Clinical trials: Digestive System Cancer
Colorectal Polyp, Colorectal Neoplasms
Real-time AI-assisted Endocyroscopy for the Diagnosis of Colorectal Lesions
Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related death worldwide. Colonoscopy is considered the preferred method of screening for colorectal cancer, and early and…
- Trial name
- NCT06791395
- Testing
- Computer-aided diagnosis (CADx) support tool
- Where
- 3 sites in China
- Volunteers
- 570 people
- Sponsor
- The First Hospital of Jilin University
Insulinoma, Nesidioblastosis
68Ga-NOTA-exendin-4 PET/CT for the Localization of Insulinoma and Diagnosis of Nesidioblastosis
This is an open-label positron emission tomography/computed tomography (PET/CT) study to investigate the diagnostic performance and evaluation efficacy of 68Ga-NOTA-exendin-4 in insulinoma and nesidioblastosis patients.
- Trial name
- NCT02560376
- Testing
- 68Ga-NOTA-exendin-4
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Familial Adenomatous Polyposis (FAP)
Observational Familial Adenomatous Polyposis Registry Study In Patients Receiving Celecoxib Compared to Control Patients
This is a registry-based observational study assessing clinical outcomes in FAP patients receiving celecoxib compared with historical/concurrent registry patients who have not received celecoxib.
- Trial name
- NCT00151476
- Testing
- Celecoxib, Routine Medical Care
- Where
- 4 sites in United States, Canada and 2 more
- Volunteers
- 68 people
- Sponsor
- Pfizer
Advanced Solid Tumor
A Phase I/IIa Study of JAB-23E73 in Patients With Advanced Solid Tumors Harboring KRAS Gene Alteration
This is a multicenter, open-label, phase I/IIa to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of pan-KRAS inhibitor JAB-23E73 in patients with advanced solid…
- Trial name
- NCT06959615
- Testing
- JAB-23E73
- Where
- 32 sites in China
- Volunteers
- 334 people
- Sponsor
- Jacobio Pharmaceuticals Co., Ltd.
Colon Adenocarcinoma
Role of Immunoscore® in Stage II-III Colorectal Cancer
The proposed study is a bidirectional analytical study, composed of a retrospective and a prospective cohorts. Patients with stage II - III colorectal cancer undergoing oncological surgery will be analyzed.
- Trial name
- NCT05422547
- Testing
- Immunoscore Colon Test
- Where
- 2 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- D'Or Institute for Research and Education
Colorectal Cancer
Omega-3 Fatty Acids and Postoperative Complications After Colorectal Surgery
To discover whether an Omega-3 fatty acid (eicosapentaenoic acid/EPA and docosahexaensyre/DHA) enriched nutritional supplement given 7 days preoperatively and 7 days postoperatively may reduce the frequency of postoperative…
- Trial name
- omega3 (NCT00488904)
- Testing
- supportan
- Where
- Denmark
- Volunteers
- 148 people
- Sponsor
- Aalborg University Hospital
Colorectal Cancer
Modulatory Effects of Active Drugs on the Endocannabinoid System on Spontaneous and Induced Contractility of the Colon
The endocannabinoid system plays important roles in the modulation of gastrointestinal motility and secretions. These effects are mainly mediated by the activation by the endocannabinoids anandamide (AEA) and…
- Trial name
- CB1 - CONTRACT (NCT05760404)
- Testing
- Surgery for colorectal cancer, in vitro study
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Choledochal Cyst
Efficacy and Safety of Surgical Treatment for Type IVa CBD
This study is a multicenter, bidirectional cohort study aimed at continuously enrolling patients with biliary dilatation from 25 medical centers in China.
- Trial name
- NCT07036848
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Peritoneal Carcinomatosis
Single-photon Emission Computed Tomography (SPECT) to Predict Peritoneal Chemotherapy
SPECT was performed in 51 patients after cytoreductive surgery in combination with intraperitoneal chemotherapy. The detected volume was compared to the number of subsequent sequential postoperative intraperitoneal chemotherapy…
- Trial name
- NCT00997633
- Where
- Sweden
- Volunteers
- 51 people
- Sponsor
- Uppsala University
Lung Cancer, Soft Tissue Sarcoma
Interaction of Docetaxel and Lonafarnib in Patients With Advanced Cancer
To determine the molecular interaction in tumor samples between docetaxel and lonafarnib.
