Clinical trials: Diphosphonates
Bone Metastases, Neuroendocrine Neoplasm
Bone Metastases in neurOendocrine NEoplasms: naTural History, Prognostic Impact and Therapeutic Approach (MONET)
This is a retrospective/prospective observational multicentric trial on patients with bone metastases from NENs. General objectives: To trace on a national scale the frequency of bone metastases in patients with neuroendocrine…
- Trial name
- MONET (NCT04720391)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- European Institute of Oncology
Osteogenesis Imperfecta
Do Bisphosphonates Alter the Skeletal Response to Mechanical Stimulation in Children With Osteogenesis Imperfecta?
Osteogenesis Imperfecta(OI) is an inherited disorder characterised by extreme fragility of the bones. Bones often break from little or no apparent cause.
- Trial name
- BAMES (NCT03208582)
- Testing
- Risedronate Sodium, Calcichew tablets
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Osteoporosis, Cerebral Palsy
Use of Oral Bisphosphonates in the Treatment of Osteoporosis of Non-walking Children With Cerebral Palsy
It is a double blind randomized study aiming at estimating the efficiency of oral bisphosphonates on the decrease of osteoporosis by comparing the evolution of densitometric values between two groups of children (treatment versus…
- Trial name
- NCT00822029
- Testing
- FOSAMAX
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Department of Clinical Research and Innovation
Crohn's Disease, Osteopenia
Zoledronate for Osteopenia in Pediatric Crohn's
Background: Up to 30% of children and adolescents with Crohn's disease have decreased bone strength, or decrease bone density, called osteopenia.
- Conditions
- Crohn's Disease, Osteopenia, Osteoporosis
- Trial name
- NCT00798473
- Testing
- zoledronic acid, IV saline infusion
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Osteoporosis, Atypical Femoral Fracture
Fracture (FX) Improvement With Teriparatide: FiX-IT Study
This open label comparison study examines the hypothesis that teriparatide given immediately following repair of an atypical subtrochanteric or diaphyseal femoral shaft fracture will enhance healing and improve bone mineral…
- Trial name
- FiX-IT (NCT01705587)
- Testing
- teriparatide
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Susan L. Greenspan
Osteogenesis Imperfecta
Zoledronic Acid in Children (1 -17 Years) With Severe Osteogenesis Imperfecta
This is an extension study to examine the long-term safety and efficacy of zoledronic acid in patients who have completed the core CZOL446H2202 study.
- Trial name
- NCT00131118
- Testing
- Zoledronic Acid
- Where
- 10 sites in United States
- Volunteers
- 127 people
- Sponsor
- Novartis Pharmaceuticals
Osteogenesis Imperfecta
Bisphosphonate Treatment of Osteogenesis Imperfecta
The primary purpose of this trial is to evaluate whether the investigational medication is safe, effective and has the ability to increase spine bone density in osteogenesis imperfecta (OI) patients.
- Trial name
- NCT00063479
- Testing
- Zoledronic Acid
- Where
- 10 sites in United States
- Volunteers
- 158 people
- Sponsor
- Novartis Pharmaceuticals
Postmenopausal Osteoporosis
Resolution of Effect of Bisphosphonates on Bone in Postmenopausal Osteoporosis
This is a 2year observational study that will recruit patients who have previously completed a randomised, open label, parallel, single centre study (TRIO Study) of three bisphosphonates: alendronate, ibandronate and risedronate.
- Trial name
- NCT01406613
- Testing
- Observation
- Where
- United Kingdom
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Bone Fragile, Bisphosphonate-Associated Osteonecrosis
Efficacy and Safety on the Use of Bisphosphonates in Paediatrics
The investigators suppose that the impact of bisphosphonate therapy is beneficial on the bone during the growth period with few adverse events.
- Conditions
- Bone Fragile, Bisphosphonate-Associated Osteonecrosis, Children, Adverse Events
- Trial name
- Bisphosphonate (NCT04012320)
- Testing
- No intervention, observational study
- Where
- France
- Volunteers
- 99 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Breast Cancer
Bisphosphonate and Anastrozole Trial - Bone Maintenance Algorithm Assessment
The purpose of this study is to evaluate the use of an oral bisphosphonate (alendronate) in preventing bone loss in postmenopausal women with early breast cancer who are receiving anastrozole therapy, and to determine how long…
- Trial name
- BATMAN (NCT00122356)
- Testing
- Alendronate sodium
- Where
- 8 sites in Australia
- Volunteers
- 303 people
- Sponsor
- Barwon Health
Osteogenesis Imperfecta
Translational Therapy in Patients With Osteogenesis Imperfecta - A Pilot Trial on Treatment With the Rankl-Antibody Denosumab
Pilot study to assess the efficacy of a therapy with the RANKL-antibody denosumab in children 5-10 years of age with mutation in COL1A1 or COL1A2 leading to Osteogenesis imperfecta.
