Whole Body Diffusion MRI for Non-invasive Lesion Detection and Therapy Follow-up: Study With Patients With Gastro-intestinal Tumors
The aim of the study is to assess the value of whole body diffusion weighted MR imaging (WB-DWI) as a non-invasive method. On one hand for pretreatment lesion detection and post-therapeutic tumor recurrence but also for early…
- Conditions
- Gastro-intestinal Tumor, Accurate Staging, Whole-body Diffusion Weighted MRI, Non-invasive
- Trial name
- s51240 (NCT01224990)
- Testing
- Whole body diffusion MRI
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pediatric Cerebral Stroke, Brain Infarction/Diagnosis
Role of Advanced Magnetic Resonance Imaging in Assessment of Pediatric Cerebral Stroke
Stroke can be ischemic, hemorrhagic, or both. Early recognition and treatment of pediatric stroke are critical in optimizing long-term functional outcomes, reducing morbidity and mortality, and preventing recurrent stroke.
- Trial name
- NCT03617159
- Testing
- Magnetic Resonance Imaging
- Volunteers
- 68 people
- Sponsor
- Assiut University
Fracture
Diffusion MRI and Growth Plate Injuries: Pilot Study
Children who suffer fractures to the growth plates (physes) of their bones are at risk for premature growth arrest which can lead to long term complications.
- Trial name
- NCT01774539
- Testing
- Diffusion MRI
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of British Columbia
Leiomyomas
Diffusion -and Perfusion Weighted MRI for Response Prediction of Symptomatic Leiomyomas Following Uterine Artery Embolization
It is known that volumetric response of leiomyomas following uterine artery embolization correlates well with patients clinical outcome.
- Trial name
- NCT01514617
- Testing
- Diffusion -and perfusion weighted MRI including iv contrast agent injection
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastrointestinal Stromal Tumors
WB-DWI for Early Prediction of Therapy Response in Patients With Advanced Metastatic GIST Treated With Regorafenib
The purpose of this study is to evaluate WB DWI as early predictor of response to treatment with regorafenib or placebo in patients with advanced metastatic GIST.
- Trial name
- NCT01265979
- Testing
- Whole body diffusion MRI
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lymphoma
Diffusion-weighted Magnetic Resonance Imaging in Post Therapy Patients With Lymphoma
The goal of this study is to determine the feasibility of the diffusion weighted Magnetic Resonance Imaging in the evaluation of the treatment response in patients with malignant lymphoma.
- Trial name
- NCT03969381
- Testing
- diffusion weighted magnetic resonance image in lymphoma
- Volunteers
- 50 people
- Sponsor
- Assiut University
Lymphoma, Hodgkin Lymphoma
Whole-body Diffusion-weighted Magnetic Resonance Imaging for Staging and Treatment Prediction of Lymphoma
Whole body diffusion-weighted imaging is a functional magnetic resonance imaging technique that characterizes tissue by probing changes in water diffusion secondary to differences in the tissue microstructure.
- Conditions
- Lymphoma, Hodgkin Lymphoma, Non-Hodgkin Lymphoma (Follicular, Diffuse B-cel Lymphoma, PTLD and Mantle Cel Lymphoma)
- Trial name
- NCT01231269
- Testing
- MRI
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sarcoma, Bone, Sarcoma, Soft Tissue
Diffusion Weighted Magnetic Resonance in Imaging Younger Patients With Newly Diagnosed Bone or Soft Tissue Sarcomas
Children with sarcomas are routinely assessed with a variety of imaging techniques that involve the use of ionizing radiation. These include computed tomography (CT), nuclear bone scan, and positron emission tomography-CT…
- Conditions
- Sarcoma, Bone, Sarcoma, Soft Tissue, Osteosarcoma, Sarcoma, Ewing
- Trial name
- NCT02415816
- Testing
- Diffusion Weighted Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- St. Jude Children's Research Hospital
Cholesteatoma
Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas
Cholesteatoma is a destructive and expanding pathologic condition consisting of keratin pearl arising from a squamous epithelium in the middle ear and/or mastoid process.
- Trial name
- NCT02903550
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Brain Ischemia
Magnetic Resonance Imaging to Investigate Silent Strokes During Neck and Skull Angioplasty
This study will use magnetic resonance imaging (MRI) to determine if silent strokes occur during angioplasty of the blood vessels in the neck or skull.
- Trial name
- NCT00015717
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parotid Tumor
MRI and Fine Needle Aspiration in the Diagnosis of Parotid Tumors
What value is given to MRI diffusion and perfusion sequences in the diagnosis of parotid tumors? Is a fine needle aspiration associated with MRI systematically necessary? The aim of the research is to study the performance of…
- Trial name
- Parotid (NCT05152056)
- Where
- France
- Volunteers
- 133 people
- Sponsor
- University Hospital, Strasbourg, France
Arthritis, Juvenile Idiopathic, Enthesitis-Related Arthritis, Juvenile
Juvenile Arthritis Quantitative Imaging
This observational study aims to develop and validate quantitative magnetic resonance imaging biomarkers as measures of disease activity in juvenile idiopathic arthritis (JIA).
- Trial name
- JAQI (NCT02684695)
- Testing
- MRI scan (adolescent spine protocol), MRI scan (whole body protocol)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Colorectal Neoplasms, Neoplasm Metastases
Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE)
Eligible patients with high risk colorectal malignancy (T3/4, spread greater than 5mm, EMVI positive) will have additional surveillance of breath hold T1, T2 and DW-MRIs (no IV contrast) post surgery six monthly for three years.
- Conditions
- Colorectal Neoplasms, Neoplasm Metastases, Hepatic Neoplasms
- Trial name
- SERENADE (NCT02246634)
- Testing
- Diffusion Weighted MRI scan
- Where
- 13 sites in United Kingdom
- Volunteers
- 282 people
- Sponsor
- Imperial College London
Cerebral Palsy, Infant Development
Neuroimaging of Babies During Natural Sleep to Assess Typical Development and Cerebral Palsy
Background: Early diagnosis of cerebral palsy (CP) is crucial, enabling intervention when neuroplasticity is at its highest. Magnetic resonance imaging (MRI) plays a vital role in CP diagnosis.
- Conditions
- Cerebral Palsy, Infant Development, Development, Infant
- Trial name
- NIBS-CP (NCT06396520)
- Testing
- No intervention, observational
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Danish Research Centre for Magnetic Resonance
Biliary Tract Neoplasm, Cholangiocarcinoma
MRCP Diagnoses EHCC Better When Combined DWI
Researching the diagnostic significance of Biliary Tract Neoplasm under combining DWI sequence with MRCP versus MRCP only separately.
- Trial name
- NCT01595217
- Testing
- 3T MRI
- Where
- China
- Volunteers
- 99 people
- Sponsor
- China Medical University, China