- Conditions
- Lung Cancer, Soft Tissue Sarcoma, Colorectal Carcinoma, Breast Cancer
- Trial name
- NCT00288444
- Testing
- Lonafarnib, Docetaxel
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Emory University
Chemotherapy Induced Oral Mucositis
Effect of Quercetin in Prevention and Treatment of Oral Mucositis
The study aims to evaluate the effect of Quercetin (a natural flavonoid) on prevention of and treatment of chemotherapy-induced oral mucositis in patients with blood malignancies.
- Trial name
- NCT01732393
- Testing
- oral quercetin capsules
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Mashhad University of Medical Sciences
Gastric Cancer
Multivisceral Resections for Locally Advanced Gastric Cancer
The goal of this observational study is to assess whether the postoperative course and survival of patients subject to multivisceral resections for locally advanced gastric cancer (cT4b) were affected by the extent of surgery.
- Trial name
- TOCCATA (NCT06103435)
- Testing
- Extent od surgical resection
- Where
- Poland
- Volunteers
- 1,476 people
- Sponsor
- Jagiellonian University
Colorectal Cancer, Metastatic Cancer
Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs in different ways may kill more tumor cells.
- Trial name
- NCT00006050
- Testing
- FOLFOX regimen, fluorouracil, isolated perfusion
- Where
- 3 sites in France
- Sponsor
- UNICANCER
Colorectal Neoplasia, Colorectal Cancer
The Longterm Risk of Advanced Colorectal Neoplasia After Colonoscopy - A Population-based Cohort Study in Hong Kong
The primary objective of this study is to analyze the 15-year cumulative incidence of advanced colorectal neoplasia and CRC-related mortality after the index colonoscopy.
- Trial name
- ACNC (NCT04815525)
- Where
- Hong Kong
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Rectal Cancer
Evaluating The Response to Pre-Operative Chemotherapy and/or Radiation Therapy For Rectal Cancer Using Three-Dimension Transrectal Ultrasound
Traditional transrectal ultrasound (TRUS) is a technique used to help determine the stage of rectal cancer. All patients at Memorial Sloan-Kettering Cancer Center with rectal cancer have an ultrasound at the beginning of their…
- Trial name
- NCT00597610
- Testing
- Transrectal ultrasound 3-D (TRUS)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lung Cancer, Breast Cancer
Plasma Metabolic Biomarkers for Multi-Cancer Diagnosis
The aim of this observational study is to comprehensively analyze the metabolites in plasma samples from multi-cancer patients using advanced mass spectrometry detection technology, in conjunction with metabolomics approaches.
- Conditions
- Lung Cancer, Breast Cancer, Colorectal Cancer, Thyroid Cancer
- Trial name
- NCT06363123
- Where
- 4 sites in China
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Metastatic Colorectal Cancer
A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer
The purpose of this study is to learn about the effects of three study medicines (encorafenib, cetuximab, and pembrolizumab) given together for the treatment of colorectal cancer that: is metastatic (spread to other parts of the…
- Trial name
- SEAMARK (NCT05217446)
- Testing
- Encorafenib, Cetuximab, Pembrolizumab
- Where
- 59 sites in United States, Australia and 13 more
- Volunteers
- 108 people
- Sponsor
- Pfizer
Colo-rectal Cancer
Clinical Study on the Expression of PHGDH and Its Prognostic Value in Colorectal Cancer Patients Receiving Immunotherapy
This study aims to evaluate the expression characteristics of PHGDH in tumor tissues based on the clinical data and pathological tissue samples of colorectal cancer patients who have previously received immunotherapy, and to…
- Trial name
- NCT07508046
- Testing
- No intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Rectal Cancer, Obesity
Does Obesity Increase the Risk of Conversion and Short Term Complications in Laparoscopic Rectal Surgery?
Obesity is on the rise in the Western population and BMI has been shown to be associated with an increased risk of per- and postoperative complications.
- Trial name
- NCT02153853
- Where
- Denmark
- Volunteers
- 335 people
- Sponsor
- Hvidovre University Hospital
Hepatocellular Carcinoma, Laser Ablation
Laser Ablation for Intermediate and Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombus
Hepatocellular carcinoma (HCC) is the fifth most-common cancer worldwide and the second most-common cause of cancer mortality. Liver resection is the first-line curative treatment for huge HCC.
- Conditions
- Hepatocellular Carcinoma, Laser Ablation, Portal Vein Tumor Thrombus
- Trial name
- NCT02724475
- Testing
- LA, 3D-CRT
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.