- Trial name
- OI-AK (NCT01799798)
- Testing
- Denosumab
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Cologne
Osteoporosis
Zometa Study in Pediatric Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia (ALL) is the most common malignancy in children. It accounts for one fourth of all childhood cancers \& 74 % of childhood leukemia.
- Trial name
- NCT01656512
- Testing
- zolendronic acid, calcium & vitamin D
- Where
- Egypt
- Volunteers
- 95 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Bone Density, Pain
Bisphosphonate Therapy in MONA Spectrum Disorder
Multicentric osteolysis, nodulosis and arthropathy (MONA) spectrum disorder is a rare inherited progressive skeletal disorder caused by mutations in the matrix metalloproteinase 2 (MMP2) gene. Treatment options are limited.
- Conditions
- Bone Density, Pain, Fracture
- Trial name
- NCT02823925
- Testing
- Pamidronate or Zoledronate
- Volunteers
- 3 people
- Sponsor
- Medical University Innsbruck
Pre-integration Failure of Dental Implant
Initial Fixation of Bisphosphonate-coated Dental Implants
16 patients will be included. Each patient receives 2 dental implants. One of them is coated with a drug, zoledronate, to improve fixation.
- Trial name
- NCT02044978
- Testing
- Zoledronate-coated dental implant
- Where
- 2 sites in Sweden
- Volunteers
- 16 people
- Sponsor
- Per Aspenberg
Orthodontic Appliance Complication
Effect of Local Subperiosteal Zoledronic Acid Injection on the Survival of Orthodontic Miniscrews
Background: Orthodontic miniscrews are widely used as temporary anchorage devices; however, failure remains a clinical concern. Bisphosphonates may enhance bone stability, but evidence on their local application is limited.
- Trial name
- NCT07546058
- Testing
- Zoledronic Acid, Normal saline (0.9% sodium chloride)
- Where
- Syria
- Volunteers
- 68 people
- Sponsor
- Latakia University
Osteoporosis
Frequency of Zoledronic Acid to Prevent Further Bone Loss in Osteoporotic Patients Requiring Androgen Deprivation Therapy for Prostate Cancer
The aim of this study is to determine if 3 monthly infusions of zoledronic acid, given over one year, improves the bone mineral density in osteoporotic patients undergoing androgen deprivation therapy for prostate cancer
- Trial name
- NCT00520052
- Testing
- zoledronic acid
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- Wirral University Teaching Hospital NHS Trust
Osteogenesis Imperfecta, Osteoporosis
Bisphosphonate Therapy for Osteogenesis Imperfecta
The study is designed to evaluate the efficacy and safety of "Bisphosphonate Therapy for Osteogenesis Imperfecta (OI)." We, the researchers at Indiana University School of Medicine, are characterizing the changes effected by oral…
- Conditions
- Osteogenesis Imperfecta, Osteoporosis, Paget Disease of Bone
- Trial name
- NCT00159419
- Testing
- Alendronate, Pamidronate
- Volunteers
- 18 people
- Sponsor
- Indiana University
Bone Metastases, Breast Cancer
Risk Factors for Skeletal Related Events in Breast Cancer Patients Receiving Bisphosphonates for Bone Metastases
Bone is the most common site of distant breast cancer recurrence, and 65-75% of women with advanced breast cancer will develop bone metastases during the course of their disease.
- Trial name
- PROVISTII (NCT01144481)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Breast Cancer
Safety and Efficacy Study of Intravenous Loading Dose of Ibandronate in Breast Cancer Patients
The purpose of the study is to determine the efficacy and safety of a three time repeated loading dose of intravenous ibandronate (ibandronic acid), 6 mg, in breast cancer patients with painful skeletal metastases.
- Trial name
- NCT00381368
- Testing
- Ibandronic acid
- Where
- 3 sites in Finland
- Volunteers
- 60 people
- Sponsor
- University of Turku
Missing Teeth, Implants
Outcome of Dental Implant Therapy in Patients Treated With Antiresorptive Medication
Aim of the study is to examine the feasibility of dental implant insertion in patients receiving high, adjuvant and low dose > 4 years.
- Conditions
- Missing Teeth, Implants, Cancer, Osteoporosis
- Trial name
- NCT04741906
- Testing
- Dental implant surgery, Prosthetic treatment
- Where
- Denmark
- Volunteers
- 225 people
- Sponsor
- Copenhagen University Hospital at Herlev